{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:35:16Z","timestamp":1791315316385,"version":"4.3.1"},"reference-count":203,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19TPA34910132"],"award-info":[{"award-number":["19TPA34910132"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Modified cholesterols such as oxidized low-density lipoprotein (OxLDL) contribute to atherosclerosis and other disorders through the promotion of foam cell formation and inflammation. In recent years, it has become evident that immune cell responses to inflammatory molecules such as OxLDLs depend on cellular metabolic functions. This review examines the known effects of OxLDL on immunometabolism and immune cell responses in atherosclerosis and several other diseases. We additionally provide context on the relationship between OxLDL and aging\/senescence and identify gaps in the literature and our current understanding in these areas.<\/jats:p>","DOI":"10.3390\/ijms252111386","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T06:00:52Z","timestamp":1729663252000},"page":"11386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Oxidized Low-Density Lipoprotein and Its Role in Immunometabolism"],"prefix":"10.3390","volume":"25","author":[{"given":"Negin","family":"Mosalmanzadeh","sequence":"first","affiliation":[{"name":"College of Health Sciences, University of Memphis, Memphis, TN 38111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandt D.","family":"Pence","sequence":"additional","affiliation":[{"name":"College of Health Sciences and Center for Nutraceutical and Dietary Supplement Research, University of Memphis, Memphis, TN 38111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Safar, M., and Frohlich, E.D. (2007). Atherosclerosis, Large Arteries and Cardiovascular Risk, Karger Medical and Scientific Publishers.","DOI":"10.1159\/isbn.978-3-318-01395-5"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cca.2013.06.006","article-title":"Foam Cells in Atherosclerosis","volume":"424","author":"Yu","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1297s","DOI":"10.1093\/ajcn\/72.5.1297s","article-title":"Lipid and Macrophage Accumulations in Arteries of Children and the Development of Atherosclerosis","volume":"72","author":"Stary","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Khosravi, M., Hosseini-Fard, R., and Najafi, M. (2018). Circulating Low Density Lipoprotein (LDL). Horm. Mol. Biol. Clin. Investig., 35.","DOI":"10.1515\/hmbci-2018-0024"},{"key":"ref_5","first-page":"61","article-title":"The Major Pathways of Lipids (Triglyceride and Cholesterol) and Lipoprotein Metabolism","volume":"33","author":"Salih","year":"2021","journal-title":"Zanco J. Pure Appl. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"20963","DOI":"10.1074\/jbc.272.34.20963","article-title":"Low Density Lipoprotein Oxidation and Its Pathobiological Significance","volume":"272","author":"Steinberg","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1172\/JCI115499","article-title":"Role of Oxidized Low Density Lipoprotein in Atherogenesis","volume":"88","author":"Witztum","year":"1991","journal-title":"J. Clin. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Saba, A., Oridupa, O., Saba, A., and Oridupa, O. (2012). Lipoproteins and Cardiovascular Diseases. Lipoproteins\u2014Role in Health and Diseases, IntechOpen.","DOI":"10.5772\/48132"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.freeradbiomed.2019.03.036","article-title":"An Update on Lipid Oxidation and Inflammation in Cardiovascular Diseases","volume":"144","author":"Zhong","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.atherosclerosis.2008.05.032","article-title":"Oxidized LDL Immune Complexes and Oxidized LDL Differentially Affect the Expression of Genes Involved with Inflammation and Survival in Human U937 Monocytic Cells","volume":"202","author":"Hammad","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Nocella, C., Bartimoccia, S., Cammisotto, V., D\u2019amico, A., Pastori, D., Frati, G., Sciarretta, S., Rosa, P., Felici, C., and Riggio, O. (2021). Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process. Antioxidants, 10.","DOI":"10.3390\/antiox10111790"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1177\/0961203308093553","article-title":"Autoimmune-Mediated Atherothrombosis","volume":"17","author":"Matsuura","year":"2008","journal-title":"Lupus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0022-2275(20)31631-X","article-title":"A Specific Ligand for \u03922-Glycoprotein I Mediates Autoantibody-Dependent Uptake of Oxidized Low Density Lipoprotein by Macrophages","volume":"42","author":"Kobayashi","year":"2001","journal-title":"J. Lipid Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1196\/annals.1361.073","article-title":"OxLDL\/Beta2GPI Complexes and Autoantibodies in Patients with Systemic Lupus Erythematosus, Systemic Sclerosis, and Antiphospholipid Syndrome: Pathogenic Implications for Vascular Involvement","volume":"1051","author":"Lopez","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41423-022-00840-x","article-title":"Immunometabolism at the Intersection of Metabolic Signaling, Cell Fate, and Systems Immunology","volume":"19","author":"Chi","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41590-018-0113-3","article-title":"Regulation of Macrophage Immunometabolism in Atherosclerosis","volume":"19","author":"Koelwyn","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/cvr\/cvz127","article-title":"Immunometabolic Function of Cholesterol in Cardiovascular Disease and Beyond","volume":"115","author":"Bonacina","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1161\/CIRCRESAHA.119.315939","article-title":"Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis","volume":"126","author":"Tabas","year":"2020","journal-title":"Circ. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2174\/187153012803832602","article-title":"Oxidative Stress in Atherosclerosis Development: The Central Role of LDL and Oxidative Burst","volume":"12","author":"Peluso","year":"2012","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1515\/CCLM.2010.212","article-title":"Potential Role of the Lipoxygenase Derived Lipid Mediators in Atherosclerosis: Leukotrienes, Lipoxins and Resolvins","volume":"48","author":"Hersberger","year":"2010","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S1050-1738(01)00096-2","article-title":"12\/15-Lipoxygenase, Oxidative Modification of LDL and Atherogenesis","volume":"11","author":"Funk","year":"2001","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood.V92.9.3007","article-title":"Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing","volume":"92","author":"Hampton","year":"1998","journal-title":"Blood"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1161\/01.ATV.0000131784.50633.4f","article-title":"Hypochlorous Acid, a Macrophage Product, Induces Endothelial Apoptosis and Tissue Factor Expression: Involvement of Myeloperoxidase-Mediated Oxidant in Plaque Erosion and Thrombogenesis","volume":"24","author":"Sugiyama","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cca.2019.02.022","article-title":"Myeloperoxidase\u2014A Bridge Linking Inflammation and Oxidative Stress with Cardiovascular Disease","volume":"493","author":"Ndrepepa","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cmi.2014.89","article-title":"NADPH Oxidases: An Overview from Structure to Innate Immunity-Associated Pathologies","volume":"12","author":"Panday","year":"2014","journal-title":"Cell. Mol. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.2174\/1381612820666141014142557","article-title":"Reactive Oxygen Species in Pathogenesis of Atherosclerosis","volume":"21","author":"Goncharov","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.chemphyslip.2011.06.006","article-title":"Pathways of Cholesterol Oxidation via Non-Enzymatic Mechanisms","volume":"164","author":"Iuliano","year":"2011","journal-title":"Chem. Phys. Lipids"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0021-9150(97)00130-5","article-title":"The Possible Role of Copper Ions in Atherogenesis: The Blue Janus","volume":"133","author":"Ferns","year":"1997","journal-title":"Atherosclerosis"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/abbi.2001.2509","article-title":"A Critical Overview of the Chemistry of Copper-Dependent Low Density Lipoprotein Oxidation: Roles of Lipid Hydroperoxides, \u03b1-Tocopherol, Thiols, and Ceruloplasmin","volume":"394","author":"Burkitt","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tox.2011.03.001","article-title":"Advances in Metal-Induced Oxidative Stress and Human Disease","volume":"283","author":"Jomova","year":"2011","journal-title":"Toxicology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1194\/jlr.M500528-JLR200","article-title":"Metabolism of ApoB Lipoproteins of Intestinal and Hepatic Origin during Constant Feeding of Small Amounts of Fat","volume":"47","author":"Zheng","year":"2006","journal-title":"J. Lipid Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/01.ATV.16.7.831","article-title":"The Yin and Yang of Oxidation in the Development of the Fatty Streak. A Review Based on the 1994 George Lyman Duff Memorial Lecture","volume":"16","author":"Navab","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1172\/JCI114562","article-title":"Minimally Modified Low Density Lipoprotein Stimulates Monocyte Endothelial Interactions","volume":"85","author":"Berliner","year":"1990","journal-title":"J. Clin. Investig."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1172\/JCI116590","article-title":"Minimally Modified Low Density Lipoprotein-Induced Inflammatory Responses in Endothelial Cells Are Mediated by Cyclic Adenosine Monophosphate","volume":"92","author":"Parhami","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0891-5849(92)90181-F","article-title":"The Role of Lipid Peroxidation and Antioxidants in Oxidative Modification of LDL","volume":"13","author":"Esterbauer","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9150(93)90217-I","article-title":"Modified Forms of Low Density Lipoprotein and Atherosclerosis","volume":"98","author":"Aviram","year":"1993","journal-title":"Atherosclerosis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/tx00014a001","article-title":"Biochemical, Structural, and Functional Properties of Oxidized Low-Density Lipoprotein","volume":"3","author":"Waeg","year":"1990","journal-title":"Chem. Res. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Itabe, H., Sawada, N., Makiyama, T., and Obama, T. (2021). Structure and Dynamics of Oxidized Lipoproteins In Vivo: Roles of High-Density Lipoprotein. Biomedicines, 9.","DOI":"10.3390\/biomedicines9060655"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.bi.52.070183.001255","article-title":"Lipoprotein Metabolism in the Macrophage: Implications for Cholesterol Deposition in Atherosclerosis","volume":"52","author":"Brown","year":"1983","journal-title":"Annu. Rev. Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1073\/pnas.76.1.333","article-title":"Binding Site on Macrophages That Mediates Uptake and Degradation of Acetylated Low Density Lipoprotein, Producing Massive Cholesterol Deposition","volume":"76","author":"Goldstein","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9238","DOI":"10.1073\/pnas.85.23.9238","article-title":"Purification and Characterization of a Bovine Acetyl Low Density Lipoprotein Receptor","volume":"85","author":"Kodama","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1001\/jama.1990.03450230083034","article-title":"Lipoproteins and Atherogenesis: Current Concepts","volume":"264","author":"Steinberg","year":"1990","journal-title":"JAMA"},{"key":"ref_43","first-page":"11811","article-title":"CD36 Is a Receptor for Oxidized Low Density Lipoprotein","volume":"268","author":"Endemannl","year":"1993","journal-title":"ASBMB"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9580","DOI":"10.1073\/pnas.92.21.9580","article-title":"The 94- To 97-KDa Mouse Macrophage Membrane Protein That Recognizes Oxidized Low Density Lipoprotein and Phosphatidylserine-Rich Liposomes Is Identical to Macrosialin, the Mouse Homologue of Human CD68","volume":"92","author":"Ramprasad","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/386073a0","article-title":"An Endothelial Receptor for Oxidized Low-Density Lipoprotein","volume":"386","author":"Sawamura","year":"1997","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0891-5849(95)02173-6","article-title":"The Role of Oxidized Lipoproteins in Atherogenesis","volume":"20","author":"Berliner","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1042\/bst0181059","article-title":"Endogenous Antioxidants and Lipoprotein Oxidation","volume":"18","author":"Esterbauer","year":"1990","journal-title":"Biochem. Soc. Trans."