{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:47:30Z","timestamp":1791859650605,"version":"4.3.4"},"reference-count":213,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Intramural funds from the National Institute of Genomic Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Periodontal disease, a multifactorial inflammatory condition affecting the supporting structures of the teeth, has been increasingly recognized for its association with various systemic diseases. Understanding the molecular comorbidities of periodontal disease is crucial for elucidating shared pathogenic mechanisms and potential therapeutic targets. In this study, we conducted comprehensive literature and biological database mining by utilizing DisGeNET2R for extracting gene\u2013disease associations, Romin for integrating and modeling molecular interaction networks, and Rentrez R libraries for accessing and retrieving relevant information from NCBI databases. This integrative bioinformatics approach enabled us to systematically identify diseases sharing associated genes, proteins, or molecular pathways with periodontitis. Our analysis revealed significant molecular overlaps between periodontal disease and several systemic conditions, including cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, and inflammatory bowel diseases. Shared molecular mechanisms implicated in the pathogenesis of these diseases and periodontitis encompassed dysregulation of inflammatory mediators, immune response pathways, oxidative stress pathways, and alterations in the extracellular matrix. Furthermore, network analysis unveiled the key hub genes and proteins (such as TNF, IL6, PTGS2, IL10, NOS3, IL1B, VEGFA, BCL2, STAT3, LEP and TP53) that play pivotal roles in the crosstalk between periodontal disease and its comorbidities, offering potential targets for therapeutic intervention. Insights gained from this integrative approach shed light on the intricate interplay between periodontal health and systemic well-being, emphasizing the importance of interdisciplinary collaboration in developing personalized treatment strategies for patients with periodontal disease and associated comorbidities.<\/jats:p>","DOI":"10.3390\/ijms251810161","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T03:36:38Z","timestamp":1727062598000},"page":"10161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Molecular Comorbidity Network of Periodontal Disease"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-8500","authenticated-orcid":false,"given":"Mireya","family":"Mart\u00ednez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Immunology, National Institute of Cardiology \u2018Ignacio Ch\u00e1vez\u2019, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-1397","authenticated-orcid":false,"given":"Enrique","family":"Hern\u00e1ndez-Lemus","sequence":"additional","affiliation":[{"name":"Computational Genomics Division, National Institute of Genomic Medicine, Mexico City 14610, Mexico"},{"name":"Center for Complexity Sciences, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Garc\u00eda, M., and Hern\u00e1ndez-Lemus, E. (2021). Periodontal inflammation and systemic diseases: An overview. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.709438"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bj.2018.12.001","article-title":"Association between periodontal pathogens and systemic disease","volume":"42","author":"Bui","year":"2019","journal-title":"Biomed. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"de Molon, R.S., Rossa, C., Thurlings, R.M., Cirelli, J.A., and Koenders, M.I. (2019). Linkage of periodontitis and rheumatoid arthritis: Current evidence and potential biological interactions. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184541"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.disamonth.2011.03.004","article-title":"Periodontal disease in children","volume":"57","author":"Alrayyes","year":"2011","journal-title":"Disease-a-Month"},{"key":"ref_5","first-page":"140","article-title":"Early Manifestation of Periodontal Disease in Children and Its Association with Familial Aggregation","volume":"88","author":"Reis","year":"2021","journal-title":"J. Dent. Child."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1902\/jop.2008.080183","article-title":"Cytokines that promote periodontal tissue destruction","volume":"79","author":"Graves","year":"2008","journal-title":"J. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Balta, M.G., Loos, B.G., and Nicu, E.A. (2017). Emerging concepts in the resolution of periodontal inflammation: A role for resolvin E1. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01682"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1055\/s-0040-1712718","article-title":"Cytokines and chemokines in periodontitis","volume":"14","author":"Ramadan","year":"2020","journal-title":"Eur. J. Dent."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Cecoro, G., Annunziata, M., Iuorio, M.T., Nastri, L., and Guida, L. (2020). Periodontitis, Low-Grade Inflammation and Systemic Health: A Scoping Review. Medicina, 56.","DOI":"10.3390\/medicina56060272"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/prd.12357","article-title":"Periodontal health and disease: The contribution of genetics","volume":"85","author":"Shaddox","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41431-020-00734-4","article-title":"Assessment and visualization of phenome-wide causal relationships using genetic data: An application to dental caries and periodontitis","volume":"29","author":"Haworth","year":"2021","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0757.2011.00415.x","article-title":"Genetic susceptibility to periodontitis","volume":"58","author":"Laine","year":"2012","journal-title":"Periodontol. 2000"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1902\/jop.2000.71.11.1699","article-title":"Evidence of a substantial genetic basis for risk of adult periodontitis","volume":"71","author":"Michalowicz","year":"2000","journal-title":"J. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1038\/s41467-019-10630-1","article-title":"Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data","volume":"10","author":"Shungin","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_16","first-page":"1914073","article-title":"Genetic factors and the risk of periodontitis development: Findings from a systematic review composed of 13 studies of meta-analysis with 71,531 participants","volume":"2017","author":"Alves","year":"2017","journal-title":"Int. J. Dent."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1177\/0022034517699786","article-title":"Genetic susceptibility contributing to periodontal and cardiovascular disease","volume":"96","author":"Aarabi","year":"2017","journal-title":"J. Dent. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/prd.12297","article-title":"The role of inflammation and genetics in periodontal disease","volume":"83","author":"Loos","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.joen.2020.11.014","article-title":"Investigation of Genetic Polymorphisms in BMP2, BMP4, SMAD6, and RUNX2 and Persistent Apical Periodontitis","volume":"47","author":"Hannegraf","year":"2021","journal-title":"J. Endod."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/hmg\/ddab085","article-title":"Runs of homozygosity are associated with staging of periodontitis in isolated populations","volume":"30","author":"Mezzavilla","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"ref_21","first-page":"ZE07","article-title":"Epigenetics and periodontitis: A contemporary review","volume":"10","author":"Ari","year":"2016","journal-title":"J. Clin. Diagn. Res. JCDR"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13148-017-0385-8","article-title":"Epigenetic regulation of inflammation in localized aggressive periodontitis","volume":"9","author":"Shaddox","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bunte, K., and Beikler, T. (2019). Th17 cells and the IL-23\/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143394"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2061868","DOI":"10.1155\/2019\/2061868","article-title":"Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis","volume":"2019","author":"Kavrikova","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Costea, C.A., Christodorescu, R., Soanc\u0103, A., Roman, A., Micu, I.C., Stratul, S.I., Rusu, D., Popescu, D.M., Popa-Wagner, A., and Bulboac\u0103, A.E. (2022). Periodontitis in ischemic stroke patients: Case definition challenges of the new classification scheme (2018). J. Clin. Med., 11.","DOI":"10.3390\/jcm11030520"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"St\u00f8dle, I.H., Sen, A., H\u00f8vik, H., Verket, A., and Koldsland, O.C. (2023). Association between periodontitis stages and self-reported diseases in a Norwegian population: The HUNT study. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-03743-z"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/prd.12421","article-title":"Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities","volume":"89","author":"Hajishengallis","year":"2022","journal-title":"Periodontol. 2000"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/prd.12435","article-title":"Viruses, periodontitis, and comorbidities","volume":"89","author":"Teles","year":"2022","journal-title":"Periodontol. 2000"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/prd.12430","article-title":"Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications","volume":"89","author":"Hajishengallis","year":"2022","journal-title":"Periodontol. 2000"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.dsx.2019.03.023","article-title":"The relationship of diabetes, periodontitis and cardiovascular disease","volume":"13","author":"Khumaedi","year":"2019","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/00325481.2018.1396876","article-title":"Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases","volume":"130","author":"Cardoso","year":"2018","journal-title":"Postgrad. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2334\/josnusd.16-0017","article-title":"Human soluble receptor for advanced glycation end products and tumor necrosis factor-\u03b1 as gingival crevicular fluid and serum markers of inflammation in chronic periodontitis and type 2 diabetes","volume":"58","author":"Singhal","year":"2016","journal-title":"J. Oral Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/jcpe.12884","article-title":"Mediation analysis of systemic inflammation on the association between periodontitis and glycaemic status","volume":"45","author":"Torrungruang","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3892\/etm.2016.3386","article-title":"Co-culture of bone marrow stem cells and macrophages indicates intermediate mechanism between local inflammation and innate immune system in diabetic periodontitis","volume":"12","author":"Wang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/jcpe.13274","article-title":"Treatment of periodontitis reduces systemic inflammation in type 2 diabetes","volume":"47","author":"Preshaw","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41368-019-0054-1","article-title":"Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial\u2013mesenchymal transition in mice","volume":"11","author":"Suh","year":"2019","journal-title":"Int. J. Oral Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/prd.12304","article-title":"Mechanisms underlying the association between periodontitis and atherosclerotic disease","volume":"83","author":"Schenkein","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/JPER.18-0560","article-title":"Periodontitis is associated with systemic inflammation and vascular endothelial dysfunction in patients with lacunar infarct","volume":"90","author":"Leira","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.hlc.2018.05.102","article-title":"Periodontal disease, systemic inflammation and the risk of cardiovascular disease","volume":"27","year":"2018","journal-title":"Heart Lung Circ."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11883-017-0696-4","article-title":"Atherosclerosis, periodontal disease, and treatment with resolvins","volume":"19","author":"Hamilton","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Furutama, D., Matsuda, S., Yamawaki, Y., Hatano, S., Okanobu, A., Memida, T., Oue, H., Fujita, T., Ouhara, K., and Kajiya, M. (2020). IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood\u2013Brain Barrier. Brain Sci., 10.","DOI":"10.3390\/brainsci10100679"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","article-title":"Periodontitis and diabetes: A two-way relationship","volume":"55","author":"Preshaw","year":"2012","journal-title":"Diabetologia"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrendo.2011.106","article-title":"Diabetes mellitus and periodontitis: A tale of two common interrelated diseases","volume":"7","author":"Lalla","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Pan, S., Hu, B., Sun, J., Yang, Z., Yu, W., He, Z., Gao, X., and Song, J. (2022). Identification of cross-talk pathways and ferroptosis-related genes in periodontitis and type 2 diabetes mellitus by bioinformatics analysis and experimental validation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1015491"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/MAJ.0b013e31828bdedf","article-title":"Oral health and type 2 diabetes","volume":"345","author":"Leite","year":"2013","journal-title":"Am. J. Med Sci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Agrafioti, P., Morin-Baxter, J., Tanagala, K.K., Dubey, S., Sims, P., Lalla, E., and Momen-Heravi, F. (2022). Decoding the role of macrophages in periodontitis and type 2 diabetes using single-cell RNA-sequencing. FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol., 36.","DOI":"10.1096\/fj.202101198R"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Almubarak, A., Tanagala, K.K.K., Papapanou, P.N., Lalla, E., and Momen-Heravi, F. (2020). Disruption of monocyte and macrophage homeostasis in periodontitis. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00330"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"de Ara\u00fajo Silva, D.N., Casarin, M., Monajemzadeh, S., de Brito Bezerra, B., Lux, R., and Pirih, F.Q. (2022). The microbiome in periodontitis and diabetes. Front. Oral Health, 3.","DOI":"10.3389\/froh.2022.859209"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.chom.2017.06.014","article-title":"Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity","volume":"22","author":"Xiao","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lu, C., Zhao, Q., Deng, J., Chen, K., Jiang, X., Ma, F., Ma, S., and Li, Z. (2022). Salivary microbiome profile of diabetes and periodontitis in a Chinese population. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.933833"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wu, C.Z., Yuan, Y.H., Liu, H.H., Li, S.S., Zhang, B.W., Chen, W., An, Z.J., Chen, S.Y., Wu, Y.Z., and Han, B. (2020). Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health, 20.","DOI":"10.1186\/s12903-020-01180-w"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1177\/00220345231179897","article-title":"Co-occurrence of periodontitis and diabetes-related complications","volume":"102","author":"Bitencourt","year":"2023","journal-title":"J. Dent. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/prd.12235","article-title":"Periodontal complications of hyperglycemia\/diabetes mellitus: Epidemiologic complexity and clinical challenge","volume":"78","author":"Kocher","year":"2018","journal-title":"Periodontol. 2000"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4093\/dmj.2012.36.6.404","article-title":"Periodontitis and insulin resistance: Casual or causal relationship?","volume":"36","author":"Gurav","year":"2012","journal-title":"Diabetes Metab. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4103\/jispcd.JISPCD_92_22","article-title":"Markers, pathways, and current evidence for periodontitis-associated insulin resistance: A narrative review","volume":"12","author":"Bains","year":"2022","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1507\/endocrj.EJ15-0350","article-title":"Association of periodontitis with insulin resistance, \u03b2-cell function, and impaired fasting glucose before onset of diabetes","volume":"62","author":"SKM","year":"2015","journal-title":"Endocr. J."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhao, P., Xu, A., and Leung, W.K. (2022). Obesity, bone loss, and periodontitis: The interlink. Biomolecules, 12.","DOI":"10.3390\/biom12070865"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41415-019-0611-1","article-title":"Review of obesity and periodontitis: An epidemiological view","volume":"227","author":"Arboleda","year":"2019","journal-title":"Br. Dent. J."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kim, C.M., Lee, S., Hwang, W., Son, E., Kim, T.W., Kim, K., and Kim, Y.H. (2022). Obesity and periodontitis: A systematic review and updated meta-analysis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.999455"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Ladeira, L.L.C., Nascimento, G.G., Leite, F.R.M., Alves-Costa, S., Barbosa, J.M.A., Alves, C.M.C., Thomaz, E.B.A.F., Batista, R.F.L., and Ribeiro, C.C.C. (2023). Obesity, insulin resistance, caries, and periodontitis: Syndemic framework. Nutrients, 15.","DOI":"10.3390\/nu15163512"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1590\/1413-81232014196.13482013","article-title":"Obesity and periodontitis: Systematic review and meta-analysis","volume":"19","author":"Marsicano","year":"2014","journal-title":"Cienc. Saude Coletiva"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/odi.13779","article-title":"Periodontitis is a factor associated with dyslipidemia","volume":"28","author":"Oliveira","year":"2022","journal-title":"Oral Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Bitencourt, F.V., Nascimento, G.G., Costa, S.A., Orrico, S.R.P., Ribeiro, C.C.C., and Leite, F.R.M. (2023). The role of dyslipidemia in periodontitis. Nutrients, 15.","DOI":"10.3390\/nu15020300"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.archoralbio.2014.11.008","article-title":"Interrelationship between diabetes and periodontitis: Role of hyperlipidemia","volume":"60","author":"Zhou","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/jioh.jioh_194_19","article-title":"Statins improve periodontal disease\u2013induced inflammatory changes and associated lipid peroxidation in patients with dyslipidemia: Two birds by one stone","volume":"12","author":"Kadhim","year":"2020","journal-title":"J. Int. Oral Health"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/jcpe.12800","article-title":"Periodontitis and Non-alcoholic Fatty Liver Disease, a population-based cohort investigation in the Study of Health in Pomerania","volume":"44","author":"Akinkugbe","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Hatasa, M., Yoshida, S., Takahashi, H., Tanaka, K., Kubotsu, Y., Ohsugi, Y., Katagiri, T., Iwata, T., and Katagiri, S. (2021). Relationship between NAFLD and periodontal disease from the view of clinical and basic research, and immunological response. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073728"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1007\/s00784-018-2726-1","article-title":"The potential association between periodontitis and non-alcoholic fatty liver disease: A systematic review","volume":"22","author":"Alakhali","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1111\/odi.14785","article-title":"Periodontitis and NAFLD-related diseases: A bidirectional two-sample Mendelian randomization study","volume":"30","author":"Qiao","year":"2023","journal-title":"Oral Diseases"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Xu, W., Zhang, Z., Yao, L., Xue, B., Xi, H., Wang, X., and Sun, S. (2022). Exploration of shared gene signatures and molecular mechanisms between periodontitis and nonalcoholic fatty liver disease. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.939751"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ahj.2021.01.009","article-title":"Periodontal disease, atrial fibrillation and stroke","volume":"235","author":"Sen","year":"2021","journal-title":"Am. Heart J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jacep.2022.08.018","article-title":"Relationship between periodontitis and atrial fibrosis in atrial fibrillation: Histological evaluation of left atrial appendages","volume":"9","author":"Miyauchi","year":"2023","journal-title":"Clin. Electrophysiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e09161","DOI":"10.1016\/j.heliyon.2022.e09161","article-title":"Association between oral health and atrial fibrillation: A systematic review","volume":"8","author":"Leelapatana","year":"2022","journal-title":"Heliyon"},{"key":"ref_75","first-page":"20","article-title":"Potential correlation between periodontitis and coronary heart disease\u2014An overview","volume":"60","author":"Shrihari","year":"2012","journal-title":"Gen. Dent."