{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:36:12Z","timestamp":1792024572904,"version":"4.4.0"},"reference-count":27,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico (DGAPA)","award":["IN200924"],"award-info":[{"award-number":["IN200924"]}]},{"name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico (DGAPA)","award":["IN200522"],"award-info":[{"award-number":["IN200522"]}]},{"name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico (DGAPA)","award":["IN216822"],"award-info":[{"award-number":["IN216822"]}]},{"name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico (DGAPA)","award":["IN216723"],"award-info":[{"award-number":["IN216723"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["IN200924"],"award-info":[{"award-number":["IN200924"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["IN200522"],"award-info":[{"award-number":["IN200522"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["IN216822"],"award-info":[{"award-number":["IN216822"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["IN216723"],"award-info":[{"award-number":["IN216723"]}]},{"name":"Departamento de Embriolog\u00eda y Gen\u00e9tica (FAC. 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MED-UNAM","award":["IN216723"],"award-info":[{"award-number":["IN216723"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aging ovary in mammals leads to the reduced production of sex hormones and a deterioration in follicle quality. The interstitial gland originates from the hypertrophy of the theca cells of atretic follicles and represents an accumulative structure of the ovary that may contribute to its aging. Here, reproductive and mature rabbit ovaries are used to determine whether the interstitial gland plays a crucial role in ovarian aging. We demonstrate that, in the mature ovary, interstitial gland cells accumulate lipid droplets and show ultrastructural characteristics of lipophagy. Furthermore, they undergo modifications and present a foamy appearance, do not express the pan-leukocyte CD-45 marker, and express CYP11A1. These cells are the first to present an increase in lipofuscin accumulation. In foamy cells, the expression of p21 remains low, PCNA expression is maintained at mature ages, and their nuclei do not show positivity for H2AX. The interstitial gland shows a significant increase in lipofuscin accumulation compared with the ovaries of younger rabbits, but lipofuscin accumulation remains constant at mature ages. Surprisingly, no accumulation of cells with DNA damage is evident, and an increase in proliferative cells is observed at the age of 36 months. We suggest that the interstitial gland initially uses lipophagy to maintain steroidogenic homeostasis and prevent cellular senescence.<\/jats:p>","DOI":"10.3390\/ijms25189906","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T08:45:53Z","timestamp":1726217153000},"page":"9906","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Interstitial Gland as a Source of Pro- or Anti-Senescent Cells during Chinchilla Rabbit Ovarian Aging"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-3497","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"D\u00edaz-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Departamento de Embriolog\u00eda y Gen\u00e9tica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Marmolejo-Valencia","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Montiel-De la Cruz","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3080-9703","authenticated-orcid":false,"given":"Gabriela","family":"Pi\u00f1\u00f3n-Z\u00e1rate","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-4918","authenticated-orcid":false,"given":"Luis M.","family":"Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-5879","authenticated-orcid":false,"given":"Silvia Ivonne","family":"Mora-Herrera","sequence":"additional","affiliation":[{"name":"Unidad de Metabol\u00f3mica y Prote\u00f3mica, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivette","family":"Caldelas","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10815-022-02478-0","article-title":"The process of ovarian aging: It is not just about oocytes and granulosa cells","volume":"39","author":"Camaioni","year":"2022","journal-title":"J. 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