{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:28:53Z","timestamp":1760146133929,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pro-rector of Research and Post-graduation (Propesp) of the Federal University of Para (UFPA)","award":["88887.840110\/2023-00","88887.919930\/2023-00","88887.842950\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00","PRO5923-2022"],"award-info":[{"award-number":["88887.840110\/2023-00","88887.919930\/2023-00","88887.842950\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00","PRO5923-2022"]}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel (CAPES)","doi-asserted-by":"publisher","award":["88887.840110\/2023-00","88887.919930\/2023-00","88887.842950\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00","PRO5923-2022"],"award-info":[{"award-number":["88887.840110\/2023-00","88887.919930\/2023-00","88887.842950\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00","PRO5923-2022"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Amazon Foundation","award":["88887.840110\/2023-00","88887.919930\/2023-00","88887.842950\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00","PRO5923-2022"],"award-info":[{"award-number":["88887.840110\/2023-00","88887.919930\/2023-00","88887.842950\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00","PRO5923-2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>It is heavily suggested that one IFNL4 gene polymorphism, rs12979860 (T\/C), exerts influence on the outcome of HBV infection, with the rs12979860-T allele being classified as a risk predictor, and the rs12979860-C allele being classified as a protective one. This study investigated whether the rs12979860 IFNL4 gene polymorphism presented any association with the clinical severity for HBV carriers in an admixed population in Northern Brazil. A total of 69 samples were investigated from infected people from the city of Bel\u00e9m-Par\u00e1. The rs12979860-T allele was positively associated with HBV infection, suggesting a higher risk of chronicity. This research\u2019s importance is that the polymorphism influence was investigated in a population of HBV carriers with a heterogeneous genetic profile, formed through the extensive admixture of different ethnic groups, including Europeans, Africans, and Natives with indigenous heritage. This analysis is particularly important since highly mixed populations do not always follow the same association patterns previously established by studies using populations classified as more genetically homogeneous, due to a different formation process.<\/jats:p>","DOI":"10.3390\/ijms251910836","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T06:30:03Z","timestamp":1728455403000},"page":"10836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association of IFNL4 Gene Polymorphisms with Hepatitis B Virus (HBV) Infection in the Northern Region of Par\u00e1, Brazil"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2264-0493","authenticated-orcid":false,"given":"\u00c1lesson Adam Fonseca","family":"Andrade","sequence":"first","affiliation":[{"name":"Human and Medical Genetics Laboratory, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"},{"name":"Postgraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Par\u00e1, Bel\u00e9m 60000-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-0366","authenticated-orcid":false,"given":"Carolina Cabral","family":"Angelim","sequence":"additional","affiliation":[{"name":"Human and Medical Genetics Laboratory, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"},{"name":"Postgraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Par\u00e1, Bel\u00e9m 60000-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5479-4059","authenticated-orcid":false,"given":"Let\u00edcia Dias","family":"Martins","sequence":"additional","affiliation":[{"name":"Human and Medical Genetics Laboratory, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"},{"name":"Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua 67030-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-0561","authenticated-orcid":false,"given":"Amanda Roberta Vieira","family":"Sacramento","sequence":"additional","affiliation":[{"name":"Human and Medical Genetics Laboratory, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"},{"name":"Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua 67030-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-4143","authenticated-orcid":false,"given":"Renata Santos de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Par\u00e1, Bel\u00e9m 60000-000, Brazil"},{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raissa Lima","family":"Correa","sequence":"additional","affiliation":[{"name":"Human and Medical Genetics Laboratory, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0278-4972","authenticated-orcid":false,"given":"Simone Regina Souza da Silva","family":"Conde","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m 66055-080, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-6507","authenticated-orcid":false,"given":"Antonio Carlos Ros\u00e1rio","family":"Vallinoto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Par\u00e1, Bel\u00e9m 60000-000, Brazil"},{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-9350","authenticated-orcid":false,"given":"Rosimar Neris Martins","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Par\u00e1, Bel\u00e9m 60000-000, Brazil"},{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greice de Lemos Cardoso","family":"Costa","sequence":"additional","affiliation":[{"name":"Human and Medical Genetics Laboratory, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"},{"name":"Postgraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Par\u00e1, Bel\u00e9m 60000-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). 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