{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:43:52Z","timestamp":1780447432902,"version":"3.54.1"},"reference-count":118,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technical Development, and Innovation of the Republic of Serbia","award":["451-03-65\/2024-03\/200111"],"award-info":[{"award-number":["451-03-65\/2024-03\/200111"]}]},{"name":"Ministry of Science, Technical Development, and Innovation of the Republic of Serbia","award":["04\/22"],"award-info":[{"award-number":["04\/22"]}]},{"name":"Innovation of the Republic of Serbia","award":["451-03-65\/2024-03\/200111"],"award-info":[{"award-number":["451-03-65\/2024-03\/200111"]}]},{"name":"Innovation of the Republic of Serbia","award":["04\/22"],"award-info":[{"award-number":["04\/22"]}]},{"name":"Faculty of Medical Sciences, University of Kragujevac, Junior Project","award":["451-03-65\/2024-03\/200111"],"award-info":[{"award-number":["451-03-65\/2024-03\/200111"]}]},{"name":"Faculty of Medical Sciences, University of Kragujevac, Junior Project","award":["04\/22"],"award-info":[{"award-number":["04\/22"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Traditionally, garlic has a valuable role in preventing and reducing the incidence of many diseases and pathophysiological disorders. Consequently, some researchers have focused on the beneficial cardiovascular properties of diallyl trisulfide (DATS), the most potent polysulfide isolated from garlic. Therefore, in this review, we collected the available data on DATS, its biochemical synthesis, metabolism and pharmacokinetics, and gathered the current knowledge and the role of DATS in cardiovascular diseases. Overall, this review summarizes the cardioprotective effects of DATS and brings together all previous findings on its protective molecular mechanisms, which are mainly based on the potent anti-apoptotic, anti-inflammatory, and antioxidant potential of this polysulfide. Our review is an important cornerstone for further basic and clinical research on DATS as a new therapeutic agent for the treatment of numerous heart diseases.<\/jats:p>","DOI":"10.3390\/ijms25189831","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T10:33:01Z","timestamp":1726050781000},"page":"9831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diallyl Trisulfide and Cardiovascular Health: Evidence and Potential Molecular Mechanisms"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-3264","authenticated-orcid":false,"given":"Jovana","family":"Novakovic","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"},{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Muric","sequence":"additional","affiliation":[{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"},{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-6085","authenticated-orcid":false,"given":"Jovana","family":"Bradic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"},{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8779-3573","authenticated-orcid":false,"given":"Galina","family":"Ramenskaya","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-8376","authenticated-orcid":false,"given":"Vladimir","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"},{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"},{"name":"Department of Human Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Jeremic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"},{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia"},{"name":"I.M. 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Top Med Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.55730\/1300-0152.2694","article-title":"The apoptotic effect of garlic (Allium sativum) derived SEVs on different types of cancer cell lines in vitro","volume":"48","author":"Yilmaz","year":"2024","journal-title":"Turk. J. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Iwar, K., Ochar, K., Seo, Y.A., Ha, B.K., and Kim, S.H. (2024). Alliums as Potential Antioxidants and Anticancer Agents. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25158079"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gao, X., Xue, Z., Ma, Q., Guo, Q., Xing, L., Santhanam, R.K., Zhang, M., and Chen, H. (2020). Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism. J. Food Biochem., 44.","DOI":"10.1111\/jfbc.13126"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sallam, K.I., Raslan, M.T., Sabala, R.F., Abd-Elghany, S.M., Mahros, M.A., and Elshebrawy, H.A. (2024). Antimicrobial effect of garlic against foodborne pathogens in ground mutton. Food Microbiol., 120.","DOI":"10.1016\/j.fm.2023.104462"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.2174\/0115680266322180240712055727","article-title":"Formulation of Garlic Essential Oil-assisted Silver Nanoparticles and Mechanistic Evaluation of their Antimicrobial Activity against a Spectrum of Pathogenic Microorganisms","volume":"24","author":"Sarangi","year":"2024","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"St\u0119pie\u0144, A.E., Trojniak, J., and Tabarkiewicz, J. (2024). Anti-Cancer and Anti-Inflammatory Properties of Black Garlic. