{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:46:52Z","timestamp":1791287212915,"version":"4.1.0"},"reference-count":89,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R01 AI157398-01"],"award-info":[{"award-number":["R01 AI157398-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Many skin diseases begin with inflammatory changes on a molecular level. To develop a more thorough understanding of skin pathology and to identify new targets for therapeutic advancements, molecular mechanisms of inflammation in the context of skin disease should be studied. Current research efforts to better understand skin disease have focused on examining the role of molecular processes at several stages of the inflammatory response such as the dysregulation of innate immunity sensors, disruption of both transcriptional and post-transcriptional regulation, and crosstalk between immune and neuronal processes (neuro-immune crosstalk). This review seeks to summarize recent developments in our understanding of inflammatory processes in skin disease and to highlight opportunities for therapeutic advancements. With a focus on publications within the past 5 years (2019\u20132024), the databases PubMed and EBSCOhost were used to search for peer-reviewed papers regarding inflammatory molecular mechanisms and skin disease. Several themes of research interest regarding inflammatory processes in skin disease were determined through extensive review and were included based on their relative representation in current research and their focus on therapeutic potential. Several skin diseases such as psoriasis, atopic dermatitis, hidradenitis suppurativa, and scleroderma were described in the paper to demonstrate the widespread influence of inflammation in skin disease.<\/jats:p>","DOI":"10.3390\/ijms251810152","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T03:36:38Z","timestamp":1727062598000},"page":"10152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology"],"prefix":"10.3390","volume":"25","author":[{"given":"Simona N.","family":"Shirley","sequence":"first","affiliation":[{"name":"Heersink School of Medicine, University of Alabama-Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4818-1846","authenticated-orcid":false,"given":"Abigail E.","family":"Watson","sequence":"additional","affiliation":[{"name":"College of Medicine, Florida State University, Tallahassee, FL 32306, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5730-0037","authenticated-orcid":false,"given":"Nabiha","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Heersink School of Medicine, University of Alabama-Birmingham, Birmingham, AL 35233, USA"},{"name":"Department of Dermatology, University of Alabama-Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/bs.apcsb.2019.09.001","article-title":"Pattern Recognition Receptors as Potential Drug Targets in Inflammatory Disorders","volume":"Volume 119","author":"McKernan","year":"2020","journal-title":"Advances in Protein Chemistry and Structural Biology"},{"key":"ref_2","first-page":"52","article-title":"Going, Toll-like Receptors in Skin Inflammation and Inflammatory Diseases","volume":"20","author":"Kumar","year":"2021","journal-title":"EXCLI J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Danis, J., and Mellett, M. (2021). Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094677"},{"key":"ref_4","first-page":"1649","article-title":"NLRP1 and NLRP3 Inflammasomes as a New Approach to Skin Carcinogenesis (Review)","volume":"19","author":"Bednarski","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/bjd\/ljad421","article-title":"Role of the NLRP1 Inflammasome in Skin Cancer and Inflammatory Skin Diseases","volume":"190","author":"Calabrese","year":"2024","journal-title":"Br. J. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Yamaguchi, H.L., Yamaguchi, Y., and Peeva, E. (2023). Role of Innate Immunity in Allergic Contact Dermatitis: An Update. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612975"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-med-051113-024537","article-title":"The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention","volume":"66","author":"Schwartz","year":"2015","journal-title":"Annu. Rev. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.abd.2023.03.001","article-title":"JAK-STAT Pathway Inhibitors in Dermatology","volume":"98","author":"Miot","year":"2023","journal-title":"An. Bras. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Furue, M., Hashimoto-Hachiya, A., and Tsuji, G. (2019). Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215424"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5114\/ada.2023.135617","article-title":"Aryl Hydrocarbon Receptor Role in Chronic Inflammatory Skin Diseases: A Narrative Review","volume":"41","author":"Dec","year":"2024","journal-title":"Adv. Dermatol. Allergol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Dopytalska, K., Czaplicka, A., Szyma\u0144ska, E., and Walecka, I. (2023). The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases\u2014A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119130"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00439-023-02588-4","article-title":"Non-Coding RNAs as Skin Disease Biomarkers, Molecular Signatures, and Therapeutic Targets","volume":"143","author":"Sun","year":"2024","journal-title":"Hum. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1111\/jcmm.17473","article-title":"circRNA: Regulatory Factors and Potential Therapeutic Targets in Inflammatory Dermatoses","volume":"26","author":"Liu","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Huang, X., Li, F., and Wang, F. (2023). Neural Regulation of Innate Immunity in Inflammatory Skin Diseases. Pharmaceuticals, 16.","DOI":"10.3390\/ph16020246"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"102212","DOI":"10.1016\/j.coi.2022.102212","article-title":"Neuroimmune Crosstalk in the Skin: A Delicate Balance Governing Inflammatory Processes","volume":"77","author":"Roger","year":"2022","journal-title":"Curr. Opin. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Rendon, A., and Sch\u00e4kel, K. (2019). Psoriasis Pathogenesis and Treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061475"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_18","first-page":"97","article-title":"Current Developments in the Immunology of Psoriasis","volume":"93","author":"Kerstan","year":"2020","journal-title":"Yale J. Biol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hu, P., Wang, M., Gao, H., Zheng, A., Li, J., Mu, D., and Tong, J. (2021). The Role of Helper T Cells in Psoriasis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.788940"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sun, L., Liu, W., and Zhang, L. (2019). The Role of Toll-Like Receptors in Skin Host Defense, Psoriasis, and Atopic Dermatitis. J. Immunol. Res., 1824624.","DOI":"10.1155\/2019\/1824624"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Nakao, M., Sugaya, M., Fujita, H., Miyagaki, T., Morimura, S., Shibata, S., Asano, Y., and Sato, S. (2020). TLR2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation through Decrease in Regulatory T Cells and Impaired IL-10 Production. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228560"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Burian, M., Schmidt, M.F., and Yazdi, A.S. (2023). The NLRP1 Inflammasome in Skin Diseases. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1111611"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ci\u0105\u017cy\u0144ska, M., Olejniczak-Staruch, I., Sobolewska-Sztychny, D., Narbutt, J., Skibi\u0144ska, M., and Lesiak, A. (2021). The Role of NLRP1, NLRP3, and AIM2 Inflammasomes in Psoriasis: Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115898"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"688","DOI":"10.25259\/IJDVL_8_2023","article-title":"JAK Inhibitor: Introduction","volume":"89","author":"Raychaudhuri","year":"2023","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Xiuli, Y., and Honglin, W. (2021). miRNAs Flowing Up and Down: The Concerto of Psoriasis. Front. Med., 8.","DOI":"10.3389\/fmed.2021.646796"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10753-021-01544-6","article-title":"Involvement of miR-214-3p\/FOXM1 Axis During the Progression of Psoriasis","volume":"45","author":"Zhao","year":"2022","journal-title":"Inflammation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4103\/ijd.ijd_305_23","article-title":"A Study of miRNA 223 Expression and Its Correlation with Disease Severity in Chronic Plaque Psoriasis","volume":"68","author":"Bantwal","year":"2023","journal-title":"Indian J. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/15476286.2023.2223486","article-title":"Implications of LncRNAs and CircRNAs in Psoriasis: A Review","volume":"20","author":"Shi","year":"2023","journal-title":"RNA Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"155853","DOI":"10.1016\/j.cyto.2022.155853","article-title":"Corrigendum to \u201cLncRNA MEG3 Suppresses PI3K\/AKT\/mTOR Signalling Pathway to Enhance Autophagy and Inhibit Inflammation in TNF-\u03b1-Treated Keratinocytes and Psoriatic Mice\u201d [Cytokine 148 (2021) 155657]","volume":"153","author":"Tang","year":"2022","journal-title":"Cytokine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/bph.16254","article-title":"Ash1L Ameliorates Psoriasis via Limiting Neuronal Activity-dependent Release of miR-let-7b","volume":"181","author":"Du","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"West, P.W., Tontini, C., Atmoko, H., Kiss, O., Garner, T., Bahri, R., Warren, R.B., Griffiths, C.E.M., Stevens, A., and Bulfone-Paus, S. (2023). Human Mast Cells Upregulate Cathepsin B, a Novel Marker of Itch in Psoriasis. Cells, 12.","DOI":"10.3390\/cells12172177"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sroka-Tomaszewska, J., and Trzeciak, M. (2021). Molecular Mechanisms of Atopic Dermatitis Pathogenesis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084130"},{"key":"ref_33","first-page":"590","article-title":"Atopic Dermatitis: Diagnosis and Treatment","volume":"101","author":"Frazier","year":"2020","journal-title":"Am. Fam. Physician"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Tamagawa-Mineoka, R. (2023). Toll-like Receptors: Their Roles in Pathomechanisms of Atopic Dermatitis. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1239244"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s00403-024-02899-0","article-title":"Cutaneous Inflammasome Driving ASC\/Gasdermin-D Activation and IL-1\u03b2-Secreting Macrophages in Severe Atopic Dermatitis","volume":"316","author":"Ramos","year":"2024","journal-title":"Arch. Dermatol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Tang, L., and Zhou, F. (2020). Inflammasomes in Common Immune-Related Skin Diseases. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00882"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jid.2023.01.013","article-title":"Skin Colonization with S. Aureus Can Lead to Increased NLRP1 Inflammasome Activation in Patients with Atopic Dermatitis","volume":"143","author":"Vaher","year":"2023","journal-title":"J. Investig. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1080\/13880209.2023.2244004","article-title":"Icariin Restrains NLRP3 Inflammasome-Mediated Th2 Immune Responses and Ameliorates Atopic Dermatitis through Modulating a Novel lncRNA MALAT1\/miR-124-3p Axis","volume":"61","author":"Zhao","year":"2023","journal-title":"Pharm. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Chang, Q.-X., Lyu, J.-L., Wu, P.-Y., Wen, K.-C., Chang, C.-C., and Chiang, H.-M. (2023). Coffea Arabica Extract Attenuates Atopic Dermatitis-like Skin Lesions by Regulating NLRP3 Inflammasome Expression and Skin Barrier Functions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512367"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"116344","DOI":"10.1016\/j.jep.2023.116344","article-title":"A Homogeneous Lonicera Japonica Polysaccharide Alleviates Atopic Dermatitis by Promoting Nrf2 Activation and NLRP3 Inflammasome Degradation via P62","volume":"309","author":"Bai","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.jsps.2022.07.003","article-title":"Angelica Yinzi Alleviates 1-Chloro-2,4-Dinitrobenzene-Induced Atopic Dermatitis by Inhibiting Activation of NLRP3 Inflammasome and down-Regulating the MAPKs\/NF-kB Signaling Pathway","volume":"30","author":"Liu","year":"2022","journal-title":"Saudi Pharm. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bbrc.2023.06.072","article-title":"Sodium Thiosulfate Ameliorates Atopic Dermatitis via Inhibiting the Activation of NLRP3 Inflammasome","volume":"673","author":"Wang","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Huang, I.-H., Chung, W.-H., Wu, P.-C., and Chen, C.-B. (2022). JAK\u2013STAT Signaling Pathway in the Pathogenesis of Atopic Dermatitis: An Updated Review. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1068260"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Carreras-Badosa, G., Maslovskaja, J., Vaher, H., Pajusaar, L., Annilo, T., L\u00e4ttekivi, F., H\u00fcbenthal, M., Rodriguez, E., Weidinger, S., and Kingo, K. (2022). miRNA Expression Profiles of the Perilesional Skin of Atopic Dermatitis and Psoriasis Patients Are Highly Similar. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-27235-2"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wang, J., Huang, Y., Wu, X., and Li, D. (2024). MicroRNA-939 Amplifies Staphylococcus Aureus-Induced Matrix Metalloproteinase Expression in Atopic Dermatitis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1354154"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.1111\/jcmm.15208","article-title":"MicroRNAs in Atopic Dermatitis: A Systematic Review","volume":"24","author":"Yu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1002\/hsr2.374","article-title":"Targeting microRNA for Improved Skin Health","volume":"4","author":"Li","year":"2021","journal-title":"Health Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"122713","DOI":"10.1016\/j.lfs.2024.122713","article-title":"Deciphering Epigenetic Regulations in the Inflammatory Pathways of Atopic Dermatitis","volume":"348","author":"Sanabani","year":"2024","journal-title":"Life Sci."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Shefler, A., Patrick, M.T., Wasikowski, R., Chen, J., Sarkar, M.K., Gudjonsson, J.E., and Tsoi, L.C. (2022). Skin-Expressing lncRNAs in Inflammatory Responses. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.835740"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.jaci.2021.11.024","article-title":"Hsa_circ_0004287 Inhibits Macrophage-Mediated Inflammation in an N6-Methyladenosine\u2013Dependent Manner in Atopic Dermatitis and Psoriasis","volume":"149","author":"Yang","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/exd.14227","article-title":"Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression Profiles","volume":"30","author":"Moldovan","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/exd.14382","article-title":"Current Views on Neuropeptides in Atopic Dermatitis","volume":"30","author":"Zhang","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.jaci.2022.03.010","article-title":"Neuroimmune Communication Regulating Pruritus in Atopic Dermatitis","volume":"149","author":"Steinhoff","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2147\/CCID.S306557","article-title":"Relationship of Substance P with the Degree of Atopic Dermatitis Severity","volume":"14","author":"Paramita","year":"2021","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Scala, E., Cacciapuoti, S., Garzorz-Stark, N., Megna, M., Marasca, C., Seiringer, P., Volz, T., Eyerich, K., and Fabbrocini, G. (2021). Hidradenitis Suppurativa: Where We Are and Where We Are Going. Cells, 10.","DOI":"10.3390\/cells10082094"},{"key":"ref_56","first-page":"E449","article-title":"Hidradenitis Suppurativa: Pathogenesis, Clinical Presentation, Epidemiology, and Comorbid Associations","volume":"60","author":"Ahmed","year":"2021","journal-title":"Int. J. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/15384101.2019.1707455","article-title":"Skin Immunity and Its Dysregulation in Atopic Dermatitis, Hidradenitis Suppurativa and Vitiligo","volume":"19","author":"Campione","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/bjd\/ljad184","article-title":"Targeting the NLRP3 Inflammasome Reduces Inflammation in Hidradenitis Suppurativa Skin","volume":"189","author":"Moran","year":"2023","journal-title":"Br. J. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.3390\/cimb46030161","article-title":"The NLRP3 Inflammasome Gene Is Overexpressed in Hidradenitis Suppurativa Lesions: A Preliminary Study on the Role of Pyroptosis in Disease Pathogenesis","volume":"46","author":"Krajewski","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Campbell, C., Mayatra, J.M., Neve, A.J., Fletcher, J.M., and Johnston, D.G.W. (2024). Inflammasomes: Emerging Therapeutic Targets in Hidradenitis Suppurativa?. Br. J. Dermatol., ljae262.","DOI":"10.1093\/bjd\/ljae262"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"McDonald, A., Karnik, R., Campbell, V., Davis, J., Chavoshi, S., Slavin, A., Sharma, K., Gollob, J., and Alavi, A. (J. Investig. Dermatol., 2024). Interleukin 1 Receptor-Associated Kinase 4 Is Overexpressed in Hidradenitis Suppurativa Skin and Correlates with Inflammatory Biomarkers, J. Investig. Dermatol., online ahead of print.","DOI":"10.1016\/j.jid.2024.04.035"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1038\/s41591-023-02635-7","article-title":"IRAK4 Degrader in Hidradenitis Suppurativa and Atopic Dermatitis: A Phase 1 Trial","volume":"29","author":"Ackerman","year":"2023","journal-title":"Nat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Duan, T., Du, Y., Xing, C., Wang, H.Y., and Wang, R.-F. (2022). Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.812774"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"30","DOI":"10.25259\/IJDVL_15_2023","article-title":"Janus-Kinase Inhibitors in Dermatology: A Review of Their Use in Psoriasis, Vitiligo, Systemic Lupus Erythematosus, Hidradenitis Suppurativa, Dermatomyositis, Lichen Planus, Lichen Planopilaris, Sarcoidosis and Graft-versus-Host Disease","volume":"90","author":"Huang","year":"2023","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bjd\/ljad345","article-title":"Hidradenitis Suppurativa: New Insights into Disease Mechanisms and an Evolving Treatment Landscape","volume":"190","author":"Krueger","year":"2024","journal-title":"Br. J. Dermatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s13555-023-00956-6","article-title":"Emerging Treatments and the Clinical Trial Landscape for Hidradenitis Suppurativa Part I: Topical and Systemic Medical Therapies","volume":"13","author":"Fragoso","year":"2023","journal-title":"Dermatol. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Napolitano, M., Fabbrocini, G., Martora, F., Picone, V., Morelli, P., and Patruno, C. (2021). Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases. Cells, 10.","DOI":"10.3390\/cells10123559"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"De Felice, B., Montanino, C., Mallardo, M., Babino, G., Mattera, E., Ragozzino, G., Argenziano, G., Daniele, A., and Nigro, E. (2022). Circulating microRNAs in Hidradenitis Suppurativa. Genes, 13.","DOI":"10.3390\/genes13091544"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Moltrasio, C., Silva, C.A., Tricarico, P.M., Marzano, A.V., Sueleman, M., and Crovella, S. (2024). Biosensing Circulating MicroRNAs in Autoinflammatory Skin Diseases: Focus on Hidradenitis Suppurativa. Front. Genet., 15.","DOI":"10.3389\/fgene.2024.1383452"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1007\/s00018-020-03554-3","article-title":"Long Non-Coding RNAs in Cutaneous Biology and Keratinocyte Carcinomas","volume":"77","author":"Piipponen","year":"2020","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Radhakrishna, U., Ratnamala, U., Jhala, D.D., Uppala, L.V., Vedangi, A., Saiyed, N., Patel, M., Shah, S.R., Rawal, R.M., and Jemec, G.B.E. (2024). Deregulated Long Non-Coding RNAs (lncRNA) as Promising Biomarkers in Hidradenitis Suppurativa. J. Clin. Med., 13.","DOI":"10.3390\/jcm13103016"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4103\/cjp.cjp_67_21","article-title":"Hidradenitis Suppurativa: Disease Pathophysiology and Sex Hormones","volume":"64","author":"Chu","year":"2021","journal-title":"Chin. J. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Abu Rached, N., Gambichler, T., Dietrich, J.W., Ocker, L., Seifert, C., Stockfleth, E., and Bechara, F.G. (2022). The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315250"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijwd.2020.02.005","article-title":"Special Considerations for Women with Hidradenitis Suppurativa","volume":"6","author":"Collier","year":"2020","journal-title":"Int. J. Womens Dermatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s12016-021-08889-8","article-title":"Current Concepts on the Pathogenesis of Systemic Sclerosis","volume":"64","author":"Truchetet","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/kjm2.12505","article-title":"Pathophysiology of Systemic Sclerosis (Scleroderma)","volume":"38","author":"Rosendahl","year":"2022","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/j.jid.2023.04.030","article-title":"Extracellular Matrix\u2013Derived Damage-Associated Molecular Patterns (DAMP): Implications in Systemic Sclerosis and Fibrosis","volume":"143","author":"Bale","year":"2023","journal-title":"J. Investig. Dermatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13075-022-02889-5","article-title":"Role of NLRP3 Inflammasome in Systemic Sclerosis","volume":"24","author":"Lin","year":"2022","journal-title":"Arthritis Res. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e003306","DOI":"10.1136\/rmdopen-2023-003306","article-title":"Dysregulation of Circulating Collagen Turnover Markers in Very Early Systemic Sclerosis","volume":"10","author":"Dobrota","year":"2024","journal-title":"RMD Open"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jdermsci.2018.04.010","article-title":"Tryptophan Photo-Product FICZ Upregulates AHR\/MEK\/ERK-Mediated MMP1 Expression: Implications in Anti-Fibrotic Phototherapy","volume":"91","author":"Murai","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1002\/jcb.24186","article-title":"Alternation of Extracellular Matrix Remodeling and Apoptosis by Activation of the Aryl Hydrocarbon Receptor Pathway in Human Periodontal Ligament Cells","volume":"113","author":"Tomokiyo","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"103168","DOI":"10.1016\/j.autrev.2022.103168","article-title":"JAK Inhibitors and Systemic Sclerosis: A Systematic Review of the Literature","volume":"21","author":"Moriana","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/2397198319865367","article-title":"The JAK\/STAT Pathway Is Activated in Systemic Sclerosis and Is Effectively Targeted by Tofacitinib","volume":"5","author":"Wang","year":"2020","journal-title":"J. Scleroderma Relat. Disord."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"102396","DOI":"10.1016\/j.autrev.2019.102396","article-title":"Role of microRNA in the Pathogenesis of Systemic Sclerosis Tissue Fibrosis and Vasculopathy","volume":"18","author":"Henry","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00403-019-01991-0","article-title":"MicroRNA in Localized Scleroderma: A Review of Literature","volume":"312","author":"Krasowska","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12967-024-05056-3","article-title":"MicroRNA-21a-5p Inhibition Alleviates Systemic Sclerosis by Targeting STAT3 Signaling","volume":"22","author":"Park","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"155124","DOI":"10.1016\/j.cyto.2020.155124","article-title":"Deregulation of Long Noncoding RNAs ANCR, TINCR, HOTTIP and SPRY4-IT1 in Plasma of Systemic Sclerosis Patients: SPRY4-IT1 as a Novel Biomarker of Scleroderma and Its Subtypes","volume":"133","author":"Hassan","year":"2020","journal-title":"Cytokine"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Bellocchi, C., Carandina, A., Montinaro, B., Targetti, E., Furlan, L., Rodrigues, G.D., Tobaldini, E., and Montano, N. (2022). The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052449"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"152268","DOI":"10.1016\/j.semarthrit.2023.152268","article-title":"Autonomic Dysfunction in Systemic Sclerosis: A Scoping Review","volume":"63","author":"Wasson","year":"2023","journal-title":"Semin. Arthritis Rheum."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/18\/10152\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:01:41Z","timestamp":1760112101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/18\/10152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,21]]},"references-count":89,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["ijms251810152"],"URL":"https:\/\/doi.org\/10.3390\/ijms251810152","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,21]]}}}