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Carver Charitable Trust","award":["R01DA052953"],"award-info":[{"award-number":["R01DA052953"]}]},{"name":"Roy J. Carver Charitable Trust","award":["5R01DA037216"],"award-info":[{"award-number":["5R01DA037216"]}]},{"name":"Roy J. Carver Charitable Trust","award":["IO1BX004440"],"award-info":[{"award-number":["IO1BX004440"]}]},{"name":"Roy J. Carver Charitable Trust","award":["3T32GM139776"],"award-info":[{"award-number":["3T32GM139776"]}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01DA052953"],"award-info":[{"award-number":["R01DA052953"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5R01DA037216"],"award-info":[{"award-number":["5R01DA037216"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["IO1BX004440"],"award-info":[{"award-number":["IO1BX004440"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["3T32GM139776"],"award-info":[{"award-number":["3T32GM139776"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Opioid-seeking behaviors depend on glutamatergic plasticity in the nucleus accumbens core (NAcc). Here we investigated whether the behavioral and synaptic effects of opioids are influenced by acid-sensing ion channel 1A (ASIC1A). We tested the effects of ASIC1A on responses to several opioids and found that Asic1a\u2212\/\u2212 mice had elevated behavioral responses to acute opioid administration as well as opioid seeking behavior in conditioned place preference (CPP). Region-restricted restoration of ASIC1A in NAcc was sufficient to reduce opioid CPP, suggesting NAcc is an important site of action. We next tested the effects of oxycodone withdrawal on dendritic spines in NAcc. We found effects of oxycodone and ASIC1A that contrasted with changes previously described following cocaine withdrawal. Finally, we examined \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated and N-methyl-D-aspartic acid (NMDA) receptor-mediated synaptic currents in NAcc. Oxycodone withdrawal, like morphine withdrawal, increased the AMPAR\/NMDAR ratio in Asic1a+\/+ mice, whereas oxycodone withdrawal reduced the AMPAR\/NMDAR ratio in Asic1a\u2212\/\u2212 mice. A single dose of oxycodone was sufficient to induce this paradoxical effect in Asic1a\u2212\/\u2212 mice, suggesting an increased sensitivity to oxycodone. We conclude that ASIC1A plays an important role in the behavioral and synaptic effects of opioids and may constitute a potential future target for developing novel therapies.<\/jats:p>","DOI":"10.3390\/ijms252111584","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T04:51:33Z","timestamp":1730177493000},"page":"11584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Acid-Sensing Ion Channel 1A (ASIC1A) in the Behavioral and Synaptic Effects of Oxycodone and Other Opioids"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-0646","authenticated-orcid":false,"given":"Margaret J.","family":"Fuller","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA"},{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Psychiatry, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah R. R.","family":"Andrys","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash C.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ghobbeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Collin J.","family":"Kreple","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-984X","authenticated-orcid":false,"given":"Rebecca J.","family":"Taugher-Hebl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5563-6637","authenticated-orcid":false,"given":"Jason J.","family":"Radley","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan T.","family":"Lalumiere","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Wemmie","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA"},{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"ref_1","unstructured":"National Vital Statistics System (2024, May 05). 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