{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:04:34Z","timestamp":1791813874620,"version":"4.3.4"},"reference-count":76,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["K08HL157653"],"award-info":[{"award-number":["K08HL157653"]}]},{"name":"American Heart Association Career Development Award (SUM)","award":["K08HL157653"],"award-info":[{"award-number":["K08HL157653"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To maintain its development, the growing fetus is directly dependent on the placenta, an organ that acts as both a modulator and mediator. As an essential component of pregnancy that is derived from both maternal and fetal tissues, the placenta facilitates the passage of all oxygen and nutrients from the expecting parent to their fetuses. Further, the placenta conveys multiple impacts of the maternal environment to the growing fetus. The timing of placental development parallels that of the fetal cardiovascular system, and placental anomalies are implicated as a potential cause of congenital heart disease. For example, congenital heart disease is more common in pregnancies complicated by maternal preeclampsia, a condition characterized by placental dysfunction. Given the placenta\u2019s intermediary links to the maternal environment and fetal health outcomes, it is an emerging focus of evolutionary medicine, which seeks to understand how interactions between humans and the environment affect our biology and give rise to disease. The present review provides an overview of the evolutionary and developmental courses of the placenta as well as their implications on infant health.<\/jats:p>","DOI":"10.3390\/ijms252011212","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T05:03:49Z","timestamp":1729227829000},"page":"11212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Placental\u2013Heart Axis: An Evolutionary Perspective"],"prefix":"10.3390","volume":"25","author":[{"given":"Jadyn","family":"Matthews","sequence":"first","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brammy","family":"Rajakumar","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2152-7998","authenticated-orcid":false,"given":"Chrystalle Katte","family":"Carreon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Boston Children\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Department of Pathology, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7816-2646","authenticated-orcid":false,"given":"Sarah U.","family":"Morton","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S6.e1","DOI":"10.1016\/j.ajog.2015.07.050","article-title":"What is the placenta?","volume":"213","author":"Burton","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R179","DOI":"10.1530\/REP-16-0325","article-title":"The evolution of the placenta","volume":"152","author":"Roberts","year":"2016","journal-title":"Reproduction"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S142","DOI":"10.1016\/j.placenta.2011.01.005","article-title":"Review: Toward an integrated evolutionary understanding of the mammalian placenta","volume":"32","author":"Wildman","year":"2011","journal-title":"Placenta"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Benagiano, G., Mancuso, S., Guo, S.-W., and Di Renzo, G.C. (2023). Events Leading to the Establishment of Pregnancy and Placental Formation: The Need to Fine-Tune the Nomenclature on Pregnancy and Gestation. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015420"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Cherubini, M., Erickson, S., and Haase, K. (2021). Modelling the Human Placental Interface In Vitro\u2014A Review. Micromachines, 12.","DOI":"10.3390\/mi12080884"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ernst, L.M., Ruchelli, E.D., Carreon, C.K., and Huff, D.S. (2019). Color Atlas of Human Fetal and Neonatal Histology, Springer.","DOI":"10.1007\/978-3-030-11425-1"},{"key":"ref_7","unstructured":"Herrick, E.J., and Bordoni, B. (2023, December 01). Embryology, Placenta, StatPearls, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551634\/."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Cole, L.A. (2010). Biological functions of hCG and hCG-related molecules. Reprod. Biol. Endocrinol., 8.","DOI":"10.1186\/1477-7827-8-102"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Roy, A., Mantay, M., Brannan, C., and Griffiths, S. (2022). Placental Tissues as Biomaterials in Regenerative Medicine. BioMed Res. Int., 2022.","DOI":"10.1155\/2022\/6751456"},{"key":"ref_10","first-page":"64","article-title":"Human Term Placental Cells: Phenotype, Properties and New Avenues in Regenerative Medicine","volume":"1","author":"Caruso","year":"2012","journal-title":"Int. J. Mol. Cell. Med."},{"key":"ref_11","unstructured":"Wang, Y., and Zhao, S. (2023, December 01). Placental Blood Circulation, Vascular Biology of the Placenta, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK53254\/."