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031801"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3390\/cimb45010046","article-title":"Garlic (Allium sativum L.) as an Ally in the Treatment of Inflammatory Bowel Diseases","volume":"45","author":"Zugaro","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5114\/bta.2022.116210","article-title":"Neuroprotective effects of onion and garlic root extracts against Alzheimer\u2019s disease in rats: Antimicrobial, histopathological, and molecular studies","volume":"103","author":"Hegazy","year":"2022","journal-title":"BioTechnologia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.1080\/10408398.2022.2043821","article-title":"Garlic: A systematic review of the effects on cardiovascular diseases","volume":"63","author":"Imaizumi","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.phymed.2015.10.015","article-title":"An umbrella review of garlic intake and risk of cardiovascular disease","volume":"23","author":"Schwingshackl","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"El-Saadony, M.T., Saad, A.M., Korma, S.A., Salem, H.M., Abd El-Mageed, T.A., Alkafaas, S.S., Elsalahaty, M.I., Elkafas, S.S., Mosa, W.F.A., and Ahmed, A.E. (2024). Garlic bioactive substances and their therapeutic applications for improving human health: A comprehensive review. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1277074"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9402849","DOI":"10.1155\/2017\/9402849","article-title":"Therapeutic Role of Functional Components in Alliums for Preventive Chronic Disease in Human Being","volume":"2017","author":"Zeng","year":"2017","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"403S","DOI":"10.3945\/jn.114.208066","article-title":"Garlic-Derived Organic Polysulfides and Myocardial Protection","volume":"146","author":"Bradley","year":"2016","journal-title":"J. Nutr."},{"key":"ref_17","first-page":"129","article-title":"Role of garlic (Allium sativum) in various diseases: An overview","volume":"1","author":"Londhe","year":"2011","journal-title":"J. Pharm. Res. Opin."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1039\/C7FO01792H","article-title":"Effects of superfoods on risk factors of metabolic syndrome: A systematic review of human intervention trials","volume":"9","author":"Plat","year":"2018","journal-title":"Food Funct."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"955S","DOI":"10.1093\/jn\/131.3.955S","article-title":"Intake of garlic and its bioactive components","volume":"131","author":"Amagase","year":"2001","journal-title":"J. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1572-5995(00)80135-0","article-title":"Recent studies on the chemistry and biological activities of the organosulfur compounds of garlic (Allium sativum)","volume":"23","author":"Kamel","year":"2000","journal-title":"Stud. Nat. Prod. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Iciek, M., Kowalczyk-Pachel, D., Bilska-Wilkosz, A., Kwiecie\u0144, I., G\u00f3rny, M., and W\u0142odek, L. (2015). S-sulfhydration as a cellular redox regulation. Biosci. Rep., 36.","DOI":"10.1042\/BSR20150147"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Anwar, A., Gould, E., Tinson, R., Groom, M., and Hamilton, C.J. (2016). Think Yellow and Keep Green-Role of Sulfanes from Garlic in Agriculture. Antioxidants, 6.","DOI":"10.3390\/antiox6010003"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5338\/KJEA.2014.33.4.381","article-title":"Determination of dimethyl disulfide, diallyl disulfide, and diallyl trisulfide in biopesticides containing Allium sativum extract by gas chromatography","volume":"33","author":"Lim","year":"2014","journal-title":"Korean J. Environ. Agric."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.canlet.2006.05.009","article-title":"Cancer chemoprevention with garlic and its constituents","volume":"247","author":"Shukla","year":"2007","journal-title":"Cancer Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/tox.22500","article-title":"Diallyl trisulfide suppresses doxorubicin-induced cardiomyocyte apoptosis by inhibiting MAPK\/NF-\u03baB signaling through attenuation of ROS generation","volume":"33","author":"Wen","year":"2018","journal-title":"Environ. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0962-4562(96)80009-9","article-title":"Essential oil safety","volume":"7","author":"Tisserand","year":"1996","journal-title":"Int. J. Aromather."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Tisserand, R., and Young, R. (2014). Constituent profiles [Internet]. Essential Oil Safety, Churchill Livingstone. [2nd ed.].","DOI":"10.1016\/B978-0-443-06241-4.00014-X"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1248\/yakushi.126.521","article-title":"Determination of the concentration of diallyl trisulfide in rat whole blood using gas chromatography with electron-capture detection and identification of its major metabolite with gas chromatography mass spectrometry","volume":"126","author":"Sun","year":"2006","journal-title":"Yakugaku Zasshi"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1089\/ars.2011.4349","article-title":"Role of cystathionine \u03b3-lyase\/hydrogen sulfide pathway in cardiovascular disease: A novel therapeutic strategy?","volume":"17","author":"Pan","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"968S","DOI":"10.1093\/jn\/131.3.968S","article-title":"Determination of allicin, S-allylcysteine and volatile metabolites of garlic in breath, plasma or simulated gastric fluids","volume":"131","author":"Rosen","year":"2001","journal-title":"J. Nutr."