{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:47:49Z","timestamp":1792176469341,"version":"4.4.0"},"reference-count":205,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health &amp; Welfare, the Ministry of Food and Drug Safety)","award":["RS-2023-00253560"],"award-info":[{"award-number":["RS-2023-00253560"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The trigeminal sensory system consists of the trigeminal nerve, the trigeminal ganglion, and the trigeminal sensory nuclei (the mesencephalic nucleus, the principal nucleus, the spinal trigeminal nucleus, and several smaller nuclei). Various sensory signals carried by the trigeminal nerve from the orofacial area travel into the trigeminal sensory system, where they are processed into integrated sensory information that is relayed to higher sensory brain areas. Thus, knowledge of the trigeminal sensory system is essential for comprehending orofacial pain. This review elucidates the individual nuclei that comprise the trigeminal sensory system and their synaptic transmission. Additionally, it discusses four types of orofacial pain and their relationship to the system. Consequently, this review aims to enhance the understanding of the mechanisms underlying orofacial pain.<\/jats:p>","DOI":"10.3390\/ijms252011306","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T06:35:00Z","timestamp":1729492500000},"page":"11306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The Trigeminal Sensory System and Orofacial Pain"],"prefix":"10.3390","volume":"25","author":[{"given":"Hyung Kyu","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-myung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juping","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-ho","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"ref_1","unstructured":"Paxinos, G. (2004). Trigeminal sensory system. The Rat Nervous System, Elsevier. [3rd ed.]. Chapter 26."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0300-9629(89)90206-5","article-title":"Cytochemistry of the trigeminal and dorsal root ganglia and spinal cord of the rat","volume":"93","year":"1989","journal-title":"Comp. Biochem. Physiol. A Comp. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0361-9230(93)90247-9","article-title":"Tooth pulp primary neurons: Cell size analysis, central connection, and carbonic anhydrase activity","volume":"30","author":"Sugimoto","year":"1993","journal-title":"Brain Res. Bull."},{"key":"ref_4","first-page":"37","article-title":"Substance P in the trigeminal system at postmortem: Evidence for a role in pain pathways in man","volume":"19","author":"Helme","year":"1983","journal-title":"Clin. Exp. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0891-0618(92)90040-W","article-title":"Calcitonin gene-related peptide in the human trigeminal sensory system at developmental and adult life stages: Immunohistochemistry, neuronal morphometry and coexistence with substance P","volume":"5","author":"Quartu","year":"1992","journal-title":"J. Chem. Neuroanat."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/00001756-199604100-00012","article-title":"trk-like immunoreactivity in the human trigeminal ganglion and subnucleus caudalis","volume":"7","author":"Quartu","year":"1996","journal-title":"Neuroreport"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0006-8993(02)03927-6","article-title":"Nociceptin immunoreactivity and receptor mRNA in the human trigeminal ganglion","volume":"964","author":"Hou","year":"2003","journal-title":"Brain Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0304-3940(02)00741-3","article-title":"Capsaicin receptor immunoreactivity in the human trigeminal ganglion","volume":"330","author":"Hou","year":"2002","journal-title":"Neurosci. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/BF00235995","article-title":"Glutamate-like immunoreactive structures in primary sensory neurons in the rat detected by a specific antiserum against glutamate","volume":"65","author":"Wanaka","year":"1987","journal-title":"Exp. Brain Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF01046588","article-title":"Glutamate-immunoreactivity in the trigeminal and dorsal root ganglia, and intraspinal neurons and fibres in the dorsal horn of the rat","volume":"23","author":"Howe","year":"1991","journal-title":"Histochem. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/cne.903090208","article-title":"An electron microscopic description of glutamate-like immunoreactive axon terminals in the rat principal sensory and spinal trigeminal nuclei","volume":"309","author":"Clements","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0301-0082(01)00021-1","article-title":"Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus","volume":"66","author":"Lazarov","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/IOP.0b013e3181837a11","article-title":"Human orbital sympathetic nerve pathways","volume":"24","author":"Thakker","year":"2008","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1076\/apab.106.3.203.4383","article-title":"Immunocytochemical localization of the AMPA receptor subunits in the mesencephalic trigeminal nucleus of the rat","volume":"106","author":"Mineff","year":"1998","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1152\/jn.1999.82.3.1465","article-title":"Oscillatory membrane potential activity in the soma of a primary afferent neuron","volume":"82","author":"Pedroarena","year":"1999","journal-title":"J. Neurophysiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2334\/josnusd.16-0845","article-title":"Projection and synaptic connectivity of trigeminal mesencephalic nucleus neurons controlling jaw reflexes","volume":"59","author":"Yoshida","year":"2017","journal-title":"J. Oral Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3181\/00379727-217-44227","article-title":"Satiation and masticatory function modulated by brain histamine in rats","volume":"217","author":"Fujise","year":"1998","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0165-3806(88)90109-5","article-title":"Structure and function of barrel \u2018precursor\u2019 cells in trigeminal nucleus principalis","volume":"471","author":"Jacquin","year":"1988","journal-title":"Brain Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/07367228709144605","article-title":"Localization of glutamate in trigeminothalamic projection neurons: A combined retrograde transport-immunohistochemical study","volume":"4","author":"Magnusson","year":"1987","journal-title":"Somatosens. Res."},{"key":"ref_20","unstructured":"Mai, J.K., and Paxinos, G. (2012). Trigeminal sensory system. The Human Nervous System, Elsevier. [3rd ed.]