{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:36:07Z","timestamp":1778740567721,"version":"3.51.4"},"reference-count":53,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic kidney disease (CKD) is often associated with dyslipidemia, marked by lipid abnormalities that can worsen kidney function and increase cardiovascular risk. A promising biomarker for evaluating kidney function and metabolic status in chronic kidney disease (CKD) is serum uromodulin (sUmod). This study sought to further investigate the relationship between sUmod levels and metabolic status in non-diabetic CKD patients. A sensitive ELISA method was used to determine sUmod levels in 90 adults with obstructive nephropathy and 30 healthy controls. Kidney function was assessed using the measured glomerular filtration rate (mGFR) through renal clearance of 99mTc-diethylenetriamine penta-acetic acid, along with cystatin C levels. Additionally, glycemic and lipid statuses were evaluated. sUmod concentrations showed a significant association with High-density lipoprotein (HDL) levels. Furthermore, CKD patients with lower sUmod levels had significantly lower Apolipoprotein A-I (Apo A-I) values compared to the control group. Significant predictors of lower sUmod concentrations identified in this study were higher glycemia (B = \u221215.939; p = 0.003) and lower HDL cholesterol levels (B = 20.588; p = 0.019). We conclude that, in addition to being significantly reduced in CKD patients, sUmod is a potential predictor of metabolic syndrome (MS) in this population. Lower sUmod concentrations, independent of mGFR, predict lower HDL cholesterol levels and higher glycemia values.<\/jats:p>","DOI":"10.3390\/ijms252011159","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T08:56:32Z","timestamp":1729155392000},"page":"11159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship Between Serum Uromodulin as a Marker of Kidney Damage and Metabolic Status in Patients with Chronic Kidney Disease of Non-Diabetic Etiology"],"prefix":"10.3390","volume":"25","author":[{"given":"Radmila","family":"\u017deravica","sequence":"first","affiliation":[{"name":"Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branislava","family":"Ilin\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1758-1141","authenticated-orcid":false,"given":"Dragan","family":"Buri\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Jakovljevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veljko","family":"Crnobrnja","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalibor","family":"Ili\u0107","sequence":"additional","affiliation":[{"name":"Center for Radiology, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija Vukmirovi\u0107","family":"Papuga","sequence":"additional","affiliation":[{"name":"Center of Laboratory Diagnostic, University Clinical Center of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Department of Nuclear Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.kint.2019.07.012","article-title":"A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases","volume":"96","author":"Jager","year":"2019","journal-title":"Kidney Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: An update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1053\/j.ackd.2010.03.002","article-title":"Awareness of chronic kidney disease among patients and providers","volume":"17","author":"Plantinga","year":"2010","journal-title":"Adv. Chronic. Kidney Dis."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mohanty, N.K., Sahoo, K.C., Pati, S., Sahu, A.K., and Mohanty, R. (2020). Prevalence of Chronic Kidney Disease in Cuttack District of Odisha, India. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17020456"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.ihj.2024.02.002","article-title":"Laboratory evaluation of lipid parameters in clinical practice","volume":"76","author":"Pancholia","year":"2024","journal-title":"Indian Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"612","DOI":"10.4093\/dmj.2023.0067","article-title":"Dyslipidemia in Patients with Chronic Kidney Disease: An Updated Overview","volume":"47","author":"Suh","year":"2023","journal-title":"Diabetes Metab. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.juro.2009.01.014","article-title":"Tamm-horsfall protein protects against urinary tract infection by proteus mirabilis","volume":"181","author":"Raffi","year":"2009","journal-title":"J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrneph.2017.101","article-title":"Uromodulin: From physiology to rare and complex kidney disorders","volume":"13","author":"Devuyst","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/j.1523-1755.2004.00867.x","article-title":"Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation","volume":"66","author":"Mo","year":"2004","journal-title":"Kidney Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1128\/IAI.70.5.2650-2656.2002","article-title":"Polarized expression of Tamm-Horsfall protein by renal tubular epithelial cells activates human granulocytes","volume":"70","author":"Kreft","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1681\/ASN.2012040338","article-title":"Uromodulin