{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:30:29Z","timestamp":1790080229075,"version":"4.0.1"},"reference-count":82,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Neurological Disorders and Stroke of the National Institutes of Health","award":["R21NS114763"],"award-info":[{"award-number":["R21NS114763"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lipids and their bioactive metabolites, notably lysophosphatidylcholine (LPC), are increasingly important in ischemic stroke research. Reduced plasma LPC levels have been linked to stroke occurrence and poor outcomes, positioning LPC as a potential prognostic or diagnostic marker. Nonetheless, the connection between plasma LPC levels and stroke severity remains unclear. This study aimed to elucidate this relationship by examining plasma LPC levels in conjunction with brain LPC levels to provide a deeper understanding of the underlying mechanisms. Adult male Sprague\u2013Dawley rats underwent transient middle cerebral artery occlusion and were randomly assigned to different groups (sham-operated, vehicle, LPC supplementation, or LPC inhibition). We measured multiple LPC species in the plasma and brain, alongside assessing sensorimotor dysfunction, cerebral perfusion, lesion volume, and markers of BBB damage, inflammation, apoptosis, and oxidative stress. Among five LPC species, plasma LPC(16:0) and LPC(18:1) showed strong correlations with sensorimotor dysfunction, lesion severity, and mechanistic biomarkers in the rat stroke model. Despite notable discrepancies between plasma and brain LPC levels, both were strongly linked to functional outcomes and mechanistic biomarkers, suggesting that LPC\u2019s prognostic value is retained extracranially. This study advances the understanding of LPC as a blood marker in ischemic stroke and highlights directions for future research to further elucidate its association with stroke severity, particularly through investigations in more clinically representative models.<\/jats:p>","DOI":"10.3390\/ijms251910649","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T03:36:03Z","timestamp":1727926563000},"page":"10649","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring Lysophosphatidylcholine as a Biomarker in Ischemic Stroke: The Plasma\u2013Brain Disjunction"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-2695","authenticated-orcid":false,"given":"Justin","family":"Turpin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549, USA"},{"name":"Translational Brain Research Laboratory, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Wadolowski","sequence":"additional","affiliation":[{"name":"Translational Brain Research Laboratory, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willians","family":"Tambo","sequence":"additional","affiliation":[{"name":"Translational Brain Research Laboratory, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Elmezzi Graduate School of Molecular Medicine at Northwell Health, Manhasset, New York, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kim","sequence":"additional","affiliation":[{"name":"Translational Brain Research Laboratory, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Biology Department, Boston College, Chestnut Hill, MA 02467, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Al Abed","sequence":"additional","affiliation":[{"name":"Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Elmezzi Graduate School of Molecular Medicine at Northwell Health, Manhasset, New York, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-434X","authenticated-orcid":false,"given":"Daniel M.","family":"Sciubba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549, USA"},{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-8778","authenticated-orcid":false,"given":"Lance B.","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Elmezzi Graduate School of Molecular Medicine at Northwell Health, Manhasset, New York, NY 11030, USA"},{"name":"Laboratory for Critical Care Physiology, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5355-2739","authenticated-orcid":false,"given":"David","family":"Ledoux","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-8616","authenticated-orcid":false,"given":"Junhwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Laboratory for Critical Care Physiology, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Powell","sequence":"additional","affiliation":[{"name":"Translational Brain Research Laboratory, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549, USA"},{"name":"Translational Brain Research Laboratory, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, NY 11030, USA"},{"name":"Elmezzi Graduate School of Molecular Medicine at Northwell Health, Manhasset, New York, NY 11030, USA"},{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1097\/CCM.0000000000004597","article-title":"Management of Acute Ischemic 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