{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:34:01Z","timestamp":1760146441955,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Ministry of Health","award":["6\/6\/4\/1\/NPZ\/2017\/1210\/13522","101008193","5216\/H2020\/2022\/2"],"award-info":[{"award-number":["6\/6\/4\/1\/NPZ\/2017\/1210\/13522","101008193","5216\/H2020\/2022\/2"]}]},{"name":"TRENDO","award":["6\/6\/4\/1\/NPZ\/2017\/1210\/13522","101008193","5216\/H2020\/2022\/2"],"award-info":[{"award-number":["6\/6\/4\/1\/NPZ\/2017\/1210\/13522","101008193","5216\/H2020\/2022\/2"]}]},{"name":"Ministry of Science and Higher Education program","award":["6\/6\/4\/1\/NPZ\/2017\/1210\/13522","101008193","5216\/H2020\/2022\/2"],"award-info":[{"award-number":["6\/6\/4\/1\/NPZ\/2017\/1210\/13522","101008193","5216\/H2020\/2022\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study aimed to evaluate the concentration of osteopontin in peritoneal fluid and plasma as potential biomarkers for diagnosing endometriosis. Osteopontin levels were measured using surface plasmon resonance imaging (SPRI) biosensors in patients suspected of having endometriosis. Plasma samples were collected from 120 patients, and peritoneal fluid was collected from 86 patients. Based on the detection of endometriosis lesions during laparoscopy, participants were divided into a study group (patients with endometriosis) and a control group (patients without endometriosis). The results showed no significant differences in plasma osteopontin levels between women with endometriosis and the control group (19.86 \u00b1 6.72 ng\/mL vs. 18.39 \u00b1 4.46 ng\/mL, p = 0.15). Similarly, peritoneal fluid osteopontin concentrations did not differ significantly between patients with and without endometriosis (19.04 \u00b1 5.37 ng\/mL vs. 17.87 \u00b1 5.13 ng\/mL, p = 0.29). Furthermore, osteopontin levels in both plasma and peritoneal fluid were not significantly associated with the stage of endometriosis, the presence of endometrioma, or the menstrual cycle phase. The findings of this study do not support osteopontin concentration as a reliable biomarker for endometriosis. However, further research is necessary to explore osteopontin\u2019s potential role in the disease.<\/jats:p>","DOI":"10.3390\/ijms252211857","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T05:30:53Z","timestamp":1730784653000},"page":"11857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is Osteopontin a Reliable Biomarker for Endometriosis?"],"prefix":"10.3390","volume":"25","author":[{"given":"Aleksandra","family":"Zygula","sequence":"first","affiliation":[{"name":"OVIklinika Infertility Center, 01-377 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Kiecka","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland"},{"name":"Angelius Provita Hospital, 40-611 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sankiewicz","sequence":"additional","affiliation":[{"name":"Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, 15-328 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Kuzmicki","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-5983","authenticated-orcid":false,"given":"Michal","family":"Ciebiera","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, 00-189 Warsaw, Poland"},{"name":"Warsaw Institute of Women\u2019s Health, 00-189 Warsaw, Poland"},{"name":"Development and Research Center of Non-Invasive Therapies, Pro-Familia Hospital, 35-302 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3647-3550","authenticated-orcid":false,"given":"Tadeusz","family":"Issat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, 01-211 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Drygas","sequence":"additional","affiliation":[{"name":"World Institute for Family Health, Calisia University, 62-800 Kalisz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Cendrowski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Gorodkiewicz","sequence":"additional","affiliation":[{"name":"Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, 15-328 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Laudanski","sequence":"additional","affiliation":[{"name":"OVIklinika Infertility Center, 01-377 Warsaw, Poland"},{"name":"Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, 02-091 Warsaw, Poland"},{"name":"Women\u2019s Health Research Institute, Calisia University, 62-800 Kalisz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"hoac009","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE guideline: Endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Hum. 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