},{"key":"ref_31","first-page":"G425","article-title":"Differentiation of mouth versus gut as site of origin of odoriferous breath gases after garlic ingestion","volume":"276","author":"Suarez","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1055\/s-2006-961471","article-title":"Metabolism of garlic constituents in the isolated perfused rat liver","volume":"58","author":"Eckard","year":"1992","journal-title":"Planta Medica"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1039\/b417639c","article-title":"Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: The chemistry of potential therapeutic agents","volume":"22","author":"Rose","year":"2005","journal-title":"Nat. Prod. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"716S","DOI":"10.1093\/jn\/136.3.716S","article-title":"Clarifying the real bioactive constituents of garlic","volume":"136","author":"Amagase","year":"2006","journal-title":"J. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"De, A., Roychowdhury, P., Bhuyan, N.R., Ko, Y.T., Singh, S.K., Dua, K., and Kuppusamy, G. (2023). Folic Acid Functionalized Diallyl Trisulfide-Solid Lipid Nanoparticles for Targeting Triple Negative Breast Cancer. Molecules, 28.","DOI":"10.3390\/molecules28031393"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.fct.2003.12.010","article-title":"The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride","volume":"42","author":"Fukao","year":"2004","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1207\/S15327914NC402_18","article-title":"Relative activities of organosulfur compounds derived from onions and garlic in increasing tissue activities of quinone reductase and glutathione transferase in rat tissues","volume":"40","author":"Munday","year":"2001","journal-title":"Nutr. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/jf010937z","article-title":"Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats","volume":"50","author":"Wu","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/15216540310001592843","article-title":"Redox reactions and electron transfer across the red cell membrane","volume":"55","author":"Kennett","year":"2003","journal-title":"IUBMB Life"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0005-2736(99)00174-1","article-title":"The mode of action of allicin: Its ready permeability through phospholipid membranes may contribute to its biological activity","volume":"1463","author":"Miron","year":"2000","journal-title":"Biochim. Et Biophys. Acta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0304-4165(97)00104-9","article-title":"The mode of action of allicin: Trapping of radicals and interaction with thiol containing proteins","volume":"1379","author":"Rabinkov","year":"1998","journal-title":"Biochim. Et Biophys. Acta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1021\/acs.orglett.5b01962","article-title":"Diallyl Trisulfide Is a Fast H2S Donor, but Diallyl Disulfide Is a Slow One: The Reaction Pathways and Intermediates of Glutathione with Polysulfides","volume":"17","author":"Liang","year":"2015","journal-title":"Org. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Verma, T., Aggarwal, A., Dey, P., Chauhan, A.K., Rashid, S., Chen, K.T., and Sharma, R. (2023). Medicinal and therapeutic properties of garlic, garlic essential oil, and garlic-based snack food: An updated review. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1120377"},{"key":"ref_45","first-page":"72","article-title":"Warfarin and garlic","volume":"246","author":"Sunter","year":"1991","journal-title":"Pharm. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.fct.2006.10.005","article-title":"Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats","volume":"45","author":"Chan","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Abou-Diwan, C., and Ritchie, J. (2011). Drug interactions with garlic and ginger supplements. Efficacy, Toxicity, Interactions with Western Drugs, and Effects on Clinical Laboratory Tests, John and Wiley and Sons.","DOI":"10.1002\/9780470910108.ch16"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"100544","DOI":"10.1016\/j.hermed.2022.100544","article-title":"A case study: Raw garlic consumption and an increased risk of bleeding","volume":"32","author":"Persaud","year":"2022","journal-title":"J. Herb. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1109S","DOI":"10.1093\/jn\/131.3.1109S","article-title":"Effects of garlic preparations on the gastrointestinal mucosa","volume":"131","author":"Hoshino","year":"2001","journal-title":"J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1046-199X(99)90092-1","article-title":"Garlic-related dermatoses: Case report and review of the literature","volume":"10","author":"Jappe","year":"1999","journal-title":"Am. J. Contact Dermat."