{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:07:22Z","timestamp":1785496042641,"version":"3.56.0"},"reference-count":43,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONACYT 2023-Frontier Science","award":["CF-2023-I-5"],"award-info":[{"award-number":["CF-2023-I-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic migraines have been described chiefly only from a clinical perspective. However, searching for reliable molecular markers has allowed for the discovery of the expression of different genes mainly associated with inflammation, neuro-vascularization, and pain-related pathways. The interest in microRNAs (miRs) that can regulate the expression of these genes has gained significant relevance since multiple miRs could play a key role in regulating these events. In this study, miRs were searched in samples from patients with chronic migraine, and the inclusion criteria were carefully reviewed. Different bioinformatic tools, such as miRbase, targetscan, miRPath, tissue atlas, and miR2Disease, were used to analyze the samples. Our findings revealed that some of the miRs were expressed more (miR-197, miR-101, miR-92a, miR-375, and miR-146b) and less (miR-133a\/b, miR-134, miR-195, and miR-340) than others. We concluded that, during chronic migraine, common pathways, such as inflammation, vascularization, neurodevelopment, nociceptive pain, and pharmacological resistance, were associated with this disease.<\/jats:p>","DOI":"10.3390\/ijms251910491","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T03:12:28Z","timestamp":1727665948000},"page":"10491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioinformatic Analysis from a Descriptive Profile of miRNAs in Chronic Migraine"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0394-6737","authenticated-orcid":false,"given":"Alvaro Jovanny","family":"Tovar-Cuevas","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Multidisciplinario en Salud, Departamento de Ciencias Biom\u00e9dicas, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Tonal\u00e1 45425, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4478-1729","authenticated-orcid":false,"given":"Roberto Carlos","family":"Rosales G\u00f3mez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Multidisciplinario en Salud, Departamento de Ciencias Biom\u00e9dicas, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Tonal\u00e1 45425, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Teresita","family":"Mart\u00edn-M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico (IIRSME), Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan Alejandro","family":"Pe\u00f1a Due\u00f1as","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Multidisciplinario en Salud, Departamento de Ciencias Biom\u00e9dicas, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Tonal\u00e1 45425, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9251-4209","authenticated-orcid":false,"given":"Flavio","family":"Sandoval-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico (IIRSME), Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"},{"name":"Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Guadalajara 44340, 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Mexico"},{"name":"Cuerpo Acad\u00e9mico UDG-CA-1096, \u201cCiencias de la Nutrici\u00f3n y Procesos Moleculares del Metabolismo\u201d, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Tonal\u00e1 45625, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Mercedes","family":"Hern\u00e1ndez Corona","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Multidisciplinario en Salud, Departamento de Ciencias Biom\u00e9dicas, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Tonal\u00e1 45425, Mexico"},{"name":"Cuerpo Acad\u00e9mico UDG-CA-1096, \u201cCiencias de la Nutrici\u00f3n y Procesos Moleculares del Metabolismo\u201d, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Tonal\u00e1 45625, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-1482","authenticated-orcid":false,"given":"Fernanda-Isadora","family":"Corona 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