{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:56:52Z","timestamp":1789585012304,"version":"build-2803163510"},"reference-count":142,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Respiratory diseases (RDs) constitute a common public health problem both in industrialized and developing countries. The comprehension of the pathophysiological mechanisms underlying these conditions and the development of new therapeutic strategies are critical for improving the quality of life of affected patients. \u03b22-adrenergic receptor (\u03b22AR) and transient receptor potential vanilloid 1 (TRPV1) are both involved in physiological responses in the airways. \u03b22AR is implicated in bronchodilation, mucociliary clearance, and anti-inflammatory effects, while TRPV1 is involved in the mediation of pain and cough reflexes. In RDs, such as respiratory infections, asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, the concentration and expression of these receptors can be altered, leading to significant consequences. In this review, we provided an update on the literature about the role of \u03b22AR and TRPV1 in these conditions. We reported how the diminished or defective expression of \u03b22AR during viral infections or prolonged therapy with \u03b22-agonists can increase the severity of these pathologies and impact the prognosis. Conversely, the role of TRPV1 was pivotal in neuroinflammation, and its modulation could lead to innovative treatment strategies in specific patients. We indicate future perspectives and potential personalized treatments in RDs through a comprehensive analysis of the roles of these receptors in the physiological and pathological mechanisms of these pathologies.<\/jats:p>","DOI":"10.3390\/ijms251910234","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T03:49:46Z","timestamp":1727149786000},"page":"10234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Update on the Role of \u03b22AR and TRPV1 in Respiratory Diseases"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-3083","authenticated-orcid":false,"given":"Sara","family":"Manti","sequence":"first","affiliation":[{"name":"Pediatric Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7421-0903","authenticated-orcid":false,"given":"Antonella","family":"Gambadauro","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4166-2030","authenticated-orcid":false,"given":"Francesca","family":"Galletta","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Pulmonology Unit, Department of Biomedical and Dental Sciences, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-1928","authenticated-orcid":false,"given":"Giovanni","family":"Piedimonte","sequence":"additional","affiliation":[{"name":"Office for Research and Departments of Pediatrics, Biochemistry, and Molecular Biology, Tulane University, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101936","DOI":"10.1016\/j.eclinm.2023.101936","article-title":"Global Burden of Chronic Respiratory Diseases and Risk Factors, 1990\u20132019: An Update from the Global Burden of Disease Study 2019","volume":"59","author":"Momtazmanesh","year":"2023","journal-title":"EClinicalMedicine"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Figueiredo, I.A.D., Ferreira, S.R.D., Fernandes, J.M., da Silva, B.A., Vasconcelos, L.H.C., and Cavalcante, F.d.A. 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