{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:57:04Z","timestamp":1785423424846,"version":"3.56.0"},"reference-count":209,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz, Poland","doi-asserted-by":"publisher","award":["503\/5-064-04\/503-01"],"award-info":[{"award-number":["503\/5-064-04\/503-01"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz, Poland","doi-asserted-by":"publisher","award":["3841\/E-41\/S\/2020"],"award-info":[{"award-number":["3841\/E-41\/S\/2020"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute of Geophysics, Polish Academy of Sciences","award":["503\/5-064-04\/503-01"],"award-info":[{"award-number":["503\/5-064-04\/503-01"]}]},{"name":"Institute of Geophysics, Polish Academy of Sciences","award":["3841\/E-41\/S\/2020"],"award-info":[{"award-number":["3841\/E-41\/S\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is a multifactorial, chronic, and inflammatory disease that severely impacts patients\u2019 quality of life. The disease is caused by genetic irregularities affected by epigenetic and environmental factors. Some of these factors may include seasonal changes, such as solar radiation, air pollution, and humidity, and changes in circadian rhythm, especially in the temporal and polar zones. Thus, some psoriasis patients report seasonal variability of symptoms. Through a comprehensive review, we aim to delve deeper into the intricate interplay between seasonality, environmental factors, and the genetic and epigenetic landscape of psoriasis. By elucidating these complex relationships, we strive to provide insights that may inform targeted interventions and personalized management strategies for individuals living with psoriasis.<\/jats:p>","DOI":"10.3390\/ijms252111670","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:11:24Z","timestamp":1730279484000},"page":"11670","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Psoriasis and Seasonality: Exploring the Genetic and Epigenetic Interactions"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9322-629X","authenticated-orcid":false,"given":"Micha\u0142","family":"Nied\u017awied\u017a","sequence":"first","affiliation":[{"name":"Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland"},{"name":"International Doctoral School, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Skibi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Ci\u0105\u017cy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Noweta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-5792","authenticated-orcid":false,"given":"Agnieszka","family":"Czerwi\u0144ska","sequence":"additional","affiliation":[{"name":"Institute of Geophysics, Polish Academy of Sciences, 01-452 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3138-3951","authenticated-orcid":false,"given":"Janusz","family":"Krzy\u015bcin","sequence":"additional","affiliation":[{"name":"Institute of Geophysics, Polish Academy of Sciences, 01-452 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Narbutt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Lesiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland"},{"name":"Laboratory of Autoinflammatory, Genetic and Rare Skin Disorders, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1056\/NEJMra1505557","article-title":"Psoriatic Arthritis","volume":"376","author":"Ritchlin","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: A systematic review of incidence and prevalence","volume":"133","author":"Parisi","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jaad.2015.05.001","article-title":"Prevalence of undiagnosed psoriatic arthritis among psoriasis patients: Systematic review and meta-analysis","volume":"73","author":"Villani","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaad.2018.06.027","article-title":"Prevalence of psoriatic arthritis in patients with psoriasis: A systematic review and meta-analysis of observational and clinical studies","volume":"80","author":"Alinaghi","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.rdc.2015.07.001","article-title":"The Epidemiology of Psoriatic Arthritis","volume":"41","author":"Ogdie","year":"2015","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/bjd.15021","article-title":"Incidence, prevalence and mortality of patients with psoriasis: A U.K. population-based cohort study","volume":"176","author":"Springate","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1038\/s41467-022-34323-4","article-title":"Shared genetic risk factors and causal association between psoriasis and coronary artery disease","volume":"13","author":"Patrick","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/jdv.12523","article-title":"Nationwide population-based study of cause-specific death rates in patients with psoriasis","volume":"29","author":"Salahadeen","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Cui, P., Li, D., Shi, L., Yan, H., Li, T., Liu, C., Wang, W., Zheng, H., Ding, N., and Li, X. (2024). Cardiovascular comorbidities among patients with psoriasis: A national register-based study in China. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-70707-w"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e15010","DOI":"10.1111\/exd.15010","article-title":"Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population-based study","volume":"33","author":"Kan","year":"2024","journal-title":"Exp. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jaad.2004.04.014","article-title":"Determinants of quality of life in patients with psoriasis: A study from the US population","volume":"51","author":"Gelfand","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1192\/j.eurpsy.2021.2249","article-title":"A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa","volume":"64","author":"Fabrazzo","year":"2021","journal-title":"Eur. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"adv00769","DOI":"10.2340\/actadv.v102.1386","article-title":"Prevalence and Odds of Anxiety Disorders and Anxiety Symptoms in Children and Adults with Psoriasis: Systematic Review and Meta-analysis","volume":"102","author":"Jalenques","year":"2022","journal-title":"Acta Derm. Venereol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Marek-Jozefowicz, L., Czajkowski, R., Borkowska, A., Nedoszytko, B., Zmijewski, M.A., Cubala, W.J., and Slominski, A.T. (2022). The Brain-Skin Axis in Psoriasis-Psychological, Psychiatric, Hormonal, and Dermatological Aspects. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020669"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jaad.2007.07.023","article-title":"Association of patient-reported psoriasis severity with income and employment","volume":"57","author":"Horn","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and clinical features of psoriasis","volume":"370","author":"Griffiths","year":"2007","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2174\/1389202923666220527111037","article-title":"Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review","volume":"23","author":"Babaie","year":"2022","journal-title":"Curr. Genom."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Queiro, R., Coto, P., Gonzalez-Lara, L., and Coto, E. (2021). Genetic Variants of the NF-kappaB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222313004"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/bjd.12375","article-title":"Heritability of psoriasis in a large twin sample","volume":"169","author":"Lonnberg","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00281-021-00843-2","article-title":"Insights into the pathogenesis of psoriatic arthritis from genetic studies","volume":"43","author":"Rahmati","year":"2021","journal-title":"Semin. Immunopathol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Capon, F. (2017). The Genetic Basis of Psoriasis. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122526"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Azuaga, A.B., Ramirez, J., and Canete, J.D. (2023). Psoriatic Arthritis: Pathogenesis and Targeted Therapies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054901"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1084\/jem.20151093","article-title":"Melanocyte antigen triggers autoimmunity in human psoriasis","volume":"212","author":"Arakawa","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"The International Psoriasis Genetics Consortium (2003). The International Psoriasis Genetics Study: Assessing linkage to 14 candidate susceptibility loci in a cohort of 942 affected sib pairs. Am. J. Hum. Genet., 73, 430\u2013437.","DOI":"10.1086\/377159"},{"key":"ref_26","first-page":"270","article-title":"Clinical and genetic associations of radiographic sacroiliitis and its different patterns in psoriatic arthritis","volume":"35","author":"Haroon","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1046\/j.1523-1747.2002.01749.x","article-title":"Searching for the major histocompatibility complex psoriasis susceptibility gene","volume":"118","author":"Capon","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/1744666X.2020.1724090","article-title":"Measurement properties of instruments assessing psoriatic arthritis symptoms for psoriasis clinical trials: A systematic literature review","volume":"16","author":"Balak","year":"2020","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.4238\/2011.October.21.6","article-title":"Association of -619C\/T polymorphism in CDSN gene and psoriasis risk: A meta-analysis","volume":"10","author":"Wu","year":"2011","journal-title":"Genet. Mol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1684\/ejd.2011.1264","article-title":"Corneodesmosomes and corneodesmosin: From the stratum corneum cohesion to the pathophysiology of genodermatoses","volume":"21","author":"Jonca","year":"2011","journal-title":"Eur. J. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.ajhg.2012.03.012","article-title":"PSORS2 is due to mutations in CARD14","volume":"90","author":"Jordan","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ajhg.2012.05.010","article-title":"Familial pityriasis rubra pilaris is caused by mutations in CARD14","volume":"91","author":"Sarig","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/jid.2014.46","article-title":"CARD14 c.526G>C (p.Asp176His) is a significant risk factor for generalized pustular psoriasis with psoriasis vulgaris in the Japanese cohort","volume":"134","author":"Sugiura","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/j.jid.2016.03.046","article-title":"The Molecular Revolution in Cutaneous Biology: EDC and Locus Control","volume":"137","author":"Oh","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ng.313","article-title":"Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis","volume":"41","author":"Zeeuwen","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/jid.2010.350","article-title":"Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6","volume":"131","author":"He","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.12659\/MSM.901083","article-title":"Association Between Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Polymorphisms and Risk of Ankylosing Spondylitis: A Meta-analysis","volume":"23","author":"Wang","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Huraib, G.B., Al Harthi, F., Arfin, M., Aljamal, A., Alrawi, A.S., and Al-Asmari, A. (2020). Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo. Biomark. Insights, 15.","DOI":"10.1177\/1177271920903038"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6916","DOI":"10.1038\/ncomms7916","article-title":"Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility","volume":"6","author":"Yin","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5980190","DOI":"10.1155\/2020\/5980190","article-title":"Immune Regulation of TNFAIP3 in Psoriasis through Its Association with Th1 and Th17 Cell Differentiation and p38 Activation","volume":"2020","author":"Jiang","year":"2020","journal-title":"J. Immunol. Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kisielnicka, A., Sobalska-Kwapis, M., Purzycka-Bohdan, D., Nedoszytko, B., Zab\u0142otna, M., Seweryn, M., Strapagiel, D., Nowicki, R.J., Reich, A., and Samotij, D. (2022). The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137396"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zalesak, M., Danisovic, L., and Harsanyi, S. (2024). Psoriasis and Psoriatic Arthritis-Associated Genes, Cytokines, and Human Leukocyte Antigens. Medicina, 60.","DOI":"10.3390\/medicina60050815"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s10067-023-06859-3","article-title":"Sex-specific differences in patients with psoriatic arthritis:a nationwide study from the Chinese Registry of Psoriatic Arthritis (CREPAR IV)","volume":"43","author":"He","year":"2024","journal-title":"Clin. Rheumatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/bjd.21627","article-title":"Biomarkers of disease progression in people with psoriasis: A scoping review","volume":"187","author":"Ramessur","year":"2022","journal-title":"Br. J. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Anand, S., Littler, D.R., Mobbs, J.I., Braun, A., Baker, D.G., Tennant, L., Purcell, A.W., Vivian, J.P., and Rossjohn, J. (2023). Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C\u221706:02. J. Biol. Chem., 299.","DOI":"10.1016\/j.jbc.2023.104930"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Czarnecka, A., Purzycka-Bohdan, D., Zab\u0142otna, M., Nowicki, R.J., R\u0119ba\u0142a, K., Bohdan, M., Grucha\u0142a, M., Wilkowska, A., and Szczerkowska-Dobosz, A. (2024). Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance-The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and FTO Gene Polymorphisms (rs9939609, rs1558902). Biomedicines, 12.","DOI":"10.3390\/biomedicines12030517"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e15151","DOI":"10.1111\/exd.15151","article-title":"Histone modification in psoriasis: Molecular mechanisms and potential therapeutic targets","volume":"33","author":"Liu","year":"2024","journal-title":"Exp. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Gu, X., Boldrup, L., Coates, P.J., Fahraeus, R., Nylander, E., Loizou, C., Olofsson, K., Norberg-Spaak, L., Garskog, O., and Nylander, K. (2016). Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites. Sci. Rep., 6.","DOI":"10.1038\/srep32579"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/jid.2011.348","article-title":"A subset of methylated CpG sites differentiate psoriatic from normal skin","volume":"132","author":"Roberson","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jid.2017.11.036","article-title":"Genome-Wide DNA Methylation Profiling Identifies Differential Methylation in Uninvolved Psoriatic Epidermis","volume":"138","author":"Verma","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13148-018-0541-9","article-title":"Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis","volume":"10","author":"Chandra","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1684\/ejd.2011.1383","article-title":"Abnormal histone modifications in PBMCs from patients with psoriasis vulgaris","volume":"21","author":"Zhang","year":"2011","journal-title":"Eur. J. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/exd.13790","article-title":"Histone modifications associated with biological drug response in moderate-to-severe psoriasis","volume":"27","author":"Reolid","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Dopytalska, K., Ciechanowicz, P., Wiszniewski, K., Szymanska, E., and Walecka, I. (2021). The Role of Epigenetic Factors in Psoriasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179294"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10142-023-01057-5","article-title":"Emerging roles of non-coding RNAs in psoriasis pathogenesis","volume":"23","author":"Ghosh","year":"2023","journal-title":"Funct. Integr. Genomics"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Antonatos, C., Grafanaki, K., Asmenoudi, P., Xiropotamos, P., Nani, P., Georgakilas, G.K., Georgiou, S., and Vasilopoulos, Y. (2022). Contribution of the Environment, Epigenetic Mechanisms and Non-Coding RNAs in Psoriasis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10081934"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1111\/exd.14871","article-title":"The role of microRNA in psoriasis: A review","volume":"32","author":"Jiang","year":"2023","journal-title":"Exp. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Mateu-Arrom, L., and Puig, L. (2023). Genetic and Epigenetic Mechanisms of Psoriasis. Genes, 14.","DOI":"10.20944\/preprints202307.1499.v1"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ncrna.2020.06.002","article-title":"The eminent roles of ncRNAs in the pathogenesis of psoriasis","volume":"5","author":"Eghtedarian","year":"2020","journal-title":"Noncoding RNA Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.2147\/IJGM.S409711","article-title":"Integrated Bioinformatics Analysis for the Identification of Key lncRNAs, mRNAs, and Potential Drugs in Clear Cell Renal Cell Carcinomas","volume":"16","author":"Liu","year":"2023","journal-title":"Int. J. Gen. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00438-020-01654-0","article-title":"Identification of potential key mRNAs and LncRNAs for psoriasis by bioinformatic analysis using weighted gene co-expression network analysis","volume":"295","author":"Li","year":"2020","journal-title":"Mol. Genet. Genomics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.celrep.2013.09.036","article-title":"Mapping of mitochondrial RNA-protein interactions by digital RNase footprinting","volume":"5","author":"Liu","year":"2013","journal-title":"Cell Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1038\/ncomms8000","article-title":"Widespread seasonal gene expression reveals annual differences in human immunity and physiology","volume":"6","author":"Dopico","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Brembilla, N.C., and Boehncke, W.H. (2023). Revisiting the interleukin 17 family of cytokines in psoriasis: Pathogenesis and potential targets for innovative therapies. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1186455"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Reinhardt, A., and Prinz, I. (2018). Whodunit? The Contribution of Interleukin (IL)-17\/IL-22-Producing gammadelta T Cells, alphabeta T Cells, and Innate Lymphoid Cells to the Pathogenesis of Spondyloarthritis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00885"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Reali, E., and Ferrari, D. (2023). From the Skin to Distant Sites: T Cells in Psoriatic Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115707"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhou, X.Y., Chen, K., and Zhang, J.A. (2022). Mast cells as important regulators in the development of psoriasis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1022986"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"100277","DOI":"10.1016\/j.xjidi.2024.100277","article-title":"Inflammatory Memory in Chronic Skin Disease","volume":"4","author":"Daccache","year":"2024","journal-title":"JID Innov."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.bpj.2023.10.035","article-title":"Between good and evil: Complexation of the human cathelicidin LL-37 with nucleic acids","volume":"123","author":"Zielke","year":"2023","journal-title":"Biophys. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/10520295.2019.1673901","article-title":"Alteration of tissue expression of human beta defensin-1 and human beta defensin-2 in psoriasis vulgaris following phototherapy","volume":"95","author":"Uzuncakmak","year":"2020","journal-title":"Biotech. Histochem."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Liang, H., Li, J., and Zhang, K. (2023). Pathogenic role of S100 proteins in psoriasis. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1191645"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Hu, P., Wang, M., Gao, H., Zheng, A., Li, J., Mu, D., and Tong, J. (2021). The Role of Helper T Cells in Psoriasis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.788940"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Schon, M.P., and Erpenbeck, L. (2018). The Interleukin-23\/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01323"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.4049\/jimmunol.1001538","article-title":"Cutting edge: A critical functional role for IL-23 in psoriasis","volume":"185","author":"Tonel","year":"2010","journal-title":"J. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Sch\u00f6n, M.P. (2019). Adaptive and Innate Immunity in Psoriasis and Other Inflammatory Disorders. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01764"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Ishimoto, T., Arakawa, Y., Vural, S., Stohr, J., Vollmer, S., Galinski, A., Siewert, K., Ruhl, G., Poluektov, Y., and Delcommenne, M. (2024). Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1374581"},{"key":"ref_77","first-page":"882","article-title":"Phototherapy: Theory and practice","volume":"21","author":"Kurz","year":"2023","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jphotobiol.2012.06.008","article-title":"Effectiveness of heliotherapy for psoriasis clearance in low and mid-latitudinal regions: A theoretical approach","volume":"115","author":"Krzyscin","year":"2012","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/php.13550","article-title":"Depth Penetration of Light into Skin as a Function of Wavelength from 200 to 1000 nm","volume":"98","author":"Finlayson","year":"2022","journal-title":"Photochem. Photobiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1039\/c3pp50413a","article-title":"Exposure of vitamins to UVB and UVA radiation generates singlet oxygen","volume":"13","author":"Knak","year":"2014","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-0625.2009.01025.x","article-title":"The role of ultraviolet radiation in melanomagenesis","volume":"19","author":"Kamenisch","year":"2010","journal-title":"Exp. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7491","DOI":"10.1021\/jp511220x","article-title":"Photoinduced Electron Transfer in DNA: Charge Shift Dynamics Between 8-Oxo-Guanine Anion and Adenine","volume":"119","author":"Zhang","year":"2015","journal-title":"J. Phys. Chem. B"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"9126","DOI":"10.3390\/ijms14059126","article-title":"Targeting the redox balance in inflammatory skin conditions","volume":"14","author":"Wagener","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1038\/jid.2015.111","article-title":"Identification of Two Loci Associated with Generalized Pustular Psoriasis","volume":"135","author":"Zhang","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41577-019-0185-9","article-title":"Photoimmunology: How ultraviolet radiation affects the immune system","volume":"19","author":"Bernard","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1016\/j.febslet.2005.04.087","article-title":"TNF-alpha enhances phenotypic and functional maturation of human epidermal Langerhans cells and induces IL-12 p40 and IP-10\/CXCL-10 production","volume":"579","author":"Bermond","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/nm.2861","article-title":"Ultraviolet radiation damages self noncoding RNA and is detected by TLR3","volume":"18","author":"Bernard","year":"2012","journal-title":"Nat. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000029842","article-title":"cis-urocanic acid induces mast cell degranulation and release of preformed TNF-alpha: A possible mechanism linking UVB and cis-urocanic acid to immunosuppression of contact hypersensitivity","volume":"12","author":"Wille","year":"1999","journal-title":"Skin. Pharmacol. Appl. Skin. Physiol."},{"key":"ref_89","first-page":"139","article-title":"An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation","volume":"95","author":"Chen","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-kappaB in biology and targeted therapy: New insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.3390\/ijms14036414","article-title":"Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy","volume":"14","author":"Lee","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Zhou, L., Jiang, A., Veenstra, J., Ozog, D.M., and Mi, Q.S. (2022). The Roles of Skin Langerhans Cells in Immune Tolerance and Cancer Immunity. Vaccines, 10.","DOI":"10.3390\/vaccines10091380"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.4049\/jimmunol.1000246","article-title":"Langerhans cells serve as immunoregulatory cells by activating NKT cells","volume":"185","author":"Fukunaga","year":"2010","journal-title":"J. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1074-7613(02)00274-1","article-title":"Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation","volume":"16","author":"Mizoguchi","year":"2002","journal-title":"Immunity"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1111\/jdv.16915","article-title":"EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris\u2014Part 1: Treatment and monitoring recommendations","volume":"34","author":"Nast","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/jdv.16926","article-title":"EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris\u2014Part 2: Specific clinical and comorbid situations","volume":"35","author":"Nast","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Addison, R., Weatherhead, S.C., Pawitri, A., Smith, G.R., Rider, A., Grantham, H.J., Cockell, S.J., and Reynolds, N.J. (2021). Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis. Redox Biol., 41.","DOI":"10.1016\/j.redox.2021.101924"},{"key":"ref_98","first-page":"e19182","article-title":"An Update on Narrowband Ultraviolet B Therapy for the Treatment of Skin Diseases","volume":"13","author":"Myers","year":"2021","journal-title":"Cureus"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Sadowska, M., Narbutt, J., and Lesiak, A. (2021). Blue Light in Dermatology. Life, 11.","DOI":"10.3390\/life11070670"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/phpp.12367","article-title":"Effects of blue light on inflammation and skin barrier recovery following acute perturbation. Pilot study results in healthy human subjects","volume":"34","author":"Falcone","year":"2018","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000333364","article-title":"Prospective randomized study on the efficacy of blue light in the treatment of psoriasis vulgaris","volume":"223","author":"Weinstabl","year":"2011","journal-title":"Dermatology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1468-3083.2011.04039.x","article-title":"Efficacy of blue light vs. red light in the treatment of psoriasis: A double-blind, randomized comparative study","volume":"26","author":"Kleinpenning","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1067\/mjd.2003.445","article-title":"Repeated exposure to blue light does not improve psoriasis","volume":"49","author":"Maari","year":"2003","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000430495","article-title":"Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris","volume":"231","author":"Pfaff","year":"2015","journal-title":"Dermatology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1039\/c6pp00406g","article-title":"A short history of phototherapy, vitamin D and skin disease","volume":"16","author":"Jarrett","year":"2017","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jphotobiol.2015.04.002","article-title":"24 hour forecast of the surface UV for the antipsoriatic heliotherapy in Poland","volume":"148","author":"Krzyscin","year":"2015","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jphotobiol.2014.07.017","article-title":"Perspectives of the antipsoriatic heliotherapy in Poland","volume":"140","author":"Krzyscin","year":"2014","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00484-020-01888-y","article-title":"Efficacy of combined liman peloid baths and heliotherapy in the treatment of psoriasis at Cervia spa, Emilia, Italy","volume":"64","author":"Melandri","year":"2020","journal-title":"Int. J. Biometeorol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fmed.2020.00083","article-title":"Effect of Dead Sea Climatotherapy on Psoriasis; A Prospective Cohort Study","volume":"7","author":"Emmanuel","year":"2020","journal-title":"Front Med."},{"key":"ref_110","first-page":"1136","article-title":"Climatotherapy at the Dead Sea for psoriasis is a highly effective anti-inflammatory treatment in the short term: An immunohistochemical study","volume":"31","author":"Emmanuel","year":"2022","journal-title":"Exp. Dermatol."},{"key":"ref_111","first-page":"288","article-title":"Solar ultraviolet radiation exposure in workers with outdoor occupations: A systematic review and call to action","volume":"63","author":"Slavinsky","year":"2024","journal-title":"Int. J. Dermatol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e2259","DOI":"10.1002\/mgg3.2259","article-title":"Systematic review on gene-sun exposure interactions in skin cancer","volume":"11","author":"Shraim","year":"2023","journal-title":"Mol. Genet. Genomic Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s40257-023-00770-y","article-title":"Climate Change, Skin Health, and Dermatologic Disease: A Guide for the Dermatologist","volume":"24","author":"Belzer","year":"2023","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jphotobiol.2018.05.012","article-title":"Perspectives of UV nowcasting to monitor personal pro-health outdoor activities","volume":"184","author":"Krzyscin","year":"2018","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s43630-023-00532-z","article-title":"Measurements of biologically effective solar radiation using erythemal weighted broadband meters","volume":"23","author":"Czerwinska","year":"2024","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/exd.13137","article-title":"Desired response to phototherapy vs photoaggravation in psoriasis: What makes the difference?","volume":"25","author":"Wolf","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1038\/jid.2009.156","article-title":"Severely photosensitive psoriasis: A phenotypically defined patient subset","volume":"129","author":"Rutter","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.clindermatol.2013.05.012","article-title":"Isomorphic phenomenon of Koebner: Facts and controversies","volume":"31","author":"Camargo","year":"2013","journal-title":"Clin. Dermatol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.2467","article-title":"Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity","volume":"44","author":"Tsoi","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/jid.2014.32","article-title":"Innate immune sensors stimulate inflammatory and immunosuppressive responses to UVB radiation","volume":"134","author":"Gallo","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"33036","DOI":"10.1074\/jbc.M112.383273","article-title":"NF-\u03baB-dependent microRNA-125b up-regulation promotes cell survival by targeting p38\u03b1 upon ultraviolet radiation","volume":"287","author":"Tan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_122","first-page":"e27666","article-title":"Physiological, Pathological, and Circadian Factors Impacting Skin Hydration","volume":"14","author":"Camilion","year":"2022","journal-title":"Cureus"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/jid.2010.395","article-title":"Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia","volume":"131","author":"Nakahigashi","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Montero-Vilchez, T., Segura-Fernandez-Nogueras, M.V., Perez-Rodriguez, I., Soler-Gongora, M., Martinez-Lopez, A., Fernandez-Gonzalez, A., Molina-Leyva, A., and Arias-Santiago, S. (2021). Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity. J. Clin. Med., 10.","DOI":"10.3390\/jcm10020359"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00403-011-1136-x","article-title":"Abnormal aquaporin-3 protein expression in hyperproliferative skin disorders","volume":"303","author":"Voss","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4103\/idoj.IDOJ_180_18","article-title":"Transepidermal Water Loss in Psoriasis: A Case-control Study","volume":"10","author":"Nikam","year":"2019","journal-title":"Indian Dermatol Online J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1046\/j.1523-1747.1998.00364.x","article-title":"Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: Implication for seasonal exacerbations of inflammatory dermatoses","volume":"111","author":"Denda","year":"1998","journal-title":"J. Investig. Dermatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-0846.2007.00275.x","article-title":"Relationships between skin properties and environmental parameters","volume":"14","author":"Cravello","year":"2008","journal-title":"Skin. Res. Technol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"100171","DOI":"10.1016\/j.xjidi.2022.100171","article-title":"Impact of Season and Other Factors on Initiation, Discontinuation, and Switching of Systemic Drug Therapy in Patients with Psoriasis: A Retrospective Study","volume":"3","author":"Liang","year":"2023","journal-title":"JID Innov."