{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:20:12Z","timestamp":1790889612819,"version":"4.1.0"},"reference-count":184,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad UTE-Ecuador"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hematologic malignancies (HMs), including leukemia, lymphoma, and multiple myeloma, involve the uncontrolled proliferation of abnormal blood cells, posing significant clinical challenges due to their heterogeneity and varied treatment responses. Despite recent advancements in therapies that have improved survival rates, particularly in chronic lymphocytic leukemia and acute lymphoblastic leukemia, treatments like chemotherapy and stem cell transplantation often disrupt gut microbiota, which can negatively impact treatment outcomes and increase infection risks. This review explores the complex, bidirectional interactions between gut microbiota and cancer treatments in patients with HMs. Gut microbiota can influence drug metabolism through mechanisms such as the production of enzymes like bacterial \u03b2-glucuronidases, which can alter drug efficacy and toxicity. Moreover, microbial metabolites like short-chain fatty acids can modulate the host immune response, enhancing treatment effectiveness. However, therapy often reduces the diversity of beneficial bacteria, such as Bifidobacterium and Faecalibacterium, while increasing pathogenic bacteria like Enterococcus and Escherichia coli. These findings highlight the critical need to preserve microbiota diversity during treatment. Future research should focus on personalized microbiome-based therapies, including probiotics, prebiotics, and fecal microbiota transplantation, to improve outcomes and quality of life for patients with hematologic malignancies.<\/jats:p>","DOI":"10.3390\/ijms251910255","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T08:54:17Z","timestamp":1727168057000},"page":"10255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Gut Microbiota Disruption in Hematologic Cancer Therapy: Molecular Insights and Implications for Treatment Efficacy"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4829-3653","authenticated-orcid":false,"given":"Patricia","family":"Guevara-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Gen\u00e9tica y Gen\u00f3mica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170129, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-6046","authenticated-orcid":false,"given":"Santiago","family":"Cadena-Ullauri","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Gen\u00e9tica y Gen\u00f3mica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170129, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elius","family":"Paz-Cruz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Gen\u00e9tica y Gen\u00f3mica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170129, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9301-2614","authenticated-orcid":false,"given":"Viviana A.","family":"Ruiz-Pozo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Gen\u00e9tica y Gen\u00f3mica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170129, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-3281","authenticated-orcid":false,"given":"Rafael","family":"Tamayo-Trujillo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Gen\u00e9tica y Gen\u00f3mica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170129, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9702-6618","authenticated-orcid":false,"given":"Alejandro","family":"Cabrera-Andrade","sequence":"additional","affiliation":[{"name":"Escuela de Enfermer\u00eda, Facultad de Ciencias de la Salud, Universidad de Las Am\u00e9ricas, Quito 170124, Ecuador"},{"name":"Grupo de Bio-Quimioinform\u00e1tica, Universidad de Las Am\u00e9ricas, Quito 170124, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4102-3965","authenticated-orcid":false,"given":"Ana Karina","family":"Zambrano","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Gen\u00e9tica y Gen\u00f3mica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170129, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (2022). 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