triggers IL-1\u03b2-dependent innate immunity via the NLRP3 inflammasome","volume":"23","author":"Darisipudi","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"F1066","DOI":"10.1152\/ajprenal.00543.2012","article-title":"Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury","volume":"304","author":"McCracken","year":"2013","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e3011","DOI":"10.1097\/MD.0000000000003011","article-title":"Plasma Uromodulin Correlates With Kidney Function and Identifies Early Stages in Chronic Kidney Disease Patients","volume":"95","author":"Steubl","year":"2016","journal-title":"Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/ndt\/gfw422","article-title":"Serum uromodulin-a marker of kidney function and renal parenchymal integrity","volume":"33","author":"Scherberich","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Thielemans, R., Speeckaert, R., Delrue, C., De Bruyne, S., Oyaert, M., and Speeckaert, M.M. (2023). Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases. Diagnostics, 13.","DOI":"10.3390\/diagnostics13193077"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1681\/ASN.2016111162","article-title":"Serum Uromodulin and Mortality Risk in Patients Undergoing Coronary Angiography","volume":"28","author":"Delgado","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Florens, N., Calzada, C., Lyasko, E., Juillard, L., and Soulage, C.O. (2016). Modified Lipids and Lipoproteins in Chronic Kidney Disease: A New Class of Uremic Toxins. Toxins, 8.","DOI":"10.3390\/toxins8120376"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Vukmirovi\u0107 Papuga, M., Bukumiri\u0107, Z., Ilin\u010di\u0107, B., Mijovi\u0107, R., \u0160a\u0161i\u0107 Ostoji\u0107, T., and \u017deravica, R. (2022). Serum Uromodulin, a Potential Biomarker of Tubulointerstitial Damage, Correlates Well with Measured GFR and ERPF in Patients with Obstructive Nephropathy. Medicina, 58.","DOI":"10.3390\/medicina58121729"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1042\/cs0680529","article-title":"Human Tamm-Horsfall glycoprotein: Urinary and plasma levels in normal subjects and patients with renal disease determined by a fully validated radioimmunoassay","volume":"68","author":"Thornley","year":"1985","journal-title":"Clin. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1053\/j.ajkd.2011.10.054","article-title":"Uromodulin in kidney injury: An instigator, bystander, or protector?","volume":"59","author":"Wu","year":"2012","journal-title":"Am. J. Kidney Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1681\/ASN.2009070725","article-title":"Uromodulin levels associate with a common UMOD variant and risk for incident CKD","volume":"21","author":"Hwang","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/HJH.0000000000001527","article-title":"The value of uromodulin as a new serum marker to predict decline in renal function","volume":"36","author":"Leiherer","year":"2018","journal-title":"J. Hypertens."},{"key":"ref_23","first-page":"1755","article-title":"The serum uromodulin level is associated with kidney function","volume":"52","author":"Risch","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_24","first-page":"995","article-title":"Serum uromodulin concentrations correlate with glomerular filtration rate in patients with chronic kidney disease","volume":"126","author":"Fedak","year":"2016","journal-title":"Pol. Arch. Med. Wewn."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e1302","DOI":"10.34067\/KID.0000000000000197","article-title":"Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene","volume":"4","author":"Nanamatsu","year":"2023","journal-title":"Kidney360"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1053\/j.ajkd.2008.03.003","article-title":"Overweight, obesity, and the development of stage 3 CKD: The Framingham Heart Study","volume":"52","author":"Foster","year":"2008","journal-title":"Am. J Kidney Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/j.ajkd.2009.07.018","article-title":"Obesity and change in estimated GFR among older adults","volume":"54","author":"Katz","year":"2009","journal-title":"Am. J. Kidney Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0272-6386(03)00020-9","article-title":"A central body fat distribution is related to renal function impairment, even in lean subjects","volume":"41","author":"Navis","year":"2003","journal-title":"Am. J. Kidney Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e007387","DOI":"10.1161\/JAHA.117.007387","article-title":"Relationship of High-Density Lipoprotein Cholesterol With Renal Function in Patients Treated With Atorvastatin","volume":"7","author":"Ong","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"You, A., Li, Y., Tomlinson, B., Yue, L., Zhao, K., Fan, H., Liu, Z., Zhang, Y., and Zheng, L. (2021). Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in China. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.644208"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1172\/JCI30163","article-title":"Molecular regulation of HDL metabolism and function: Implications for novel therapies","volume":"116","author":"Rader","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1161\/ATVBAHA.108.173575","article-title":"Antiinflammatory actions of HDL: A new insight","volume":"28","author":"Rye","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.cmet.2008.03.001","article-title":"HDL, ABC transporters, and cholesterol efflux: Implications for the treatment of atherosclerosis","volume":"7","author":"Tall","year":"2008","journal-title":"Cell Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-3-319-09665-0_10","article-title":"Dysfunctional HDL: From structure-function-relationships to biomarkers","volume":"224","author":"Riwanto","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic Kidney Disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"ref_36","first-page":"2","article-title":"1. Pathophysiology and Classification of Kidney Diseases","volume":"20","year":"2009","journal-title":"EJIFCC"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00467-013-2494-8","article-title":"Remnant nephron physiology and the progression of chronic kidney disease","volume":"29","author":"Schnaper","year":"2014","journal-title":"Pediatr. Nephrol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2169\/internalmedicine.1342-22","article-title":"The Versatile Role of Uromodulin in Renal Homeostasis and Its Relevance in Chronic Kidney Disease","volume":"63","author":"Takata","year":"2024","journal-title":"Intern. Med."},{"key":"ref_39","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Levin","year":"2013","journal-title":"Kidney Int. Suppl."},{"key":"ref_40","unstructured":"(2020). Global, regional, and national burden of chronic kidney disease, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 395, 709\u2013733."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: Analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4239\/wjd.v8.i5.172","article-title":"Effects of glycaemic management on diabetic kidney disease","volume":"8","author":"MacIsaac","year":"2017","journal-title":"World J. Diabetes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/ki.2009.401","article-title":"Role of oxidants\/inflammation in declining renal function in chronic kidney disease and normal aging","volume":"76","author":"Vlassara","year":"2009","journal-title":"Kidney Int. Suppl."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.291.7.844","article-title":"Predictors of new-onset kidney disease in a community-based population","volume":"291","author":"Fox","year":"2004","journal-title":"JAMA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1046\/j.1523-1755.2000.00056.x","article-title":"Tobacco, hypertension, and vascular disease: Risk factors for renal functional decline in an older population","volume":"57","author":"Bleyer","year":"2000","journal-title":"Kidney Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1530\/EC-19-0352","article-title":"Serum uromodulin is inversely associated with the metabolic syndrome in the KORA F4 study","volume":"8","author":"Then","year":"2019","journal-title":"Endocr. Connect."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.soard.2019.05.002","article-title":"Serum uromodulin and Roux-en-Y gastric bypass: Improvement of a marker reflecting nephron mass","volume":"15","author":"Scheurlen","year":"2019","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e5798","DOI":"10.1097\/MD.0000000000005798","article-title":"Serum uromodulin is associated with impaired glucose metabolism","volume":"96","author":"Leiherer","year":"2017","journal-title":"Medicine"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIR.0000000000001168","article-title":"2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA Guideline for the Management of Patients with Chronic Coronary Disease: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"148","author":"Virani","year":"2023","journal-title":"Circulation"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5414\/CN109220","article-title":"A study of urinary Tamm-Horsfall protein excretion in adult type 2 diabetes mellitus","volume":"90","author":"Zheng","year":"2018","journal-title":"Clin. Nephrol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/ndt\/gfae008","article-title":"Uromodulin biology","volume":"39","author":"Karagiannidis","year":"2024","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_52","first-page":"i\u2013ii+S1\u2013S266","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification","volume":"39","author":"Levey","year":"2002","journal-title":"Am. J. Kidney Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/01.mnm.0000136715.71820.4a","article-title":"Guidelines for the measurement of glomerular filtration rate using plasma sampling","volume":"25","author":"Fleming","year":"2004","journal-title":"Nucl. Med. Commun."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/20\/11159\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:15:09Z","timestamp":1760112909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/20\/11159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":53,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["ijms252011159"],"URL":"https:\/\/doi.org\/10.3390\/ijms252011159","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]}}}