{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:11:03Z","timestamp":1789834263459,"version":"4.0.1"},"reference-count":158,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Higher Committee for Education Development in Iraq (HCED)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>B cell lymphoma 6 (BCL6) is a conserved multi-domain protein that functions principally as a transcriptional repressor. This protein regulates many pivotal aspects of immune cell development and function. BCL6 is critical for germinal center (GC) formation and the development of high-affinity antibodies, with key roles in the generation and function of GC B cells, follicular helper T (Tfh) cells, follicular regulatory T (Tfr) cells, and various immune memory cells. BCL6 also controls macrophage production and function as well as performing a myriad of additional roles outside of the immune system. Many of these regulatory functions are conserved throughout evolution. The BCL6 gene is also important in human oncology, particularly in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL), but also extending to many in other cancers, including a unique role in resistance to a variety of therapies, which collectively make BCL6 inhibitors highly sought-after.<\/jats:p>","DOI":"10.3390\/ijms252010968","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T04:02:58Z","timestamp":1728878578000},"page":"10968","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and Beyond"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-4905","authenticated-orcid":false,"given":"Clifford","family":"Liongue","sequence":"first","affiliation":[{"name":"School of Medicine, Deakin University, Geelong, VIC 3216, Australia"},{"name":"Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farooq L. J.","family":"Almohaisen","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University, Geelong, VIC 3216, Australia"},{"name":"Department of Medical Laboratory Techniques, Southern Technical University, Basra 61001, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-7975","authenticated-orcid":false,"given":"Alister C.","family":"Ward","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University, Geelong, VIC 3216, Australia"},{"name":"Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.8235596","article-title":"Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma","volume":"262","author":"Ye","year":"1993","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1126\/science.276.5312.589","article-title":"Control of inflammation, cytokine expression, and germinal center formation by BCL-6","volume":"276","author":"Dent","year":"1997","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nature03147","article-title":"The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells","volume":"432","author":"Phan","year":"2004","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","article-title":"Bcl6 mediates the development of T follicular helper cells","volume":"325","author":"Nurieva","year":"2009","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.it.2021.02.002","article-title":"Bcl6-mediated transcriptional regulation of follicular helper T cells (TFH)","volume":"42","author":"Choi","year":"2021","journal-title":"Trends Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4049\/jimmunol.173.2.883","article-title":"Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells","volume":"173","author":"Ichii","year":"2004","journal-title":"J. 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