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3109\/10715769809065814","article-title":"Implications of Lag Time Concept in the Oxidation of LDL","volume":"28","author":"Parthasarathy","year":"1998","journal-title":"Free Radic. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0891-5849(00)00236-7","article-title":"Molecular Action of Vitamin E in Lipoprotein Oxidation: Implications for Atherosclerosis","volume":"28","author":"Thomas","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Halliwell, B., and Gutteridge, J.M.C. (2015). Free Radicals in Biology and Medicine, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780198717478.001.0001"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0005-2760(90)90124-G","article-title":"Ultraviolet-Treated Lipoproteins as a Model System for the Study of the Biological Effects of Lipid Peroxides on Cultured Cells. II. Uptake and Cytotoxicity of Ultraviolet-Treated LDL on Lymphoid Cell Lines","volume":"1045","author":"Lopez","year":"1990","journal-title":"Biochi. Biophys. Acta (BBA) Lipids Lipid Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1056\/NEJM198904063201407","article-title":"Beyond Cholesterol. Modifications of Low-Density Lipoprotein That Increase Its Atherogenicity","volume":"320","author":"Epstein","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A Guide to Immunometabolism for Immunologists","volume":"16","author":"Kishton","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev-immunol-032713-120236","article-title":"Metabolic Regulation of Immune Responses","volume":"32","author":"Ganeshan","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01316-8","article-title":"The Cancer Metabolic Reprogramming and Immune Response","volume":"20","author":"Xia","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Srivastava, A., and Mannam, P. (2015). Warburg Revisited: Lessons for Innate Immunity and Sepsis. Front. Physiol., 6.","DOI":"10.3389\/fphys.2015.00070"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Domblides, C., Lartigue, L., and Faustin, B. (2018). Metabolic Stress in the Immune Function of T Cells, Macrophages and Dendritic Cells. Cells, 7.","DOI":"10.3390\/cells7070068"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Palmer, C.S., Ostrowski, M., Balderson, B., Christian, N., and Crowe, S.M. (2015). Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions. Front. Immunol., 6.","DOI":"10.3389\/fimmu.2015.00001"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Wang, S., Liu, G., Li, Y., and Pan, Y. (2022). Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.840029"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Sun, J.X., Xu, X.H., and Jin, L. (2022). Effects of Metabolism on Macrophage Polarization Under Different Disease Backgrounds. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.880286"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Huang, C.H., Yang, T.T., and Lin, K.I. (2024). Mechanisms and Functions of SUMOylation in Health and Disease: A Review Focusing on Immune Cells. J. Biomed. Sci., 31.","DOI":"10.1186\/s12929-024-01003-y"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Kempkes, R.W.M., Joosten, I., Koenen, H.J.P.M., and He, X. (2019). Metabolic Pathways Involved in Regulatory T Cell Functionality. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02839"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Rangel Rivera, G.O., Knochelmann, H.M., Dwyer, C.J., Smith, A.S., Wyatt, M.M., Rivera-Reyes, A.M., Thaxton, J.E., and Paulos, C.M. (2021). Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.645242"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Tomaszewicz, M., Ronowska, A., Zieli\u0144ski, M., Jankowska-Kulawy, A., and Trzonkowski, P. (2023). T Regulatory Cells Metabolism: The Influence on Functional Properties and Treatment Potential. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1122063"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3390\/cells4020178","article-title":"Scavenger Receptor Structure and Function in Health and Disease","volume":"4","author":"Zani","year":"2015","journal-title":"Cells"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Zingg, J.-M., Vlad, A., Ricciarelli, R., Pizzimenti, S., Muzio, G., and Barrera, G. (2021). Oxidized LDLs as Signaling Molecules. Antioxidants, 10.","DOI":"10.3390\/antiox10081184"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kloc, M., Kubiak, J.Z., and Ghobrial, R.M. (2022). Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214154"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e20211314","DOI":"10.1084\/jem.20211314","article-title":"CD36, a Signaling Receptor and Fatty Acid Transporter That Regulates Immune Cell Metabolism and Fate","volume":"219","author":"Chen","year":"2022","journal-title":"J. Exp. Med."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Sukhorukov, V.N., Khotina, V.A., Chegodaev, Y.S., Ivanova, E., Soben, I.A., and Orekhov, A.N. (2020). Lipid Metabolism in Macrophages: Focus on Atherosclerosis. Biomedicines, 8.","DOI":"10.3390\/biomedicines8080262"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Le\u00f3n, M.E., Loaeza-Reyes, K.J., Matias-Cervantes, C.A., Mayoral-Andrade, G., P\u00e9rez-Campos, E.L., P\u00e9rez-Campos-Mayoral, L., Hern\u00e1ndez-Huerta, M.T., Zenteno, E., P\u00e9rez-Cervera, Y., and Pina-Canseco, S. (2024). LOX-1 in Cardiovascular Disease: A Comprehensive Molecular and Clinical Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105276"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"762759","DOI":"10.1155\/2013\/762759","article-title":"Oxidized LDL in Inflammation: From Bench to Bedside","volume":"2013","author":"Tekin","year":"2013","journal-title":"Mediat. Inflamm"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Gutierrez-Pajares, J.L., Hassen, C.B., Chevalier, S., and Frank, P.G. (2016). SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00338"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1172\/JCI14011","article-title":"Scavenger Receptor Class B Type I Is a Multiligand HDL Receptor That Influences Diverse Physiologic Systems","volume":"108","author":"Krieger","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Mushenkova, N.V., Bezsonov, E.E., Orekhova, V.A., Popkova, T.V., Starodubova, A.V., and Orekhov, A.N. (2021). Recognition of Oxidized Lipids by Macrophages and Its Role in Atherosclerosis Development. