{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:55:00Z","timestamp":1782345300112,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Swedish Research Council","award":["2017\u201302051"],"award-info":[{"award-number":["2017\u201302051"]}]},{"name":"The Swedish Research Council","award":["2021\u201301378"],"award-info":[{"award-number":["2021\u201301378"]}]},{"name":"The Swedish Research Council","award":["2016\u20130349"],"award-info":[{"award-number":["2016\u20130349"]}]},{"name":"The Swedish Research Council","award":["2021\u20130855"],"award-info":[{"award-number":["2021\u20130855"]}]},{"name":"Stockholm County Council","award":["2017\u201302051"],"award-info":[{"award-number":["2017\u201302051"]}]},{"name":"Stockholm County Council","award":["2021\u201301378"],"award-info":[{"award-number":["2021\u201301378"]}]},{"name":"Stockholm County Council","award":["2016\u20130349"],"award-info":[{"award-number":["2016\u20130349"]}]},{"name":"Stockholm County Council","award":["2021\u20130855"],"award-info":[{"award-number":["2021\u20130855"]}]},{"name":"Karolinska Institutet","award":["2017\u201302051"],"award-info":[{"award-number":["2017\u201302051"]}]},{"name":"Karolinska Institutet","award":["2021\u201301378"],"award-info":[{"award-number":["2021\u201301378"]}]},{"name":"Karolinska Institutet","award":["2016\u20130349"],"award-info":[{"award-number":["2016\u20130349"]}]},{"name":"Karolinska Institutet","award":["2021\u20130855"],"award-info":[{"award-number":["2021\u20130855"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Women with polycystic ovary syndrome (PCOS) have varying difficulties in achieving weight loss by lifestyle intervention, which may depend on adipose tissue metabolism. The objective was to study baseline subcutaneous adipose tissue gene expression as a prediction of weight loss by lifestyle intervention in obese\/overweight women with PCOS. This is a secondary analysis of a randomized controlled trial where women with PCOS, aged 18\u201340 and body mass index (BMI) \u2265 27 were initially randomized to either a 4-month behavioral modification program or minimal intervention according to standard care. Baseline subcutaneous adipose tissue gene expression was related to weight change after the lifestyle intervention. A total of 55 obese\/overweight women provided subcutaneous adipose samples at study entry. Weight loss was significant after behavioral modification (\u22122.2%, p = 0.0014), while there was no significant weight loss in the control group (\u22121.1%, p = 0.12). In microarray analysis of adipose samples, expression of 40 genes differed significantly between subgroups of those with the greatest weight loss or weight gain. 10 genes were involved in metabolic pathways including glutathione metabolism, gluconeogenesis, and pyruvate metabolism. Results were confirmed by real-time polymerase chain reaction (RT-PCR) in all 55 subjects. Expressions of GSTM5, ANLN, and H3C2 correlated with weight change (R = \u22120.41, p = 0.002; R = \u22120.31, p = 0.023 and R = \u22120.32, p = 0.016, respectively). GSTM5, involved in glutathione metabolism, was the strongest predictor of weight loss, and together with baseline waist-hip ratio (WHR) explained 31% of the variation in body weight change. This study shows that baseline subcutaneous adipose tissue genes play a role for body weight outcome in response to lifestyle intervention in overweight\/obese women with PCOS.<\/jats:p>","DOI":"10.3390\/ijms252111566","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T07:04:04Z","timestamp":1730099044000},"page":"11566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Weight Changes Are Linked to Adipose Tissue Genes in Overweight Women with Polycystic Ovary Syndrome"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6274-8354","authenticated-orcid":false,"given":"Anton","family":"Hellberg","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Salamon","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Ujvari","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Department of Microbiology, Tumor and Cell Biology, National Pandemic Centre, Centre for Translational Microbiome Research, Karolinska Institutet, 17165 Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Ryd\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Medicine Huddinge (H7), Karolinska Institutet, C2-94 Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica Lind\u00e9n","family":"Hirschberg","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Department of Gynecology and Reproductive Medicine, Karolinska University Hospital Solna, 17176 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1210\/clinem\/dgad463","article-title":"Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome","volume":"108","author":"Teede","year":"2023","journal-title":"J. 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