{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:29:47Z","timestamp":1760146187634,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Hospital of Guadeloupe","award":["SO 04-07","RG08\/008"],"award-info":[{"award-number":["SO 04-07","RG08\/008"]}]},{"name":"British Heart Foundation","award":["SO 04-07","RG08\/008"],"award-info":[{"award-number":["SO 04-07","RG08\/008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A lower mortality rate from coronary artery disease (CAD) and a more favourable lipid profile have been reported in Afro-Caribbeans compared with people of European ancestry. The aim of this study was to determine whether common lipid variants identified in other populations are associated with lipid levels and CAD in Afro-Caribbeans. We studied 705 Afro-Caribbeans (192 with CAD) who were genotyped for 13 lipid-associated variants. We calculated three polygenic risk scores (PRSs) for elevated LDL (LDL-PRS), decreased HDL (HDL-PRS), and elevated triglycerides (TG-PRS). LDL-PRS, HDL-PRS, and TG-PRS were associated with LDL, HDL, and TG levels, respectively. The LDL-PRS was positively associated with LDL &gt; 2.6 mmol\/L and with LDL &gt; 3.0 mmol\/L with ORs (odds ratios) of 1.33 (95% confidence interval (CI) = 1.14\u20131.56) and 1.40 (CI = 1.21\u20131.62), respectively. The HDL-PRS was associated with a low HDL category (HDL &lt; 1.03 mmol\/L) with an OR of 1.3 (CI = 1.04\u20131.63) and inversely associated with a high HDL category (HDL &gt; 1.55 mmol\/L) with an OR of 0.79 (CI = 0.65\u20130.96). The LDL-PRS was positively associated with CAD after adjustment for age, gender, hypertension, diabetes, and smoking with an OR of 1.27 (CI = 1.06\u20131.51) but not the HDL-PRS nor the TG-PRS. Results of the present study indicate that common lipid variants are associated with lipid levels and prevalent CAD in Afro-Caribbeans.<\/jats:p>","DOI":"10.3390\/ijms252011140","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T03:49:34Z","timestamp":1729136974000},"page":"11140","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Common Gene Variants on Lipid Levels and Risk of Coronary Heart Disease in Afro-Caribbeans"],"prefix":"10.3390","volume":"25","author":[{"given":"Laurent","family":"Larifla","sequence":"first","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"},{"name":"Laboratoire de Math\u00e9matiques Informatique et Applications (LAMIA), UR 1_1, University of Antilles, 97157 Pointe-\u00e0-Pitre, France"},{"name":"Department of Cardiology, University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Bassien-Capsa","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz-Line","family":"Velayoudom","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"},{"name":"Laboratoire de Math\u00e9matiques Informatique et Applications (LAMIA), UR 1_1, University of Antilles, 97157 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaneva","family":"Chingan-Martino","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0567-143X","authenticated-orcid":false,"given":"Yaovi","family":"Afassinou","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"Ancedy","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"},{"name":"Department of Cardiology, University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Galantine","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Galantine","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livy","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Martino","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Numeric","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital of Martinique, 97261 Fort-de France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0035-5632","authenticated-orcid":false,"given":"Lydia","family":"Foucan","sequence":"additional","affiliation":[{"name":"Research Team on Cardiometabolic Risk (ECM-RCM), University Hospital of Guadeloupe, 97159 Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-6547","authenticated-orcid":false,"given":"Steve E.","family":"Humphries","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. 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