{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:33:34Z","timestamp":1760146414644,"version":"build-2065373602"},"reference-count":97,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007636","name":"Ernst et Lucie Schmidheiny","doi-asserted-by":"publisher","award":["F02-13024","189003"],"award-info":[{"award-number":["F02-13024","189003"]}],"id":[{"id":"10.13039\/501100007636","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swiss National Foundation","award":["F02-13024","189003"],"award-info":[{"award-number":["F02-13024","189003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Metabolic dysfunction-associated fatty liver disease (MASLD) is a common liver and health issue associated with heightened cardiovascular disease (CVD) risk, with Cytokeratin 18 (CK-18) as a marker of liver injury across the MASLD to cirrhosis spectrum. Autoantibodies against apolipoprotein A-1 (AAA-1s) predict increased CVD risk, promoting atherosclerosis and liver steatosis in apoE\u2212\/\u2212 mice, though their impact on liver inflammation and fibrosis remains unclear. This study examined AAA-1s\u2019 impact on low-grade inflammation, liver steatosis, and fibrosis using a MASLD mouse model exposed to AAA-1s passive immunization (PI). Ten-week-old male C57BL\/6J mice under a high-fat diet underwent PI with AAA-1s or control antibodies for ten days. Compared to controls, AAA-1-immunized mice showed higher plasma CK-18 (5.3 vs. 2.1 pg\/mL, p = 0.031), IL-6 (13 vs. 6.9 pg\/mL, p = 0.035), IL-10 (27.3 vs. 9.8 pg\/mL, p = 0.007), TNF-\u03b1 (32.1 vs. 24.2 pg\/mL, p = 0.032), and liver steatosis (93.4% vs. 73.8%, p = 0.007). Transcriptomic analyses revealed hepatic upregulation of pro-fibrotic mRNAs in AAA-1-recipient mice, though histological changes were absent. In conclusion, short-term AAA-1 PI exacerbated liver steatosis, inflammation, and pro-fibrotic gene expression, suggesting that AAA-1s may play a role in MASLD progression. Further research with prolonged AAA-1 exposure is warranted to clarify their potential role in liver fibrosis and associated complications.<\/jats:p>","DOI":"10.3390\/ijms252211875","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T06:30:48Z","timestamp":1730788248000},"page":"11875","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Linking Antibodies Against Apolipoprotein A-1 to Metabolic Dysfunction-Associated Steatohepatitis in Mice"],"prefix":"10.3390","volume":"25","author":[{"given":"Sabrina","family":"Pagano","sequence":"first","affiliation":[{"name":"Division of Laboratory Medicine, Diagnostic Department, Geneva University Hospitals, 1211 Geneva, Switzerland"},{"name":"Department of Medicine, Medical Faculty, Geneva University, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Somm","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Department of Internal Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland"},{"name":"Department of Cell Physiology and Metabolism, University of Geneva, 1211 Geneva, Switzerland"},{"name":"Diabetes Center, the Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Juillard","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical Faculty, Geneva University, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-5857","authenticated-orcid":false,"given":"Nicolas","family":"Liaudet","sequence":"additional","affiliation":[{"name":"Bioimaging Core Facility, Medical Faculty, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Ino","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Department of Internal Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland"},{"name":"Department of Cell Physiology and Metabolism, University of Geneva, 1211 Geneva, Switzerland"},{"name":"Diabetes Center, the Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology, Diagnostic Department, Geneva University Hospitals, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Braunersreuther","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology, Diagnostic Department, Geneva University Hospitals, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-3137","authenticated-orcid":false,"given":"Fran\u00e7ois R.","family":"Jornayvaz","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Department of Internal Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland"},{"name":"Department of Cell Physiology and