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/jcpe.12284","article-title":"Periodontitis in coronary heart disease patients: Strong association between bleeding on probing and systemic biomarkers","volume":"41","author":"Bokhari","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1001\/jama.284.11.1406","article-title":"Periodontal disease and coronary heart disease risk","volume":"284","author":"Hujoel","year":"2000","journal-title":"JAMA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ahj.2007.06.037","article-title":"The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: A meta-analysis","volume":"154","author":"Bahekar","year":"2007","journal-title":"Am. Heart J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MBC.0000000000000928","article-title":"Periodontitis, coronary heart disease and myocardial infarction: Treat one, benefit all","volume":"31","author":"Nocini","year":"2020","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ajh.2008.330","article-title":"Association of chronic periodontitis with left ventricular mass and central blood pressure in treated patients with essential hypertension","volume":"22","author":"Franek","year":"2009","journal-title":"Am. J. Hypertens."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.33963\/KP.a2021.0161","article-title":"Periodontitis as an inflammatory trigger in hypertension: From basic immunology to clinical implications","volume":"79","author":"Szczepaniak","year":"2021","journal-title":"Pol. Heart J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/cvr\/cvz201","article-title":"Periodontitis is associated with hypertension: A systematic review and meta-analysis","volume":"116","author":"Suvan","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"768237","DOI":"10.1155\/2014\/768237","article-title":"Association between hypertension and periodontitis: Possible mechanisms","volume":"2014","author":"Leong","year":"2014","journal-title":"Sci. World J."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Rosa, R.A.C., Rodrigues, J.V.S., Cl\u00e1udio, M.M., Franciscon, J.P.S., Mulinari-Santos, G., Cirelli, T., de Molon, R.S., Gouveia Garcia, V., and Theodoro, L.H. (2023). The relationship between hypertension and periodontitis: A cross-sectional study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12155140"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11906-021-01140-x","article-title":"Periodontitis, blood pressure, and the risk and control of arterial hypertension: Epidemiological, clinical, and pathophysiological aspects\u2014Review of the literature and clinical trials","volume":"23","author":"Surma","year":"2021","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Yang, S., Zhao, L.S., Cai, C., Shi, Q., Wen, N., and Xu, J. (2018). Association between periodontitis and peripheral artery disease: A systematic review and meta-analysis. BMC Cardiovasc. Disord., 18.","DOI":"10.1186\/s12872-018-0879-0"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"81","DOI":"10.31083\/j.rcm.2019.02.52","article-title":"The risk of periodontitis for peripheral vascular disease: A systematic review","volume":"20","author":"Wang","year":"2019","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.atherosclerosis.2020.02.012","article-title":"Risk of peripheral arterial disease in patients with periodontitis: A nationwide, population-based, matched cohort study","volume":"297","author":"Cho","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5051\/jpis.2018.48.6.337","article-title":"Accelerated inflammation in peripheral artery disease patients with periodontitis","volume":"48","author":"Kure","year":"2018","journal-title":"J. Periodontal Implant Sci."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Jacobi, N., Walther, C., Borof, K., Heydecke, G., Seedorf, U., Lamprecht, R., Beikler, T., Debus, S.E., Waldeyer, C., and Blankenberg, S. (2021). The association of periodontitis and peripheral arterial occlusive disease in a prospective population-based cross-sectional cohort study. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102048"},{"key":"ref_91","first-page":"527","article-title":"Apical periodontitis and atherosclerosis: Is there a link? Review of the literature and potential mechanism of linkage","volume":"48","author":"Febbraio","year":"2017","journal-title":"Quintessence Int."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/1040841X.2020.1724872","article-title":"Exploring the putative interactions between chronic kidney disease and chronic periodontitis","volume":"46","author":"Hickey","year":"2020","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"6034546","DOI":"10.1155\/2019\/6034546","article-title":"Periodontitis and rheumatoid arthritis: The same inflammatory mediators?","volume":"2019","author":"Ceccarelli","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2907062","DOI":"10.1155\/2019\/2907062","article-title":"Are there any common genetic risk markers for rheumatoid arthritis and periodontal diseases? A case-control study","volume":"2019","author":"Schulz","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Ba\u00f1uelos, E., Mukherjee, A., Darrah, E., and Andrade, F. (2019). Rheumatoid arthritis-associated mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091309"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Pessoa, L., Aleti, G., Choudhury, S., Nguyen, D., Yaskell, T., Zhang, Y., Li, W., Nelson, K.E., Neto, L.L.S., and Sant\u2019Ana, A.C. (2019). Host-microbial interactions in systemic lupus erythematosus and periodontitis. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02602"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"7963","DOI":"10.3748\/wjg.v22.i35.7963","article-title":"Periodontal and inflammatory bowel diseases: Is there evidence of complex pathogenic interactions?","volume":"22","author":"Figueredo","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.joen.2016.11.004","article-title":"Prevalence of apical periodontitis in patients with inflammatory bowel diseases: A retrospective clinical study","volume":"43","author":"Piras","year":"2017","journal-title":"J. Endod."