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Alternative mRNA splicing (AS) is a key regulatory mechanism underlying these changes. However, the whole status of molecules involved in the splicing process in human HF is unknown. Therefore, we analysed the spliceosome transcriptome in cardiac tissue (n = 36) from control subjects and HF patients (with ischaemic (ICM) and dilated (DCM) cardiomyopathies) using RNA-seq. We found greater deregulation of spliceosome machinery in ICM. Specifically, we showed widespread upregulation of the E and C complex components, highlighting an increase in SNRPD2 (FC = 1.35, p &lt; 0.05) and DHX35 (FC = 1.34, p &lt; 0.001) mRNA levels. In contrast, we observed generalised downregulation of the A complex and cardiac-specific AS factors, such as the multifunctional protein PCBP2 (FC = \u22121.29, p &lt; 0.001) and the RNA binding proteins QKI (FC = \u22121.35, p &lt; 0.01). In addition, we found a relationship between SNPRD2 (an E complex component) and the left ventricular mass index in ICM patients (r = 0.779; p &lt; 0.01). On the other hand, we observed the specific underexpression of DDX46 (FC = \u22121.29), RBM17 (FC = \u22121.33), SDE2 (FC = \u22121.35) and RBFOX1 (FC = \u22121.33), p &lt; 0.05, in DCM patients. Therefore, these aetiology-related alterations may indicate the differential involvement of the splicing process in the development of ICM and DCM.<\/jats:p>","DOI":"10.3390\/ijms25179590","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T08:46:22Z","timestamp":1725439582000},"page":"9590","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Transcriptomic Alterations in Spliceosome Components in Advanced Heart Failure: Status of Cardiac-Specific Alternative Splicing Factors"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0872-1318","authenticated-orcid":false,"given":"Isaac","family":"Gim\u00e9nez-Escamilla","sequence":"first","affiliation":[{"name":"Clinical and Translational Research in Cardiology Unit, Health Research Institute Hospital La Fe (IIS La Fe), Avd. 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Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/labinvest.2014.54","article-title":"RNA-sequencing analysis reveals new alterations in cardiomyocyte cytoskeletal genes in patients with heart failure","volume":"94","author":"Herrer","year":"2014","journal-title":"Lab. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Tarazon, E., Rosello-Lleti, E., Rivera, M., Ortega, A., Molina-Navarro, M.M., Trivino, J.C., Lago, F., Gonzalez-Juanatey, J.R., Orosa, P., and Montero, J.A. (2014). RNA sequencing analysis and atrial natriuretic peptide production in patients with dilated and ischemic cardiomyopathy. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090157"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gimenez-Escamilla, I., Benedicto, C., Perez-Carrillo, L., Delgado-Arija, M., Gonzalez-Torrent, I., Vilchez, R., Martinez-Dolz, L., Portoles, M., Tarazon, E., and Rosello-Lleti, E. (2024). Alterations in Mitochondrial Oxidative Phosphorylation System: Relationship of Complex V and Cardiac Dysfunction in Human Heart Failure. Antioxidants, 13.","DOI":"10.3390\/antiox13030285"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1111\/j.1582-4934.2012.01565.x","article-title":"Cardiac protein changes in ischaemic and dilated cardiomyopathy: A proteomic study of human left ventricular tissue","volume":"16","author":"Alonso","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1242\/dmm.009787","article-title":"Understanding cardiovascular disease: A journey through the genome (and what we found there)","volume":"5","author":"Dopazo","year":"2012","journal-title":"Dis. Models Mech."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.csbj.2020.12.009","article-title":"Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing","volume":"19","author":"Jiang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.cell.2015.05.050","article-title":"SnapShot: Spliceosome Dynamics I","volume":"161","author":"Wahl","year":"2015","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Cao, J., Wei, Z., Nie, Y., and Chen, H.Z. (2024). Therapeutic potential of alternative splicing in cardiovascular diseases. EBioMedicine, 101.","DOI":"10.1016\/j.ebiom.2024.104995"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Badr, E., ElHefnawi, M., and Heath, L.S. (2016). Computational Identification of Tissue-Specific Splicing Regulatory Elements in Human Genes from RNA-Seq Data. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166978"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41392-024-01734-2","article-title":"Alternative splicing and related RNA binding proteins in human health and disease","volume":"9","author":"Tao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7689","DOI":"10.1073\/pnas.1707741114","article-title":"Identification of pathogenic gene mutations in LMNA and MYBPC3 that alter RNA splicing","volume":"114","author":"Ito","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nm.2693","article-title":"RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing","volume":"18","author":"Guo","year":"2012","journal-title":"Nat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1016\/j.celrep.2016.05.002","article-title":"Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes","volume":"15","author":"Nutter","year":"2016","journal-title":"Cell Rep."