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Development","award":["R21HD102628"],"award-info":[{"award-number":["R21HD102628"]}]},{"name":"the National Council for Scientific and Technological Development","award":["R21HD113796"],"award-info":[{"award-number":["R21HD113796"]}]},{"name":"the National Council for Scientific and Technological Development","award":["R01DK104375"],"award-info":[{"award-number":["R01DK104375"]}]},{"name":"the National Council for Scientific and Technological Development","award":["R21AI164232"],"award-info":[{"award-number":["R21AI164232"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The two-kidney, one-clip (2K1C) Goldblatt rodent model elicits a reduction in renal blood flow (RBF) in the clipped kidney (CK). The reduced RBF and oxygen bio-ability causes the accumulation of the tricarboxylic cycle intermediary, \u03b1-ketoglutarate, which activates the oxoglutarate receptor-1 (OXGR1). In the kidney, OXGR1 is abundantly expressed in intercalated cells (ICs) of the collecting duct (CD), thus contributing to sodium transport and electrolyte balance. The (pro)renin receptor (PRR), a member of the renin\u2013angiotensin system (RAS), is a key regulator of sodium reabsorption and blood pressure (BP) that is expressed in ICs. The PRR is upregulated in 2K1C rats. Here, we tested the hypothesis that chronic reduction in RBF in the CK leads to OXGR1-dependent PRR upregulation in the CD and alters sodium balance and BP in 2K1C mice. To determine the role of OXGR1 in regulating the PRR in the CDs during renovascular hypertension, we performed 2K1C Goldblatt surgery (clip = 0.13 mm internal gap, 14 days) in two groups of male mice: (1) mice treated with Montelukast (OXGR1 antagonist; 5 mg\/Kg\/day); (2) OXGR1\u2212\/\u2212 knockout mice. Wild-type and sham-operated mice were used as controls. After 14 days, 2K1C mice showed increased systolic BP (SBP) (108 \u00b1 11 vs. control 82 \u00b1 5 mmHg, p &lt; 0.01) and a lower natriuretic response after the saline challenge test. The CK group showed upregulation of erythropoietin, augmented \u03b1-ketoglutarate, and increased PRR expression in the renal medulla. The CK of OXGR1 knockout mice and mice subjected to the OXGR1 antagonist elicited impaired PRR upregulation, attenuated SBP, and better natriuretic responses. In 2K1C mice, the effect of reduced RBF on the OXGR1-dependent PRR upregulation in the CK may contribute to the anti-natriuretic and increased SBP responses.<\/jats:p>","DOI":"10.3390\/ijms251810045","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T03:34:20Z","timestamp":1726716860000},"page":"10045","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["OXGR1-Dependent (Pro)Renin Receptor Upregulation in Collecting Ducts of the Clipped Kidney Contributes to Na+ Balance in Goldblatt Hypertensive Mice"],"prefix":"10.3390","volume":"25","author":[{"given":"Pilar","family":"C\u00e1rdenas","sequence":"first","affiliation":[{"name":"Institute of Chemistry, Pontificia Universidad Cato\u00f3lica de Valparai\u00f3so, Valparai\u00f3so 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9736-637X","authenticated-orcid":false,"given":"Camila","family":"Nu\u00f1ez-Allimant","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Pontificia Universidad Cato\u00f3lica de Valparai\u00f3so, Valparai\u00f3so 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4538-9492","authenticated-orcid":false,"given":"Katherin","family":"Silva","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Pontificia Universidad Cato\u00f3lica de Valparai\u00f3so, Valparai\u00f3so 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Cid-Salinas","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Pontificia Universidad Cato\u00f3lica de Valparai\u00f3so, Valparai\u00f3so 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison C.","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Pontificia Universidad Cato\u00f3lica de Valparai\u00f3so, Valparai\u00f3so 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9776-3298","authenticated-orcid":false,"given":"Zoe","family":"Vallotton","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-6284","authenticated-orcid":false,"given":"Ram\u00f3n A.","family":"Lorca","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5117-6979","authenticated-orcid":false,"given":"Lilian Caroline Gon\u00e7alves de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Disciplina de Nefrologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce E","family":"Casarini","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Disciplina de Nefrologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0297-7598","authenticated-orcid":false,"given":"Carlos","family":"C\u00e9spedes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Science, Universidad San Sebasti\u00e1n, Santiago 7510602, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minolfa C.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-1448","authenticated-orcid":false,"given":"Alexis A.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Pontificia Universidad Cato\u00f3lica de Valparai\u00f3so, Valparai\u00f3so 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1440-1681.2009.05292.x","article-title":"(Pro)renin receptor contributes to diabetic nephropathy by enhancing renal inflammation","volume":"37","author":"Matavelli","year":"2010","journal-title":"Clin. 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