{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:41:29Z","timestamp":1790959289700,"version":"4.1.0"},"reference-count":71,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["P20GM103434"],"award-info":[{"award-number":["P20GM103434"]}]},{"name":"National Institutes of Health","award":["P20GM121299"],"award-info":[{"award-number":["P20GM121299"]}]},{"name":"National Institutes of Health","award":["U54GM104942"],"award-info":[{"award-number":["U54GM104942"]}]},{"name":"THE EDWARDS FOUNDATION (BC1) at the Edwards Comprehensive Cancer Center","award":["P20GM103434"],"award-info":[{"award-number":["P20GM103434"]}]},{"name":"THE EDWARDS FOUNDATION (BC1) at the Edwards Comprehensive Cancer Center","award":["P20GM121299"],"award-info":[{"award-number":["P20GM121299"]}]},{"name":"THE EDWARDS FOUNDATION (BC1) at the Edwards Comprehensive Cancer Center","award":["U54GM104942"],"award-info":[{"award-number":["U54GM104942"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Breast cancer is the most common cancer in women with multiple risk factors including smoking, genetics, environmental factors, and obesity. Smoking and obesity are the top two risk factors for the development of breast cancer. The effect of obesity on adipose tissue mediates the pathogenesis of breast cancer in the context of obesity. Triple-negative breast cancer (TNBC) is a breast cancer subtype within which the cells lack estrogen, progesterone, and HER2 receptors. TNBC is the deadliest breast cancer subtype. The 5-year survival rates for patients with TNBC are 8\u201316% lower than the 5-year survival rates for patients with estrogen-receptor-positive breast tumors. In addition, TNBC patients have early relapse rates (3\u20135 years after diagnosis). Obesity is associated with an increased risk for TNBC, larger TNBC tumors, and increased breast cancer metastasis compared with lean women. Thus, novel therapeutic approaches are warranted to treat TNBC in the context of obesity. In this paper, we show that peritumor breast adipose-derived secretome (ADS) from patients with a high (&gt;30) BMI is a stronger inducer of TNBC cell invasiveness and JAG1 expression than peritumor breast ADS from patients with low (&lt;30) BMI. These findings indicate that patient BMI-associated changes in peritumor AT induce changes in peritumor ADS, which in turn acts on TNBC cells to stimulate JAG1 expression and cancer cell invasiveness.<\/jats:p>","DOI":"10.3390\/ijms251910592","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T07:41:49Z","timestamp":1727768509000},"page":"10592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High BMI Is Associated with Changes in Peritumor Breast Adipose Tissue That Increase the Invasive Activity of Triple-Negative Breast Cancer Cells"],"prefix":"10.3390","volume":"25","author":[{"given":"Cora E.","family":"Miracle","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea L.","family":"McCallister","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2632-2230","authenticated-orcid":false,"given":"Krista L.","family":"Denning","sequence":"additional","affiliation":[{"name":"Cabell Huntington Hospital Laboratory, Department of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Russell","sequence":"additional","affiliation":[{"name":"Cabell Huntington Hospital Laboratory, Department of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Allen","sequence":"additional","affiliation":[{"name":"Cabell Huntington Hospital Laboratory, Department of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Cabell Huntington Hospital Laboratory, Department of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Legenza","sequence":"additional","affiliation":[{"name":"Edwards Comprehensive Cancer Center, Department of Oncology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Krutzler-Berry","sequence":"additional","affiliation":[{"name":"Edwards Comprehensive Cancer Center, Department of Oncology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis B.","family":"Salisbury","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","article-title":"Current and future burden of breast cancer: Global statistics for 2020 and 2040","volume":"66","author":"Arnold","year":"2022","journal-title":"Breast"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.191367098","article-title":"Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications","volume":"98","author":"Perou","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ccr.2006.10.008","article-title":"A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes","volume":"10","author":"Neve","year":"2006","journal-title":"Cancer Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1172\/JCI45014","article-title":"Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies","volume":"121","author":"Lehmann","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1158\/2159-8290.CD-18-1177","article-title":"Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment","volume":"9","author":"Lin","year":"2019","journal-title":"Cancer Discov."