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/prd.12313","article-title":"New developments in neutrophil biology and periodontitis","volume":"82","author":"Hajishengallis","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4103\/jisp.jisp_622_18","article-title":"Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in chronic periodontitis before and after nonsurgical therapy","volume":"23","author":"Acharya","year":"2019","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Wang, Y., Hu, Y., Pan, K., Li, H., Shang, S., Wang, Y., Tang, G., and Han, X. (2020). In-vivo imaging revealed antigen-directed gingival B10 infiltration in experimental periodontitis. Biochim. Biophys. Acta (BBA)-Mol. Basis Dis., 1867.","DOI":"10.1016\/j.bbadis.2020.165991"},{"key":"ref_102","first-page":"1381","article-title":"Oral manifestations of systemic disease","volume":"82","author":"Chi","year":"2010","journal-title":"Am. Fam. Physician"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/odi.12271","article-title":"Association of chronic periodontitis and psoriasis: Periodontal status with severity of psoriasis","volume":"21","author":"Sharma","year":"2015","journal-title":"Oral Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/jdv.14051","article-title":"Periodontitis and risk of psoriasis: A systematic review and meta-analysis","volume":"31","author":"Ungprasert","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/1744666X.2019.1700113","article-title":"Periodontitis: A newly identified comorbidity in psoriasis and psoriatic arthritis","volume":"16","author":"Antal","year":"2020","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/JPER.18-0394","article-title":"Periodontitis as another comorbidity associated with psoriasis: A case-control study","volume":"90","author":"Mendes","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s10157-023-02411-4","article-title":"Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy","volume":"28","author":"Ito","year":"2024","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Nagasawa, Y., Misaki, T., Ito, S., Naka, S., Wato, K., Nomura, R., Matsumoto-Nakano, M., and Nakano, K. (2022). Title IgA nephropathy and oral bacterial species related to dental caries and periodontitis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020725"},{"key":"ref_109","first-page":"43","article-title":"Detection and significance of IL-6 and TNF-\u03b1 in patients with Graves disease and periodontitis","volume":"27","author":"Wang","year":"2018","journal-title":"Shanghai Kou Qiang Yi Xue = Shanghai J. Stomatol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/jre.13240","article-title":"Periodontitis and thyroid function: A bidirectional Mendelian randomization study","volume":"59","author":"Gao","year":"2024","journal-title":"J. Periodontal Res."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Inchingolo, F., Inchingolo, A.M., Inchingolo, A.D., Fatone, M.C., Ferrante, L., Avantario, P., Fiore, A., Palermo, A., Amenduni, T., and Galante, F. (2024). Bidirectional Association between Periodontitis and Thyroid Disease: A Scoping Review. Int. J. Environ. Res. Public Health, 21.","DOI":"10.3390\/ijerph21070860"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Yang, B., Pang, X., Guan, J., Liu, X., Li, X., Wang, Y., Chen, Z., and Cheng, B. (2023). The association of periodontal diseases and Sjogren\u2019s syndrome: A systematic review and meta-analysis. Front. Med., 9.","DOI":"10.3389\/fmed.2022.904638"},{"key":"ref_113","first-page":"163","article-title":"Clinical Evaluation of Periodontal Status and IL-6 Gingival Fluid Level in Patients with Sjogren\u2019s Syndrome","volume":"49","author":"Gheorghe","year":"2023","journal-title":"Curr. Health Sci. J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/jop.13070","article-title":"Association of salivary inflammatory biomarkers with primary Sj\u00f6gren\u2019s syndrome","volume":"49","author":"Serrano","year":"2020","journal-title":"J. Oral Pathol. Med."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Liu, Y., Liu, N., Sun, P., Liu, Y., and Hua, W. (2024). Periodontitis and Sjogren\u2019s syndrome: A bidirectional two-sample mendelian randomization study. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04151-7"},{"key":"ref_116","first-page":"S225","article-title":"Sjogren\u2019s syndrome is not a risk factor for periodontal disease: A systematic review","volume":"37","author":"Maarse","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jds.2020.11.015","article-title":"Periodontal conditions in patients with Sj\u00f6gren\u2019s syndrome: A meta-analysis","volume":"16","author":"Wu","year":"2021","journal-title":"J. Dent. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.oraloncology.2015.11.013","article-title":"Oral microbiome, periodontitis and risk of head and neck cancer","volume":"53","year":"2016","journal-title":"Oral Oncol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1047-2797(02)00425-8","article-title":"An exploration of the periodontitis\u2013cancer association","volume":"13","author":"Hujoel","year":"2003","journal-title":"Ann. Epidemiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jdent.2009.10.007","article-title":"The association between periodontal disease and cancer: A review of the literature","volume":"38","author":"Fitzpatrick","year":"2010","journal-title":"J. Dent."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/0022034519827565","article-title":"Association of periodontitis with oral cancer: A case-control study","volume":"98","author":"Shin","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Shao, J., Wu, L., Leng, W.D., Fang, C., Zhu, Y.J., Jin, Y.H., and Zeng, X.T. (2018). Periodontal disease and breast cancer: A meta-analysis of 173,162 participants. Front. Oncol., 8.","DOI":"10.3389\/fonc.2018.00601"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/epirev\/mxx006","article-title":"Periodontal disease, tooth loss, and cancer risk","volume":"39","author":"Michaud","year":"2017","journal-title":"Epidemiol. Rev."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/annonc\/mdx019","article-title":"Periodontal disease, edentulism, and pancreatic cancer: A meta-analysis","volume":"28","author":"Maisonneuve","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/0022034520963710","article-title":"Periodontal Inflammation Primes the Systemic Innate Immune Response","volume":"100","author":"Fine","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1002\/ijc.31254","article-title":"Periodontitis and cancer mortality: Register-based cohort study of 68,273 adults in 10-year follow-up","volume":"142","author":"But","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/s41388-019-1084-z","article-title":"Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells","volume":"39","author":"Cheng","year":"2020","journal-title":"Oncogene"},{"key":"ref_128","first-page":"1","article-title":"Association between oral pathogens and prostate cancer: Building the relationship","volume":"7","author":"Alluri","year":"2019","journal-title":"Am. J. Clin. Exp. Urol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/ger.12188","article-title":"Parkinson\u2019s disease and periodontitis\u2013the missing link? A review","volume":"33","author":"Kaur","year":"2016","journal-title":"Gerodontology"},{"key":"ref_130","first-page":"23940","article-title":"Periodontitis and Alzheimers disease","volume":"23","year":"2020","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_131","first-page":"231","article-title":"Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells: Role of epigenetic modifications to the inflammation","volume":"61","author":"Diomede","year":"2017","journal-title":"Eur. J. Histochem. EJH"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/ger.12431","article-title":"Systemic inflammatory impact of periodontitis on cognitive impairment","volume":"37","author":"Barrios","year":"2020","journal-title":"Gerodontology"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/jcpe.13267","article-title":"Periodontitis and systemic markers of neurodegeneration: A case\u2013control study","volume":"47","author":"Leira","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Hashioka, S., Inoue, K., Hayashida, M., Wake, R., Oh-Nishi, A., and Miyaoka, T. (2018). Implications of systemic inflammation and periodontitis for major depression. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00483"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Teixeira, F.B., Saito, M.T., Matheus, F.C., Prediger, R.D., Yamada, E.S., Maia, C.S., and Lima, R.R. (2017). Periodontitis and Alzheimer\u2019s disease: A possible comorbidity between oral chronic inflammatory condition and neuroinflammation. Front. Aging Neurosci., 9.","DOI":"10.3389\/fnagi.2017.00327"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Toraman, A., Toraman, E., \u00d6zkaraca, M., and Budak, H. (2022). Increased nociceptive sensitivity is associated with periodontal inflammation and expression of chronic pain genes in gingival tissues of male rats. Chem.-Biol. Interact., 366.","DOI":"10.1016\/j.cbi.2022.110128"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"9315","DOI":"10.1007\/s11033-023-08829-z","article-title":"Evaluated periodontal tissues and oxidative stress in rats with neuropathic pain-like behavior","volume":"50","author":"Toraman","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1177\/00220345211069956","article-title":"Nociceptor neurons magnify host responses to aggravate periodontitis","volume":"101","author":"Wang","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/jicd.12087","article-title":"Relationship between levels of neuropeptide S ubstance P in periodontal disease and chronic pain: A literature review","volume":"5","author":"Camparis","year":"2014","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/odi.13228","article-title":"Periodontitis and respiratory diseases: A systematic review with meta-analysis","volume":"26","author":"Trindade","year":"2020","journal-title":"Oral Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s40496-018-0171-5","article-title":"Periodontitis and respiratory diseases: What does the recent evidence point to?","volume":"5","author":"Muthu","year":"2018","journal-title":"Curr. Oral Health Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/jcpe.13767","article-title":"The association between respiratory diseases and periodontitis: A systematic review and meta-analysis","volume":"50","author":"Molina","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1902\/jop.2017.170363","article-title":"Association between asthma and periodontal disease: A systematic review and meta-analysis","volume":"89","author":"Moraschini","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.lfs.2019.03.005","article-title":"Is there an association between asthma and periodontal disease among adults? Systematic review and meta-analysis","volume":"223","author":"Ferreira","year":"2019","journal-title":"Life Sci."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Park, S.J., Jung, H.J., Park, M.W., Choi, H.G., Kim, H., and Wee, J.H. (2023). Association between Asthma and Periodontitis. Diagnostics, 13.","DOI":"10.3390\/diagnostics13243637"},{"key":"ref_146","first-page":"82","article-title":"Humoral Immunity in the Context of the Relationship between Periodontitis and Severe Asthma Literature Review","volume":"18","author":"Trindade","year":"2019","journal-title":"EC Dent. Sci."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Mainas, G., Nibali, L., Ide, M., Mahmeed, W.A., Al-Rasadi, K., Al-Alawi, K., Banach, M., Banerjee, Y., Ceriello, A., and Cesur, M. (2022). Associations between periodontitis, COVID-19, and cardiometabolic complications: Molecular mechanisms and clinical evidence. Metabolites, 13.","DOI":"10.3390\/metabo13010040"},{"key":"ref_148","first-page":"11","article-title":"Association between periodontitis and nosocomial pneumonia: A systematic review and meta-analysis of observational studies","volume":"18","author":"Jeronimo","year":"2019","journal-title":"Oral Health Prev. Dent."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.15562\/bmj.v12i3.4646","article-title":"The role of the immune response in the development of pneumonia arising from oral periodontitis: A literature review","volume":"12","author":"Hutomo","year":"2023","journal-title":"Bali Med. J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1902\/jop.2014.140229","article-title":"Investigating the association between obstructive sleep apnea and periodontitis","volume":"86","author":"Loke","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Lembo, D., Caroccia, F., Lopes, C., Moscagiuri, F., Sinjari, B., and D\u2019Attilio, M. (2021). Obstructive sleep apnea and periodontal disease: A systematic review. Medicina, 57.","DOI":"10.3390\/medicina57060640"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s11325-022-02668-1","article-title":"A meta-analysis on the association between obstructive sleep apnea and periodontitis","volume":"27","author":"Zhu","year":"2023","journal-title":"Sleep Breath."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1902\/jop.2016.160365","article-title":"Does obstructive sleep apnea increase the risk for periodontal disease? A case-control study","volume":"88","author":"Kiyan","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Ge, S., Zhai, G., Yu, S., Cui, Z., Si, S., and Chou, X. (2022). Incidence and risk of periodontitis in obstructive sleep apnea: A meta-analysis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0271738"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Liu, S., Fu, Y., Ziebolz, D., Li, S., Schmalz, G., and Li, F. (2022). Transcriptomic analysis reveals pathophysiological relationship between chronic obstructive pulmonary disease (COPD) and periodontitis. BMC Med. Genom., 15.","DOI":"10.1186\/s12920-022-01278-w"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/jcpe.13334","article-title":"The clinical and inflammatory relationships between periodontitis and chronic obstructive pulmonary disease","volume":"47","author":"Sapey","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/0022034519833630","article-title":"Periodontitis is associated with chronic obstructive pulmonary disease","volume":"98","author":"Takeuchi","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.job.2015.09.001","article-title":"Chronic obstructive pulmonary disease and periodontitis\u2013unwinding their linking mechanisms","volume":"58","author":"Ramesh","year":"2016","journal-title":"J. Oral Biosci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/prd.12422","article-title":"Osteoporosis and periodontal diseases\u2013An update on their association and mechanistic links","volume":"89","author":"Yu","year":"2022","journal-title":"Periodontol. 