Metabolism, University of Geneva, 1211 Geneva, Switzerland"},{"name":"Diabetes Center, the Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Vuilleumier","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Diagnostic Department, Geneva University Hospitals, 1211 Geneva, Switzerland"},{"name":"Department of Medicine, Medical Faculty, Geneva University, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"Mafld: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/hep.26717","article-title":"Extrahepatic Complications of Nonalcoholic Fatty Liver Disease","volume":"59","author":"Armstrong","year":"2014","journal-title":"Hepatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S2468-1253(21)00020-0","article-title":"Non-Alcoholic Fatty Liver Disease: A Multisystem Disease Requiring a Multidisciplinary and Holistic Approach","volume":"6","author":"Targher","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global Burden of Nafld and Nash: Trends, Predictions, Risk Factors and Prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00280-007-0437-4","article-title":"Qualification of M30 and M65 Elisas as Surrogate Biomarkers of Cell Death: Long Term Antigen Stability in Cancer Patient Plasma","volume":"60","author":"Cummings","year":"2007","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/hep.24734","article-title":"Prospective Biopsy-Controlled Evaluation of Cell Death Biomarkers for Prediction of Liver Fibrosis and Nonalcoholic Steatohepatitis","volume":"55","author":"Joka","year":"2012","journal-title":"Hepatology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9252536","DOI":"10.1155\/2018\/9252536","article-title":"Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, Nafld Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease","volume":"2018","author":"Kosasih","year":"2018","journal-title":"Int. J. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cca.2010.12.030","article-title":"Increased Total Cytokeratin-18 Serum and Urine Levels in Chronic Kidney Disease","volume":"412","author":"Roth","year":"2011","journal-title":"Clin. Chim. Acta"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/0004563218796259","article-title":"Elevated Serum Cytokeratin-18 Concentration in Patients with Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease","volume":"56","author":"Chang","year":"2019","journal-title":"Ann. Clin. Biochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/cdd.2013.138","article-title":"Cell Death and Diseases Related to Oxidative Stress: 4-Hydroxynonenal (Hne) in the Balance","volume":"20","author":"Dalleau","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-med-043010-144749","article-title":"Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders","volume":"63","author":"Ozcan","year":"2012","journal-title":"Annu. Rev. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pagano, S., Bakker, S.J.L., Juillard, C., Dullaart, R.P.F., and Vuilleumier, N. (2023). Serum Level of Cytokeratin 18 (M65) as a Prognostic Marker of High Cardiovascular Disease Risk in Individuals with Non-Alcoholic Fatty Liver Disease. Biomolecules, 13.","DOI":"10.20944\/preprints202306.1654.v1"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/ajprhc.ajprhc_42_22","article-title":"Correlation of Cytokeratin-18 as a Marker of Cardiovascular Risk Assessment in Nonalcoholic Fatty Liver Disease in Nonobese and Nondiabetic Patients: Two Years Prospective Study","volume":"14","author":"Rasool","year":"2022","journal-title":"Asian J. Pharm. Res. Health Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5198359","DOI":"10.1155\/2020\/5198359","article-title":"Elevated Serum Level of Cytokeratin 18 M65ed Is an Independent Indicator of Cardiometabolic Disorders","volume":"2020","author":"Qian","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/MCA.0b013e328330d56a","article-title":"Serial Changes in Circulating M30 Antigen, a Biomarker of Apoptosis, in Patients with Acute Coronary Syndromes: Relationship with the Severity of Coronary Artery Disease","volume":"20","author":"Senturk","year":"2009","journal-title":"Coron. Artery Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/MCA.0000000000000416","article-title":"The Predictive Value of M30 and Oxidative Stress for Left Ventricular Remodeling in Patients with Anterior St-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention","volume":"27","author":"Turkoglu","year":"2016","journal-title":"Coron. Artery Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1160\/TH16-03-0248","article-title":"Association between Anti-Apolipoprotein a-1 Antibodies and Cardiovascular Disease in the General Population Results from the Colaus Study","volume":"116","author":"Antiochos","year":"2016","journal-title":"Thromb. Haemost."