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However, the use of non-drug treatments is increasingly becoming a recommended strategy. In this context, the effects of supplementation of FM patients with an olive (poly)phenol, vitamin C, and vitamin B preparation were investigated in this work, analyzing complete blood count, biochemical, lipid, and coagulation profiles, and inflammation and oxidation status in blood samples. To gain a better understanding of the molecular mechanisms and pathways involved in the etiology of FM, a proteomic study was also performed to investigate the mechanisms of action of the supplement. Our results show that the nutraceutical lowers the lipid profile, namely cholesterol, and improves the oxidative status of patients as well as their quality of life, suggesting that this product could be beneficial in the co-treatment of FM. ClinicalTrials.gov (ID: NCT06348537).<\/jats:p>","DOI":"10.3390\/ijms25189935","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T01:52:31Z","timestamp":1726624351000},"page":"9935","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nutraceutical Supplementation as a Potential Non-Drug Treatment for Fibromyalgia: Effects on Lipid Profile, Oxidative Status, and Quality of Life"],"prefix":"10.3390","volume":"25","author":[{"given":"Salvador","family":"de la Cruz Cazorla","sequence":"first","affiliation":[{"name":"Department of Experimental Biology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-5320","authenticated-orcid":false,"given":"Santos","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5547-5279","authenticated-orcid":false,"given":"Alma","family":"Rus","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Granada, 18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Molina-Ortega","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, University of Granada, 18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Oca\u00f1a","sequence":"additional","affiliation":[{"name":"Unit of Clinic Analyses, Hospital Universitario Ciudad de Ja\u00e9n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1756-1723","authenticated-orcid":false,"given":"Francesco","family":"Visioli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Padova, 35121 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa del","family":"Moral","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jurado-Priego, L.N., Cueto-Urena, C., Ramirez-Exposito, M.J., and Martinez-Martos, J.M. 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