{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:08:51Z","timestamp":1791828531407,"version":"4.3.4"},"reference-count":48,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UNESP (PROPG\/PROPE N\u00b0 05\/2022","award":["4313\/2022 PROPG\/PROPE N\u00b0 05\/2022"],"award-info":[{"award-number":["4313\/2022 PROPG\/PROPE N\u00b0 05\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of proline- and glutamine-rich proteins, widely termed \u201cgluten\u201d, in genetically susceptible individuals. CD induces an altered immune response that leads to chronic inflammation and duodenal mucosal damage. Currently, there are no specific tests for the accurate diagnosis of CD, and no drugs are available to treat this condition. The only available treatment strategy is lifelong adherence to a gluten-free diet. However, some studies have investigated the involvement of microRNAs (miRNAs) in CD pathogenesis. miRNAs are small noncoding ribonucleic acid molecules that regulate gene expression. Despite the growing number of studies on the role of miRNAs in autoimmune disorders, data on miRNAs and CD are scarce. Therefore, this study aimed to perform a literature review to summarize CD, miRNAs, and the potential interactions between miRNAs and CD in adults. This review shows that miRNA expression can suppress or stimulate pathways related to CD pathogenesis by regulating cell proliferation and differentiation, regulatory T-cell development, innate immune response, activation of the inflammatory cascade, focal adhesion, T-cell commitment, tissue transglutaminase synthesis, and cell cycle. Thus, identifying miRNAs and their related effects on CD could open new possibilities for diagnosis, prognosis, and follow-up of biomarkers.<\/jats:p>","DOI":"10.3390\/ijms25179412","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T09:39:32Z","timestamp":1725010772000},"page":"9412","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Expression of MicroRNAs in Adults with Celiac Disease: A Narrative Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Francielen Furieri","family":"Rigo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Medical School, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-3468","authenticated-orcid":false,"given":"Ellen Cristina Souza de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Elisa Valencise","family":"Quaglio","sequence":"additional","affiliation":[{"name":"Verum Ingredients, Botucatu Technology Park, Botucatu 18605-525, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Dam\u00e1sio","family":"Moutinho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Division of Clinical Gastroenterology and Hepatology, University of S\u00e3o Paulo School of Medicine (USP), S\u00e3o Paulo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-1073","authenticated-orcid":false,"given":"Luiz Claudio","family":"Di Stasi","sequence":"additional","affiliation":[{"name":"Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTec), Department of Biophysics and Pharmacology, Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-8906","authenticated-orcid":false,"given":"Ligia Yukie","family":"Sassaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/ajg.2015.219","article-title":"Gluten introduction, breastfeeding, and celiac disease: Back to the drawing board","volume":"111","author":"Lebwohl","year":"2016","journal-title":"Am. 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