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Varga, Z.V., Pipicz, M., Baan, J.A., Baranyai, T., Koncsos, G., Leszek, P., Kusmierczyk, M., Sanchez-Cabo, F., Garcia-Pavia, P., and Brenner, G.J. (2017). Alternative Splicing of NOX4 in the Failing Human Heart. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00935"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"D132","DOI":"10.1093\/nar\/gks999","article-title":"Spliceosome database: A tool for tracking components of the spliceosome","volume":"41","author":"Cvitkovic","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"D1003","DOI":"10.1093\/nar\/gkac888","article-title":"Genenames.org: The HGNC resources in 2023","volume":"51","author":"Seal","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCRESAHA.115.307872","article-title":"RNA Splicing: Regulation and Dysregulation in the Heart","volume":"118","author":"Pinto","year":"2016","journal-title":"Circ. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur. J. Heart Fail"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41576-022-00556-8","article-title":"Regulation of pre-mRNA splicing: Roles in physiology and disease, and therapeutic prospects","volume":"24","author":"Rogalska","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41586-019-1523-6","article-title":"A unified mechanism for intron and exon definition and back-splicing","volume":"573","author":"Li","year":"2019","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.1038\/s41467-023-41207-8","article-title":"Coordination of alternative splicing and alternative polyadenylation revealed by targeted long read sequencing","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.4049\/jimmunol.1601872","article-title":"Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation","volume":"199","author":"Qiu","year":"2017","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e003688","DOI":"10.1161\/CIRCHEARTFAILURE.116.003688","article-title":"Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure","volume":"10","author":"Bansal","year":"2017","journal-title":"Circ. Heart Fail."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Hu, Z., Li, M., Huo, Z., Chen, L., Liu, S., Deng, K., Lu, X., Chen, S., Fu, Y., and Xu, A. (2022). U1 snRNP proteins promote proximal alternative polyadenylation sites by directly interacting with 3\u2032 end processing core factors. J. Mol. Cell Biol., 14.","DOI":"10.1093\/jmcb\/mjac054"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ribera, J., Portoles, I., Cordoba-Jover, B., Rodriguez-Vita, J., Casals, G., Gonzalez-de la Presa, B., Graupera, M., Solsona-Vilarrasa, E., Garcia-Ruiz, C., and Fernandez-Checa, J.C. (2021). The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice. Commun. Biol., 4.","DOI":"10.1038\/s42003-021-02722-w"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1261\/rna.078977.121","article-title":"A model for DHX15 mediated disassembly of A-complex spliceosomes","volume":"28","author":"Amorello","year":"2022","journal-title":"RNA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3814747","DOI":"10.1155\/2018\/3814747","article-title":"A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming","volume":"2018","author":"Zhou","year":"2018","journal-title":"Stem Cells Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature10147","article-title":"Heart regeneration","volume":"473","author":"Laflamme","year":"2011","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1038\/s41467-024-47253-0","article-title":"PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5 -splice-site selection causing tissue-specific defects","volume":"15","author":"Atkinson","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1038\/s41467-022-30433-1","article-title":"Autophagy regulation by RNA alternative splicing and implications in human diseases","volume":"13","author":"Klionsky","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1080\/15548627.2018.1501251","article-title":"Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing","volume":"14","author":"Xu","year":"2018","journal-title":"Autophagy"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Chang, X., Toan, S., Li, R., and Zhou, H. (2022). Therapeutic strategies in ischemic cardiomyopathy: Focus on mitochondrial quality surveillance. EBioMedicine, 84.","DOI":"10.1016\/j.ebiom.2022.104260"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ye, J., Ying, J., Chen, H., Wu, Z., Huang, C., Zhang, C., Chen, Z., and Chen, H. (2024). PPIH acts as a potential predictive biomarker for patients with common solid tumors. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12446-9"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6246","DOI":"10.1038\/s41467-022-34042-w","article-title":"Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1016\/j.cub.2021.09.004","article-title":"Coupling of spliceosome complexity to intron diversity","volume":"31","author":"Perry","year":"2021","journal-title":"Curr. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1093\/nar\/gkz150","article-title":"Structural basis for RNA translocation by DEAH-box ATPases","volume":"47","author":"Hamann","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.1523\/JNEUROSCI.2265-04.2004","article-title":"Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity","volume":"24","author":"Dreyer","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Rosello-Lleti, E., Carnicer, R., Tarazon, E., Ortega, A., Gil-Cayuela, C., Lago, F., Gonzalez-Juanatey, J.R., Portoles, M., and Rivera, M. (2016). Human Ischemic Cardiomyopathy Shows Cardiac Nos1 Translocation and its Increased Levels are Related to Left Ventricular Performance. Sci. Rep., 6.","DOI":"10.1038\/srep24060"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Coltri, P., Effenberger, K., Chalkley, R.J., Burlingame, A.L., and Jurica, M.S. (2011). Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019061"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jacc.2009.05.038","article-title":"Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy","volume":"54","author":"Brauch","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yjmcc.2023.04.003","article-title":"Splicing factors in the heart: Uncovering shared and unique targets","volume":"179","author":"Pinto","year":"2023","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.bbamcr.2006.09.003","article-title":"Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22","volume":"1763","author":"Montaville","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.bbamcr.2010.11.010","article-title":"Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7","volume":"1813","author":"Janowicz","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4579806","DOI":"10.1155\/2019\/4579806","article-title":"MicroRNA-155 Promotes Myocardial Infarction-Induced Apoptosis by Targeting RNA-Binding Protein QKI","volume":"2019","author":"Guo","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-020-20327-5","article-title":"QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/cvr\/cvad007","article-title":"The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes","volume":"119","author":"Aufiero","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.bbrc.2015.06.139","article-title":"The RNA-binding protein PCBP2 inhibits Ang II-induced hypertrophy of cardiomyocytes though promoting GPR56 mRNA degeneration","volume":"464","author":"Zhang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/CIRCRESAHA.118.314515","article-title":"Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction","volume":"125","author":"Camafeita","year":"2019","journal-title":"Circ. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1161\/CIRCRESAHA.122.321728","article-title":"RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function","volume":"131","author":"Akerberg","year":"2022","journal-title":"Circ. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E3020","DOI":"10.1073\/pnas.1508461112","article-title":"hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function","volume":"112","author":"Ye","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e162124","DOI":"10.1172\/jci.insight.162124","article-title":"Malat1 deficiency prevents neonatal heart regeneration by inducing cardiomyocyte binucleation","volume":"8","author":"Aslan","year":"2023","journal-title":"JCI Insight"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Soubise, B., Jiang, Y., Douet-Guilbert, N., and Troadec, M.B. (2022). RBM22, a Key Player of Pre-mRNA Splicing and Gene Expression Regulation, Is Altered in Cancer. Cancers, 14.","DOI":"10.3390\/cancers14030643"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1172\/JCI84015","article-title":"RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure","volume":"126","author":"Gao","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/15476286.2023.2239601","article-title":"Pre-mRNA splicing-associated diseases and therapies","volume":"20","author":"Love","year":"2023","journal-title":"RNA Biol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zong, F.Y., Fu, X., Wei, W.J., Luo, Y.G., Heiner, M., Cao, L.J., Fang, Z., Fang, R., Lu, D., and Ji, H. (2014). The RNA-binding protein QKI suppresses cancer-associated aberrant splicing. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004289"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/dvdy.214","article-title":"Spliceosomopathies: Diseases and mechanisms","volume":"249","author":"Griffin","year":"2020","journal-title":"Dev. Dyn."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Love, M.I., Huber, W., and Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol., 15.","DOI":"10.1186\/s13059-014-0550-8"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014A Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: A Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1513\/pats.200701-011GC","article-title":"The Council for International Organizations and Medical Sciences (CIOMS) guidelines on ethics of clinical trials","volume":"4","author":"Macrae","year":"2007","journal-title":"Proc. Am. Thorac. Soc."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/17\/9590\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:48:36Z","timestamp":1760111316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/17\/9590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":69,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["ijms25179590"],"URL":"https:\/\/doi.org\/10.3390\/ijms25179590","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]}}}