. Chapter 31."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/cne.902470407","article-title":"Co-localization of fixative-modified glutamate and glutaminase in neurons of the spinal trigeminal nucleus of the rat: An immunohistochemical and immunoradiochemical analysis","volume":"247","author":"Magnusson","year":"1986","journal-title":"J. Comp. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3109\/08990229009144715","article-title":"Principalis- or parabrachial-projecting spinal trigeminal neurons do not stain for GABA or GAD","volume":"7","author":"Haring","year":"1990","journal-title":"Somatosens. Mot. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/cne.902230406","article-title":"The central projections of tooth pulp afferent neurons in the rat as determined by the transganglionic transport of horseradish peroxidase","volume":"223","author":"Marfurt","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0014-4886(91)90099-X","article-title":"Difference in central projection of primary afferents innervating facial and intraoral structures in the rat","volume":"111","author":"Takemura","year":"1991","journal-title":"Exp. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1212\/WNL.38.10.1529","article-title":"Intraoral sensation in patients with brainstem lesions: Role of the rostral spinal trigeminal nuclei in pons","volume":"38","author":"Graham","year":"1988","journal-title":"Neurology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3109\/08990229009144716","article-title":"Intersubnuclear connections within the rat trigeminal brainstem complex","volume":"7","author":"Jacquin","year":"1990","journal-title":"Somatosens. Mot. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/cne.902820104","article-title":"Structure-function relationships in rat brainstem subnucleus interpolaris: III. Local circuit neurons","volume":"282","author":"Jacquin","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/cne.902820105","article-title":"Structure-function relationships in rat brainstem subnucleus interpolaris: IV. Projection neurons","volume":"282","author":"Jacquin","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/cne.902200204","article-title":"Studies of the principal sensory and spinal trigeminal nuclei of the rat: Projections to the superior colliculus, inferior olive, and cerebellum","volume":"220","author":"Huerta","year":"1983","journal-title":"J. Comp. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0306-4522(89)90115-2","article-title":"A quantitative study of the projections of the gracile, cuneate and trigeminal nuclei and of the medullary reticular formation to the thalamus in the rat","volume":"32","author":"Kemplay","year":"1989","journal-title":"Neuroscience"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0306-4522(91)90136-C","article-title":"A comparison of the distribution and morphology of thalamic, cerebellar and spinal projection neurons in rat trigeminal nucleus interpolaris","volume":"40","author":"Phelan","year":"1991","journal-title":"Neuroscience"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/cne.903140202","article-title":"Thalamic processing of vibrissal information in the rat. I. Afferent input to the medial ventral posterior and posterior nuclei","volume":"314","author":"Chiaia","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/jnnp.2005.068601","article-title":"Sneeze related area in the medulla: Localisation of the human sneezing centre?","volume":"77","author":"Grandes","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_34","unstructured":"Kawamura, Y., and Dubner, R. (1981). Anatomical similarities between medullary and spinal dorsal horns. Oral-Facial Sensory and Motor Functions, Quintessence Publishing Co."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/cne.901800213","article-title":"Golgi studies of the neurons in layer II of the dorsal horn of the medulla (trigeminal nucleus caudalis)","volume":"180","author":"Gobel","year":"1978","journal-title":"J. Comp. Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0079-6123(08)61867-1","article-title":"An ascending general homeostatic afferent pathway originating in lamina I","volume":"107","author":"Craig","year":"1996","journal-title":"Prog. Brain Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1468-2982.2002.00324.x","article-title":"Neuropeptide expression in the human trigeminal nucleus caudalis and in the cervical spinal cord C1 and C2","volume":"22","author":"Uddman","year":"2002","journal-title":"Cephalalgia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0006-8993(79)90225-7","article-title":"Neurons in marginal layer of trigeminal nucleus caudalis projecting to ventrobasal complex (VG) and posterior nuclear group (PO) demonstrated by retrograde labeling with horseradish peroxidase","volume":"166","author":"Shigenaga","year":"1979","journal-title":"Brain Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0006-8993(83)90928-9","article-title":"The cells of origin of cat trigeminothalamic projections: Especially in the caudal medulla","volume":"277","author":"Shigenaga","year":"1983","journal-title":"Brain Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/cne.903210308","article-title":"Diencephalic projections from the superficial and deep laminae of the medullary dorsal horn in the rat","volume":"321","author":"Iwata","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/cne.903070408","article-title":"Trigeminal projections to the nucleus submedius of the thalamus in the rat","volume":"307","author":"Yoshida","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1096-9861(19981012)400:1<125::AID-CNE9>3.0.CO;2-B","article-title":"Cells of origin of the trigeminohypothalamic tract in the rat","volume":"400","author":"Malick","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/cne.903390106","article-title":"Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin","volume":"339","author":"Slugg","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1523\/JNEUROSCI.17-10-03751.1997","article-title":"Transneuronal labeling of a nociceptive pathway, the spino-(trigemino-)parabrachio-amygdaloid, in the rat","volume":"17","author":"Jasmin","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0306-4522(87)90102-3","article-title":"A quantitative light microscopic analysis and ultrastructural description of cholecystokinin-like immunoreactivity in the spinal trigeminal nucleus of the rat","volume":"20","author":"Clements","year":"1987","journal-title":"Neuroscience"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(96)00623-3","article-title":"Distribution of somatostatin receptors in the adult human brainstem","volume":"734","author":"Carpentier","year":"1996","journal-title":"Brain Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Covenas, R., Martin, F., Belda, M., Smith, V., Salinas, P., Rivada, E., Diaz-Cabiale, Z., Narvaez, J.A., Marcos, P., and Tramu, G. (2003). Mapping of neurokinin-like immunoreactivity in the human brainstem. BMC Neurosci., 4.","DOI":"10.1186\/1471-2202-4-3"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF00268020","article-title":"Gamma-aminobutyric acid-immunoreactive neurons in the rat trigeminal nuclei","volume":"99","author":"Ginestal","year":"1993","journal-title":"Histochemistry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/cne.901580206","article-title":"Fiber projections from trigeminal nucleus caudalis in primate (squirrel monkey and baboon)","volume":"158","author":"Tiwari","year":"1974","journal-title":"J. Comp. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0006-8993(79)90973-9","article-title":"Trigeminal nociceptive and non-nociceptive neurones: Brain stem intranuclear projections and modulation by orofacial, periqueductal gray and nucleus raphe magnus stimuli","volume":"170","author":"Hu","year":"1979","journal-title":"Brain Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1152\/jn.1990.64.1.28","article-title":"Structure-function relationships in rat brain stem subnucleus interpolaris. IX. Inputs from subnucleus caudalis","volume":"64","author":"Hallas","year":"1990","journal-title":"J. Neurophysiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0006-8993(87)90506-3","article-title":"Ascending and descending internuclear projections within the trigeminal sensory nuclear complex","volume":"425","author":"Nasution","year":"1987","journal-title":"Brain Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/0306-4522(84)90018-6","article-title":"Ascending and descending internuclear connections of the trigeminal sensory nuclei in the cat. A study with the retrograde and anterograde horseradish peroxidase technique","volume":"12","author":"Ikeda","year":"1984","journal-title":"Neuroscience"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0006-8993(82)90728-4","article-title":"Origin of ascending intratrigeminal pathways in the cat","volume":"236","author":"Panneton","year":"1982","journal-title":"Brain Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0304-3940(82)90022-2","article-title":"Termination and cells of origin of the ascending intra-nuclear fibers in the spinal trigeminal nucleus of the cat. A study with the horseradish peroxidase technique","volume":"31","author":"Ikeda","year":"1982","journal-title":"Neurosci. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/1096-9861(20001225)428:4<641::AID-CNE5>3.0.CO;2-Q","article-title":"Intracellular labeling study of neurons in the superficial part of the magnocellular layer of the medullary dorsal horn of the rat","volume":"428","author":"Li","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0306-4522(84)90298-7","article-title":"The morphology of neurons in trigeminal nucleus oralis projecting to the medullary dorsal horn (trigeminal nucleus caudalis): A retrograde horseradish peroxidase and Golgi study","volume":"13","author":"Falls","year":"1984","journal-title":"Neuroscience"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0006-8993(84)90743-1","article-title":"Termination in trigeminal nucleus oralis of ascending intratrigeminal axons originating from neurons in the medullary dorsal horn: An HRP study in the rat employing light and electron microscopy","volume":"290","author":"Falls","year":"1984","journal-title":"Brain Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0306-4522(83)90303-2","article-title":"Projections from brain stem nuclei to the spinal trigeminal nucleus in the cat","volume":"9","author":"Lovick","year":"1983","journal-title":"Neuroscience"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0306-4522(01)00456-0","article-title":"Ascending connections from the caudal part to the oral part of the spinal trigeminal nucleus in the rat","volume":"109","author":"Voisin","year":"2002","journal-title":"Neuroscience"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/(SICI)1096-9861(19980222)391:4<526::AID-CNE8>3.0.CO;2-2","article-title":"Trigeminal-reticular connections: Possible pathways for nociception-induced cardiovascular reflex responses in the rat","volume":"391","author":"Esser","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jneumeth.2007.08.011","article-title":"Pharmacological analysis of excitatory and inhibitory synaptic transmission in horizontal brainstem slices preserving three subnuclei of spinal trigeminal nucleus","volume":"167","author":"Han","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0006-8993(72)90169-2","article-title":"Anatomical studies of the organization of the spinal V nucleus: The deep bundles and the spinal V tract","volume":"48","author":"Gobel","year":"1972","journal-title":"Brain Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/08990229309028833","article-title":"The central projections of the monkey tooth pulp afferent neurons","volume":"10","author":"Takemura","year":"1993","journal-title":"Somatosens. Mot. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(81)90880-5","article-title":"An HRP study of the central projections of primary trigeminal neurons which innervate tooth pulps in the cat","volume":"210","author":"Arvidsson","year":"1981","journal-title":"Brain Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/cne.902510303","article-title":"Topographic representation of lower and upper teeth within the trigeminal sensory nuclei of adult cat as demonstrated by the transganglionic transport of horseradish peroxidase","volume":"251","author":"Shigenaga","year":"1986","journal-title":"J. Comp. Neurol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/0014-4886(87)90217-2","article-title":"Topographic organization of central terminal region of different sensory branches of the rat mandibular nerve","volume":"96","author":"Takemura","year":"1987","journal-title":"Exp. Neurol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/154405910308201001","article-title":"Pain in the trigeminal system: From orofacial nociception to neural network modeling","volume":"82","author":"Woda","year":"2003","journal-title":"J. Dent. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1167\/iovs.05-0088","article-title":"Parasympathetic mediated pupillary dilation elicited by lingual nerve stimulation in cats","volume":"46","author":"Tanaka","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0006-8993(84)90796-0","article-title":"Edinger-Westphal nucleus: Cholecystokinin immunocytochemistry and projections to spinal cord and trigeminal nucleus in the cat","volume":"299","author":"Maciewicz","year":"1984","journal-title":"Brain Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2005.01.091","article-title":"Patterns of fos expression in the rostral medulla and caudal pons evoked by noxious craniovascular stimulation and periaqueductal gray stimulation in the cat","volume":"1045","author":"Knight","year":"2005","journal-title":"Brain Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0006-8993(90)90125-U","article-title":"CNS projections to the pterygopalatine parasympathetic preganglionic neurons in the rat: A retrograde transneuronal viral cell body labeling study","volume":"534","author":"Spencer","year":"1990","journal-title":"Brain Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"R492","DOI":"10.1152\/ajpregu.2002.282.2.R492","article-title":"Involvement of trigeminal spinal nucleus in parasympathetic reflex vasodilatation in cat lower lip","volume":"282","author":"Mizuta","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/(SICI)1096-9861(19970217)378:3<425::AID-CNE9>3.0.CO;2-5","article-title":"Central projection of calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive trigeminal primary neurons in the rat","volume":"378","author":"Sugimoto","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0306-4522(95)00297-V","article-title":"Brainstem neurons expressing c-Fos immunoreactivity following irritant chemical stimulation of the rat\u2019s tongue","volume":"69","author":"Carstens","year":"1995","journal-title":"Neuroscience"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/00001756-200003200-00037","article-title":"The up-regulation of preprodynorphin mRNA in trigeminoparabrachial neurons after inflammation","volume":"11","author":"Imbe","year":"2000","journal-title":"Neuroreport"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000047887","article-title":"Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain","volume":"169","author":"Imbe","year":"2001","journal-title":"Cells Tissues Organs"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/cne.902830207","article-title":"Viscerotopic representation of the upper alimentary tract in the rat: Sensory ganglia and nuclei of the solitary and spinal trigeminal tracts","volume":"283","author":"Altschuler","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.brainres.2005.01.021","article-title":"Calbindin D28k-containing neurons in the paratrigeminal nucleus receive convergent nociceptive information and project to nucleus of the solitary tract in rat","volume":"1038","author":"Ma","year":"2005","journal-title":"Brain Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pain.2006.01.038","article-title":"Role of the paratrigeminal nucleus in nocifensive responses of rats to chemical, thermal and mechanical stimuli applied to the hind paw","volume":"122","author":"Koepp","year":"2006","journal-title":"Pain"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1469-7793.2000.00503.x","article-title":"Primary afferent synaptic responses recorded from trigeminal caudal neurons in a mandibular nerve-brainstem preparation of neonatal rats","volume":"524","author":"Onodera","year":"2000","journal-title":"J. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3940(95)11316-O","article-title":"Expression of glutamate (AMPA type) and gamma-aminobutyric acid (GABA)A receptors in the rat caudal trigeminal spinal nucleus","volume":"186","author":"Kondo","year":"1995","journal-title":"Neurosci. Lett."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Chalupnik, P., and Szymanska, E. (2023). Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031908"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2007.09.070","article-title":"Kainate receptors are primarily postsynaptic to SP-containing axon terminals in the trigeminal dorsal horn","volume":"1184","author":"Hegarty","year":"2007","journal-title":"Brain Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: Implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1126\/science.1075333","article-title":"Postsynaptic signaling and plasticity mechanisms","volume":"298","author":"Sheng","year":"2002","journal-title":"Science"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1046\/j.1460-9568.2000.01028.x","article-title":"Long-term potentiation of primary afferent neurotransmission at trigeminal synapses of juvenile rats","volume":"12","author":"Hamba","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.pain.2005.01.008","article-title":"Characterization of long-term potentiation of primary afferent transmission at trigeminal synapses of juvenile rats: Essential role of subtype 5 metabotropic glutamate receptors","volume":"114","author":"Liang","year":"2005","journal-title":"Pain"},{"key":"ref_89","first-page":"9","article-title":"Understanding LTP in pain pathways","volume":"3","year":"2007","journal-title":"Mol. Pain"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1152\/jn.00944.2001","article-title":"Central sensitization of nociceptive neurons in trigeminal subnucleus oralis depends on integrity of subnucleus caudalis","volume":"88","author":"Chiang","year":"2002","journal-title":"J. Neurophysiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1523\/JNEUROSCI.18-10-03529.1998","article-title":"Morphine administered in the substantia gelatinosa of the spinal trigeminal nucleus caudalis inhibits nociceptive activities in the spinal trigeminal nucleus oralis","volume":"18","author":"Dallel","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/WNR.0b013e3282fd695b","article-title":"N-methyl-D-aspartate-dependent long-term potentiation of excitatory transmission in trigeminal subnucleus oralis","volume":"19","author":"Youn","year":"2008","journal-title":"Neuroreport"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neulet.2013.11.056","article-title":"Long-term potentiation by activation of group I metabotropic glutamate receptors at excitatory synapses in the spinal trigeminal subnucleus oralis","volume":"560","author":"Youn","year":"2014","journal-title":"Neurosci. Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainresbull.2014.08.003","article-title":"Differential roles of signal transduction mechanisms in long-term potentiation of excitatory synaptic transmission induced by activation of group I mGluRs in the spinal trigeminal subnucleus oralis","volume":"108","author":"Youn","year":"2014","journal-title":"Brain Res. Bull."