{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:49:09Z","timestamp":1784242149321,"version":"3.55.0"},"reference-count":49,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kaohsiung Medical University","award":["KMU-S102011"],"award-info":[{"award-number":["KMU-S102011"]}]},{"name":"Kaohsiung Medical University","award":["KMU-CSTC1-ACA-01"],"award-info":[{"award-number":["KMU-CSTC1-ACA-01"]}]},{"name":"Kaohsiung Medical University","award":["KMU-S107026"],"award-info":[{"award-number":["KMU-S107026"]}]},{"name":"Kaohsiung Medical University","award":["KMU-S112017"],"award-info":[{"award-number":["KMU-S112017"]}]},{"name":"Kaohsiung Medical University","award":["KMUH109-9M55"],"award-info":[{"award-number":["KMUH109-9M55"]}]},{"name":"Kaohsiung Medical University","award":["KMUH111-1R69"],"award-info":[{"award-number":["KMUH111-1R69"]}]},{"name":"Kaohsiung Medical University","award":["KMUH112-2R70"],"award-info":[{"award-number":["KMUH112-2R70"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMU-S102011"],"award-info":[{"award-number":["KMU-S102011"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMU-CSTC1-ACA-01"],"award-info":[{"award-number":["KMU-CSTC1-ACA-01"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMU-S107026"],"award-info":[{"award-number":["KMU-S107026"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMU-S112017"],"award-info":[{"award-number":["KMU-S112017"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH109-9M55"],"award-info":[{"award-number":["KMUH109-9M55"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH111-1R69"],"award-info":[{"award-number":["KMUH111-1R69"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH112-2R70"],"award-info":[{"award-number":["KMUH112-2R70"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We aimed to evaluate the effect of black soybean extract cream (BSEC) on 2,4-dinitrochlorobenzene (DNCB)-induced dermatitis in murine models mimicking inflammatory dermatitis observed in humans. In this DNCB-induced model, BALB\/c mice were spread with 100 \u03bcL of 2% DNCB twice a week for two weeks to induce skin inflammation on the shaved back skin; then, a placebo or BSEC that consisted of the volatile fraction derived from the seeds of Glycine max (L.) Merr. was applied to the DNCB-sensitized mice for 7 days. Gross visual analysis was conducted to assess the impact of BSEC on dermatitis, and an enzyme-linked immunosorbent assay (ELISA) was subsequently performed to detect inflammatory cytokines in the presence or absence of BSEC after DNCB sensitization. Lastly, the possible mechanisms responsible for the effects of BSEC on inflammatory dermatitis were investigated in a human leukemia monocytic cell line, THP-1. Our study showed that BSEC displayed antioxidant and anti-inflammatory effects. BSEC has the ability to diminish dermatitis, and all three experiments demonstrated that BSEC effectively reduced the progression of dermatitis while significantly suppressing inflammatory responses in the preclinical models. Consequently, BSEC exhibited promising phytotherapy for inflammatory dermatitis, potentially attributed to its anti-inflammatory and antioxidant properties.<\/jats:p>","DOI":"10.3390\/ijms252111598","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T04:51:33Z","timestamp":1730177493000},"page":"11598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring Black Soybean Extract Cream for Inflammatory Dermatitis\u2014Toward Radiation Dermatitis Relief"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-4641","authenticated-orcid":false,"given":"Hsin-Hua","family":"Lee","sequence":"first","affiliation":[{"name":"Ph.D. Program in Environmental and Occupational Medicine, National Health Research Institutes, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Radiation Oncology, Faculty of Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-3149","authenticated-orcid":false,"given":"Yu-Hsiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joh-Jong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Gerontological and Long-Term Care Business, Fooyin University, Kaohsiung 831, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9432-5284","authenticated-orcid":false,"given":"Ming-Yii","family":"Huang","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Environmental and Occupational Medicine, National Health Research Institutes, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Radiation Oncology, Faculty of Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2147\/CMAR.S188655","article-title":"Radiation-induced skin reactions: Mechanism and treatment","volume":"11","author":"Wei","year":"2019","journal-title":"Cancer Manag. 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