{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:30:26Z","timestamp":1785198626959,"version":"3.55.0"},"reference-count":67,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Center","award":["2011\/03\/N\/NZ5\/05899"],"award-info":[{"award-number":["2011\/03\/N\/NZ5\/05899"]}]},{"name":"National Science Center","award":["2013\/09\/B\/NZ5\/00790"],"award-info":[{"award-number":["2013\/09\/B\/NZ5\/00790"]}]},{"name":"European Union Regional Development Fund","award":["2011\/03\/N\/NZ5\/05899"],"award-info":[{"award-number":["2011\/03\/N\/NZ5\/05899"]}]},{"name":"European Union Regional Development Fund","award":["2013\/09\/B\/NZ5\/00790"],"award-info":[{"award-number":["2013\/09\/B\/NZ5\/00790"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis is a common chronic disorder characterized by the growth of endometrium-like tissue outside the uterine cavity. The disease is associated with chronic inflammation and pelvic pain and may have an impact on the patient\u2019s fertility. The causative factors and pathophysiology of the disease are still poorly recognized. The dysregulation of the immune system, aberrant tissue remodeling, and angiogenesis contribute to the disease progression. In endometriosis patients, the proteins regulating the breakdown and reorganization of the connective tissue, e.g., collagenases, and other proteases, as well as their inhibitors, show an incorrect pattern of expression. Here, we report that the expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK), one of the inhibitors of connective tissue proteases, is elevated in endometrioma cysts as compared to normal endometrium from unaffected women. We also demonstrate a reduced level of miR200b in endometriotic tissue that correlates with RECK mRNA levels. Furthermore, we employ the 12Z cell line, derived from a peritoneal endometriotic lesion, and the Ishikawa cell line, originating from endometrial adenocarcinoma to identify RECK as a direct target of miR200b. The described effect of miR200b on RECK, together with the aberrant expression of both genes in endometrioma, may help to understand the role played by the tissue remodeling system in the pathogenesis of endometriosis.<\/jats:p>","DOI":"10.3390\/ijms252111594","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T04:51:33Z","timestamp":1730177493000},"page":"11594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expression of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) Gene and Its Regulation by miR200b in Ovarian Endometriosis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-0598","authenticated-orcid":false,"given":"Agata","family":"Gozdz","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, ul. T. Cha\u0142ubi\u0144skiego 5, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-6734","authenticated-orcid":false,"given":"Rados\u0142aw B.","family":"Maksym","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, ul. T. Cha\u0142ubi\u0144skiego 5, 02-004 Warsaw, Poland"},{"name":"1st Department of Obstetrics and Gynecology, Centre for Postgraduate Medical Education, ul. \u017belazna 90, 01-004 Warsaw, Poland"},{"name":"Center for Molecular Biophysics UPR 4301 CNRS, 45071 Orleans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"\u015acie\u017cy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, ul. T. Cha\u0142ubi\u0144skiego 5, 02-004 Warsaw, Poland"},{"name":"Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-2496","authenticated-orcid":false,"given":"Martin","family":"G\u00f6tte","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital M\u00fcnster, Albert-Schweitzer-Campus 1, 48149 M\u00fcnster, Germany"},{"name":"Cells-in-Motion Interfaculty Centre (CiMIC), University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Kieda","sequence":"additional","affiliation":[{"name":"Center for Molecular Biophysics UPR 4301 CNRS, 45071 Orleans, France"},{"name":"Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-1791","authenticated-orcid":false,"given":"Pawe\u0142 K.","family":"W\u0142odarski","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, ul. T. Cha\u0142ubi\u0144skiego 5, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-8476","authenticated-orcid":false,"given":"Jacek","family":"Malejczyk","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, ul. T. Cha\u0142ubi\u0144skiego 5, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. Engl. J. 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