{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T05:57:53Z","timestamp":1778392673882,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ram\u00f3n de la Fuente Mu\u00f1iz National Institute of Psychiatry","award":["CF-2023-G-112"],"award-info":[{"award-number":["CF-2023-G-112"]}]},{"name":"Ram\u00f3n de la Fuente Mu\u00f1iz National Institute of Psychiatry","award":["254773"],"award-info":[{"award-number":["254773"]}]},{"name":"Consejo Nacional de Humanidades Ciencia y Tecnolog\u00eda (CONAHCYT)","award":["CF-2023-G-112"],"award-info":[{"award-number":["CF-2023-G-112"]}]},{"name":"Consejo Nacional de Humanidades Ciencia y Tecnolog\u00eda (CONAHCYT)","award":["254773"],"award-info":[{"award-number":["254773"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Antidepressant response is a multifactorial process related to biological and environmental factors, where brain-derived neurotrophic factor (BDNF) may play an important role in modulating depressive and anxious symptoms. We aimed to analyze how BDNF impacts antidepressant response, considering the levels of anxiety. Methods: A total of 40 depressed adults were included. We evaluated initial serum BDNF, anxiety through the State\u2013Trait Anxiety Inventory (STAI), and the severity of depressive symptoms by the Hamilton Depression Rating Scale (HDRS). Participants received antidepressant treatment for 8 weeks, and response to treatment was evaluated according to the final HDRS scores. Results: Basal BDNF was higher in responders compared to non-responder depressed patients, in addition to being inversely associated with the severity of anxiety and depression. Conclusions: Baseline BDNF serum is an adequate predictive factor for response to antidepressant treatment with SSRI, with lower pre-treatment levels of BDNF associated with higher anxiety symptoms after treatment. Stress levels could influence the response to treatment, but its association was not conclusive.<\/jats:p>","DOI":"10.3390\/ijms251910373","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T08:20:52Z","timestamp":1727338852000},"page":"10373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Are BDNF and Stress Levels Related to Antidepressant Response?"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-7605","authenticated-orcid":false,"given":"M\u00f3nica","family":"Flores-Ramos","sequence":"first","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Cl\u00ednica, Subdirecci\u00f3n de Investigaciones Cl\u00ednicas, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calzada M\u00e9xico Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City C.P. 14370, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-7847","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Vega-Rosas","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurog\u00e9nesis, Subdirecci\u00f3n de Investigaciones Cl\u00ednicas, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calzada M\u00e9xico-Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City C.P. 14370, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5934-2360","authenticated-orcid":false,"given":"Nadia","family":"Palomera-Garfias","sequence":"additional","affiliation":[{"name":"Servicio Social, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Salvador D\u00edaz Mir\u00f3n esq. Plan de San Luis S\/N, Miguel Hidalgo, Casco de Santo Tomas, Mexico City C.P. 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Saracco-Alvarez","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n Cl\u00ednica, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calzada M\u00e9xico-Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City, C.P. 14370, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-1588","authenticated-orcid":false,"given":"Gerardo Bernab\u00e9","family":"Ram\u00edrez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurog\u00e9nesis, Subdirecci\u00f3n de Investigaciones Cl\u00ednicas, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calzada M\u00e9xico-Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City C.P. 14370, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2005). Yearbook of the United Nations 2005, United Nations."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","article-title":"Evaluation of Outcomes with Citalopram for Depression Using Measurement-Based Care in STAR*D: Implications for Clinical Practice","volume":"163","author":"Trivedi","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Carrillo, A., Verheyen, V.J., Van Nuijs, A.L.N., Fern\u00e1ndez, M.F., and Remy, S. (2023). Brain-derived neurotrophic factor (BDNF): An effect biomarker of neurodevelopment in human biomonitoring programs. Front. 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