{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:49:10Z","timestamp":1787028550971,"version":"build-2736575974"},"reference-count":98,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Autonomous University of Mexico (UNAM) DGAPA-PAPIIT","award":["IN226619"],"award-info":[{"award-number":["IN226619"]}]},{"name":"National Autonomous University of Mexico (UNAM) DGAPA-PAPIIT","award":["CBF2023-2024-1422"],"award-info":[{"award-number":["CBF2023-2024-1422"]}]},{"name":"Consejo Nacional de Humanidades, Ciencia y Tecnolog\u00eda (CONAHCYT) \u201cProgramas Nacionales Estrat\u00e9gicos de Ciencia, Tecnolog\u00eda y Vinculaci\u00f3n con los Sectores Social, P\u00fablico y Privado\u201d","award":["IN226619"],"award-info":[{"award-number":["IN226619"]}]},{"name":"Consejo Nacional de Humanidades, Ciencia y Tecnolog\u00eda (CONAHCYT) \u201cProgramas Nacionales Estrat\u00e9gicos de Ciencia, Tecnolog\u00eda y Vinculaci\u00f3n con los Sectores Social, P\u00fablico y Privado\u201d","award":["CBF2023-2024-1422"],"award-info":[{"award-number":["CBF2023-2024-1422"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diabetes is a metabolic disease with a high worldwide prevalence and an important factor in mortality and disability in the population. Complications can be reduced or prevented with lifestyle changes in physical activity, dietary habits, and smoking cessation. High-protein diets (HPDs, &gt;30% or &gt;1.0 g\/Kg\/day) decrease hyperglycemia in part due to their content of branched-chain amino acids (BCAAs), mainly leucine. Leucine (and other BCAAs) improve glucose metabolism by directly signaling in the medio-basal hypothalamus (MBH), increasing liver insulin sensitivity. To determine the effectiveness of an HPD to lower hyperglycemia, we analyzed the results of published clinical studies focusing on the levels of fasting plasma glucose and\/or glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus (T2DM). We carried out a systematic search for clinical studies using HPDs. We searched five databases (Scopus, Web of Science, PubMed, Epistemonikos, and Cochrane), collecting 179 articles and finally selecting 8 articles to analyze their results. In conclusion, HPDs are an effective alternative to reduce hyperglycemia in patients with T2DM, especially so-called Paleolithic diets, due to their higher-quality protein from animal and vegetal sources and their exclusion of grains, dairy products, salt, refined fats, and added sugars.<\/jats:p>","DOI":"10.3390\/ijms252010959","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T08:10:16Z","timestamp":1728634216000},"page":"10959","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of a High-Protein Diet to Lower Glycemic Levels in Type 2 Diabetes Mellitus: A Systematic Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Mar\u00eda Nelly","family":"Flores-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Escuela de Medicina, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0335-8564","authenticated-orcid":false,"given":"Hilda","family":"Mart\u00ednez-Coria","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-6039","authenticated-orcid":false,"given":"H\u00e9ctor E.","family":"L\u00f3pez-Vald\u00e9s","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Arteaga-Silva","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, Mexico City 09340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Arrieta-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n B\u00e1sica, Divisi\u00f3n de Investigaci\u00f3n, Instituto Nacional de Geriatr\u00eda, Secretar\u00eda de Salud, Mexico City 10200, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7174-8647","authenticated-orcid":false,"given":"Roger","family":"Guti\u00e9rrez-Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Escuela de Medicina, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2019). 2. 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