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13058-020-01296-5","article-title":"Triple-negative breast cancer molecular subtyping and treatment progress","volume":"22","author":"Yin","year":"2020","journal-title":"Breast Cancer Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/cncr.22836","article-title":"Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: A single-institution compilation compared with the National Cancer Institute\u2019s Surveillance, Epidemiology, and End Results database","volume":"110","author":"Morris","year":"2007","journal-title":"Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Prakash, O., Hossain, F., Danos, D., Lassak, A., Scribner, R., and Miele, L. (2020). Racial Disparities in Triple Negative Breast Cancer: A Review of the Role of Biologic and Non-biologic Factors. Front. Public. Health, 8.","DOI":"10.3389\/fpubh.2020.576964"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e2421846","DOI":"10.1001\/jamanetworkopen.2024.21846","article-title":"Obesity and Early-Onset Breast Cancer and Specific Molecular Subtype Diagnosis in Black and White Women: NIMHD Social Epigenomics Program","volume":"7","author":"Sudan","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3816\/CBC.2009.n.005","article-title":"Survival outcomes for patients with metastatic triple-negative breast cancer: Implications for clinical practice and trial design","volume":"9","author":"Kassam","year":"2009","journal-title":"Clin. Breast Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10549-012-2339-3","article-title":"Obesity as a risk factor for triple-negative breast cancers: A systematic review and meta-analysis","volume":"137","author":"Pierobon","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_12","first-page":"935","article-title":"Triple-negative breast cancer and its association with obesity","volume":"7","author":"Sun","year":"2017","journal-title":"Mol. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10552-009-9331-1","article-title":"The epidemiology of triple-negative breast cancer, including race","volume":"20","author":"Trivers","year":"2009","journal-title":"Cancer Causes Control"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jss.2013.05.037","article-title":"Does obesity have an effect on outcomes in triple-negative breast cancer?","volume":"184","author":"Mowad","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1056\/NEJMsa1909301","article-title":"Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity","volume":"381","author":"Ward","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1001\/jama.2016.6458","article-title":"Trends in Obesity Among Adults in the United States, 2005 to 2014","volume":"315","author":"Flegal","year":"2016","journal-title":"JAMA"},{"key":"ref_17","first-page":"1","article-title":"Prevalence of Obesity Among Adults and Youth: United States, 2015\u20132016","volume":"288","author":"Hales","year":"2017","journal-title":"NCHS Data Brief"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.metabol.2018.11.001","article-title":"Obesity and cancer risk: Emerging biological mechanisms and perspectives","volume":"92","author":"Avgerinos","year":"2019","journal-title":"Metabolism"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/jnci\/djq526","article-title":"Associations of breast cancer risk factors with tumor subtypes: A pooled analysis from the Breast Cancer Association Consortium studies","volume":"103","author":"Yang","year":"2011","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/jamaoncol.2015.1546","article-title":"Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women\u2019s Health Initiative Randomized Clinical Trials","volume":"1","author":"Neuhouser","year":"2015","journal-title":"JAMA Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/ijc.23943","article-title":"Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status\u2014A meta-analysis","volume":"124","author":"Suzuki","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1200\/JCO.2010.29.7614","article-title":"Effect of obesity on prognosis after early-stage breast cancer","volume":"29","author":"Ewertz","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1210\/endrev\/bnad015","article-title":"Update on Adipose Tissue and Cancer","volume":"44","author":"Brown","year":"2023","journal-title":"Endocr. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1194\/jlr.R094060","article-title":"Beyond adiponectin and leptin: Adipose tissue-derived mediators of inter-organ communication","volume":"60","author":"Funcke","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrendo.2014.94","article-title":"Obesity and cancer\u2014Mechanisms underlying tumour progression and recurrence","volume":"10","author":"Park","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.trecan.2018.03.004","article-title":"Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors","volume":"4","author":"Lengyel","year":"2018","journal-title":"Trends Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1200\/JCO.2016.67.4283","article-title":"Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation","volume":"34","author":"Iyengar","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Thompson, C., Rahman, M.M., Singh, S., Arthur, S., Sierra-Bakhshi, C., Russell, R., Denning, K., Sundaram, U., and Salisbury, T. (2021). The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136706"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e172868","DOI":"10.1172\/jci.insight.172868","article-title":"Calorie restriction outperforms bariatric surgery in a murine model of obesity and triple-negative breast