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0091-6749(97)70266-5","article-title":"Occupational asthma induced by garlic dust","volume":"100","author":"Anibarro","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_52","first-page":"103","article-title":"Health effects of garlic","volume":"72","author":"Tattelman","year":"2005","journal-title":"Am. Fam. Physician"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1080\/09712119.2023.2282518","article-title":"Heavy consumption of garlic (Allium sativum) exert nephro- and pulmonary toxicity at maternal and embryonic level in the Albino rats","volume":"51","author":"Kamal","year":"2023","journal-title":"J. Appl. Anim. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"27474","DOI":"10.1021\/acsami.6b06466","article-title":"Novel H2S Releasing Nanofibrous Coating for In Vivo Dermal Wound Regeneration","volume":"8","author":"Wu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.2174\/0929867325666180212120504","article-title":"The Role of Hydrogen Sulfide and H2S-donors in Myocardial Protection Against Ischemia\/Reperfusion Injury","volume":"25","author":"Citi","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1124\/jpet.116.235119","article-title":"Cardioprotection by H2S Donors: Nitric Oxide-Dependent and -Independent Mechanisms","volume":"358","author":"Chatzianastasiou","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1152\/japplphysiol.00672.2012","article-title":"Diallyl trisulfide and diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats","volume":"114","author":"Huang","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijcard.2012.09.080","article-title":"Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK\/NF\u03baB signaling via attenuating ROS generation","volume":"168","author":"Kuo","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_60","first-page":"39","article-title":"Effect of allitridum on remodeling of the transient outward potassium current of ventricular myocytes of spontaneously hypertensive rats","volume":"50","author":"Dan","year":"2015","journal-title":"Yao Xue Xue Bao=Acta Pharm. Sin."},{"key":"ref_61","first-page":"132","article-title":"Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C","volume":"22","author":"Zhang","year":"2001","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"74791","DOI":"10.18632\/oncotarget.20422","article-title":"Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT\/GSK-3\u03b2\/HIF-1\u03b1 activation","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11010-019-03577-w","article-title":"The cardioprotective effects of diallyl trisulfide on diabetic rats with ex vivo induced ischemia\/reperfusion injury","volume":"460","author":"Jeremic","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Jeremic, J.N., Jakovljevic, V.L., Zivkovic, V.I., Srejovic, I.M., Bradic, J.V., Milosavljevic, I.M., Mitrovic, S.L., Jovicic, N.U., Bolevich, S.B., and Svistunov, A.A. (2020). Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239100"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"H2410","DOI":"10.1152\/ajpheart.00044.2012","article-title":"The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability","volume":"302","author":"Predmore","year":"2012","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2147\/IJN.S186225","article-title":"Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia-reperfusion injury","volume":"14","author":"Wang","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/CIRCHEARTFAILURE.113.000299","article-title":"Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis","volume":"6","author":"Polhemus","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2018.09.001","article-title":"Donor heart preservation with a novel long-term and slow-releasing hydrogen sulfide system","volume":"81","author":"Sun","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.jep.2011.08.051","article-title":"The effects of allitridi and amiodarone on the conduction system and reverse use-dependence in the isolated hearts of rats with myocardial infarction","volume":"141","author":"Xing","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/00325481.2019.1681215","article-title":"Type 2 diabetes mellitus and cardiovascular risk; what the pharmacotherapy can change through the epigenetics","volume":"132","author":"Mihaleva","year":"2020","journal-title":"Postgrad. Med. J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejphar.2005.04.031","article-title":"Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats","volume":"516","author":"Liu","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s10495-017-1378-y","article-title":"Diallyl trisulfide ameliorates myocardial ischemia-reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: Role of SIRT1 activation","volume":"22","author":"Yu","year":"2017","journal-title":"Apoptosis Int. J. Program. Cell Death"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.hfc.2019.06.007","article-title":"Hypertension and Heart Failure","volume":"15","author":"Slivnick","year":"2019","journal-title":"Heart Fail. Clin."