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080915"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0163-7827(79)90003-1","article-title":"Role of Acylcoenzyme A: Cholesterol o-Acyltransferase in Cholesterol Metabolism","volume":"18","author":"Spector","year":"1979","journal-title":"Prog. Lipid Res."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Liao, Y., Zhu, E., and Zhou, W. (2021). Ox-LDL Aggravates the Oxidative Stress and Inflammatory Responses of THP-1 Macrophages by Reducing the Inhibition Effect of MiR-491-5p on MMP-9. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.697236"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8563845","DOI":"10.1155\/2019\/8563845","article-title":"Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation","volume":"2019","author":"Marchio","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Dai, H., Thomson, A.W., and Rogers, N.M. (2019). Dendritic Cells as Sensors, Mediators, and Regulators of Ischemic Injury. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02418"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Sun, L., Zhang, W., Zhao, Y., Wang, F., Liu, S., Liu, L., Zhao, L., Lu, W., Li, M., and Xu, Y. (2020). Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01456"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1084\/jem.20041236","article-title":"Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes","volume":"200","author":"Miller","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1182\/blood-2006-02-006361","article-title":"Dendritic Cells and HIV-Specific CD4+ T Cells: HIV Antigen Presentation, T-Cell Activation, and Viral Transfer","volume":"108","author":"Moris","year":"2006","journal-title":"Blood"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12964-023-01077-5","article-title":"Role of Oxidative Stress and Inflammation-Related Signaling Pathways in Doxorubicin-Induced Cardiomyopathy","volume":"21","author":"Shi","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Poznyak, A.V., Nikiforov, N.G., Markin, A.M., Kashirskikh, D.A., Myasoedova, V.A., Gerasimova, E.V., and Orekhov, A.N. (2021). Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.613780"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0167-0115(00)00105-1","article-title":"Reactive Oxygen Species and Vascular Cell Apoptosis in Response to Angiotensin II and Pro-Atherosclerotic Factors","volume":"90","author":"Dimmeler","year":"2000","journal-title":"Regul. Pept."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Paj\u0105k, B., Zieli\u0144ski, R., and Priebe, W. (2024). The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity. Molecules, 29.","DOI":"10.3390\/molecules29061298"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Findeisen, H.M., Voges, V.C., Braun, L.C., Sonnenberg, J., Schwarz, D., K\u00f6rner, H., Reinecke, H., and Sohrabi, Y. (2022). LXR\u03b1 Regulates OxLDL-Induced Trained Immunity in Macrophages. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116166"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wani, K., Alharthi, H., Alghamdi, A., Sabico, S., and Al-Daghri, N.M. (2021). Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18020511"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Meyers, A.K., and Zhu, X. (2020). The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging. Cells, 9.","DOI":"10.3390\/cells9081808"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41392-022-00955-7","article-title":"Inflammation and Atherosclerosis: Signaling Pathways and Therapeutic Intervention","volume":"7","author":"Kong","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1152\/physrev.00005.2005","article-title":"ATP-Binding Cassette Transporter A1: A Cell Cholesterol Exporter That Protects against Cardiovascular Disease","volume":"85","author":"Oram","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Jiang, H., Zhou, Y., Nabavi, S.M., Sahebkar, A., Little, P.J., Xu, S., Weng, J., and Ge, J. (2022). Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.925923"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Harjunp\u00e4\u00e4, H., Asens, M.L., Guenther, C., and Fagerholm, S.C. (2019). Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01078"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Sluiter, T.J., van Buul, J.D., Huveneers, S., Quax, P.H.A., and de Vries, M.R. (2021). Endothelial Barrier Function and Leukocyte Transmigration in Atherosclerosis. Biomedicines, 9.","DOI":"10.3390\/biomedicines9040328"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Batty, M., Bennett, M.R., and Yu, E. (2022). The Role of Oxidative Stress in Atherosclerosis. Cells, 11.","DOI":"10.3390\/cells11233843"},{"key":"ref_95","first-page":"2525","article-title":"Inflammation during the Life Cycle of the Atherosclerotic Plaque","volume":"117","author":"Libby","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Liu, X., He, W., Hong, X., Li, D., Chen, Z., Wang, Y., Chen, Z., Luan, Y., and Zhang, W. (2022). New Insights into Fibrous Cap Thickness of Vulnerable Plaques Assessed by Optical Coherence Tomography. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02896-z"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Alonso-Herranz, L., Albarr\u00e1n-Ju\u00e1rez, J., and Bentzon, J.F. (2023). Mechanisms of Fibrous Cap Formation in Atherosclerosis. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1254114"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12933-019-0870-9","article-title":"Inflammatory Cytokines in Type 2 Diabetes Mellitus as Facilitators of Hypercoagulation and Abnormal Clot Formation","volume":"18","author":"Randeria","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Sohrabi, Y., Lagache, S.M.M., Schnack, L., Godfrey, R., Kahles, F., Bruemmer, D., Waltenberger, J., and Findeisen, H.M. (2019). MTOR-Dependent Oxidative Stress Regulates OxLDL-Induced Trained Innate Immunity in Human Monocytes. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.03155"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.3389\/fimmu.2019.02993","article-title":"New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages","volume":"10","author":"Vidal","year":"2020","journal-title":"Front Immunol"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Wu, L., Yan, Z., Jiang, Y., Chen, Y., Du, J., Guo, L., Xu, J., Luo, Z., and Liu, Y. (2023). Metabolic Regulation of Dendritic Cell Activation and Immune Function during Inflammation. