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Curcumin is a bioactive compound extracted from turmeric with several pharmacological activities. Curcumin is a multifaceted anticancer agent through mechanisms including the modulation of signaling pathways, inhibition of cell proliferation, induction of apoptosis, and production of reactive oxygen species. However, the poor water solubility and bioavailability of curcumin create important barriers in its clinical application. This review elaborates on the therapeutic potential of curcumin in breast cancer treatment, focusing on the efficacy of different administration routes and synergistic effects with other therapeutic agents. The intravenous administration of curcumin-loaded nanoparticles significantly improves bioavailability and therapeutic outcomes compared to oral routes. Innovative formulations, such as nano-emulsifying drug delivery systems, have shown promise in enhancing oral bioavailability. While intravenous delivery ensures higher bioavailability and direct action on tumor cells, it is more invasive and expensive than oral administration. Advancing research on curcumin in breast cancer treatment is essential for improving therapeutic outcomes and enhancing the quality of life of patients.<\/jats:p>","DOI":"10.3390\/ijms252111492","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T04:15:02Z","timestamp":1730088902000},"page":"11492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Curcumin Administration Routes in Breast Cancer Treatment"],"prefix":"10.3390","volume":"25","author":[{"given":"Bianca","family":"Mayo","sequence":"first","affiliation":[{"name":"Nutrition and Dietetic School, Universidad Finis Terrae, Santiago 7501014, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Penroz","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetic School, Universidad Finis Terrae, Santiago 7501014, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-6438","authenticated-orcid":false,"given":"Keila","family":"Torres","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetic School, Universidad Finis Terrae, Santiago 7501014, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-3519","authenticated-orcid":false,"given":"Layla","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetic School, Universidad Finis Terrae, Santiago 7501014, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","article-title":"Current and Future Burden of Breast Cancer: Global Statistics for 2020 and 2040","volume":"66","author":"Arnold","year":"2022","journal-title":"Breast"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2147\/BCTT.S380754","article-title":"Breast Cancer Subtypes and Prognosis: Answers to Subgroup Classification Questions, Identifying the Worst Subgroup in Our Single-Center Series","volume":"14","author":"Cosar","year":"2022","journal-title":"Breast Cancer Targets Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10555-020-09905-7","article-title":"Regulation of Breast Cancer Metastasis Signaling by MiRNAs","volume":"39","author":"Petri","year":"2020","journal-title":"Cancer Metastasis Rev."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Giordano, A., and Tommonaro, G. 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