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jdiacomp.2016.02.014","article-title":"Anti-Apolipoprotein a-1 Autoantibodies as Risk Biomarker for Cardiovascular Diseases in Type 2 Diabetes Mellitus","volume":"30","author":"Rasheed","year":"2016","journal-title":"J. Diabetes Complicat."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mongin, D., Pagano, S., Lamacchia, C., Juillard, C., Antinori-Malaspina, P., Dan, D., Ciurea, A., Moller, B., Gabay, C., and Finckh, A. (2024). Anti-Apolipoprotein a-1 Igg, Incident Cardiovascular Events, and Lipid Paradox in Rheumatoid Arthritis. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1386192"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1055\/s-0038-1645857","article-title":"Antibodies against Hdl Components in Ischaemic Stroke and Coronary Artery Disease","volume":"118","author":"Batuca","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1093\/rheumatology\/kead009","article-title":"Humoral Responses against Hdl Are Linked to Lipoprotein Traits, Atherosclerosis, Inflammation and Pathogenic Pathways during Early Arthritis Stages","volume":"62","author":"Lopez","year":"2023","journal-title":"Rheumatology"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Sciascia, S., Cecchi, I., Radin, M., Rubini, E., Suarez, A., Roccatello, D., and Rodriguez-Carrio, J. (2019). Igg Anti-High-Density Lipoproteins Antibodies Discriminate between Arterial and Venous Events in Thrombotic Antiphospholipid Syndrome Patients. Front. Med., 6.","DOI":"10.3389\/fmed.2019.00211"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"243158","DOI":"10.1155\/2012\/243158","article-title":"Anti-Apolipoprotein a-1 Igg Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals","volume":"2012","author":"Quercioli","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e13410","DOI":"10.1111\/eci.13410","article-title":"Anti-Apoa-1 Iggs Predict Resistance to Waist Circumference Reduction after Mediterranean Diet","volume":"51","author":"Carbone","year":"2021","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11695-021-05738-7","article-title":"Bariatric Surgery Leads to a Reduction in Antibodies to Apolipoprotein a-1: A Prospective Cohort Study","volume":"32","author":"Adam","year":"2022","journal-title":"Obes. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Pagano, S., Magenta, A., D\u2019Agostino, M., Martino, F., Barill\u00e0, F., Satta, N., Frias, M.A., Ronca, A., Mach, F., and Gencer, B. (2019). Anti-Apoa-1 Iggs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation. J. Clin. Med., 8.","DOI":"10.3390\/jcm8122035"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1186\/s12967-023-04569-7","article-title":"Antibody against Apolipoprotein-A1, Non-Alcoholic Fatty Liver Disease and Cardiovascular Risk: A Translational Study","volume":"21","author":"Pagano","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.3390\/cimb44100320","article-title":"Western Diet-Fed Apoe Knockout Male Mice as an Experimental Model of Non-Alcoholic Steatohepatitis","volume":"44","author":"Camargo","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Schierwagen, R., Maybuchen, L., Zimmer, S., Hittatiya, K., Back, C., Klein, S., Uschner, F.E., Reul, W., Boor, P., and Nickenig, G. (2015). Seven Weeks of Western Diet in Apolipoprotein-E-Deficient Mice Induce Metabolic Syndrome and Non-Alcoholic Steatohepatitis with Liver Fibrosis. Sci. Rep., 5.","DOI":"10.1038\/srep12931"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sugasawa, T., Ono, S., Yonamine, M., Fujita, S.I., Matsumoto, Y., Aoki, K., Nakano, T., Tamai, S., Yoshida, Y., and Kawakami, Y. (2021). One Week of Cdahfd Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver. Int. J. Mol. Sci., 22.","DOI":"10.20944\/preprints202105.0136.v1"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1160\/TH14-12-1039","article-title":"Anti-Apoa-1 Auto-Antibodies Increase Mouse Atherosclerotic Plaque Vulnerability, Myocardial Necrosis and Mortality Triggering Tlr2 and Tlr4","volume":"114","author":"Montecucco","year":"2015","journal-title":"Thromb. Haemost."