{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:38:34Z","timestamp":1784770714528,"version":"3.55.0"},"reference-count":27,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>One of complications of diabetes mellitus is diabetic nephropathy. In Mexico, in traditional medicine, Buddleja cordata Humb. Bonpl. &amp; Kunth, (\u201ctepoz\u00e1n blanco\u201d) is a shrub plant used for the treatment of rheumatic diseases, postpartum bath, stomachache, skin burns, diarrhea in children, sores, and cancer. Objectives: We examined the effect of methanol extract of leaves of B. cordata on the expression of pro-inflammatory cytokines and its antioxidant effects in diabetic nephropathy. Methods: We used the streptozotocin-induced diabetes mellitus model in rats; these were treated with methanol extract from leaves of B. cordata at 50 and 100 mg\/kg (orally) for 4 weeks. Kidney weight\/total body weight ratio and proteins\/DNA, proteinuria and creatinine clearance, Western blot of nuclear factor \u03ba\u0392 (NFkB) p65 (cytoplasm and nucleus), peroxisome proliferator activated receptor gamma (PPAR\u03b3), and activities of glutathione peroxidase, superoxide dismutase, and catalase were determined.<\/jats:p>","DOI":"10.3390\/ijms252111432","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T09:11:47Z","timestamp":1729761107000},"page":"11432","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Buddleja cordata Leaf Extract on Diabetic Nephropathy in Rats"],"prefix":"10.3390","volume":"25","author":[{"given":"Elizabeth Alejandrina Guzm\u00e1n","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Medical Surgeon Career, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla 54090, State of Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Miranda","family":"Oca\u00f1a","sequence":"additional","affiliation":[{"name":"Biology Career, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla 54090, State of Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Ortiz","family":"Pedraza","sequence":"additional","affiliation":[{"name":"Biology Career, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla 54090, State of Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia Gar\u00edn","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Pharmacobiology Laboratory, Biology Career, FES Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla 54090, State of Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n San Miguel","family":"Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Montecillo Campus, Postgraduate College, Texcoco 56230, State of Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn Palomar","family":"Morales","sequence":"additional","affiliation":[{"name":"Diabetes Mellitus Metabolism Laboratory, Biology Career, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla 54090, State of Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Segura","family":"Cobos","sequence":"additional","affiliation":[{"name":"Medical Surgeon Career, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla 54090, State of Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Giralt-L\u00f3pez, A., Molina-Van den Bosch, M., Vergara, A., Garc\u00eda-Carro, C., Seron, D., Jacobs-Cach\u00e1, C., and Soler, M.J. 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