{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:16:13Z","timestamp":1780359373732,"version":"3.54.1"},"reference-count":68,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ROQUETTE"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>KLEPTOSE\u00ae CRYSMEB methylated cyclodextrin derivative displays less methylated group substitution than randomly methylated cyclodextrin. It has demonstrated an impact on atherosclerosis and neurological diseases, linked in part to cholesterol complexation and immune response, however, its impact on inflammatory cascade pathways is not clear. Thus, the impact of KLEPTOSE\u00ae CRYSMEB on various pharmacological targets was assessed using human umbilical vein endothelial cells under physiological and inflammatory conditions, followed by screening against twelve human primary cell-based systems designed to model complex human tissue and disease biology of the vasculature, skin, lung, and inflammatory tissues using the BioMAP\u00ae Diversity PLUS\u00ae panel. Finally, its anti-inflammatory mechanism was investigated on peripheral blood mononuclear cells to evaluate anti-inflammatory or pro-resolving properties. The results showed that KLEPTOSE\u00ae CRYSMEB can modulate the immune system in vitro and potentially manage vascular issues by stimulating the expression of molecules involved in the crosstalk between immune cells and other cell types. It showed anti-inflammatory effects that were driven by the inhibition of pro-inflammatory cytokine secretion and could have different impacts on different tissue types. Moreover, this cyclodextrin showed no clear impact on pro-resolving lipid mediators. Additionally, it appeared that the mechanism of action of KLEPTOSE\u00ae CRYSMEB seems to not be shared by other well-known anti-inflammatory molecules. Finally, KLEPTOSE\u00ae CRYSMEB may have an anti-inflammatory impact, which could be due to its effect on receptors such as TLR or direct complexation with LPS or PGE2, and conversely, this methylated cyclodextrin could stimulate a pro-inflammatory response involving lipid mediators and on proteins involved in communication with immune cells, probably via interaction with membrane cholesterol.<\/jats:p>","DOI":"10.3390\/ijms25179748","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T09:21:00Z","timestamp":1725873660000},"page":"9748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Methylated Cyclodextrin KLEPTOSE\u00ae CRYSMEB on Inflammatory Responses in Human In Vitro Models"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-4645","authenticated-orcid":false,"given":"Damien","family":"Truffin","sequence":"first","affiliation":[{"name":"Roquette Fr\u00e8res, Rue de la Haute Loge, 62136 Lestrem, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Marchand","sequence":"additional","affiliation":[{"name":"ProfileHIT, 7 Rue du Buisson, 44680 Sainte-Pazanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Chatelais","sequence":"additional","affiliation":[{"name":"ProfileHIT, 7 Rue du Buisson, 44680 Sainte-Pazanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rald","family":"Ch\u00eane","sequence":"additional","affiliation":[{"name":"Ambiotis, 3 Can Biotech 3 r Satellites, 31400 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Saias","sequence":"additional","affiliation":[{"name":"Ambiotis, 3 Can Biotech 3 r Satellites, 31400 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Herbst","sequence":"additional","affiliation":[{"name":"Eurofins Discovery, 6 Research Park Drive, St. Charles, MO 63304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Lipner","sequence":"additional","affiliation":[{"name":"Eurofins Discovery, 6 Research Park Drive, St. Charles, MO 63304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair J.","family":"King","sequence":"additional","affiliation":[{"name":"Eurofins Discovery, 6 Research Park Drive, St. Charles, MO 63304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.fct.2005.03.007","article-title":"2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): A toxicology review","volume":"43","author":"Gould","year":"2005","journal-title":"Food Chem. 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