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significant economic losses in agriculture. It is usually triggered by pathogenic bacteria and is associated with chronic postpartum reproductive tract infections. Bacterial lipopolysaccharides (LPSs) are known to increase levels of reactive oxygen species (ROS), leading to oxidative stress and inflammation through the activation of the NF-\u03baB signaling pathway and the inhibition of Nrf2 nuclear translocation, which regulates antioxidant response elements (AREs). The effectiveness of the conventional management strategy involving antibiotics is decreasing due to resistance and residual concerns. This review explores the potential therapeutic benefits of targeting the Nrf2\/Kelch-like ECH-associated protein 1 (Keap1)\/NF-\u03baB signaling pathway to alleviate LPS-induced endometritis. We discuss recent advancements in veterinary medicine that utilize exogenous antioxidants to modulate these pathways, thereby reducing oxidative stress and inflammatory responses in endometrial cells. This review highlights the efficacy of several bioactive compounds that enhance Nrf2 signaling and suppress NF-\u03baB activation, offering protective effects against oxidative damage and inflammation. By examining various in vitro studies, this review emphasizes the emerging role of these signaling pathways in developing new therapeutic strategies that could potentially replace or supplement traditional treatments and mitigate the economic impacts of endometritis in livestock.<\/jats:p>","DOI":"10.3390\/ijms251910319","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T16:16:37Z","timestamp":1727280997000},"page":"10319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["An Overview of Bioactive Compounds\u2019 Role in Modulating the Nrf2\/Keap1\/NF-\u03baB Pathway to Alleviate Lipopolysaccharide-Induced Endometritis"],"prefix":"10.3390","volume":"25","author":[{"given":"Muhammad Zahoor","family":"Khan","sequence":"first","affiliation":[{"name":"College of Agricultural Science and Engineering, Liaocheng University, Liaocheng 522000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Agricultural Science and Engineering, Liaocheng University, Liaocheng 522000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Agricultural Science and Engineering, Liaocheng University, Liaocheng 522000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyan","family":"Kou","sequence":"additional","affiliation":[{"name":"College of Agricultural Science and Engineering, Liaocheng University, Liaocheng 522000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8165-1811","authenticated-orcid":false,"given":"Adnan","family":"Khan","sequence":"additional","affiliation":[{"name":"Animal Genomics Laboratory, School of Agriculture and Food Science, University College Dublin, D04 V1W8 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahat Ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, CAS-TWAS Center of Excellence for Emerging Infectious Diseases, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Zahoor","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien, 90372 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfa","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Agricultural Science and Engineering, Liaocheng University, Liaocheng 522000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, K., Feng, H., Zhang, J., Guo, Z., Yan, Z., Wang, G., Wang, X., Wang, L., and Li, J. 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