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1002\/ski2.104","article-title":"Transepidermal water loss (TEWL): Environment and pollution\u2014A systematic review","volume":"2","author":"Green","year":"2022","journal-title":"Skin. Health Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijwd.2020.07.003","article-title":"The influence of climate change on skin cancer incidence\u2014A review of the evidence","volume":"7","author":"Parker","year":"2021","journal-title":"Int. J. Womens Dermatol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"100162","DOI":"10.1016\/j.joclim.2022.100162","article-title":"The dermatological manifestations of extreme weather events: A comprehensive review of skin disease and vulnerability","volume":"8","author":"Parker","year":"2022","journal-title":"J. Clim. Change Health"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e14840","DOI":"10.1111\/dth.14840","article-title":"The impact of air pollution on skin and related disorders: A comprehensive review","volume":"34","author":"Abolhasani","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.smim.2015.10.002","article-title":"Aryl hydrocarbon receptor: Linking environment to immunity","volume":"27","author":"Cella","year":"2015","journal-title":"Semin. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"van Voorhis, M., Knopp, S., Julliard, W., Fechner, J.H., Zhang, X., Schauer, J.J., and Mezrich, J.D. (2013). Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0082545"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1038\/jid.2009.85","article-title":"Aryl hydrocarbon receptor is an ozone sensor in human skin","volume":"129","author":"Afaq","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature06880","article-title":"Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor","volume":"453","author":"Quintana","year":"2008","journal-title":"Nature"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e15931","DOI":"10.1111\/dth.15931","article-title":"Tapinarof for the treatment of psoriasis","volume":"35","author":"Nogueira","year":"2022","journal-title":"Dermatol. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/1744666X.2016.1212660","article-title":"Environmental risk factors and their role in the management of atopic dermatitis","volume":"13","author":"Kantor","year":"2017","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"141850","DOI":"10.1016\/j.chemosphere.2024.141850","article-title":"Chemical composition and source apportionment of ambient PM2.5 in a coastal urban area, Northern Poland","volume":"356","author":"Siudek","year":"2024","journal-title":"Chemosphere"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Ayinde, B.O., Musa, M.R., and Ayinde, A.O. (2024). Application of machine learning models and landsat 8 data for estimating seasonal pm 2.5 concentrations. Environ. Anal. Health Toxicol., 39.","DOI":"10.5620\/eaht.2024011"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1001\/jamadermatol.2021.6019","article-title":"Association Between Short-term Exposure to Environmental Air Pollution and Psoriasis Flare","volume":"158","author":"Bellinato","year":"2022","journal-title":"JAMA Dermatol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Liaw, F.Y., Chen, W.L., Kao, T.W., Chang, Y.W., and Huang, C.F. (2017). Exploring the link between cadmium and psoriasis in a nationally representative sample. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-01827-9"},{"key":"ref_144","unstructured":"(2024, March 10). European Environmental Agency. Available online: https:\/\/www.eea.europa.eu\/en."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/bjd.12670","article-title":"Psoriasis and smoking: A systematic review and meta-analysis","volume":"170","author":"Armstrong","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1365-2133.2011.10526.x","article-title":"Smoking and pathogenesis of psoriasis: A review of oxidative, inflammatory and genetic mechanisms","volume":"165","author":"Armstrong","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"117ra119","DOI":"10.1126\/scitranslmed.3003041","article-title":"Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema","volume":"4","author":"Shan","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Mleczko, M., Gerkowicz, A., and Krasowska, D. (2022). Chronic Inflammation as the Underlying Mechanism of the Development of Lung Diseases in Psoriasis: A Systematic Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031767"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3109\/09546634.2015.1107180","article-title":"Association between psoriasis and chronic obstructive pulmonary disease: A systematic review and meta-analysis","volume":"27","author":"Ungprasert","year":"2016","journal-title":"J. Dermatolog Treat."},{"key":"ref_150","first-page":"e0145221","article-title":"The association between psoriasis and chronic obstructive pulmonary disease: A systematic review and meta-analysis","volume":"10","author":"Ghazanfar","year":"2024","journal-title":"Ital. J. Dermatol. Venerol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2500\/aap.2018.39.4109","article-title":"Association between psoriasis and asthma risk: A meta-analysis","volume":"39","author":"Wang","year":"2018","journal-title":"Allergy Asthma Proc."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Ger, T.Y., Fu, Y., and Chi, C.C. (2020). Bidirectional Association Between Psoriasis and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-62834-x"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Purzycka-Bohdan, D., Kisielnicka, A., Zab\u0142otna, M., Nedoszytko, B., Nowicki, R.J., Reich, A., Samotij, D., Szcz\u0119ch, J., Krasowska, D., and Bartosi\u0144ska, J. (2022). Chronic Plaque Psoriasis in Poland: Disease Severity, Prevalence of Comorbidities, and Quality of Life. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051254"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"300060520964024","DOI":"10.1177\/0300060520964024","article-title":"Impact of smoking on psoriasis risk and treatment efficacy: A meta-analysis","volume":"48","author":"Zhou","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Xie, W., Xiao, S., Huang, H., and Zhang, Z. (2022). Incidence of and Risk Factors for Paradoxical Psoriasis or Psoriasiform Lesions in Inflammatory Bowel Disease Patients Receiving Anti-TNF Therapy: Systematic Review With Meta-Analysis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.847160"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/jid.2012.285","article-title":"Rotating night-shift work and risk of psoriasis in US women","volume":"133","author":"Li","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Huang, Y., Jing, D., Su, J., Huang, Z., Liu, H., Tao, J., He, M., Chen, X., Shen, M., and Xiao, Y. (2021). Association of Night Shift Work With Chronic Spontaneous Urticaria and Effect Modification by Circadian Dysfunction Among Workers. Front. Public Health, 9.","DOI":"10.3389\/fpubh.2021.751579"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1530\/JME-19-0153","article-title":"Circadian clock genes and the transcriptional architecture of the clock mechanism","volume":"63","author":"Cox","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41583-018-0026-z","article-title":"Generation of circadian rhythms in the suprachiasmatic nucleus","volume":"19","author":"Hastings","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1002\/1873-3468.14192","article-title":"The circadian clock and diseases of the skin","volume":"595","author":"Duan","year":"2021","journal-title":"FEBS Lett."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.cell.2019.04.025","article-title":"Defining the Independence of the Liver Circadian Clock","volume":"177","author":"Koronowski","year":"2019","journal-title":"Cell"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1101\/gad.346460.120","article-title":"Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks","volume":"35","author":"Sinturel","year":"2021","journal-title":"Genes. Dev."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Clarkson-Townsend, D.A., Everson, T.M., Deyssenroth, M.A., Burt, A.A., Hermetz, K.E., Hao, K., Chen, J., and Marsit, C.J. (2019). Maternal circadian disruption is associated with variation in placental DNA methylation. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215745"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Nemeth, V., Horvath, S., Kinyo, A., Gyulai, R., and Lengyel, Z. (2021). Expression Patterns of Clock Gene mRNAs and Clock Proteins in Human Psoriatic Skin Samples. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010121"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/0748730414563537","article-title":"The circadian clock in skin: Implications for adult stem cells, tissue regeneration, cancer, aging, and immunity","volume":"30","author":"Plikus","year":"2015","journal-title":"J. Biol. Rhythms"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1038\/jid.2015.316","article-title":"Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice","volume":"135","author":"Ando","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"12662","DOI":"10.1073\/pnas.1209965109","article-title":"Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines","volume":"109","author":"Narasimamurthy","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.1243884","article-title":"TH17 cell differentiation is regulated by the circadian clock","volume":"342","author":"Yu","year":"2013","journal-title":"Science"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jdermsci.2020.03.006","article-title":"High-throughput transcriptome and pathogenesis analysis of clinical psoriasis","volume":"98","author":"Yu","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"18528","DOI":"10.1073\/pnas.1907563116","article-title":"The nuclear receptor REV-ERBalpha modulates Th17 cell-mediated autoimmune disease","volume":"116","author":"Chang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Hirotsu, C., Rydlewski, M., Araujo, M.S., Tufik, S., and Andersen, M.L. (2012). Sleep loss and cytokines levels in an experimental model of psoriasis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051183"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1073\/pnas.1915773117","article-title":"Circadian control of interferon-sensitive gene expression in murine skin","volume":"117","author":"Greenberg","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2174\/1568026615666150220120946","article-title":"Antioxidant properties of melatonin and its potential action in diseases","volume":"15","author":"Karaaslan","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.alit.2022.06.008","article-title":"Time will tell about mast cells: Circadian control of mast cell activation","volume":"71","author":"Nakao","year":"2022","journal-title":"Allergol. Int."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1515\/cclm-2013-0957","article-title":"Serum melatonin levels in psoriasis and associated depressive symptoms","volume":"52","author":"Kartha","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000448122","article-title":"Major Depression and Psoriasis: A Psychodermatological Phenomenon","volume":"29","author":"Tohid","year":"2016","journal-title":"Skin. Pharmacol. Physiol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Scuderi, S.A., Cucinotta, L., Filippone, A., Lanza, M., Campolo, M., Paterniti, I., and Esposito, E. (2022). Effect of Melatonin on Psoriatic Phenotype in Human Reconstructed Skin Model. Biomedicines, 10.","DOI":"10.3390\/biomedicines10040752"},{"key":"ref_179","first-page":"e263","article-title":"Topical corticosteroids application in the evening is more effective than in the morning in psoriasis: Results of a prospective comparative study","volume":"31","author":"Nguyen","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: Systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"ref_181","unstructured":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392, 1789\u20131858."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/ced.14713","article-title":"The incidence of psoriasis in Chile: An analysis of the National Waiting List Repository","volume":"46","author":"Lecaros","year":"2021","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaut.2017.06.001","article-title":"Seasonality and autoimmune diseases: The contribution of the four seasons to the mosaic of autoimmunity","volume":"82","author":"Watad","year":"2017","journal-title":"J. Autoimmun."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Adawi, M., Damiani, G., Bragazzi, N.L., Bridgewood, C., Pacifico, A., Conic, R.R.Z., Morrone, A., Malagoli, P., Pigatto, P.D.M., and Amital, H. (2019). The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study. Nutrients, 11.","DOI":"10.3390\/nu11030601"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1080\/07420528.2019.1678629","article-title":"Psoriatic and psoriatic arthritis patients with and without jet-lag: Does it matter for disease severity scores? Insights and implications from a pilot, prospective study","volume":"36","author":"Damiani","year":"2019","journal-title":"Chronobiol. Int."