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1345\/aph.1L319","article-title":"Effects of garlic on blood pressure in patients with and without systolic hypertension: A meta-analysis","volume":"42","author":"Reinhart","year":"2008","journal-title":"Ann. Pharmacother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/10641963.2010.531833","article-title":"Comparison of the hypotensive and bradycardic activity of ginkgo, garlic, and onion extracts","volume":"33","author":"Brankovic","year":"2011","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","article-title":"Cardiovascular remodelling in coronary artery disease and heart failure","volume":"383","author":"Heusch","year":"2014","journal-title":"Lancet"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/bph.12811","article-title":"The role of gasotransmitters NO, H2S and CO in myocardial ischaemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning","volume":"172","author":"Andreadou","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1039\/c2an35208g","article-title":"Real time measurement of myocardial oxygen dynamics during cardiac ischemia-reperfusion of rats","volume":"137","author":"Lee","year":"2012","journal-title":"Analyst"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0140-6736(12)60916-7","article-title":"Cardioprotection: Chances and challenges of its translation to the clinic","volume":"381","author":"Heusch","year":"2013","journal-title":"Lancet"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Zhang, G., Gao, S., Li, X., Zhang, L., Tan, H., Xu, L., Chen, Y., Geng, Y., Lin, Y., and Aertker, B. (2015). Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats. Sci. Rep., 5.","DOI":"10.1038\/srep09858"},{"key":"ref_82","first-page":"518","article-title":"Emerging molecular therapies targeting myocardial infarction-related arrhythmias","volume":"19","author":"Driessen","year":"2017","journal-title":"Europace"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1111\/ajt.15539","article-title":"Supplementing preservation solution with mitochondria-targeted H2S donor AP39 protects cardiac grafts from prolonged cold ischemia-reperfusion injury in heart transplantation","volume":"19","author":"Zhu","year":"2019","journal-title":"Am. J. Transplant."},{"key":"ref_84","first-page":"764","article-title":"Aged garlic extract enhances production of nitric oxide","volume":"80","author":"Morihara","year":"2007","journal-title":"Life Sci."},{"key":"ref_85","first-page":"479","article-title":"Development and evaluation of DATS-loaded liposomes in vitro and in vivo","volume":"15","author":"Zhang","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Alrumaihi, F., Khan, M.A., Babiker, A., Alsaweed, M., Azam, F., Allemailem, K.S., Almatroudi, A.A., Ahamad, S.R., Alsugoor, M.H., and Alharbi, K.N. (2022). Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo and In Silico Analysis. Molecules, 27.","DOI":"10.3390\/molecules27072192"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijcard.2015.05.111","article-title":"Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide","volume":"195","author":"Tsai","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.ijcard.2012.12.004","article-title":"Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K\/Akt-dependent activation of Nrf2 in cardiomyocytes","volume":"168","author":"Tsai","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejphar.2014.01.010","article-title":"A role for diallyl trisulfide in mitochondrial antioxidative stress contributes to its protective effects against vascular endothelial impairment","volume":"725","author":"Liu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1002\/mnfr.200900278","article-title":"Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein","volume":"54","author":"Lei","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0026-0495(00)80077-3","article-title":"What is oxidative stress?","volume":"49","author":"Betteridge","year":"2000","journal-title":"Metabolism"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","article-title":"Mitochondrial dysfunction and oxidative stress in heart disease","volume":"51","author":"Peoples","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1253\/circj.CJ-16-1097","article-title":"Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism","volume":"81","author":"Hayashida","year":"2017","journal-title":"Circ. J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1021\/jf060043k","article-title":"DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-\u03baB activation in RAW 264.7 macrophages","volume":"54","author":"Liu","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.intimp.2015.10.033","article-title":"Diallyl trisulfide inhibits naphthalene-induced oxidative injury and the production of inflammatory responses in A549 cells and mice","volume":"29","author":"Zhang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1177\/1933719114549845","article-title":"Relationship of Advanced Glycation End Products With Cardiovascular Disease in Menopausal Women","volume":"22","author":"Merhi","year":"2015","journal-title":"Reprod. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1042\/BST0351040","article-title":"The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia\/reperfusion injury","volume":"35","author":"Churchill","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Hsieh, D.J., Ng, S.C., Zeng, R.Y., Padma, V.V., Huang, C.Y., and Kuo, W.W. (2020). Diallyl Trisulfide (DATS) Suppresses AGE-Induced Cardiomyocyte Apoptosis by Targeting ROS-Mediated PKC\u03b4 Activation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072608"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"100136","DOI":"10.1016\/j.crtox.2023.100136","article-title":"Activation of PI3K\/Akt mediates the protective effect of diallyl trisulfide on doxorubicin induced cardiac apoptosis","volume":"5","author":"Wen","year":"2023","journal-title":"Curr. Res. Toxicol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/10253890.2012.680526","article-title":"Involvement of oxidative stress and mitogen-activated protein kinase signaling pathways in heat stress-induced injury in the rat small intestine","volume":"16","author":"Yu","year":"2013","journal-title":"Int. J. Biol. Stress."