{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:00:00Z","timestamp":1792000800434,"version":"4.4.0"},"reference-count":92,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Unione europea-Next Generation EU","award":["202284LP94"],"award-info":[{"award-number":["202284LP94"]}]},{"name":"Unione europea-Next Generation EU","award":["B53D23021210006"],"award-info":[{"award-number":["B53D23021210006"]}]},{"name":"Unione europea-Next Generation EU","award":["2022LTJTNCW"],"award-info":[{"award-number":["2022LTJTNCW"]}]},{"name":"Unione europea-Next Generation EU","award":["E53D23009950006"],"award-info":[{"award-number":["E53D23009950006"]}]},{"name":"Piano Nazionale di Ripresa e Resilienza (PNRR)\u2014Missione 4 \u201cIstruzione e Ricerca\u201d\u2014Componente C2\u2014Investimento 1.1","award":["202284LP94"],"award-info":[{"award-number":["202284LP94"]}]},{"name":"Piano Nazionale di Ripresa e Resilienza (PNRR)\u2014Missione 4 \u201cIstruzione e Ricerca\u201d\u2014Componente C2\u2014Investimento 1.1","award":["B53D23021210006"],"award-info":[{"award-number":["B53D23021210006"]}]},{"name":"Piano Nazionale di Ripresa e Resilienza (PNRR)\u2014Missione 4 \u201cIstruzione e Ricerca\u201d\u2014Componente C2\u2014Investimento 1.1","award":["2022LTJTNCW"],"award-info":[{"award-number":["2022LTJTNCW"]}]},{"name":"Piano Nazionale di Ripresa e Resilienza (PNRR)\u2014Missione 4 \u201cIstruzione e Ricerca\u201d\u2014Componente C2\u2014Investimento 1.1","award":["E53D23009950006"],"award-info":[{"award-number":["E53D23009950006"]}]},{"name":"Fondo per il Programma Nazionale di Ricerca e Progetti di Rilevante Interesse Nazionale (PRIN)","award":["202284LP94"],"award-info":[{"award-number":["202284LP94"]}]},{"name":"Fondo per il Programma Nazionale di Ricerca e Progetti di Rilevante Interesse Nazionale (PRIN)","award":["B53D23021210006"],"award-info":[{"award-number":["B53D23021210006"]}]},{"name":"Fondo per il Programma Nazionale di Ricerca e Progetti di Rilevante Interesse Nazionale (PRIN)","award":["2022LTJTNCW"],"award-info":[{"award-number":["2022LTJTNCW"]}]},{"name":"Fondo per il Programma Nazionale di Ricerca e Progetti di Rilevante Interesse Nazionale (PRIN)","award":["E53D23009950006"],"award-info":[{"award-number":["E53D23009950006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The dysregulated NF-\u03baB basal activity is a common feature of human thyroid carcinomas, especially in poorly differentiated or undifferentiated forms that, even if rare, are often resistant to standard therapies, and, therefore, are uncurable. Despite the molecular mechanisms leading to NF-\u03baB activation in thyroid cancer being only partially understood, during the last few years, it has become clear that NF-\u03baB contributes in different ways to the oncogenic potential of thyroid neoplastic cells. Indeed, it enhances their proliferation and viability, promotes their migration to and colonization of distant organs, and fuels their microenvironment. In addition, NF-\u03baB signaling plays an important role in cancer stem cells from more aggressive thyroid carcinomas. Interfering with the different upstream and\/or downstream pathways that drive NF-\u03baB activity in thyroid neoplastic cells is an attractive strategy for the development of novel therapeutic drugs capable of overcoming the therapy resistance of advanced thyroid carcinomas. This review focuses on the recent findings about the key functions of NF-\u03baB in thyroid cancer and discusses the potential implications of targeting NF-\u03baB in advanced thyroid carcinomas.<\/jats:p>","DOI":"10.3390\/ijms252111464","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T07:51:29Z","timestamp":1729842689000},"page":"11464","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["NF-\u03baB in Thyroid Cancer: An Update"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-8053","authenticated-orcid":false,"given":"Elvira","family":"Crescenzi","sequence":"first","affiliation":[{"name":"Istituto per l\u2019Endocrinologia e l\u2019Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (CNR), Via S. Pansini, 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-9623","authenticated-orcid":false,"given":"Antonio","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, Via S. Pansini, 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-3596","authenticated-orcid":false,"given":"Francesco","family":"Pacifico","sequence":"additional","affiliation":[{"name":"Istituto per l\u2019Endocrinologia e l\u2019Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (CNR), Via S. Pansini, 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/jama.2023.26348","article-title":"Thyroid Cancer: A Review","volume":"331","author":"Boucai","year":"2024","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00428-024-03752-5","article-title":"Poorly differentiated thyroid carcinomas: Conceptual controversy and clinical impact","volume":"484","author":"Rodrigo","year":"2024","journal-title":"Virchows Arch."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/mco.2023.2695","article-title":"Anaplastic thyroid cancer: Pathogenesis, prognostic factors and genetic landscape","volume":"19","author":"Alhejaily","year":"2023","journal-title":"Mol. Clin. 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