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Recent evidence reveals connections between neuroinflammatory processes and intestinal microbiota alterations in the progression of this pathology. This comprehensive review explores the intricate relationships between them, highlighting their combined impact on PD. Neuroinflammation, characterized by immune activation in the central nervous system, is increasingly acknowledged as a critical factor in the development of PD. Concurrently, alterations in the gut microbiota composition have been linked to PD, suggesting a potential modulatory role in disease progression. Thus, bidirectional communication along the gut\u2013brain axis has become pivotal in comprehending the pathogenesis of PD. Furthermore, we explore emerging therapeutic strategies that target these interconnected pathways, providing insights into potential avenues for PD treatment. The elucidation of these intricate relationships establishes a promising foundation for innovative therapeutic strategies aimed at altering disease progression and improving the quality of life for individuals affected by PD.<\/jats:p>","DOI":"10.3390\/ijms252111629","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T10:45:35Z","timestamp":1730198735000},"page":"11629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Convergence of Neuroinflammation, Microbiota, and Parkinson\u2019s Disease: Therapeutic Insights and Prospects"],"prefix":"10.3390","volume":"25","author":[{"given":"Nerea","family":"Dom\u00ednguez Rojo","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Enfermer\u00eda y Terapia Ocupacional, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"},{"name":"Instituto Universitario de Investigaci\u00f3n Biosanitaria de Extremadura (INUBE), 10003 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2662-1167","authenticated-orcid":false,"given":"Mercedes","family":"Blanco Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Enfermer\u00eda y Terapia Ocupacional, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"},{"name":"Instituto Universitario de Investigaci\u00f3n Biosanitaria de Extremadura (INUBE), 10003 C\u00e1ceres, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-8247","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Cava","sequence":"additional","affiliation":[{"name":"Tradinnoval Research Group, INBIO G+C, Departamento de Producci\u00f3n Animal y Ciencia de los Alimentos, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Enfermer\u00eda y Terapia Ocupacional, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"},{"name":"Instituto Universitario de Investigaci\u00f3n Biosanitaria de Extremadura (INUBE), 10003 C\u00e1ceres, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saray","family":"Canales Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Enfermer\u00eda y Terapia Ocupacional, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"},{"name":"Instituto Universitario de Investigaci\u00f3n Biosanitaria de Extremadura (INUBE), 10003 C\u00e1ceres, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0163-2953","authenticated-orcid":false,"given":"Rosa Ana","family":"Gonz\u00e1lez Polo","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Enfermer\u00eda y Terapia Ocupacional, Universidad de Extremadura, 10003 C\u00e1ceres, Spain"},{"name":"Instituto Universitario de Investigaci\u00f3n Biosanitaria de Extremadura (INUBE), 10003 C\u00e1ceres, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. 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