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tcm.2012.01.005","article-title":"Protection of the heart against ischemia\/reperfusion by silent information regulator 1","volume":"21","author":"Yamamoto","year":"2011","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11906-019-1009-9","article-title":"Effect of Garlic\u2019s Active Constituents in Inflammation, Obesity and Cardiovascular Disease","volume":"22","author":"Quesada","year":"2020","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ncomms2371","article-title":"A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1159\/000453208","article-title":"Exogenous hydrogen sulfide attenuates high glucose-induced cardiotoxicity by inhibiting NLRP3 inflammasome activation by suppressing TLR4\/NF-\u03baB pathway in H9c2 cells","volume":"40","author":"Huang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3892\/ijmm.2014.2036","article-title":"Diallyl trisulfide exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 macrophages by suppressing the Toll-like receptor 4\/nuclear factor-\u03baB pathway","volume":"35","author":"Lee","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/mnfr.201200843","article-title":"Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators","volume":"57","author":"You","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/ecp.10.134","article-title":"Hydrogen sulfide and inflammation: The good, the bad, the ugly and the promising","volume":"4","author":"Whiteman","year":"2011","journal-title":"Expert. Rev. Clin. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/07853890.2017.1417631","article-title":"The role of mitochondrial dysfunction in cardiovascular disease: A brief review","volume":"50","author":"Chistiakov","year":"2018","journal-title":"Ann. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10557-020-07000-1","article-title":"Diallyl Trisulfide Suppresses Angiotensin II-Induced Vascular Remodeling Via Inhibition of Mitochondrial Fission","volume":"34","author":"Lu","year":"2020","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s00592-019-01366-x","article-title":"Diallyl trisulfide attenuates hyperglycemia-induced endothelial apoptosis by inhibition of Drp1-mediated mitochondrial fission","volume":"56","author":"Hao","year":"2019","journal-title":"Acta Diabetol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/jcb.25016","article-title":"Regulation of mitochondrial morphology by positive feedback interaction between PKC\u03b4 and Drp1 in vascular smooth muscle cell","volume":"116","author":"Lim","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Sunaga, D., Tanno, M., Kuno, A., Ishikawa, S., Ogasawara, M., Yano, T., Miki, T., and Miura, T. (2014). Accelerated recovery of mitochondrial membrane potential by GSK-3\u03b2 inactivation affords cardiomyocytes protection from oxidant-induced necrosis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112529"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.biopha.2017.10.118","article-title":"Role of endogenous hydrogen sulfide in cardiac mitochondrial preservation during ischemia reperfusion injury","volume":"97","author":"Nandi","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.drudis.2015.04.009","article-title":"Herbal drugs against cardiovascular disease: Traditional medicine and modern development","volume":"20","author":"Li","year":"2015","journal-title":"Drug Discov. Today"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1139\/cjpp-2012-0315","article-title":"Garlic and cardioprotection: Insights into the molecular mechanisms","volume":"91","author":"Khatua","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1440-1681.2011.05511.x","article-title":"Allitridi inhibits transient outward potassium currents in human atrial myocytes","volume":"38","author":"Deng","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/01.CIR.81.2.686","article-title":"Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence","volume":"81","author":"Hondeghem","year":"1990","journal-title":"Circulation"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"H521","DOI":"10.1152\/ajpheart.00458.2017","article-title":"Loss of caveolin-3-dependent regulation of ICa in rat ventricular myocytes in heart failure","volume":"314","author":"Bryant","year":"2018","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/18\/9831\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:53:59Z","timestamp":1760111639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/18\/9831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":118,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["ijms25189831"],"URL":"https:\/\/doi.org\/10.3390\/ijms25189831","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]}}}