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1140749"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3892\/ijo.2023.5518","article-title":"Effects of Glycolysis on the Polarization and Function of Tumor-Associated Macrophages (Review)","volume":"62","author":"Cao","year":"2023","journal-title":"Int. J. Oncol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Williams, N.C., and O\u2019Neill, L.A.J. (2018). A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00141"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.4049\/jimmunol.1701522","article-title":"Toll-like Receptor 4-Induced Glycolytic Burst in Human Monocyte-Derived Dendritic Cells Results from P38-Dependent Stabilization of HIF-1\u03b1 and Increased Hexokinase II Expression","volume":"201","author":"Diaz","year":"2018","journal-title":"J. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic Reprogramming in Macrophages and Dendritic Cells in Innate Immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Canton, M., S\u00e1nchez-Rodr\u00edguez, R., Spera, I., Venegas, F.C., Favia, M., Viola, A., and Castegna, A. (2021). Reactive Oxygen Species in Macrophages: Sources and Targets. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.734229"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.180.7.4697","article-title":"Hypoxia and Hypoxia-Inducible Factor-1\u03b1 Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function","volume":"180","author":"Jantsch","year":"2008","journal-title":"J. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Ouyang, Z., Zhong, J., Shen, J., and Zeng, Y. (2023). The Cell Origins of Foam Cell and Lipid Metabolism Regulated by Mechanical Stress in Atherosclerosis. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1179828"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07202","article-title":"Integration of Metabolism and Inflammation by Lipid-Activated Nuclear Receptors","volume":"454","author":"Bensinger","year":"2008","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Zhang, J., Dai, W., and Chen, Y. (2022). Editorial: The Roles of Lipids in Immunometabolism: The Crosstalk Between Lipid Metabolisms and Inflammation. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.938535"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Bilotta, M.T., Petillo, S., Santoni, A., and Cippitelli, M. (2020). Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.584303"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Liu, Y., Xu, R., Gu, H., Zhang, E., Qu, J., Cao, W., Huang, X., Yan, H., He, J., and Cai, Z. (2021). Metabolic Reprogramming in Macrophage Responses. Biomark. Res., 9.","DOI":"10.1186\/s40364-020-00251-y"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Lorey, M.B., \u00d6\u00f6rni, K., and Kovanen, P.T. (2022). Modified Lipoproteins Induce Arterial Wall Inflammation During Atherogenesis. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.841545"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Vassiliou, E., and Farias-Pereira, R. (2023). Impact of Lipid Metabolism on Macrophage Polarization: Implications for Inflammation and Tumor Immunity. Int J Mol Sci, 24.","DOI":"10.3390\/ijms241512032"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1476-511X-10-229","article-title":"M2 Macrophages Exhibit Higher Sensitivity to OxLDL-Induced Lipotoxicity than Other Monocyte\/Macrophage Subtypes","volume":"10","author":"Isa","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Vanditha, M., Das, S., John, M., Vanditha, M., Das, S., and John, M. (2022). Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease. Fatty Acids\u2014From Biosynthesis to Human Health, IntechOpen.","DOI":"10.5772\/intechopen.105746"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Bellini, R., Bonacina, F., and Norata, G.D. (2022). Crosstalk between Dendritic Cells and T Lymphocytes during Atherogenesis: Focus on Antigen Presentation and Break of Tolerance. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.934314"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Britsch, S., Langer, H., Duerschmied, D., and Becher, T. (2024). The Evolving Role of Dendritic Cells in Atherosclerosis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042450"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Vrieling, F., Wilson, L., Rensen, P.C.N., Walzl, G., Ottenhoff, T.H.M., and Joosten, S.A. (2019). Oxidized Low-Density Lipoprotein (OxLDL) Supports Mycobacterium Tuberculosis Survival in Macrophages by Inducing Lysosomal Dysfunction. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007724"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Chen, C., and Khismatullin, D.B. (2015). Oxidized Low-Density Lipoprotein Contributes to Atherogenesis via Co-Activation of Macrophages and Mast Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0123088"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Kulovic-Sissawo, A., Tocantins, C., Diniz, M.S., Weiss, E., Steiner, A., Tokic, S., Madreiter-Sokolowski, C.T., Pereira, S.P., and Hiden, U. (2024). Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells. Biology, 13.","DOI":"10.3390\/biology13020070"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12974-024-03016-8","article-title":"Mitochondrial and Metabolic Dysfunction of Peripheral Immune Cells in Multiple Sclerosis","volume":"21","author":"Wang","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"H852","DOI":"10.1152\/ajpheart.00015.2005","article-title":"Oxidized LDL Induces Mitochondrially Associated Reactive Oxygen\/Nitrogen Species Formation in Endothelial Cells","volume":"289","author":"Zmijewski","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41580-021-00415-0","article-title":"The Assembly, Regulation and Function of the Mitochondrial Respiratory Chain","volume":"23","author":"Vercellino","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Pramanik, K.C., Boreddy, S.R., and Srivastava, S.K. (2011). Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020151"},{"key":"ref_126","first-page":"3","article-title":"Bin Mitochondrial Electron Transport Chain, ROS Generation and Uncoupling (Review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuint.2010.12.016","article-title":"Mitochondrial Dysfunction in Brain Aging: Role of Oxidative Stress and Cardiolipin","volume":"58","author":"Paradies","year":"2011","journal-title":"Neurochem. Int."