{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:21:17Z","timestamp":1778170877148,"version":"3.51.4"},"reference-count":49,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007076","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["IG-23794"],"award-info":[{"award-number":["IG-23794"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["SG-2019-12371540"],"award-info":[{"award-number":["SG-2019-12371540"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health \u201cStarting Grant\u201d","doi-asserted-by":"publisher","award":["IG-23794"],"award-info":[{"award-number":["IG-23794"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health \u201cStarting Grant\u201d","doi-asserted-by":"publisher","award":["SG-2019-12371540"],"award-info":[{"award-number":["SG-2019-12371540"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Background: The minor G-allele of FOXO3 rs2802292 is associated with human longevity. The aim of this study was to test the protective effect of the variant against the association with type 2 Diabetes and NAFLD. Methods: rs2802292 was genotyped in a large population of middle-aged subjects (n = 650) from a small city in Southern Italy. All participants were interviewed to collect information about lifestyle and dietary habits; clinical characteristics were recorded, and blood samples were collected from all subjects. The association between rs2802292 and NAFLD or diabetes was tested using a logistic model and mediation analysis adjusted for covariates. Results: Overall, the results indicated a statistical association between diabetes and rs2802292, especially for the TT genotype (OR = 2.14, 1.01 to 4.53 95% C.I., p = 0.05) or in any case for those who possess the G-allele (OR = 0.45, 0.25 to 0.81 95% C.I., p = 0.008). Furthermore, we found a mediation effect of rs2802292 on diabetes (as mediator) and NAFLD. There is no direct relationship between rs2802292 and NAFLD, but the effect is direct (\u03b2 = 0.10, \u22120.003 to 0.12 95% C.I., p = 0.04) on diabetes, but only in TT genotypes. Conclusions: The data on our cohort indicate that the longevity-associated FOXO3 variant may have protective effects against diabetes and NAFLD.<\/jats:p>","DOI":"10.3390\/ijms25179512","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T12:22:33Z","timestamp":1725366153000},"page":"9512","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the Relationship of rs2802292 with Diabetes and NAFLD in a Southern Italian Cohort\u2014Nutrihep Study"],"prefix":"10.3390","volume":"25","author":[{"given":"Giovanna","family":"Forte","sequence":"first","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-673X","authenticated-orcid":false,"given":"Rossella","family":"Donghia","sequence":"additional","affiliation":[{"name":"Data Science Unit, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Lepore Signorile","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7891-6057","authenticated-orcid":false,"given":"Rossella","family":"Tatoli","sequence":"additional","affiliation":[{"name":"Data Science Unit, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-348X","authenticated-orcid":false,"given":"Caterina","family":"Bonfiglio","sequence":"additional","affiliation":[{"name":"Data Science Unit, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Losito","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"De Marco","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Manghisi","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena Anna","family":"Guglielmi","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Disciglio","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candida","family":"Fasano","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Sanese","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Cariola","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia Lucia","family":"Buonadonna","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3843-1618","authenticated-orcid":false,"given":"Valentina","family":"Grossi","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-8060","authenticated-orcid":false,"given":"Gianluigi","family":"Giannelli","sequence":"additional","affiliation":[{"name":"Scientific Direction, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Simone","sequence":"additional","affiliation":[{"name":"Medical Genetics, National Institute of Gastroenterology, IRCCS \u201cSaverio de Bellis\u201d Research Hospital, 70013 Castellana Grotte, Italy"},{"name":"Medical Genetics, Department of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J), University of Bari Aldo Moro, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,1]]},"reference":[{"key":"ref_1","unstructured":"(2024, June 19). 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