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"203663","DOI":"10.1016\/j.cdev.2021.203663","article-title":"Heart defects and embryonic lethality in Asb2 knock out mice correlate with placental defects","volume":"165","author":"Park","year":"2021","journal-title":"Cells Dev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1515\/jpm-2022-0478","article-title":"Patterns of placental injury in various types of fetal congenital heart disease","volume":"51","author":"Stanek","year":"2023","journal-title":"J. Perinat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e2210633119","DOI":"10.1073\/pnas.2210633119","article-title":"Conservation at the uterine\u2013placental interface","volume":"119","author":"Scott","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/00039890209602094","article-title":"Environmental Exposures to Lead and Cadmium Measured in Human Placenta","volume":"57","author":"Vinas","year":"2002","journal-title":"Arch. Environ. Health Int. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/npp.2015.231","article-title":"The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming","volume":"41","author":"Bronson","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e569","DOI":"10.1542\/neo.24-9-e569","article-title":"The Placenta in Congenital Heart Disease: Form, Function and Outcomes","volume":"24","author":"Josowitz","year":"2023","journal-title":"NeoReviews"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/pd.5515","article-title":"The association between severe fetal congenital heart defects and placental vascular malperfusion lesions","volume":"39","author":"Miremberg","year":"2019","journal-title":"Prenat. Diagn."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Garcia-Martin, I., Penketh, R.J.A., Garay, S.M., Jones, R.E., Grimstead, J.W., Baird, D.M., and John, R.M. (2021). Symptoms of Prenatal Depression Associated with Shorter Telomeres in Female Placenta. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147458"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41390-021-01521-7","article-title":"Neuroplacentology in congenital heart disease: Placental connections to neurodevelopmental outcomes","volume":"91","author":"Leon","year":"2022","journal-title":"Pediatr. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement","volume":"140","author":"Khong","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41379-021-00747-4","article-title":"Four major patterns of placental injury: A stepwise guide for understanding and implementing the 2016 Amsterdam consensus","volume":"34","author":"Redline","year":"2021","journal-title":"Mod. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Courtney, J.A., Cnota, J.F., and Jones, H.N. (2018). The Role of Abnormal Placentation in Congenital Heart Disease; Cause, Correlate, or Consequence?. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.01045"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Olmos-Ortiz, A., Flores-Espinosa, P., D\u00edaz, L., Vel\u00e1zquez, P., Ram\u00edrez-Isarraraz, C., and Zaga-Clavellina, V. (2021). Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158087"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.21037\/tp-21-297","article-title":"Genetics of congenital heart disease: A narrative review of recent advances and clinical implications","volume":"10","author":"Yasuhara","year":"2021","journal-title":"Transl. Pediatr."},{"key":"ref_26","unstructured":"Ramirez Alcantara, J., and Mendez, M.D. (2023, December 01). Interrupted Aortic Arch, StatPearls, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532902\/."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Demianczyk, A., Marshall, M., and Rao, R. (2023, December 01). Optimizing Quality of Life in Children with Complex Congenital Heart Disease|Current Treatment Options in Pediatrics. Available online: https:\/\/link.springer.com\/article\/10.1007\/s40746-024-00303-7.","DOI":"10.1007\/s40746-024-00303-7"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41569-021-00587-4","article-title":"Genomic frontiers in congenital heart disease","volume":"19","author":"Morton","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1161\/CIRCULATIONAHA.116.021793","article-title":"Congenital Heart Defects and Indices of Placental and Fetal Growth in a Nationwide Study of 924\u2009422 Liveborn Infants","volume":"134","author":"Matthiesen","year":"2016","journal-title":"Circulation"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e997","DOI":"10.1161\/CIR.0000000000001211","article-title":"Neurodevelopmental Outcomes for Individuals With Congenital Heart Disease: Updates in Neuroprotection, Risk-Stratification, Evaluation, and Management: A Scientific Statement From the American Heart Association","volume":"149","author":"Sood","year":"2024","journal-title":"Circulation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jnr.24603","article-title":"The placenta-brain-axis","volume":"99","author":"Rosenfeld","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000439527","article-title":"Severity of Fetal Brain Abnormalities in Congenital Heart Disease in Relation to the Main Expected Pattern of in utero Brain Blood Supply","volume":"39","author":"Masoller","year":"2016","journal-title":"Fetal Diagn. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/s41467-023-36740-5","article-title":"Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease","volume":"14","author":"Radford","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Schlatterer, S.D., Murnick, J., Jacobs, M., White, L., Donofrio, M.T., and Limperopoulos, C. (2019). Placental Pathology and Neuroimaging Correlates in Neonates with Congenital Heart Disease. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-40894-y"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S1071-55760300121-7","article-title":"Expression and secretion of the vascular cell adhesion molecule-1 in human placenta and its decrease in fetal growth restriction","volume":"10","author":"Rajashekhar","year":"2003","journal-title":"J. Soc. Gynecol. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41467-024-45647-8","article-title":"PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1093\/cercor\/bhs281","article-title":"Delayed cortical development in fetuses with complex congenital heart disease","volume":"23","author":"Clouchoux","year":"2013","journal-title":"Cereb. Cortex"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/CIRCULATIONAHA.109.865568","article-title":"Brain volume and metabolism in fetuses with congenital heart disease: Evaluation with quantitative magnetic resonance imaging and spectroscopy","volume":"121","author":"Limperopoulos","year":"2010","journal-title":"Circulation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.3174\/ajnr.A5628","article-title":"Volumetric Brain MRI Study in Fetuses with Congenital Heart Disease","volume":"39","author":"Olshaker","year":"2018","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jpeds.2013.06.045","article-title":"Cortical folding is altered before surgery in infants with congenital heart disease","volume":"163","author":"Ortinau","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.jtcvs.2011.10.039","article-title":"Regional alterations in cerebral growth exist preoperatively in infants with congenital heart disease","volume":"143","author":"Ortinau","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.nicl.2018.09.029","article-title":"Prenatal to postnatal trajectory of brain growth in complex congenital heart disease","volume":"20","author":"Ortinau","year":"2018","journal-title":"NeuroImage Clin."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1093\/cercor\/bhy235","article-title":"Early-Emerging Sulcal Patterns Are Atypical in Fetuses with Congenital Heart Disease","volume":"29","author":"Ortinau","year":"2019","journal-title":"Cereb. Cortex"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Pike, N.A., Roy, B., Cabrera-Mino, C., Halnon, N.J., Lewis, A.B., Shao, X., Wang, D.J.J., and Kumar, R. (2024). Compromised Cerebral Arterial Perfusion, Altered Brain Tissue Integrity, and Cognitive Impairment in Adolescents with Complex Congenital Heart Disease. J. Cardiovasc. Dev. Dis., 11.","DOI":"10.3390\/jcdd11080236"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/pd.5374","article-title":"Fetuses with single ventricle congenital heart disease manifest impairment of regional brain growth","volume":"38","author":"Rajagopalan","year":"2018","journal-title":"Prenat. Diagn."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1161\/CIRCULATIONAHA.114.013051","article-title":"Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease","volume":"131","author":"Sun","year":"2015","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jacc.2022.10.029","article-title":"Declining Incidence of Postoperative Neonatal Brain Injury in Congenital Heart Disease","volume":"81","author":"Peyvandi","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1017\/S1047951120003534","article-title":"Neurodevelopmental evaluation strategies for children with congenital heart disease aged birth through 5 years: Recommendations from the cardiac neurodevelopmental outcome collaborative","volume":"30","author":"Ware","year":"2020","journal-title":"Cardiol. Young"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/chd.12686","article-title":"Neurodevelopmental assessment of infants with congenital heart disease in the early postoperative period","volume":"14","author":"Butler","year":"2019","journal-title":"Congenit. Heart Dis."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Marable, C.A., Roell, K., Kuban, K., O\u2019Shea, T.M., and Fry, R.C. (2022). Placental transcriptional signatures associated with cerebral white matter damage in the neonate. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.1017953"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.21037\/tp-20-226","article-title":"Maternal hyperoxygenation in congenital heart disease","volume":"10","author":"Lee","year":"2021","journal-title":"Transl. Pediatr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1111\/echo.13722","article-title":"Maternal hyperoxygenation: A potential therapy for congenital heart disease in the fetuses? A systematic review of the current literature","volume":"34","author":"Vyas","year":"2017","journal-title":"Echocardiography"},{"key":"ref_53","first-page":"1265","article-title":"Evolutionary medicine: Update on the relevance to family practice","volume":"54","author":"Naugler","year":"2008","journal-title":"Can. Fam. Physician Med. Fam. Can."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"R\u00fchli, F.J., and Henneberg, M. (2013). New perspectives on evolutionary medicine: The relevance of microevolution for human health and disease. BMC Med., 11.","DOI":"10.1186\/1741-7015-11-115"},{"key":"ref_55","unstructured":"(2023, December 01). Diabetes Prevalence Expected to Double Globally by 2050. AJMC. Available online: https:\/\/www.ajmc.com\/view\/diabetes-prevalence-expected-to-double-globally-by-2050."},{"key":"ref_56","unstructured":"Lieberman, M.D. (2013). The Story of the Human Body, Crown Publishers\/Random House."