{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:25:35Z","timestamp":1787955935491,"version":"build-2784847793"},"reference-count":44,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Better mechanistic understanding of desmosome disruption and acantholysis in Grover\u2019s disease (GD) may improve management of this disease. Recent molecular studies highlighted promising pathways to be explored by directly comparing GD and selected features of associated skin diseases. The association between GD and cutaneous keratinocyte carcinomas, the most prevalent non-melanoma skin cancers (NMSC), is not completely characterized. To review the medical literature regarding GD-associated cutaneous keratinocyte cancers, focusing on molecular features, pathophysiological mechanisms, and disease associations, to help guide future research and patient management. GD has been associated with a variety of skin conditions, but its association with skin cancers has been rarely reported. Between 1983 and 2024, only nine scientific papers presented data supporting this association. Interestingly, we found that GD may mimic multiple NMSCs, as few authors reported GD cases misdiagnosed as multiple cutaneous squamous cell carcinomas for more than 4 years or the presence of superficial basal cell carcinoma-like areas associated with focal acantholysis. In conclusion: (a) GD may be an imitator of multiple NMSCs, and (b) the relationship between GD and NMSCs may reveal promising pathways for the mechanistic understanding of desmosome disruption and acantholysis in GD and may even lead to its reclassification as a distinctive syndrome.<\/jats:p>","DOI":"10.3390\/ijms25179713","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T05:59:08Z","timestamp":1725861548000},"page":"9713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Grover\u2019s Disease Association with Cutaneous Keratinocyte Cancers: More than a Coincidence?"],"prefix":"10.3390","volume":"25","author":[{"given":"Roxana","family":"Nedelcu","sequence":"first","affiliation":[{"name":"Pathophysiology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Derma360 Clinic, 011273 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6052-9027","authenticated-orcid":false,"given":"Alexandra","family":"Dobre","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Oncologic Dermatology Department, Elias Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-6066","authenticated-orcid":false,"given":"Gabriela","family":"Turcu","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Derma360 Clinic, 011273 Bucharest, Romania"},{"name":"Dermatology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan","family":"Andrei","sequence":"additional","affiliation":[{"name":"Dermatology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania"},{"name":"Synevo, 014192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1380-1424","authenticated-orcid":false,"given":"Elena","family":"Balasescu","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentina","family":"Pantelimon","sequence":"additional","affiliation":[{"name":"Derma360 Clinic, 011273 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"David-Niculescu","sequence":"additional","affiliation":[{"name":"Derma360 Clinic, 011273 Bucharest, Romania"},{"name":"Dermatology Department, \u201cGrigore Alexandrescu\u201d Emergency Pediatric Hospital, 011743 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Dobritoiu","sequence":"additional","affiliation":[{"name":"Derma360 Clinic, 011273 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Radu","sequence":"additional","affiliation":[{"name":"Dermatology Department, Central Military Emergency Hospital \u201cDr.Carol Davila\u201d, 010242 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgiana Roxana","family":"Zaharia","sequence":"additional","affiliation":[{"name":"Dermatology Department, Central Military Emergency Hospital \u201cDr.Carol Davila\u201d, 010242 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionela","family":"Hulea","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Brinzea","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Derma360 Clinic, 011273 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cProf. Dr. Matei Bal\u0219\u201d, 021105 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Manea","sequence":"additional","affiliation":[{"name":"Dermatology Department, Piti\u00e9-Salp\u00eatri\u00e8re University Hospital, Public Assistance\u2014Paris Hosiptals\u2014AP-HP\u2014Charles Foix, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Gherghiceanu","sequence":"additional","affiliation":[{"name":"Cellular, Molecular Biology & Histology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Ultrastructural Pathology and Bioimaging Lab, Victor Babe\u015f National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ion","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1001\/archderm.1970.04000040048010","article-title":"Transient Acantholytic Dermatosis","volume":"101","author":"Grover","year":"1970","journal-title":"Arch. 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