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/sj.bjp.0704467","article-title":"Redox\/ROS Regulation of Lipopolysaccharide-Induced Mitogen-Activated Protein Kinase (MAPK) Activation and MAPK-Mediated TNF-\u03b1 Biosynthesis","volume":"135","author":"Haddad","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"C136","DOI":"10.1152\/ajpcell.00389.2021","article-title":"Mitochondrial DNA Damage as Driver of Cellular Outcomes","volume":"322","author":"Nadalutti","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1161\/01.RES.0000258450.44413.96","article-title":"Mitochondrial Dysfunction in Atherosclerosis","volume":"100","author":"Madamanchi","year":"2007","journal-title":"Circ. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1161\/01.RES.0000051886.43510.90","article-title":"Oxidized LDL Promotes Peroxide-Mediated Mitochondrial Dysfunction and Cell Death in Human Macrophages","volume":"92","author":"Asmis","year":"2003","journal-title":"Circ. Res."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Hortov\u00e1-Kohoutkov\u00e1, M., L\u00e1zni\u010dkov\u00e1, P., and Fri\u010d, J. (2021). How Immune-Cell Fate and Function Are Determined by Metabolic Pathway Choice: The Bioenergetics Underlying the Immune Response. Bioessays, 43.","DOI":"10.1002\/bies.202000067"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1002\/jcp.29228","article-title":"The Role of Glucose Homeostasis on Immune Function in Response to Exercise: The Impact of Low or Higher Energetic Conditions","volume":"235","author":"Dorneles","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_134","first-page":"30","article-title":"Changing the Energy of an Immune Response","volume":"2","author":"Piganelli","year":"2013","journal-title":"Am. J. Clin. Exp. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12948-017-0077-0","article-title":"Immunosenescence in Aging: Between Immune Cells Depletion and Cytokines up-Regulation","volume":"15","author":"Ventura","year":"2017","journal-title":"Clin. Mol. Allergy"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Zhang, W., Yang, F., Wang, Y., Jiao, F., Zhang, H., Wang, L., and Gong, Z. (2019). Inhibition of HDAC6 Attenuates LPS-Induced Inflammation in Macrophages by Regulating Oxidative Stress and Suppressing the TLR4-MAPK\/NF-\u039aB Pathways. Biomed. Pharmacother., 117.","DOI":"10.1016\/j.biopha.2019.109166"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Litwiniuk, A., Baranowska-Bik, A., Doma\u0144ska, A., Kalisz, M., and Bik, W. (2021). Contribution of Mitochondrial Dysfunction Combined with NLRP3 Inflammasome Activation in Selected Neurodegenerative Diseases. Pharmaceuticals, 14.","DOI":"10.3390\/ph14121221"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop Between NLRP3 Inflammasome and Reactive Oxygen Species","volume":"36","author":"Dominic","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mito.2020.12.013","article-title":"The Involvement of Autophagy in the Maintenance of Endothelial Homeostasis: The Role of Mitochondria","volume":"57","author":"Dymkowska","year":"2021","journal-title":"Mitochondrion"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Carresi, C., Mollace, R., Macr\u00ec, R., Scicchitano, M., Bosco, F., Scarano, F., Coppoletta, A.R., Guarnieri, L., Ruga, S., and Zito, M.C. (2021). Oxidative Stress Triggers Defective Autophagy in Endothelial Cells: Role in Atherothrombosis Development. Antioxidants, 10.","DOI":"10.3390\/antiox10030387"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"7687083","DOI":"10.1155\/2018\/7687083","article-title":"Defective Autophagy in Atherosclerosis: To Die or to Senesce?","volume":"2018","author":"Grootaert","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Busanello, E.N.B., Marques, A.C., Lorza-Gil, E., de Oliveira, H.C.F., Vercesi, A.E., Busanello, E.N.B., Marques, A.C., Lorza-Gil, E., de Oliveira, H.C.F., and Vercesi, A.E. (2017). Mitochondrial Oxidative Stress and Calcium-Dependent Permeability Transition Are Key Players in the Mechanisms of Statins-Associated Side Effects. Mitochondrial Diseases, IntechOpen.","DOI":"10.5772\/intechopen.71610"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ceca.2011.04.007","article-title":"Mitochondrial Permeability Transition in Ca2+-Dependent Apoptosis and Necrosis","volume":"50","author":"Rasola","year":"2011","journal-title":"Cell Calcium"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000103747","article-title":"Mitochondrial Permeability Transition Pore Opening as an Endpoint to Initiate Cell Death and as a Putative Target for Cardioprotection","volume":"20","author":"Javadov","year":"2007","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/physrev.00024.2005","article-title":"Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways","volume":"86","author":"Tedgui","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4161\/cam.1.4.5321","article-title":"Role of Cell Adhesion Molecules and Immune-Cell Migration in the Initiation, Onset and Development of Atherosclerosis","volume":"1","author":"Chi","year":"2007","journal-title":"Cell Adhes. Migr."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/10715760410001665244","article-title":"Dual Role of Oxidized LDL on the NF-KappaB Signaling Pathway","volume":"38","author":"Robbesyn","year":"2004","journal-title":"Free Radic. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10557-011-6341-5","article-title":"Oxidized LDL, LOX-1 and Atherosclerosis","volume":"25","author":"Mitra","year":"2011","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/CS20070430","article-title":"MAPK Signalling in Cardiovascular Health and Disease: Molecular Mechanisms and Therapeutic Targets","volume":"115","author":"Muslin","year":"2008","journal-title":"Clin. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"jcs255687","DOI":"10.1242\/jcs.255687","article-title":"Mixed Signals\u2014How Trypanosoma Cruzi Exploits Host-Cell Communication and Signaling to Establish Infection","volume":"134","author":"Batista","year":"2021","journal-title":"J. Cell Sci."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Al-Roub, A., Akhter, N., Al-Rashed, F., Wilson, A., Alzaid, F., Al-Mulla, F., Sindhu, S., and Ahmad, R. (2023). TNF\u03b1 Induces Matrix Metalloproteinase-9 Expression in Monocytic Cells through ACSL1\/JNK\/ERK\/NF-KB Signaling Pathways. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-41514-6"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0171-2985(97)80025-3","article-title":"Regulation of NF-\u039aB Activation by MAP Kinase Cascades","volume":"198","author":"Ferrari","year":"1997","journal-title":"Immunobiology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.2147\/JIR.S344730","article-title":"Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis","volume":"14","author":"Jiang","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00011-013-0633-0","article-title":"TNF-\u03b1 Signalling and Inflammation: Interactions between Old Acquaintances","volume":"62","year":"2013","journal-title":"Inflamm. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/imr.12615","article-title":"Function and Regulation of IL-1\u03b1 in Inflammatory Diseases and Cancer","volume":"281","author":"Malik","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"109130","DOI":"10.1016\/j.intimp.2022.109130","article-title":"Interleukin-6 Cytokine: An Overview of the Immune Regulation, Immune Dysregulation, and Therapeutic Approach","volume":"111","author":"Aliyu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Narazaki, M., and Kishimoto, T. (2018). The Two-Faced Cytokine IL-6 in Host Defense and Diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113528"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cytogfr.2016.07.001","article-title":"Role of Interleukin-18 in the Pathophysiology of Allergic Diseases","volume":"32","author":"Sanders","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"M\u00e1rquez, A.B., van der Vorst, E.P.C., and Maas, S.L. (2021). Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential. J. Clin. Med., 10.","DOI":"10.3390\/jcm10173825"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.cca.2010.07.006","article-title":"MCP-1: Chemoattractant with a Role beyond Immunity: A Review","volume":"411","author":"Yadav","year":"2010","journal-title":"Clin. Chim. Acta"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Vellasamy, D.M., Lee, S.J., Goh, K.W., Goh, B.H., Tang, Y.Q., Ming, L.C., and Yap, W.H. (2022). Targeting Immune Senescence in Atherosclerosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113059"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Kumari, R., and Jat, P. (2021). Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.645593"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"549","DOI":"10.5483\/BMBRep.2015.48.10.122","article-title":"From Cell Senescence to Age-Related Diseases: Differential Mechanisms of Action of Senescence-Associated Secretory Phenotypes","volume":"48","author":"Byun","year":"2015","journal-title":"BMB Rep."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1515\/BC.2008.031","article-title":"Cellular Responses to Reactive Oxygen Species-Induced DNA Damage and Aging","volume":"389","author":"Bertram","year":"2008","journal-title":"Biol. Chem."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.freeradbiomed.2017.03.030","article-title":"Oxidative DNA Damage & Repair: An Introduction","volume":"107","author":"Cadet","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Carusillo, A., and Mussolino, C. (2020). DNA Damage: From Threat to Treatment. Cells, 9.","DOI":"10.3390\/cells9071665"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1007\/s00018-014-1666-4","article-title":"Functional Interplay between ATM\/ATR-Mediated DNA Damage Response and DNA Repair Pathways in Oxidative Stress","volume":"71","author":"Yan","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1038\/onc.2012.640","article-title":"Senescence and Aging: The Critical Roles of P53","volume":"32","author":"Rufini","year":"2013","journal-title":"Oncogene"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Pawge, G., and Khatik, G.L. (2021). P53 Regulated Senescence Mechanism and Role of Its Modulators in Age-Related Disorders. Biochem. Pharmacol., 190.","DOI":"10.1016\/j.bcp.2021.114651"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrm2848","article-title":"Telomeres: Protecting Chromosomes against Genome Instability","volume":"11","author":"Karlseder","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1002\/anie.201002387","article-title":"Telomeres and Telomerase: The Means to the End (Nobel Lecture)","volume":"49","author":"Blackburn","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2147\/CIA.S256425","article-title":"Shelterin Complex at Telomeres: Implications in Ageing","volume":"15","author":"Mir","year":"2020","journal-title":"Clin. Interv. Aging"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e12487","DOI":"10.1111\/micc.12487","article-title":"The Role of Senescence, Telomere Dysfunction and Shelterin in Vascular Aging","volume":"26","author":"Liu","year":"2019","journal-title":"Microcirculation"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-genet-032918-021921","article-title":"Shelterin-Mediated Telomere Protection","volume":"52","year":"2018","journal-title":"Annu. Rev. Genet."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"13742","DOI":"10.1073\/pnas.93.24.13742","article-title":"Involvement of the Cyclin-Dependent Kinase Inhibitor P16 (INK4a) in Replicative Senescence of Normal Human Fibroblasts","volume":"93","author":"Alcorta","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Safwan-Zaiter, H., Wagner, N., and Wagner, K.D. (2022). P16INK4A-More Than a Senescence Marker. Life, 12.","DOI":"10.3390\/life12091332"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00109-008-0358-7","article-title":"DNA Damage, Vascular Senescence and Atherosclerosis","volume":"86","author":"Andreassi","year":"2008","journal-title":"J. Mol. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e000241","DOI":"10.1161\/JAHA.113.000241","article-title":"Hypercholesterolemia Induces Oxidant Stress That Accelerates the Ageing of Hematopoietic Stem Cells","volume":"3","author":"Tie","year":"2014","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.bbabio.2015.05.021","article-title":"The Role of Mitochondrial Dysfunction in Age-Related Diseases","volume":"1847","author":"Lane","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) Bioenerg."