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.lfs.2017.09.005","article-title":"Postsynaptic N-type or P\/Q-type calcium channels mediate long-term potentiation by group I metabotropic glutamate receptors in the trigeminal oralis","volume":"188","author":"Weon","year":"2017","journal-title":"Life Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2014.05.019","article-title":"Theta-burst stimulation induces LTP at excitatory and inhibitory synapses in the spinal trigeminal subnucleus interpolaris","volume":"574","author":"Song","year":"2014","journal-title":"Neurosci. Lett."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.lfs.2015.11.024","article-title":"Essential roles of mGluR1 and inhibitory synaptic transmission in NMDA-independent long-term potentiation in the spinal trigeminal interpolaris","volume":"144","author":"Kim","year":"2016","journal-title":"Life Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1523\/JNEUROSCI.4627-07.2008","article-title":"Inhibitory gating of vibrissal inputs in the brainstem","volume":"28","author":"Furuta","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/206097a0","article-title":"Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated Fibres","volume":"206","author":"Mendell","year":"1965","journal-title":"Nature"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0301-0082(97)00067-1","article-title":"Sensitization of pain pathways in the spinal cord: Cellular mechanisms","volume":"54","author":"Baranauskas","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/0959-4388(93)90062-4","article-title":"Central hyperexcitability triggered by noxious inputs","volume":"3","author":"McMahon","year":"1993","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_102","first-page":"1","article-title":"Selective activation of A-delta and C nociceptive afferents by different parameters of nociceptive heat stimulation: A tool for analysis of central mechanisms of pain","volume":"68","author":"Price","year":"1996","journal-title":"Pain"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0166-2236(94)90018-3","article-title":"Modulation of spinal excitability: Co-operation between neurokinin and excitatory amino acid neurotransmitters","volume":"17","author":"Urban","year":"1994","journal-title":"Trends Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1460-9568.1999.00404.x","article-title":"Stimulus-function, wind-up and modulation by diffuse noxious inhibitory controls of responses of convergent neurons of the spinal trigeminal nucleus oralis","volume":"11","author":"Dallel","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brainres.2005.03.044","article-title":"Properties of neurons in the trigeminal nucleus caudalis responding to noxious dural and facial stimulation","volume":"1046","author":"Bolton","year":"2005","journal-title":"Brain Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3959(98)00028-1","article-title":"Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: Evidence for altered temporal summation of pain","volume":"76","author":"Maixner","year":"1998","journal-title":"Pain"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1152\/jn.1998.80.5.2621","article-title":"NMDA receptor mechanisms contribute to neuroplasticity induced in caudalis nociceptive neurons by tooth pulp stimulation","volume":"80","author":"Chiang","year":"1998","journal-title":"J. Neurophysiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0304-3959(91)90087-E","article-title":"Pain and hyperalgesia following tissue injury: New mechanisms and new treatments","volume":"44","author":"Dubner","year":"1991","journal-title":"Pain"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3959(92)90131-T","article-title":"Stimulation of craniofacial muscle afferents induces prolonged facilitatory effects in trigeminal nociceptive brain-stem neurones","volume":"48","author":"Hu","year":"1992","journal-title":"Pain"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1152\/jn.2001.85.5.1836","article-title":"Neuroplasticity induced by tooth pulp stimulation in trigeminal subnucleus oralis involves NMDA receptor mechanisms","volume":"85","author":"Park","year":"2001","journal-title":"J. Neurophysiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.coms.2007.12.001","article-title":"Neuropathic orofacial pain","volume":"20","author":"Benoliel","year":"2008","journal-title":"Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/B978-0-12-385198-7.00009-6","article-title":"Physiological mechanisms of neuropathic pain: The orofacial region","volume":"97","author":"Iwata","year":"2011","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Liu, Y.J., Li, Y.L., Fang, Z.H., Liao, H.L., Zhang, Y.Y., Lin, J., Liu, F., and Shen, J.F. (2022). NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain. Front. Cell. Neurosci., 16.","DOI":"10.3389\/fncel.2022.999509"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"77","DOI":"10.17245\/jdapm.2019.19.2.77","article-title":"Role of neuron and non-neuronal cell communication in persistent orofacial pain","volume":"19","author":"Iwata","year":"2019","journal-title":"J. Dent. Anesth. Pain Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1744806917714693","DOI":"10.1177\/1744806917714693","article-title":"Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy; cause and effect?","volume":"13","author":"Aromolaran","year":"2017","journal-title":"Mol. Pain."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Momose, A., Yabe, M., Chiba, S., Kumakawa, K., Shiraiwa, Y., and Mizukami, H. (2019). Role of Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated Pruritus. Medicines, 6.","DOI":"10.3390\/medicines6040110"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1744806919858801","DOI":"10.1177\/1744806919858801","article-title":"Na(v)1.7 and Na(v)1.8: Role in the pathophysiology of pain","volume":"15","author":"Hameed","year":"2019","journal-title":"Mol. Pain."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41573-021-00268-4","article-title":"Advances in TRP channel drug discovery: From target validation to clinical studies","volume":"21","author":"Koivisto","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and Central Sensitization in Chronic and Widespread Pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: A generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J. Pain."