{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:12:25Z","timestamp":1775794345501,"version":"3.50.1"},"reference-count":134,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish National Science Centre","award":["2020\/04\/X\/NZ2\/02172"],"award-info":[{"award-number":["2020\/04\/X\/NZ2\/02172"]}]},{"name":"Polish National Science Centre","award":["POLBIOGEN"],"award-info":[{"award-number":["POLBIOGEN"]}]},{"name":"Biocodex Microbiota Foundation","award":["2020\/04\/X\/NZ2\/02172"],"award-info":[{"award-number":["2020\/04\/X\/NZ2\/02172"]}]},{"name":"Biocodex Microbiota Foundation","award":["POLBIOGEN"],"award-info":[{"award-number":["POLBIOGEN"]}]},{"name":"Foundation for the Development of Biotechnology and Genetics","award":["2020\/04\/X\/NZ2\/02172"],"award-info":[{"award-number":["2020\/04\/X\/NZ2\/02172"]}]},{"name":"Foundation for the Development of Biotechnology and Genetics","award":["POLBIOGEN"],"award-info":[{"award-number":["POLBIOGEN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inflammatory bowel disease (IBD) is an incurable, chronic disorder of the gastrointestinal tract whose incidence increases every year. Scientific research constantly delivers new information about the disease and its multivariate, complex etiology. Nevertheless, full discovery and understanding of the complete mechanism of IBD pathogenesis still pose a significant challenge to today\u2019s science. Recent studies have unanimously confirmed the association of gut microbial dysbiosis with IBD and its contribution to the regulation of the inflammatory process. It transpires that the altered composition of pathogenic and commensal bacteria is not only characteristic of disturbed intestinal homeostasis in IBD, but also of viruses, parasites, and fungi, which are active in the intestine. The crucial function of the microbial metabolome in the human body is altered, which causes a wide range of effects on the host, thus providing a basis for the disease. On the other hand, human genomic and functional research has revealed more loci that play an essential role in gut homeostasis regulation, the immune response, and intestinal epithelial function. This review aims to organize and summarize the currently available knowledge concerning the role and interaction of crucial factors associated with IBD pathogenesis, notably, host genetic composition, intestinal microbiota and metabolome, and immune regulation.<\/jats:p>","DOI":"10.3390\/ijms25179589","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T08:46:22Z","timestamp":1725439582000},"page":"9589","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Role of Host Genetics and Intestinal Microbiota and Metabolome as a New Insight into IBD Pathogenesis"],"prefix":"10.3390","volume":"25","author":[{"given":"Oliwia","family":"Zakerska-Banaszak","sequence":"first","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0433-2729","authenticated-orcid":false,"given":"Joanna","family":"Zuraszek-Szymanska","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-5038","authenticated-orcid":false,"given":"Piotr","family":"Eder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Ladziak","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5601-7002","authenticated-orcid":false,"given":"Ryszard","family":"Slomski","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-107X","authenticated-orcid":false,"given":"Marzena","family":"Skrzypczak-Zielinska","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.15585\/mmwr.mm6542a3","article-title":"Prevalence of Inflammatory Bowel Disease Among Adults Aged \u226518 Years\u2014United States, 2015","volume":"65","author":"Dahlhamer","year":"2016","journal-title":"MMWR Morb. 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