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"eoab010","DOI":"10.1093\/emph\/eoab010","article-title":"An evolutionary mismatch narrative to improve lifestyle medicine: A patient education hypothesis","volume":"9","author":"Basile","year":"2021","journal-title":"Evol. Med. Public Health"},{"key":"ref_58","first-page":"1","article-title":"Darwinian Medicine","volume":"3","author":"Nesse","year":"1999","journal-title":"Life Sci. Res. Life Sci. Res. Publ. China"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e69398","DOI":"10.7554\/eLife.69398","article-title":"Evolutionary medicine","volume":"10","author":"Perry","year":"2021","journal-title":"eLife"},{"key":"ref_60","unstructured":"Challa, H.J., Bandlamudi, M., and Uppaluri, K.R. (2023, December 01). Paleolithic Diet, StatPearls, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482457\/."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Natterson-Horowitz, B., Aktipis, A., Fox, M., Gluckman, P.D., Low, F.M., Mace, R., Read, A., Turner, P.E., and Blumstein, D.T. (2023). The future of evolutionary medicine: Sparking innovation in biomedicine and public health. Front. Sci., 1.","DOI":"10.3389\/fsci.2023.997136"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/00333549141291S206","article-title":"The social determinants of health: It\u2019s time to consider the causes of the causes","volume":"129","author":"Braveman","year":"2014","journal-title":"Public Health Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/pch\/pxx146","article-title":"Early life environment and social determinants of cardiac health in children with congenital heart disease","volume":"23","author":"Wong","year":"2018","journal-title":"Paediatr. Child Health"},{"key":"ref_64","unstructured":"Bhatt, J. (2023, December 01). Your Zip Code, Your Health|AHA News. Available online: https:\/\/www.aha.org\/news\/insights-and-analysis\/2018-05-16-your-zip-code-your-health."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Rutherford, J.N. (2023, December 01). Fetal Signaling through Placental Structure and Endocrine Function: Illustrations and Implications from a Nonhuman primate model\u2014Rutherford\u20142009\u2014American Journal of Human Biology\u2014Wiley Online Library. Available online: https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.20923.","DOI":"10.1002\/ajhb.20923"},{"key":"ref_66","unstructured":"Dorey, F. (2023, December 01). How do We Affect Our Evolution?-The Australian Museum. Available online: https:\/\/australian.museum\/learn\/science\/human-evolution\/how-do-we-affect-our-evolution\/."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"m2511","DOI":"10.1136\/bmj.m2511","article-title":"Health effects of vitamin and mineral supplements","volume":"369","author":"Zhang","year":"2020","journal-title":"BMJ"},{"key":"ref_68","unstructured":"Air Pollution and Your Health (2024, August 23). National Institute of Environmental Health Sciences, Available online: https:\/\/www.niehs.nih.gov\/health\/topics\/agents\/air-pollution."},{"key":"ref_69","first-page":"E31","article-title":"Air pollution and chronic airway diseases: What should people know and do?","volume":"8","author":"Jiang","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/eurheartj\/ehq032","article-title":"Mortality in adult congenital heart disease","volume":"31","author":"Verheugt","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.rbmo.2012.03.017","article-title":"Placental adaptations to the maternal\u2013fetal environment: Implications for fetal growth and developmental programming","volume":"25","author":"Sandovici","year":"2012","journal-title":"Reprod. BioMed. Online"},{"key":"ref_72","first-page":"371","article-title":"Placental adaptations supporting fetal growth during normal and adverse gestational environments","volume":"108","year":"2023","journal-title":"Physiol. Soc."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e2218049120","DOI":"10.1073\/pnas.2218049120","article-title":"Adaptive structural and functional evolution of the placenta protects fetal growth in high-elevation deer mice","volume":"120","author":"Wilsterman","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.placenta.2011.03.001","article-title":"Effects of famine on placental size and efficiency","volume":"32","author":"Roseboom","year":"2011","journal-title":"Placenta"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2023.1100724","article-title":"Racial differences in the associations between adiposity, placental growth hormone and inflammatory cytokines in pregnant women","volume":"14","author":"Williams","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1752-4571.2010.00164.x","article-title":"How evolutionary principles improve the understanding of human health and disease","volume":"4","author":"Gluckman","year":"2011","journal-title":"Evol. Appl."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/20\/11212\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:15:56Z","timestamp":1760112956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/20\/11212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":76,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["ijms252011212"],"URL":"https:\/\/doi.org\/10.3390\/ijms252011212","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,18]]}}}