{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:32:11Z","timestamp":1771673531979,"version":"3.50.1"},"reference-count":149,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Science and Technology in Theranostics and Biotechnology (INCT-TeraNano, CNPq Process n\u00ba 403193\/2022-2 and Minas Gerais State Research Support Foundation (FAPEMIG) Process n\u00ba CBB\u2014APQ-03613-17)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis poses a significant challenge due its lethality, involving multiple organ dysfunction and impaired immune responses. Among several factors affecting sepsis, monocytes play a crucial role; however, their phenotype, proteomic profile, and function in septic shock remain unclear. Our aim was to fully characterize the subpopulations and proteomic profiles of monocytes seen in septic shock cases and discuss their possible impact on the disease. Peripheral blood monocyte subpopulations were phenotype based on CD14\/CD16 expression by flow cytometry, and proteins were extracted from the monocytes of individuals with septic shock and healthy controls to identify changes in the global protein expression in these cells. Analysis using 2D-nanoUPLC-UDMSE identified 67 differentially expressed proteins in shock patients compared to controls, in which 44 were upregulated and 23 downregulated. These proteins are involved in monocyte reprogramming, immune dysfunction, severe hypotension, hypo-responsiveness to vasoconstrictors, vasodilation, endothelial dysfunction, vascular injury, and blood clotting, elucidating the disease severity and therapeutic challenges of septic shock. This study identified critical biological targets in monocytes that could serve as potential biomarkers for the diagnosis, prognosis, and treatment of septic shock, providing new insights into the pathophysiology of the disease.<\/jats:p>","DOI":"10.3390\/ijms251910641","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T03:36:03Z","timestamp":1727926563000},"page":"10641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Modulation of Septic Shock: A Proteomic Approach"],"prefix":"10.3390","volume":"25","author":[{"given":"Patr\u00edcia Terra","family":"Alves","sequence":"first","affiliation":[{"name":"Laboratory of Nanobiotechnology, Institute of Biotechnology, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia 38402-022, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-7285","authenticated-orcid":false,"given":"Aline Gomes","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Hematology and Oncology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto 14040-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-6318","authenticated-orcid":false,"given":"Victor Alexandre F.","family":"Bastos","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Institute of Biotechnology, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia 38408-100, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduarda L.","family":"Miguel","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia 38408-100, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto C\u00e9sar S.","family":"Ramos","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia 38408-100, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. C.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Arthritis Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada"},{"name":"Lorraine Protein Biochemistry Group, Graduate Program in Neurology, Gaffr\u00e9e e Guinle University Hospital, Rio de Janeiro 20270-004, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-4861","authenticated-orcid":false,"given":"Luiz Ricardo","family":"Goulart","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiotechnology, Institute of Biotechnology, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia 38402-022, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-757X","authenticated-orcid":false,"given":"Th\u00falio M.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiotechnology, Institute of Biotechnology, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia 38402-022, MG, Brazil"},{"name":"School of Medicine, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia 38408-100, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensiv. 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