{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:52:30Z","timestamp":1780699950684,"version":"3.54.1"},"reference-count":39,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea","award":["2017R1C1B5015547"],"award-info":[{"award-number":["2017R1C1B5015547"]}]},{"name":"National Research Foundation of Korea","award":["2019R1F1A1060787"],"award-info":[{"award-number":["2019R1F1A1060787"]}]},{"name":"National Research Foundation of Korea","award":["2022R1A2C1010554"],"award-info":[{"award-number":["2022R1A2C1010554"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Recent studies have highlighted the potential of Mesenchymal Stem Cells (MSCs) as an alternative treatment for Alopecia Areata (AA) due to their immunosuppressive properties. While MSCs have shown promise in cell experiments, their effectiveness in vivo remains uncertain. This study aims to validate local administration of MSC therapy\u2019s efficacy in AA treatment through animal experiments. AA was induced through Interferon-gamma (IFN-\u03b3) administration in mice, and MSC treatment (MSCT)\u2019s effects were assessed visually and through tissue analysis. The MSC-treated group showed more hair regrowth compared to the control (CTL) group. MSCT notably reduced local inflammatory cytokines (JAK1, JAK2, STAT1, STAT3, IFN-\u03b3R, IL-1\u03b2, IL-16, IL-17\u03b1, and IL-18) in AA-induced mice\u2019s skin, but systemic cytokine levels remained unchanged. Furthermore, MSC treatment normalized the expression of Wnt\/\u03b2-catenin signaling pathway genes (LEF1 and \u03b2-catenin) and growth factors (FGF7 and FGF2), which are crucial for hair cycle regulation. This study lays the groundwork for further exploring MSCs as a potential treatment for AA, but more research is needed to fully understand their therapeutic potential.<\/jats:p>","DOI":"10.3390\/ijms25179236","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T07:53:37Z","timestamp":1724658817000},"page":"9236","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mesenchymal Stem Cell Therapy in Alopecia Areata: Visual and Molecular Evidence from a Mouse Model"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-9383","authenticated-orcid":false,"given":"Song-Hee","family":"Park","sequence":"first","affiliation":[{"name":"Department of Dermatology, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-0761","authenticated-orcid":false,"given":"Seo-Won","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-5586","authenticated-orcid":false,"given":"Yu-Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-4760","authenticated-orcid":false,"given":"Hoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1670-0995","authenticated-orcid":false,"given":"Jung-Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/jid.2013.464","article-title":"Lifetime incidence risk of alopecia areata estimated at 2.1% by Rochester Epidemiology Project, 1990\u20132009","volume":"134","author":"Mirzoyev","year":"2014","journal-title":"J. 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