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia Function in the Central Nervous System During Health and Neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Kang, W., Hernandez, S.P., Rahman, M.S., Voigt, K., and Malvaso, A. (2022). Inhibitory Control Development: A Network Neuroscience Perspective. Front. Psychol., 13.","DOI":"10.3389\/fpsyg.2022.651547"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Bista, P., and Imlach, W.L. (2019). Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain. Medicines, 6.","DOI":"10.3390\/medicines6030091"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Chen, T.S., Huang, T.H., Lai, M.C., and Huang, C.W. (2023). The Role of Glutamate Receptors in Epilepsy. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030783"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coph.2011.10.018","article-title":"Hyperalgesia by synaptic long-term potentiation (LTP): An update","volume":"12","author":"Sandkuhler","year":"2012","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"100622","DOI":"10.1016\/j.bbih.2023.100622","article-title":"Microglia cause structural remodeling of noradrenergic axon in the trigeminal spinal subnucleus caudalis after infraorbital nerve injury in rats","volume":"30","author":"Hayashi","year":"2023","journal-title":"Brain Behav. Immun. Health."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.bbi.2012.03.004","article-title":"Heterogeneity of macrophages in injured trigeminal nerves: Cytokine\/chemokine expressing vs. phagocytic macrophages","volume":"26","author":"Lee","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_128","unstructured":"Schwartzkroin, P.A. (2009). Properties of Interneurons and their Relation to Epilepsy. Encyclopedia of Basic Epilepsy Research, Oxford Academic Press."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Charlton, T., Prowse, N., McFee, A., Heiratifar, N., Fortin, T., Paquette, C., and Hayley, S. (2023). Brain-derived neurotrophic factor (BDNF) has direct anti-inflammatory effects on microglia. Front. Cell. Neurosci., 17.","DOI":"10.3389\/fncel.2023.1188672"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-444-53825-3.00006-1","article-title":"Chapter 1\u2014Importance of chloride homeostasis in the operation of rhythmic motor networks","volume":"188","author":"Viemari","year":"2011","journal-title":"Prog. Brain Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1007\/s12035-021-02284-2","article-title":"Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain","volume":"58","author":"Luo","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Sleczkowska, M., Misra, K., Santoro, S., Gerrits, M.M., Hoeijmakers, J.G.J., and Grp, P.S. (2023). Ion Channel Genes in Painful Neuropathies. Biomedicines, 11.","DOI":"10.3390\/biomedicines11102680"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Theile, J.W., and Cummins, T.R. (2011). Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes. Front. Pharmacol., 2.","DOI":"10.3389\/fphar.2011.00054"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/j.1532-2149.2013.00331.x","article-title":"TRPA1 and TRPV1 are differentially involved in heat nociception of mice","volume":"17","author":"Hoffmann","year":"2013","journal-title":"Eur. J. Pain"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan","year":"2006","journal-title":"Neuron"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Alles, S.R.A., and Smith, P.A. (2021). Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets. Front. Pain Res., 2.","DOI":"10.3389\/fpain.2021.750583"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/bja\/aet128","article-title":"Neuroinflammation and the generation of neuropathic pain","volume":"111","author":"Ellis","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4110\/in.2012.12.2.41","article-title":"Glia as a Link between Neuroinflammation and Neuropathic Pain","volume":"12","author":"Jha","year":"2012","journal-title":"Immune Netw."},{"key":"ref_139","first-page":"e43555","article-title":"Role of Microglia in Neuropathic Pain","volume":"15","author":"Karavis","year":"2023","journal-title":"Cureus"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1056\/NEJMra1914484","article-title":"Trigeminal Neuralgia","volume":"383","author":"Cruccu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Simone, M., Choucha, A., Dannhoff, G., Kong, D.-S., Zoia, C., and Iaconetta, G. (2024). Treating Trigeminal Schwannoma through a Transorbital Approach: A Systemic Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13133701"},{"key":"ref_142","unstructured":"Zakrzewska, J.M., Chen, H.I., and Lee, J.Y.K. (2013). Trigeminal and Glossopharyngeal Neuralgia. Wall and Melzack\u2019s Textbook of Pain, Elsevier Saunders. [6th ed.]. Chapter 66."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/jns.1989.70.1.0001","article-title":"Microvascular compression: An alternative view and hypothesis","volume":"70","author":"Adams","year":"1989","journal-title":"J. Neurosurg."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Gerwin, R. (2020). Chronic Facial Pain: Trigeminal Neuralgia, Persistent Idiopathic Facial Pain, and Myofascial Pain Syndrome-An Evidence-Based Narrative Review and Etiological Hypothesis. Int. J. Environ. Res. Public Health., 17.","DOI":"10.3390\/ijerph17197012"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3171\/jns.2002.96.3.0527","article-title":"Predictors of outcome in surgically managed patients with typical and atypical trigeminal neuralgia: Comparison of results following microvascular decompression","volume":"96","author":"Kassam","year":"2002","journal-title":"J. Neurosurg."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3171\/2014.1.JNS131410","article-title":"Trigeminal neuralgia occurs and recurs in the absence of neurovascular compression","volume":"120","author":"Lee","year":"2014","journal-title":"J. Neurosurg."