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000250983","article-title":"Psoriasis in North India. Geographical variations","volume":"155","author":"Bedi","year":"1977","journal-title":"Dermatologica"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1590\/abd1806-4841.20187309","article-title":"Seasonality of the hospitalizations at a dermatologic ward (2007\u20132017)","volume":"93","author":"Brito","year":"2018","journal-title":"An. Bras. Dermatol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1111\/jdv.16791","article-title":"Diurnal and seasonal variation in psoriasis symptoms","volume":"35","author":"Ferguson","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-4632.2004.01828.x","article-title":"Seasonal variation of dermatologic disease in the USA: A study of office visits from 1990 to 1998","volume":"43","author":"Hancox","year":"2004","journal-title":"Int. J. Dermatol."},{"key":"ref_190","first-page":"191","article-title":"Psoriasis. A statistical, clinical and laboratory investigation of 255 psoriatics and matched healthy controls","volume":"44","author":"Hellgren","year":"1964","journal-title":"Acta Derm. Venereol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1346-8138.1998.tb02357.x","article-title":"Factors influencing psoriasis: An analysis based upon the extent of involvement and clinical type","volume":"25","author":"Park","year":"1998","journal-title":"J. Dermatol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jaad.2015.06.001","article-title":"Seasonal variation of acne and psoriasis: A 3-year study using the Physician Global Assessment severity scale","volume":"73","author":"Pascoe","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/ijd.13229","article-title":"Seasonal variations in dermatologic and dermatopathologic diagnoses: A retrospective 15-year analysis of dermatopathologic data","volume":"55","author":"Harvell","year":"2016","journal-title":"Int. J. Dermatol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"e006450","DOI":"10.1136\/bmjopen-2014-006450","article-title":"Epidemiology of psoriasis and palmoplantar pustulosis: A nationwide study using the Japanese national claims database","volume":"5","author":"Kubota","year":"2015","journal-title":"BMJ Open"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1136\/postgradmedj-2019-136766","article-title":"Seasonality and global public interest in psoriasis: An infodemiology study","volume":"96","author":"Wu","year":"2020","journal-title":"Postgrad. Med. J."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/1346-8138.13806","article-title":"Critical role of environmental factors in the pathogenesis of psoriasis","volume":"44","author":"Zeng","year":"2017","journal-title":"J. Dermatol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1111\/jdv.17434","article-title":"ActiPso: Definition of activity types for psoriatic disease: A novel marker for an advanced disease classification","volume":"35","author":"Mrowietz","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2147\/CCID.S312556","article-title":"Seasonal Variation of Psoriasis and Its Impact in the Therapeutic Management: A Retrospective Study on Chinese Patients","volume":"14","author":"Zheng","year":"2021","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/srt.13102","article-title":"Psoriasis and seasonal variation: A systematic review on reports from Northern and Central Europe-Little overall variation but distinctive subsets with improvement in summer or wintertime","volume":"28","author":"Jensen","year":"2022","journal-title":"Skin. Res. Technol."},{"key":"ref_200","unstructured":"(2024, March 10). Air Quality in Europe 2022. Available online: https:\/\/www.eea.europa.eu\/publications\/air-quality-in-europe-2022."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"111024","DOI":"10.1016\/j.nut.2020.111024","article-title":"Effectiveness of oral vitamin D supplementation in lessening disease severity among patients with psoriasis: A systematic review and meta-analysis of randomized controlled trials","volume":"82","author":"Theodoridis","year":"2021","journal-title":"Nutrition"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamadermatol.2018.1412","article-title":"Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review","volume":"154","author":"Ford","year":"2018","journal-title":"JAMA Dermatol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/jdv.12210","article-title":"Factors influencing seasonal patterns of relapse in anti-TNF psoriatic responders after temporary drug discontinuation","volume":"28","author":"Ruano","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5114\/ada.2024.135917","article-title":"Does the effectiveness of biological medications in the treatment for psoriasis depend on the moment of starting therapy? A preliminary study","volume":"41","author":"Noweta","year":"2024","journal-title":"Postepy Dermatol. Alergol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/archderm.1937.01470240043003","article-title":"Psoriasis: A statistical study of two hundred and thirty-one cases","volume":"35","author":"Crawford","year":"1937","journal-title":"Arch. Dermatol. Syphilol."},{"key":"ref_206","first-page":"92","article-title":"Psoriasis on the Faroe Islands; a preliminary report","volume":"34","author":"Lomholt","year":"1954","journal-title":"Acta Derm. Venereol."},{"key":"ref_207","first-page":"1","article-title":"An epidemiological survey of psoriasis in the greater Helsinki area","volume":"124","author":"Torppa","year":"1986","journal-title":"Acta Derm. Venereol. Suppl. (Stockh.)"},{"key":"ref_208","first-page":"242","article-title":"The effect of endogenous and exogenous factors on psoriasis vulgaris. A clinical study","volume":"175","author":"Knopf","year":"1989","journal-title":"Dermatol. Monatsschr."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00403-019-01921-0","article-title":"Seasonal variation in the internet searches for psoriasis","volume":"311","year":"2019","journal-title":"Arch. Dermatol. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/21\/11670\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:24:16Z","timestamp":1760113456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/21\/11670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":209,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["ijms252111670"],"URL":"https:\/\/doi.org\/10.3390\/ijms252111670","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]}}}