{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:37:09Z","timestamp":1789425429737,"version":"build-2803163510"},"reference-count":57,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine, Pharmacy, Science and Technology \u201cGeorge Emil Palade\u201d of T\u00e2rgu Mure\u0219 Research","award":["163\/1\/10.01.2023"],"award-info":[{"award-number":["163\/1\/10.01.2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Circulating biomarkers have been proposed for early identification of aortic dilatation progression associated with bicuspid aortic valve (BAV), but matrix metalloproteinases (MMPs) are distinguished as signatures of increased extracellular matrix degradation, a landmark of aneurysm formation. The current study aims to identify the role of MMP-1, MMP-2, MMP-9, and the MMP inhibitor, TIMP-1, in identifying aortic dilation in children with BAV. We conducted a study on 73 children divided into two study groups, depending on the presence of aortic dilatation (group 1\u201343 BAV controls and group 2\u201330 children with BAV and aortic dilatation). Each patient underwent a cardiac ultrasound and, in each case, serum MMP-1, MMP-2, MMP-9, and TIMP-1 were quantified using xMAP technology. Comparison of the MMPs between the two study groups revealed significantly higher values only in the case of TIMP-1, among BAV controls. Moreover, the same TIMP-1 inversely correlated with aortic annulus absolute size and z score, as well as with ascending aorta z score. No particular correlation between the aortic phenotype and the presence of aortic dilatation was found. Future longitudinal research starting at pediatric ages could show the significance of MMPs screening in BAV individuals as predictors of aortic aneurysm formation.<\/jats:p>","DOI":"10.3390\/ijms251910538","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T04:57:28Z","timestamp":1727672248000},"page":"10538","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Circulating Matrix Metalloproteinases for Prediction of Aortic Dilatation in Children with Bicuspid Aortic Valve: A Single-Center, Observational Study"],"prefix":"10.3390","volume":"25","author":[{"given":"Amalia","family":"F\u0103g\u0103r\u0103\u0219an","sequence":"first","affiliation":[{"name":"Department of Pediatrics III, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No 50, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Oana","family":"S\u0103s\u0103ran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics III, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No 38, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Gozar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics III, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No 50, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics III, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No 50, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"\u0218uteu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics III, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No 50, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simina","family":"Ghiragosian-Rusu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics III, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No 50, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4588-5076","authenticated-orcid":false,"given":"Flavia Cristina","family":"Al-Akel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No 50, 540136 T\u00e2rgu Mure\u0219, Romania"},{"name":"Pathophysiology Department, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boglarka","family":"Szabo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation of T\u00e2rgu Mure\u0219, Gheorghe Marinescu Street No 50, 540136 T\u00e2rgu Mure\u0219, 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