{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:49:01Z","timestamp":1792198141884,"version":"4.4.0"},"reference-count":152,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health Department of the Basque Government","award":["2017111003"],"award-info":[{"award-number":["2017111003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Despite recent advances in treatment options, stroke remains a highly prevalent and devastating condition with significant socioeconomic impact. Recanalization therapies, including intravenous thrombolysis and endovascular treatments, have revolutionized stroke management and prognosis, providing a promising framework for exploring new therapeutic strategies. Endothelial dysfunction plays a critical role in the pathophysiology, progression, and prognosis of stroke. This review aims to synthesize the current evidence regarding the involvement of the nitric oxide (NO)\/endothelium pathway in ischemic stroke, with a particular focus on aging, response to recanalization therapies, and therapeutic approaches. While significant progress has been made in recent years in understanding the relationship between endothelial dysfunction and stroke, many uncertainties persist, and although treatments targeting this pathway are promising, they have yet to demonstrate clear clinical benefits.<\/jats:p>","DOI":"10.3390\/ijms252111631","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T12:09:18Z","timestamp":1730203758000},"page":"11631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Understanding Endothelial Dysfunction and Its Role in Ischemic Stroke After the Outbreak of Recanalization Therapies"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-868X","authenticated-orcid":false,"given":"Patricia","family":"de la Riva","sequence":"first","affiliation":[{"name":"Department of Neurology, Donostia University Hospital, Dr Begiristain sn., 20003 San Sebastian, Spain"},{"name":"Ictus, Biogipuzkoa Institute, Doctor Begiristain sn., 20003 San Sebastian, Spain"},{"name":"Facultad de Ciencias de la Salud, Deusto University, Mundaiz 50, 20003 San Sebastian, Spain"},{"name":"Red de Investigaci\u00f3n Cooperativa Orientada a Resultados en Salud (RICORS)-Ictus, Instituto Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1807-4297","authenticated-orcid":false,"given":"Juan","family":"Marta-Enguita","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donostia University Hospital, Dr Begiristain sn., 20003 San Sebastian, Spain"},{"name":"Ictus, Biogipuzkoa Institute, Doctor Begiristain sn., 20003 San Sebastian, Spain"},{"name":"Facultad de Ciencias de la Salud, Deusto University, Mundaiz 50, 20003 San Sebastian, Spain"},{"name":"Red de Investigaci\u00f3n Cooperativa Orientada a Resultados en Salud (RICORS)-Ictus, Instituto Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9316-1772","authenticated-orcid":false,"given":"Jon","family":"Rodr\u00edguez-Antig\u00fcedad","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit and Institut d\u2019Investigacions Biomediques-Sant Pau, Hospital Sant Pau, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bergareche","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donostia University Hospital, Dr Begiristain sn., 20003 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9509-4032","authenticated-orcid":false,"given":"Adolfo L\u00f3pez","family":"de Munain","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donostia University Hospital, Dr Begiristain sn., 20003 San Sebastian, Spain"},{"name":"Ictus, Biogipuzkoa Institute, Doctor Begiristain sn., 20003 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S1474-4422(24)00369-7","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990\u20132021: A systematic analysis for the Global Burden of Disease Study 2021","volume":"23","author":"Feigin","year":"2024","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kuriakose, D., and Xiao, Z. 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