{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:41:34Z","timestamp":1764841294485,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Estatal de Ciencia y Tecnolog\u00eda de Jalisco (COECYTJAL)","award":["10217-2022"],"award-info":[{"award-number":["10217-2022"]}]},{"name":"Centro Universitario de Ciencias de la Salud","award":["10217-2022"],"award-info":[{"award-number":["10217-2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is the main endocrine disorder in women of reproductive age worldwide. This condition is often associated with various metabolic alterations that contribute to the development of metabolic syndrome (MetS). Recent research suggests that branched-chain amino acid (BCAA) dysregulation is observed in PCOS. This study aims to investigate the relationship between dietary patterns, body composition, metabolic analytes, and serum amino acid levels in Mexican women with PCOS. Utilizing a cross-sectional design, we found that both study groups, PCOS (n = 24) and PCOS + MetS (n = 21), exhibited increased relative fat mass and dietary habits characterized by high simple sugar intake and low protein consumption, correlating with levels of relative fat mass and leptin. Notably, serum concentrations of BCAAs and glutamic acid were significantly elevated in the PCOS + MetS group. Our findings suggest that a metabolic approach may enhance the prediction and management of MetS in women with PCOS, highlighting the importance of dietary interventions in this population.<\/jats:p>","DOI":"10.3390\/ijms252111821","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T03:57:34Z","timestamp":1730692654000},"page":"11821","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Dietary Patterns and Serum Amino Acid Profile on Metabolic Syndrome Development in Mexican Women with Polycystic Ovary Syndrome"],"prefix":"10.3390","volume":"25","author":[{"given":"Midory S\u00e1nchez","family":"Renter\u00eda","sequence":"first","affiliation":[{"name":"Master in Medical Microbiology, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Arturo Parra","family":"Montoya","sequence":"additional","affiliation":[{"name":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Civil Juan I. Menchaca, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine Sosa","family":"Romero","sequence":"additional","affiliation":[{"name":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Civil Juan I. Menchaca, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizbeth","family":"de Jes\u00fas Gonz\u00e1lez Pi\u00f1uelas","sequence":"additional","affiliation":[{"name":"Laboratorio de Diagn\u00f3stico de Enfermedades Emergentes y Reemergentes, Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana M.","family":"L\u00f3pez-Barradas","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Granados-Portillo","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariel Garc\u00eda","family":"Chagoll\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Laura Pereira","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.","family":"Gillevet","sequence":"additional","affiliation":[{"name":"Microbiome Analysis Center, George Mason University, Manassas, VA 20110, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4749-2498","authenticated-orcid":false,"given":"Natali Vega","family":"Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Diagn\u00f3stico de Enfermedades Emergentes y Reemergentes, Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"},{"name":"Instituto de Investigaci\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Pe\u00f1a Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Diagn\u00f3stico de Enfermedades Emergentes y Reemergentes, Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S2213-8587(22)00163-2","article-title":"Polycystic ovary syndrome","volume":"10","author":"Joham","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/humrep\/deaa371","article-title":"Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017","volume":"36","author":"Liu","year":"2021","journal-title":"Hum. 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