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"e12792","DOI":"10.1111\/acel.12792","article-title":"Human Electronegative LDL Induces Mitochondrial Dysfunction and Premature Senescence of Vascular Cells in Vivo","volume":"17","author":"Wang","year":"2018","journal-title":"Aging Cell"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/mutage\/gel048","article-title":"Mitochondrial Dysfunction, Persistently Elevated Levels of Reactive Oxygen Species and Radiation-Induced Genomic Instability: A Review","volume":"21","author":"Kim","year":"2006","journal-title":"Mutagenesis"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cyto.2019.01.013","article-title":"The Senescence-Associated Secretory Phenotype and Its Regulation","volume":"117","author":"Rowell","year":"2019","journal-title":"Cytokine"},{"key":"ref_183","first-page":"460","article-title":"Senescence-Associated Secretory Phenotype (SASP) Involvement in the Development of Cancer, Aging and Age Related Diseases GACETA M\u00c9DICA DE M\u00c9XICO REVIEW ARTICLE Correspondence","volume":"151","year":"2015","journal-title":"Gac. Med. Mex."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/acel.12455","article-title":"Cellular Senescence Impact on Immune Cell Fate and Function","volume":"15","author":"Vicente","year":"2016","journal-title":"Aging Cell"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"101275","DOI":"10.1016\/j.smim.2019.04.003","article-title":"Senescent Cell Clearance by the Immune System: Emerging Therapeutic Opportunities","volume":"40","author":"Prata","year":"2018","journal-title":"Semin. Immunol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.matbio.2017.10.004","article-title":"Extracellular Matrix Alterations in Senescent Cells and Their Significance in Tissue Homeostasis","volume":"75\u201376","author":"Mavrogonatou","year":"2019","journal-title":"Matrix Biol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1200\/JCO.2002.10.088","article-title":"Vascular Permeability Factor\/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy","volume":"20","author":"Dvorak","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jgg.2014.08.001","article-title":"Endothelial Cell Senescence and Age-Related Vascular Diseases","volume":"41","author":"Tian","year":"2014","journal-title":"J. Genet. Genomics"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Poznyak, A.V., Grechko, A.V., Orekhova, V.A., Chegodaev, Y.S., Wu, W.K., and Orekhov, A.N. (2020). Oxidative Stress and Antioxidants in Atherosclerosis Development and Treatment. Biology, 9.","DOI":"10.3390\/biology9030060"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2005.11.001","article-title":"Dietary Antioxidants in Preventing Atherogenesis","volume":"187","author":"Kaliora","year":"2006","journal-title":"Atherosclerosis"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0008-6363(00)00247-9","article-title":"Vascular Effects of HMG CoA-Reductase Inhibitors (Statins) Unrelated to Cholesterol Lowering: New Concepts for Cardiovascular Disease","volume":"49","author":"Lefer","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"ref_192","first-page":"483","article-title":"Statins: A New Insight into Their Mechanisms of Action and Consequent Pleiotropic Effects","volume":"59","author":"Owczarek","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic Effects of Statins on the Cardiovascular System","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ. Res."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Ben Mrid, R., Bouchmaa, N., Ainani, H., El Fatimy, R., Malka, G., and Mazini, L. (2022). Anti-Rheumatoid Drugs Advancements: New Insights into the Molecular Treatment of Rheumatoid Arthritis. Biomed. Pharmacother., 151.","DOI":"10.1016\/j.biopha.2022.113126"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00000441-200302000-00005","article-title":"New Indications for Treatment of Chronic Inflammation by TNF-Alpha Blockade","volume":"325","author":"Reimold","year":"2003","journal-title":"Am. J. Med. Sci."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Sharifi-Rad, M., Anil Kumar, N.V., Zucca, P., Varoni, E.M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P.V., Azzini, E., and Peluso, I. (2020). Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00694"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.clinbiochem.2010.04.056","article-title":"Effects of Lifestyle Modification on Oxidized LDL, Reactive Oxygen Species Production and Endothelial Cell Viability in Patients with Coronary Artery Disease","volume":"43","author":"Srimahachota","year":"2010","journal-title":"Clin Biochem"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Mellendick, K., Shanahan, L., Wideman, L., Calkins, S., Keane, S., and Lovelady, C. (2018). Diets Rich in Fruits and Vegetables Are Associated with Lower Cardiovascular Disease Risk in Adolescents. Nutrients, 10.","DOI":"10.3390\/nu10020136"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Trakaki, A., and Marsche, G. (2021). Current Understanding of the Immunomodulatory Activities of High-Density Lipoproteins. Biomedicines, 9.","DOI":"10.3390\/biomedicines9060587"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"111526","DOI":"10.1016\/j.mad.2021.111526","article-title":"Senotherapeutics: Targeting Senescent Cells for the Main Age-Related Diseases","volume":"197","author":"Boccardi","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"571846","DOI":"10.1155\/2012\/571846","article-title":"Immune Response to Lipoproteins in Atherosclerosis","volume":"2012","author":"Samson","year":"2012","journal-title":"Cholesterol"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/978-3-030-29168-6_10","article-title":"Scavenger Receptor and Targeting Strategies","volume":"39","author":"Lokhande","year":"2019","journal-title":"Target. Intracell. Drug Deliv. Recept. Mediat. Endocytosis"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.2174\/0929867324666170227121619","article-title":"Therapeutic Targeting of NLRP3 Inflammasomes by Natural Products and Pharmaceuticals: A Novel Mechanistic Approach for Inflammatory Diseases","volume":"24","author":"Jahan","year":"2017","journal-title":"Curr. Med. Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/21\/11386\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:18:31Z","timestamp":1760113111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/21\/11386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":203,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["ijms252111386"],"URL":"https:\/\/doi.org\/10.3390\/ijms252111386","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]}}}