{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:52:48Z","timestamp":1790873568885,"version":"4.1.0"},"reference-count":73,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Science Foundation","award":["#24-74-10002"],"award-info":[{"award-number":["#24-74-10002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>According to the current data, the endometrium acts as a \u201csensor\u201d of embryo quality, which promotes the implantation of euploid embryos and prevents the implantation and\/or subsequent development of genetically abnormal embryos. The present review addresses the nature of the \u201csensory function\u201d of the endometrium and highlights the necessity for assessing its functional status. The first section examines the evolutionary origin of the \u201csensory\u201d ability of the endometrium as a consequence of spontaneous decidualization that occurred in placental animals. The second section details the mechanisms for implementing this function at the cellular level. In particular, the recent findings of the appearance of different cell subpopulations during decidualization are described, and their role in implantation is discussed. The pathological consequences of an imbalance among these subpopulations are also discussed. Finally, the third section summarizes information on currently available clinical tools to assess endometrial functional status. The advantages and disadvantages of the approaches are emphasized, and possible options for developing more advanced technologies for assessing the \u201csensory\u201d function of the endometrium are proposed.<\/jats:p>","DOI":"10.3390\/ijms25179746","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T09:21:00Z","timestamp":1725873660000},"page":"9746","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Role of the Endometrium in Implantation: A Modern View"],"prefix":"10.3390","volume":"25","author":[{"given":"Pavel I.","family":"Deryabin","sequence":"first","affiliation":[{"name":"Mechanisms of Cellular Senescence Laboratory, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, Saint-Petersburg 194064, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-7588","authenticated-orcid":false,"given":"Aleksandra V.","family":"Borodkina","sequence":"additional","affiliation":[{"name":"Mechanisms of Cellular Senescence Laboratory, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, Saint-Petersburg 194064, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"ref_1","unstructured":"European IVF Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE), Smeenk, J., Wyns, C., De Geyter, C., Kupka, M., Bergh, C., Cuevas Saiz, I., De Neubourg, D., Rezabek, K., and Tandler-Schneider, A. 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