2000"},{"key":"ref_160","first-page":"401","article-title":"Periodontitis and osteoporosis","volume":"36","author":"Straka","year":"2015","journal-title":"Neuroendocrinol. Lett."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s11914-016-0330-3","article-title":"Osteoporosis and periodontitis","volume":"14","author":"Wang","year":"2016","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Hong, S.J., Yang, B.E., Yoo, D.M., Kim, S.J., Choi, H.G., and Byun, S.H. (2021). Analysis of the relationship between periodontitis and osteoporosis\/fractures: A cross-sectional study. BMC Oral Health, 21.","DOI":"10.1186\/s12903-021-01496-1"},{"key":"ref_163","first-page":"42","article-title":"Study regarding the quantification of RANKL levels in patients with chronic periodontitis and osteoporosis","volume":"8","author":"Sufaru","year":"2016","journal-title":"Rom. J. Oral Rehabil."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11657-019-0643-9","article-title":"An investigation of the bidirectional link between osteoporosis and periodontitis","volume":"14","author":"Penoni","year":"2019","journal-title":"Arch. Osteoporos."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1902\/jop.2017.170071","article-title":"Association between periodontitis and amyloid \u03b2 peptide in elderly people with and without cognitive impairment","volume":"88","author":"Barrios","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5051\/jpis.2015.45.1.14","article-title":"Comparison of serum amyloid A protein and C-reactive protein levels as inflammatory markers in periodontitis","volume":"45","author":"Ardila","year":"2015","journal-title":"J. Periodontal Implant Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/JPER.17-0243","article-title":"Serum, salivary, and tissue levels of plasminogen in familial Mediterranean fever, amyloidosis, and chronic periodontitis","volume":"89","author":"Karahan","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/0022034518796456","article-title":"Serum amyloid A contributes to chronic apical periodontitis via TLR2 and TLR4","volume":"98","author":"Hirai","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1536\/ihj.14-247","article-title":"Effect of periodontitis on cardiovascular manifestations in Marfan syndrome critical common role of TGF-\u03b2","volume":"56","author":"Suzuki","year":"2015","journal-title":"Int. Heart J."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e6606","DOI":"10.7717\/peerj.6606","article-title":"Periodontal condition in growing subjects with Marfan Syndrome: A case-control study","volume":"7","author":"Venza","year":"2019","journal-title":"PeerJ"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Cervino, G., Cicci\u00f9, M., De Stefano, R., Falcomat\u00e0, D., Bianchi, A., Crimi, S., Laino, L., Herford, A.S., Gaeta, M., and Fiorillo, L. (2020). Oral health in patients with Marfan syndrome. Arch. Oral Biol., 116.","DOI":"10.1016\/j.archoralbio.2020.104745"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.archoralbio.2018.02.017","article-title":"Fibrillin-1 insufficiency alters periodontal wound healing failure in a mouse model of Marfan syndrome","volume":"90","author":"Handa","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Hanisch, M., Wiemann, S., Jung, S., Kleinheinz, J., and Bohner, L. (2018). Oral health-related quality of life in people with rare hereditary connective tissue disorders: Marfan syndrome. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15112382"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"983782","DOI":"10.1155\/2015\/983782","article-title":"Inflammation biomarkers of advanced disease in nongingival tissues of chronic periodontitis patients","volume":"2015","author":"Silva","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/jre.12381","article-title":"A novel chemically modified curcumin reduces inflammation-mediated connective tissue breakdown in a rat model of diabetes: Periodontal and systemic effects","volume":"52","author":"Elburki","year":"2017","journal-title":"J. Periodontal Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12342","article-title":"Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way","volume":"84","author":"Sczepanik","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"219","DOI":"10.25122\/jml-2019-0113","article-title":"A comparative study of connective tissue metabolism indices in experimental comorbidity-free periodontitis and periodontitis combined with thyroid dysfunction","volume":"13","author":"Shcherba","year":"2020","journal-title":"J. Med. Life"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/jre.13030","article-title":"Cellular expression of epigenetic markers and oxidative stress in periodontitis lesions of smokers and non-smokers","volume":"57","author":"Dionigi","year":"2022","journal-title":"J. Periodontal Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"517","DOI":"10.17219\/acem\/133753","article-title":"Crocin attenuates oxidative and inflammatory stress-related periodontitis in cardiac tissues in rats","volume":"30","author":"Kocaman","year":"2021","journal-title":"Adv. Clin. Exp. Med. Off. Organ Wroc. Med Univ."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/jcpe.13370","article-title":"Cellular expression of DNA damage\/repair and reactive oxygen\/nitrogen species in human periodontitis and peri-implantitis lesions","volume":"47","author":"Dionigi","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Machado, V., Escalda, C., Proen\u00e7a, L., Mendes, J.J., and Botelho, J. (2020). Is there a bidirectional association between polycystic ovarian syndrome and periodontitis? A systematic review and meta-analysis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061961"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Dou, Y., Xin, J., Zhou, P., Tang, J., Xie, H., Fan, W., Zhang, Z., and Wu, D. (2023). Bidirectional association between polycystic ovary syndrome and periodontal diseases. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1008675"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s43032-020-00310-7","article-title":"The relationship between polycystic ovarian syndrome, periodontal disease, and osteoporosis","volume":"28","author":"Young","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Wu, P., Zhang, X., Zhou, P., Zhang, W., Li, D., Lv, M., and Liao, X. (2021). Assessment of bidirectional relationships between polycystic ovary syndrome and periodontitis: Insights from a mendelian randomization analysis. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.644101"},{"key":"ref_185","first-page":"141","article-title":"Oral pathology induced by excess or deficiency of glucocorticoids in adults","volume":"7","author":"Guja","year":"2020","journal-title":"J. Mind Med. Sci."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Bug\u0103l\u0103, N.M., Carsote, M., Stoica, L.E., Albulescu, D.M., \u0162uculin\u0103, M.J., Preda, S.A., Boicea, A.R., and Alexandru, D.O. (2022). New approach to addison disease: Oral manifestations due to endocrine dysfunction and comorbidity burden. Diagnostics, 12.","DOI":"10.3390\/diagnostics12092080"},{"key":"ref_187","first-page":"61","article-title":"Influence of Systemic Conditions on Periodontium-Exploring the Oral Systemic Connection: A Mini-Review","volume":"4","author":"Mahendra","year":"2022","journal-title":"Int. J. Drug Res. Dent. Sci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jobcr.2023.01.009","article-title":"Role of hormones in bone remodeling in the craniofacial complex: A review","volume":"13","author":"Tunheim","year":"2023","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1016\/j.jaip.2020.05.041","article-title":"Association between self-reported dental hygiene practices and dental procedure-related recurrent angioedema attacks in HAE subjects: A multicenter survey","volume":"8","author":"Singh","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Hanisch, M., Hoffmann, T., Bohner, L., Hanisch, L., Benz, K., Kleinheinz, J., and Jackowski, J. (2019). Rare diseases with periodontal manifestations. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16050867"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.bcp.2010.06.017","article-title":"Complement and periodontitis","volume":"80","author":"Hajishengallis","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"100694","DOI":"10.1016\/j.waojou.2022.100694","article-title":"Throat microbiota alterations in patients with hereditary angioedema","volume":"15","author":"Wang","year":"2022","journal-title":"World Allergy Organ. J."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: A key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/ni.3858","article-title":"Novel mechanisms and functions of complement","volume":"18","author":"Hajishengallis","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41577-019-0168-x","article-title":"New insights into the immune functions of complement","volume":"19","author":"Reis","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.it.2010.01.002","article-title":"Crosstalk pathways between Toll-like receptors and the complement system","volume":"31","author":"Hajishengallis","year":"2010","journal-title":"Trends Immunol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1007\/s10753-020-01234-9","article-title":"A follicle-stimulating hormone exacerbates the progression of periapical inflammation through modulating the cytokine release in periodontal tissue","volume":"43","author":"Qian","year":"2020","journal-title":"Inflammation"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/jcpe.13414","article-title":"Oxidative stress links periodontal inflammation and renal function","volume":"48","author":"Sharma","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Li, L., Zhang, Y.L., Liu, X.Y., Meng, X., Zhao, R.Q., Ou, L.L., Li, B.Z., and Xing, T. (2021). Periodontitis exacerbates and promotes the progression of chronic kidney disease through oral flora, cytokines, and oxidative stress. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.656372"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Shang, J., Liu, H., Zheng, Y., and Zhang, Z. (2023). Role of oxidative stress in the relationship between periodontitis and systemic diseases. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1210449"},{"key":"ref_201","first-page":"e22016","article-title":"A cross-sectional study of serum glutathione peroxidase: An antioxidative marker in chronic periodontitis and chronic kidney disease","volume":"14","author":"Palathingal","year":"2022","journal-title":"Cureus"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2019.10.012","article-title":"Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity","volume":"146","author":"Ademowo","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Ganimusa, I., Chew, E., and Lu, E.M.C. (2024). Vitamin D deficiency, Chronic kidney disease and Periodontitis. Medicina, 60.","DOI":"10.20944\/preprints202401.1787.v1"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/odi.14062","article-title":"Association between chronic kidney disease and periodontitis. A systematic review and metanalysis","volume":"29","author":"Serni","year":"2023","journal-title":"Oral Dis."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/odi.13236","article-title":"Association between severe periodontitis and chronic kidney disease severity in predialytic patients: A cross-sectional study","volume":"26","author":"Cunha","year":"2020","journal-title":"Oral Dis."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"03000605211033266","DOI":"10.1177\/03000605211033266","article-title":"Periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults","volume":"49","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_207","first-page":"744","article-title":"The relationship between periodontal and kidney disease: A critical review","volume":"53","author":"Priyamvara","year":"2022","journal-title":"Quintessence Int."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/prd.12298","article-title":"Diabetes as a risk factor for periodontal disease\u2014Plausible mechanisms","volume":"83","author":"Polak","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1177\/00220345221098910","article-title":"Systemic multimorbidity clusters in people with periodontitis","volume":"101","author":"Larvin","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3122\/jabfm.2022.220207R1","article-title":"The Prevalence of Periodontitis Among US Adults with Multimorbidity Using NHANES Data 2011\u20132014","volume":"36","author":"Furgal","year":"2023","journal-title":"J. Am. Board Fam. Med."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/cdoe.12812","article-title":"Periodontitis and risk of immune-mediated systemic conditions: A systematic review and meta-analysis","volume":"51","author":"Larvin","year":"2023","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/00220345241228834","article-title":"Social Disadvantage and Multimorbidity Including Oral Conditions in the United States","volume":"103","author":"Mirza","year":"2024","journal-title":"J. Dent. Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4103\/jispcd.JISPCD_11_23","article-title":"Investigating the influence of periodontal disease on the association between complex multimorbidity and health: A cross-sectional study","volume":"13","author":"Alqahtani","year":"2023","journal-title":"J. Int. Soc. Prev. 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