{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:27:53Z","timestamp":1790832473653,"version":"4.1.0"},"reference-count":127,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81803895"],"award-info":[{"award-number":["81803895"]}]},{"name":"National Natural Science Foundation of China","award":["ZR2021YQ57"],"award-info":[{"award-number":["ZR2021YQ57"]}]},{"name":"National Natural Science Foundation of China","award":["2020M682131"],"award-info":[{"award-number":["2020M682131"]}]},{"name":"National Natural Science Foundation of China","award":["2021T140357"],"award-info":[{"award-number":["2021T140357"]}]},{"name":"Shandong Province Natural Science Foundation","award":["81803895"],"award-info":[{"award-number":["81803895"]}]},{"name":"Shandong Province Natural Science Foundation","award":["ZR2021YQ57"],"award-info":[{"award-number":["ZR2021YQ57"]}]},{"name":"Shandong Province Natural Science Foundation","award":["2020M682131"],"award-info":[{"award-number":["2020M682131"]}]},{"name":"Shandong Province Natural Science Foundation","award":["2021T140357"],"award-info":[{"award-number":["2021T140357"]}]},{"name":"China Postdoctoral Science Foundation","award":["81803895"],"award-info":[{"award-number":["81803895"]}]},{"name":"China Postdoctoral Science Foundation","award":["ZR2021YQ57"],"award-info":[{"award-number":["ZR2021YQ57"]}]},{"name":"China Postdoctoral Science Foundation","award":["2020M682131"],"award-info":[{"award-number":["2020M682131"]}]},{"name":"China Postdoctoral Science Foundation","award":["2021T140357"],"award-info":[{"award-number":["2021T140357"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mitochondria are a unique type of semi-autonomous organelle within the cell that carry out essential functions crucial for the cell\u2019s survival and well-being. They are the location where eukaryotic cells carry out energy metabolism. Aside from producing the majority of ATP through oxidative phosphorylation, which provides essential energy for cellular functions, mitochondria also participate in other metabolic processes within the cell, such as the electron transport chain, citric acid cycle, and \u03b2-oxidation of fatty acids. Furthermore, mitochondria regulate the production and elimination of ROS, the synthesis of nucleotides and amino acids, the balance of calcium ions, and the process of cell death. Therefore, it is widely accepted that mitochondrial dysfunction is a factor that causes or contributes to the development and advancement of various diseases. These include common systemic diseases, such as aging, diabetes, Parkinson\u2019s disease, and cancer, as well as rare metabolic disorders, like Kearns\u2013Sayre syndrome, Leigh disease, and mitochondrial myopathy. This overview outlines the various mechanisms by which mitochondria are involved in numerous illnesses and cellular physiological activities. Additionally, it provides new discoveries regarding the involvement of mitochondria in both disorders and the maintenance of good health.<\/jats:p>","DOI":"10.3390\/ijms25189975","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T01:52:31Z","timestamp":1726624351000},"page":"9975","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["New Insights into Mitochondria in Health and Diseases"],"prefix":"10.3390","volume":"25","author":[{"given":"Ya","family":"Li","sequence":"first","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.siny.2011.05.004","article-title":"Mitochondrial disorders caused by mutations in respiratory chain assembly factors","volume":"16","author":"Diaz","year":"2011","journal-title":"Semin. 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