{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:43:43Z","timestamp":1792532623700,"version":"4.5.0"},"reference-count":129,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Bia\u0142ystok","award":["B.SUB.24.503"],"award-info":[{"award-number":["B.SUB.24.503"]}]},{"name":"Medical University of Bia\u0142ystok","award":["B.SUB.24.165"],"award-info":[{"award-number":["B.SUB.24.165"]}]},{"name":"Medical University of Bia\u0142ystok","award":["B.SUB.24.559"],"award-info":[{"award-number":["B.SUB.24.559"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A presynaptic protein called \u03b1-synuclein plays a crucial role in synaptic function and neurotransmitter release. However, its misfolding and aggregation have been implicated in a variety of neurodegenerative diseases, particularly Parkinson\u2019s disease, dementia with Lewy bodies, and multiple system atrophy. Emerging evidence suggests that \u03b1-synuclein interacts with various cellular pathways, including mitochondrial dysfunction, oxidative stress, and neuroinflammation, which contributes to neuronal cell death. Moreover, \u03b1-synuclein has been involved in the propagation of neurodegenerative processes through prion-like mechanisms, where misfolded proteins induce similar conformational changes in neighboring neurons. Understanding the multifaced roles of \u03b1-synuclein in neurodegeneration not only aids in acquiring more knowledge about the pathophysiology of these diseases but also highlights potential biomarkers and therapeutic targets for intervention in alpha-synucleinopathies. In this review, we provide a summary of the mechanisms by which \u03b1-synuclein contributes to neurodegenerative processes, focusing on its misfolding, oligomerization, and the formation of insoluble fibrils that form characteristic Lewy bodies. Furthermore, we compare the potential value of \u03b1-synuclein species in diagnosing and differentiating selected neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/ijms25179197","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T05:16:24Z","timestamp":1724649384000},"page":"9197","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The Role of \u03b1-Synuclein in Etiology of Neurodegenerative Diseases"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-5232","authenticated-orcid":false,"given":"Daria","family":"Krawczuk","sequence":"first","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Groblewska","sequence":"additional","affiliation":[{"name":"Department of Biochemical Diagnostics, University Hospital in Bia\u0142ystok, 15-269 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Mroczko","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Winkel","sequence":"additional","affiliation":[{"name":"Dementia Disorders Centre, Medical University of Wroclaw, 50-425 \u015acinawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-8479","authenticated-orcid":false,"given":"Barbara","family":"Mroczko","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"},{"name":"Department of Biochemical Diagnostics, University Hospital in Bia\u0142ystok, 15-269 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.stem.2023.03.017","article-title":"Advancing cell therapy for neurodegenerative diseases","volume":"30","author":"Temple","year":"2023","journal-title":"Cell Stem Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/imm.12922","article-title":"Inflammation in CNS neurodegenerative diseases","volume":"154","author":"Stephenson","year":"2018","journal-title":"Immunology"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Singh, A., Kukreti, R., Saso, L., and Kukreti, S. 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