cancer","volume":"8","author":"Camp","year":"2023","journal-title":"JCI Insight"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gonzalez Suarez, N., Fernandez-Marrero, Y., Torabidastgerdooei, S., and Annabi, B. (2022). EGCG Prevents the Onset of an Inflammatory and Cancer-Associated Adipocyte-like Phenotype in Adipose-Derived Mesenchymal Stem\/Stromal Cells in Response to the Triple-Negative Breast Cancer Secretome. Nutrients, 14.","DOI":"10.3390\/nu14051099"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"111362","DOI":"10.1016\/j.celrep.2022.111362","article-title":"Adipocyte mesenchymal transition contributes to mammary tumor progression","volume":"40","author":"Zhu","year":"2022","journal-title":"Cell Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1158\/2159-8290.CD-13-0286","article-title":"Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets","volume":"4","author":"Balko","year":"2014","journal-title":"Cancer Discov."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.2147\/OTT.S109606","article-title":"NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells","volume":"9","author":"Zhong","year":"2016","journal-title":"Onco Targets Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1634\/theoncologist.2011-0377","article-title":"High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients","volume":"17","author":"Bartholomeusz","year":"2012","journal-title":"Oncologist"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Anand, K., Patel, T., Niravath, P., Rodriguez, A., Darcourt, J., Belcheva, A., Boone, T., Ensor, J., and Chang, J. (2021). Targeting mTOR and DNA repair pathways in residual triple negative breast cancer post neoadjuvant chemotherapy. Sci. Rep., 11.","DOI":"10.1038\/s41598-020-80081-y"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1158\/0008-5472.CAN-05-1069","article-title":"High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival","volume":"65","author":"Reedijk","year":"2005","journal-title":"Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10549-007-9805-3","article-title":"JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer","volume":"111","author":"Reedijk","year":"2008","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_38","first-page":"628","article-title":"Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells","volume":"42","author":"Ma","year":"2019","journal-title":"Mol. Cells"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Messeha, S.S., Zarmouh, N.O., Mendonca, P., Alwagdani, H., Kolta, M.G., and Soliman, K.F.A. (2018). The inhibitory effects of plumbagin on the NF-\u049bB pathway and CCL2 release in racially different triple-negative breast cancer cells. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0201116"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Piwarski, S.A., Thompson, C., Chaudhry, A.R., Denvir, J., Primerano, D.A., Fan, J., and Salisbury, T.B. (2020). The putative endogenous AHR ligand ITE reduces JAG1 and associated NOTCH1 signaling in triple negative breast cancer cells. Biochem. Pharmacol., 174.","DOI":"10.1016\/j.bcp.2020.113845"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12964-018-0309-z","article-title":"Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression","volume":"16","author":"He","year":"2018","journal-title":"Cell Commun. Signal"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Manore, S.G., Doheny, D.L., Wong, G.L., and Lo, H.W. (2022). IL-6\/JAK\/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.866014"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: From growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Qiao, X., Ma, B., Sun, W., Zhang, N., Liu, Y., Jia, L., and Liu, C. (2022). JAG1 is associated with the prognosis and metastasis in breast cancer. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-26241-8"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Xiu, M.X., Liu, Y.M., and Kuang, B.H. (2020). The oncogenic role of Jagged1\/Notch signaling in cancer. Biomed. Pharmacother., 129.","DOI":"10.1016\/j.biopha.2020.110416"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1600-065X.2012.01099.x","article-title":"NF-\u03baB and the link between inflammation and cancer","volume":"246","author":"DiDonato","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1158\/0008-5472.CAN-10-2523","article-title":"Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer","volume":"71","author":"Shimizu","year":"2011","journal-title":"Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zaoui, M., Morel, M., Ferrand, N., Fellahi, S., Bastard, J.P., Lamazi\u00e8re, A., Larsen, A.K., B\u00e9r\u00e9ziat, V., Atlan, M., and Sabbah, M. (2019). Breast-Associated Adipocytes Secretome Induce Fatty Acid Uptake and Invasiveness in Breast Cancer Cells via CD36 Independently of Body Mass Index, Menopausal Status and Mammary Density. Cancers, 11.","DOI":"10.3390\/cancers11122012"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s12094-022-03035-y","article-title":"Adipocytes secretome from normal and tumor breast favor breast cancer invasion by metabolic reprogramming","volume":"25","author":"Zaoui","year":"2023","journal-title":"Clin. Transl. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"24495","DOI":"10.18632\/oncotarget.8336","article-title":"Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5","volume":"7","author":"Liguoro","year":"2016","journal-title":"Oncotarget"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1158\/1055-9965.EPI-22-0013","article-title":"Obesity and Breast Cancer Metastasis across Genomic Subtypes","volume":"31","author":"Olsson","year":"2022","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1158\/0008-5472.CAN-16-0651","article-title":"Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer","volume":"76","author":"Lazar","year":"2016","journal-title":"Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"81880","DOI":"10.18632\/oncotarget.18737","article-title":"Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"47239","DOI":"10.18632\/oncotarget.17592","article-title":"Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth","volume":"8","author":"Lapeire","year":"2017","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1158\/0008-5472.CAN-10-3323","article-title":"Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion","volume":"71","author":"Dirat","year":"2011","journal-title":"Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40170-016-0163-7","article-title":"Adipocyte lipolysis links obesity to breast cancer growth: Adipocyte-derived fatty acids drive breast cancer cell proliferation and migration","volume":"5","author":"Balaban","year":"2017","journal-title":"Cancer Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"9712","DOI":"10.1158\/0008-5472.CAN-08-1952","article-title":"Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor","volume":"68","author":"Saxena","year":"2008","journal-title":"Cancer Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/modpathol.3800785","article-title":"High-level JAG1 mRNA and protein predict poor outcome in breast cancer","volume":"20","author":"Dickson","year":"2007","journal-title":"Mod. Pathol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1038\/s41467-020-18860-4","article-title":"Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1","volume":"11","author":"Jiang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ccell.2018.07.009","article-title":"Notch Signaling in the Tumor Microenvironment","volume":"34","author":"Meurette","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1172\/JCI32533","article-title":"IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland","volume":"117","author":"Sansone","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1073\/pnas.1815345116","article-title":"Toward understanding cancer stem cell heterogeneity in the tumor microenvironment","volume":"116","author":"Bocci","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/ijc.28496","article-title":"Obesity induced a leptin-Notch signaling axis in breast cancer","volume":"134","author":"Battle","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1530\/ERC-11-0075","article-title":"Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells","volume":"18","author":"Knight","year":"2011","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1158\/0008-5472.CAN-14-0160","article-title":"Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak\/STAT3 signaling","volume":"74","author":"Lapeire","year":"2014","journal-title":"Cancer Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e07273","DOI":"10.1016\/j.heliyon.2021.e07273","article-title":"Biological characteristics of a sub-population of cancer stem cells from two triple-negative breast tumour cell lines","volume":"7","author":"Alfaro","year":"2021","journal-title":"Heliyon"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ajpath.2017.09.018","article-title":"Obesity and Triple-Negative Breast Cancer: Disparities, Controversies, and Biology","volume":"188","author":"Dietze","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Miracle, C.E., McCallister, C.L., Egleton, R.D., and Salisbury, T.B. (2024). Mechanisms by which obesity regulates inflammation and anti-tumor immunity in cancer. Biochem. Biophys. Res. Commun., 733.","DOI":"10.1016\/j.bbrc.2024.150437"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"103650","DOI":"10.1016\/j.esmoop.2024.103650","article-title":"Efficacy of adjuvant chemotherapy schedules for breast cancer according to body mass index: Results from the phase III GIM2 trial","volume":"9","author":"Poggio","year":"2024","journal-title":"ESMO Open"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Roncato, R., Peruzzi, E., Gerratana, L., Posocco, B., Nuzzo, S., Montico, M., Orleni, M., Corsetti, S., Bartoletti, M., and Gagno, S. (2023). Clinical impact of body mass index on palbociclib treatment outcomes and effect on exposure. Biomed. Pharmacother., 164.","DOI":"10.1016\/j.biopha.2023.114906"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.breast.2017.11.004","article-title":"Impact of body mass index on the clinical outcomes of patients with HER2-positive metastatic breast cancer","volume":"37","author":"Martel","year":"2018","journal-title":"Breast"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/19\/10592\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:08:41Z","timestamp":1760112521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/19\/10592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":71,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["ijms251910592"],"URL":"https:\/\/doi.org\/10.3390\/ijms251910592","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]}}}