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1227\/00006123-199006000-00019","article-title":"An unusual cause for trigeminal neuralgia: Contralateral meningioma of the posterior fossa","volume":"26","author":"Haddad","year":"1990","journal-title":"Neurosurgery"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1212\/WNL.49.4.1142","article-title":"Trigeminal neuralgia in patients with multiple sclerosis: Lesion localization with magnetic resonance imaging","volume":"49","author":"Gass","year":"1997","journal-title":"Neurology"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00002508-200201000-00002","article-title":"Pathophysiology of trigeminal neuralgia: The ignition hypothesis","volume":"18","author":"Devor","year":"2002","journal-title":"Clin. J. Pain"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pain.2008.12.026","article-title":"Trigeminal neuralgia and pain related to multiple sclerosis","volume":"143","author":"Cruccu","year":"2009","journal-title":"Pain"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/j.pain.0000000000001777","article-title":"Trigeminal neuralgia associated with a solitary pontine lesion: Clinical and neuroimaging definition of a new syndrome","volume":"161","author":"Tohyama","year":"2020","journal-title":"Pain"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1111\/head.12441","article-title":"Trigeminal neuralgia\u2014A prospective systematic study of clinical characteristics in 158 patients","volume":"54","author":"Maarbjerg","year":"2014","journal-title":"Headache"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11916-019-0810-0","article-title":"A Comprehensive Review of Trigeminal Neuralgia","volume":"23","author":"Jones","year":"2019","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"70","DOI":"10.5812\/aapm.2164","article-title":"Trigeminal neuralgia: Frequency of occurrence in different nerve branches","volume":"1","author":"Bangash","year":"2011","journal-title":"Anesth. Pain Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/WNR.0000000000000632","article-title":"Changes in the expression of voltage-gated sodium channels Nav1.3, Nav1.7, Nav1.8, and Nav1.9 in rat trigeminal ganglia following chronic constriction injury","volume":"27","author":"Xu","year":"2016","journal-title":"Neuroreport"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1080\/00207454.2019.1595616","article-title":"The expression of voltage-gated sodium channels in trigeminal nerve following chronic constriction injury in rats","volume":"129","author":"Liu","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"ref_157","first-page":"45","article-title":"KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia","volume":"11","author":"Ikeda","year":"2015","journal-title":"Mol. Pain"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neulet.2017.11.026","article-title":"Role of KCNQ2 channels in orofacial cold sensitivity: KCNQ2 upregulation in trigeminal ganglion neurons after infraorbital nerve chronic constrictive injury","volume":"664","author":"Ling","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2119\/molmed.2016.00131","article-title":"A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia","volume":"22","author":"Tanaka","year":"2016","journal-title":"Mol. Med."},{"key":"ref_160","unstructured":"Crue, B.L. (1970). Trigeminal Pain. Pain and Suffering, Ch. C. Thomas."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3171\/jns.1967.26.1part2.0175","article-title":"Evidence for a central etiology of tic douloureux","volume":"26","author":"King","year":"1967","journal-title":"J. Neurosurg."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/j.1526-4610.2004.4200_1.x","article-title":"Trigeminal neuralgia due to pontine infarction","volume":"44","author":"Peker","year":"2004","journal-title":"Headache"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of Migraine: A Disorder of Sensory Processing","volume":"97","author":"Goadsby","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/0333102417736900","article-title":"Recognizing the role of CGRP and CGRP receptors in migraine and its treatment","volume":"39","author":"Edvinsson","year":"2019","journal-title":"Cephalalgia"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1523\/JNEUROSCI.0373-15.2015","article-title":"Migraine: Multiple processes, complex pathophysiology","volume":"35","author":"Burstein","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrneurol.2017.137","article-title":"Human models of migraine\u2014Short-term pain for long-term gain","volume":"13","author":"Ashina","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"g1416","DOI":"10.1136\/bmj.g1416","article-title":"Chronic migraine","volume":"348","author":"Schwedt","year":"2014","journal-title":"BMJ"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/14737175.2016.1216796","article-title":"Advances in the understanding of cluster headache","volume":"17","author":"Leone","year":"2017","journal-title":"Expert Rev. Neurother."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/brain\/aww097","article-title":"The migraine generator revisited: Continuous scanning of the migraine cycle over 30 days and three spontaneous attacks","volume":"139","author":"Schulte","year":"2016","journal-title":"Brain"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"18006","DOI":"10.1038\/nrdp.2018.6","article-title":"Cluster headache","volume":"4","author":"May","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Noseda, R., and Burstein, R. (2013). Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain. Pain, 154.","DOI":"10.1016\/j.pain.2013.07.021"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.neuron.2015.04.004","article-title":"The stroke-migraine depolarization continuum","volume":"86","author":"Dreier","year":"2015","journal-title":"Neuron"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies\u2014Successful translation from bench to clinic","volume":"14","author":"Edvinsson","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/0333102415607070","article-title":"Non-invasive vagus nerve stimulation for PREVention and Acute treatment of chronic cluster headache (PREVA): A randomised controlled study","volume":"36","author":"Gaul","year":"2016","journal-title":"Cephalalgia"},{"key":"ref_175","unstructured":"IHS (2018). The International Classification of Headache Disorders (3rd ed., edited by Headache Classification Committee of the International Headache Society). Cephalalgia, 38, 1\u2013211."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.tripleo.2006.11.009","article-title":"Management of burning mouth syndrome: Systematic review and management recommendations","volume":"103","author":"Patton","year":"2007","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_177","first-page":"117","article-title":"Pain and pain behavior in burning mouth syndrome: A pain diary study","volume":"26","author":"Forssell","year":"2012","journal-title":"J. Orofac. Pain"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1111\/bjd.13613","article-title":"The prevalence of burning mouth syndrome: A population-based study","volume":"172","author":"Kohorst","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1600-0714.1999.tb02052.x","article-title":"Burning mouth syndrome: Prevalence and associated factors","volume":"28","author":"Bergdahl","year":"1999","journal-title":"J. Oral Pathol. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1926269","DOI":"10.1155\/2017\/1926269","article-title":"Burning Mouth Syndrome: Aetiopathogenesis and Principles of Management","volume":"2017","author":"Feller","year":"2017","journal-title":"Pain Res. Manag."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Hanna, R., Bensadoun, R.J., Beken, S.V., Burton, P., Carroll, J., and Benedicenti, S. (2022). Outpatient Oral Neuropathic Pain Management with Photobiomodulation Therapy: A Prospective Analgesic Pharmacotherapy-Paralleled Feasibility Trial. Antioxidants, 11.","DOI":"10.3390\/antiox11030533"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/odi.12630","article-title":"Taste function assessed by electrogustometry in burning mouth syndrome: A case-control study","volume":"23","author":"Braud","year":"2017","journal-title":"Oral Dis."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jop.12350","article-title":"Characteristic changes of saliva and taste in burning mouth syndrome patients","volume":"45","author":"Imura","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-0714.2009.00824.x","article-title":"Oral pain perception and taste in burning mouth syndrome","volume":"39","author":"Just","year":"2010","journal-title":"J. Oral Pathol. Med."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1601-0825.2010.01660.x","article-title":"Somesthetic, gustatory, olfactory function and salivary flow in patients with neuropathic trigeminal pain","volume":"16","author":"Siviero","year":"2010","journal-title":"Oral Dis."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/chemse\/11.4.485","article-title":"Psychophysical evidence of taste dysfunction in burning mouth syndrome","volume":"11","author":"Grushka","year":"1986","journal-title":"Chem. Senses"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jpain.2003.09.002","article-title":"Sialochemical and gustatory analysis in patients with oral sensory complaints","volume":"5","author":"Nagler","year":"2004","journal-title":"J. Pain"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/ejn.13156","article-title":"Grey matter changes of the pain matrix in patients with burning mouth syndrome","volume":"43","author":"Sinding","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/154411130301400405","article-title":"Update on burning mouth syndrome: Overview and patient management","volume":"14","author":"Scala","year":"2003","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/odi.12454","article-title":"Peripheral nervous system involvement in primary burning mouth syndrome\u2014Results of a pilot study","volume":"22","author":"Puhakka","year":"2016","journal-title":"Oral Dis."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.jocn.2006.09.002","article-title":"Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score","volume":"14","author":"Yilmaz","year":"2007","journal-title":"J. Clin. Neurosci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ijom.2010.03.013","article-title":"Sensory purinergic receptor P2X3 is elevated in burning mouth syndrome","volume":"39","author":"Beneng","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/joor.12795","article-title":"An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives","volume":"46","author":"Imamura","year":"2019","journal-title":"J. Oral Rehabil."},{"key":"ref_194","first-page":"523","article-title":"Epithelial expression of vanilloid and cannabinoid receptors: A potential role in burning mouth syndrome pathogenesis","volume":"29","author":"Borsani","year":"2014","journal-title":"Histol. Histopathol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jpain.2007.03.001","article-title":"P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain","volume":"8","author":"Shinoda","year":"2007","journal-title":"J. Pain"},{"key":"ref_196","first-page":"328","article-title":"Nerve growth factor synthesis and its regulatory mechanisms: An approach to therapeutic induction of nerve growth factor synthesis","volume":"2","author":"Furukawa","year":"1990","journal-title":"Cerebrovasc. Brain Metab. Rev."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1038\/sj.emboj.7600893","article-title":"NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels","volume":"24","author":"Zhang","year":"2005","journal-title":"EMBO J."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pain.2009.11.016","article-title":"Effect of lingual nerve block on burning mouth syndrome (stomatodynia): A randomized crossover trial","volume":"149","author":"Dubray","year":"2010","journal-title":"Pain"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jds.2019.04.007","article-title":"Topical application in burning mouth syndrome","volume":"14","author":"Khan","year":"2019","journal-title":"J. Dent. Sci."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.physbeh.2012.06.013","article-title":"Taste damage (otitis media, tonsillectomy and head and neck cancer), oral sensations and BMI","volume":"107","author":"Bartoshuk","year":"2012","journal-title":"Physiol. Behav."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tripleo.2011.02.035","article-title":"The role of sensory input of the chorda tympani nerve and the number of fungiform papillae in burning mouth syndrome","volume":"112","author":"Gomes","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s00415-018-8776-0","article-title":"Post-traumatic taste disorders: A case series","volume":"265","author":"Cecchini","year":"2018","journal-title":"J. Neurol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1600-0722.2006.00401.x","article-title":"Taste deficits related to dental deafferentation: An electrogustometric study in humans","volume":"114","author":"Boucher","year":"2006","journal-title":"Eur. J. Oral Sci."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.clinph.2011.07.054","article-title":"Pathophysiology of primary burning mouth syndrome","volume":"123","author":"Jaaskelainen","year":"2012","journal-title":"Clin. Neurophysiol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"628","DOI":"10.14219\/jada.archive.2007.0234","article-title":"Evidence of chorda tympani dysfunction in patients with burning mouth syndrome","volume":"138","author":"Eliav","year":"2007","journal-title":"J. Am. Dent. Assoc."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/20\/11306\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:17:22Z","timestamp":1760113042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/20\/11306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":205,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["ijms252011306"],"URL":"https:\/\/doi.org\/10.3390\/ijms252011306","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,21]]}}}