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/eurheartj\/ehq521","article-title":"Anti-Apolipoprotein a-1 Auto-Antibodies Are Active Mediators of Atherosclerotic Plaque Vulnerability","volume":"32","author":"Montecucco","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N.J., Dower, S., and Crossman, D.C. (2009). Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005073"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"G1324","DOI":"10.1152\/ajpgi.90564.2008","article-title":"Interleukin-1 Participates in the Progression from Liver Injury to Fibrosis","volume":"296","author":"Gieling","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCRESAHA.115.306656","article-title":"From C-Reactive Protein to Interleukin-6 to Interleukin-1: Moving Upstream to Identify Novel Targets for Atheroprotection","volume":"118","author":"Ridker","year":"2016","journal-title":"Circ. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/hep.28456","article-title":"Interleukin-1 and Inflammasomes in Alcoholic Liver Disease\/Acute Alcoholic Hepatitis and Nonalcoholic Fatty Liver Disease\/Nonalcoholic Steatohepatitis","volume":"64","author":"Tilg","year":"2016","journal-title":"Hepatology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/hep4.1971","article-title":"A New Detection System for Serum Fragmented Cytokeratin 18 as a Biomarker Reflecting Histologic Activities of Human Nonalcoholic Steatohepatitis","volume":"6","author":"Eguchi","year":"2022","journal-title":"Hepatol. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/MOG.0b013e3283525cb8","article-title":"Keratins: Markers and Modulators of Liver Disease","volume":"28","author":"Strnad","year":"2012","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/MEG.0000000000001385","article-title":"Serum Cytokeratin-18 and Its Relation to Liver Fibrosis and Steatosis Diagnosed by Fibroscan and Controlled Attenuation Parameter in Nonalcoholic Fatty Liver Disease and Hepatitis C Virus Patients","volume":"31","author":"Darweesh","year":"2019","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Jiao, Y., Chen, H., Gu, T., Wang, L., Postlethwaite, A., and Gu, W. (2015). Molecular Network of Important Genes for Systemic Sclerosis-Related Progressive Lung Fibrosis. BMC Res. Notes, 8.","DOI":"10.1186\/s13104-015-1510-4"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/s41590-019-0417-y","article-title":"The Macrophage Tetraspan Ms4a4a Enhances Dectin-1-Dependent Nk Cell-Mediated Resistance to Metastasis","volume":"20","author":"Mattiola","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ajpath.2014.11.002","article-title":"Matricellular Protein Periostin Contributes to Hepatic Inflammation and Fibrosis","volume":"185","author":"Huang","year":"2015","journal-title":"Am. J. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"12781","DOI":"10.1074\/jbc.RA117.001601","article-title":"Periostin Promotes Liver Fibrogenesis by Activating Lysyl Oxidase in Hepatic Stellate Cells","volume":"293","author":"Kumar","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nm1619","article-title":"Periostin Induces Proliferation of Differentiated Cardiomyocytes and Promotes Cardiac Repair","volume":"13","author":"Kuhn","year":"2007","journal-title":"Nat. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2332\/allergolint.13-RAI-0663","article-title":"Periostin in Allergic Inflammation","volume":"63","author":"Izuhara","year":"2014","journal-title":"Allergol. Int."},{"key":"ref_46","first-page":"56","article-title":"Targeting Gpr65 Alleviates Hepatic Inflammation and Fibrosis by Suppressing the Jnk and Nf-Kappab Pathways","volume":"10","author":"Zhang","year":"2023","journal-title":"Mil. Med. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Rajak, S., Gupta, P., Anjum, B., Raza, S., Tewari, A., Ghosh, S., Tripathi, M., Singh, B.K., and Sinha, R.A. (2022). Role of Akr1b10 and Akr1b8 in the Pathogenesis of Non-Alcoholic Steatohepatitis (Nash) in Mouse. Biochim. Biophys. Acta Mol. Basis Dis., 1868.","DOI":"10.1016\/j.bbadis.2021.166319"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"101462","DOI":"10.1016\/j.molmet.2022.101462","article-title":"Serum Amyloid A1 Exacerbates Hepatic Steatosis Via Tlr4-Mediated Nf-Kappab Signaling Pathway","volume":"59","author":"Jiang","year":"2022","journal-title":"Mol. Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e143690","DOI":"10.1172\/JCI143690","article-title":"Lipid-Induced Endothelial Vascular Cell Adhesion Molecule 1 Promotes Nonalcoholic Steatohepatitis Pathogenesis","volume":"131","author":"Furuta","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/ijo.2017.102","article-title":"Serum Vascular Cell Adhesion Molecule-1 Predicts Significant Liver Fibrosis in Non-Alcoholic Fatty Liver Disease","volume":"41","author":"Lefere","year":"2017","journal-title":"Int. J. Obes."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1365-2796.2012.02530.x","article-title":"Anti-Apolipoprotein a-1 Igg in Patients with Myocardial Infarction Promotes Inflammation through Tlr2\/Cd14 Complex","volume":"272","author":"Pagano","year":"2012","journal-title":"J. Intern. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1160\/TH12-10-0714","article-title":"Serum Levels of Anti-Apolipoprotein a-1 Auto-Antibodies and Myeloperoxidase as Predictors of Major Adverse Cardiovascular Events after Carotid Endarterectomy","volume":"109","author":"Vuilleumier","year":"2013","journal-title":"Thromb. Haemost."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1440-1746.2007.05002.x","article-title":"Guidelines for the Assessment and Management of Non-Alcoholic Fatty Liver Disease in the Asia-Pacific Region: Executive Summary","volume":"22","author":"Farrell","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and Validation of a Histological Scoring System for Nonalcoholic Fatty Liver Disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1053\/j.gastro.2005.03.084","article-title":"Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease","volume":"128","author":"Ratziu","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_56","first-page":"540","article-title":"Meso-Scale Discovery Assay Detects the Changes of Plasma Cytokine Levels in Mice after Low or High Let Ionizing Irradiation","volume":"34","author":"Jia","year":"2021","journal-title":"Biomed. Environ. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Bankhead, P., Loughrey, M.B., Fernandez, J.A., Dombrowski, Y., McArt, D.G., Dunne, P.D., McQuaid, S., Gray, R.T., Murray, L.J., and Coleman, H.G. (2017). Qupath: Open Source Software for Digital Pathology Image Analysis. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-17204-5"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.csbj.2024.04.061","article-title":"Challenges and Opportunities in Processing Nanostring Ncounter Data","volume":"23","author":"Chilimoniuk","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/14737159.2019.1623672","article-title":"Application of Nanostring Technologies in Companion Diagnostic Development","volume":"19","author":"Eastel","year":"2019","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/BJ20050887","article-title":"As160, the Akt Substrate Regulating Glut4 Translocation, Has a Functional Rab Gtpase-Activating Protein Domain","volume":"391","author":"Miinea","year":"2005","journal-title":"Biochem. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"19896","DOI":"10.1073\/pnas.1310838110","article-title":"Dimerization of Ltbetar by Ltalpha1beta2 Is Necessary and Sufficient for Signal Transduction","volume":"110","author":"Sudhamsu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"21013","DOI":"10.1074\/jbc.M512908200","article-title":"Tlr8-Mediated Nf-Kappab and Jnk Activation Are Tak1-Independent and Mekk3-Dependent","volume":"281","author":"Qin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2174\/1874467208666150817112529","article-title":"Role of Early Growth Response-1 in the Development of Alcohol-Induced Steatosis","volume":"10","author":"Thomes","year":"2017","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_64","first-page":"5358","article-title":"Periostin Secreted by Epithelial Ovarian Carcinoma Is a Ligand for Alpha(V)Beta(3) and Alpha(V)Beta(5) Integrins and Promotes Cell Motility","volume":"62","author":"Gillan","year":"2002","journal-title":"Cancer Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.immuni.2016.05.007","article-title":"Genetic Coding Variant in Gpr65 Alters Lysosomal Ph and Links Lysosomal Dysfunction with Colitis Risk","volume":"44","author":"Lassen","year":"2016","journal-title":"Immunity"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41588-021-00803-4","article-title":"Gain-of-Function Variants in Syk Cause Immune Dysregulation and Systemic Inflammation in Humans and Mice","volume":"53","author":"Wang","year":"2021","journal-title":"Nat. Genet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1749-6632.1982.tb22136.x","article-title":"Saa, an Apoprotein of Hdl: Its Structure and Function","volume":"389","author":"Benditt","year":"1982","journal-title":"Ann. N. Y Acad. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1074\/jbc.273.8.4530","article-title":"Structure of the Human Macrophage Marco Receptor and Characterization of Its Bacteria-Binding Region","volume":"273","author":"Elomaa","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.1111\/jcmm.17599","article-title":"Polyguanine Alleviated Autoimmune Hepatitis through Regulation of Macrophage Receptor with Collagenous Structure and Tlr4-Trif-Nf-Kappab Signalling","volume":"26","author":"Cai","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nm.3443","article-title":"Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Require Fcgammar Interactions for Protection against Influenza Virus in Vivo","volume":"20","author":"DiLillo","year":"2014","journal-title":"Nat. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/hep.20999","article-title":"Jnk1 but Not Jnk2 Promotes the Development of Steatohepatitis in Mice","volume":"43","author":"Schattenberg","year":"2006","journal-title":"Hepatology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biocel.2010.09.014","article-title":"Iqgap1 Translocates to the Nucleus in Early S-Phase and Contributes to Cell Cycle Progression after DNA Replication Arrest","volume":"43","author":"Johnson","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.omtn.2021.12.020","article-title":"Silencing Iqgap1 Alleviates Hepatic Fibrogenesis Via Blocking Bone Marrow Mesenchymal Stromal Cell Recruitment to Fibrotic Liver","volume":"27","author":"Ma","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.jhep.2021.11.031","article-title":"Taz-Induced Cybb Contributes to Liver Tumor Formation in Non-Alcoholic Steatohepatitis","volume":"76","author":"Wang","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.immuni.2023.05.014","article-title":"Identification of an Il-1 Receptor Mutation Driving Autoinflammation Directs Il-1-Targeted Drug Design","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35085597","article-title":"Tak1 Is a Ubiquitin-Dependent Kinase of Mkk and Ikk","volume":"412","author":"Wang","year":"2001","journal-title":"Nature"},{"key":"ref_77","first-page":"1","article-title":"The Role of Endothelial Lipase in Lipid Metabolism, Inflammation, and Cancer","volume":"33","author":"Yu","year":"2018","journal-title":"Histol. Histopathol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1053\/j.gastro.2006.05.048","article-title":"Nadph Oxidase in the Liver: Defensive, Offensive, or Fibrogenic?","volume":"131","author":"Bataller","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"803037","DOI":"10.3389\/fimmu.2021.803037","article-title":"Macrophage Polarization and Its Role in Liver Disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.3390\/cells8121503","article-title":"The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis","volume":"8","author":"Hintermann","year":"2019","journal-title":"Cells"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.cmet.2017.07.009","article-title":"Acetyl Coa Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation","volume":"26","author":"Kim","year":"2017","journal-title":"Cell Metab."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"34002","DOI":"10.1074\/jbc.M803957200","article-title":"Fgd2, a Cdc42-Specific Exchange Factor Expressed by Antigen-Presenting Cells, Localizes to Early Endosomes and Active Membrane Ruffles","volume":"283","author":"Huber","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.molmed.2019.05.010","article-title":"Angptl4 in Metabolic and Cardiovascular Disease","volume":"25","author":"Aryal","year":"2019","journal-title":"Trends Mol. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.4049\/jimmunol.167.7.3668","article-title":"Cd84 Functions as a Homophilic Adhesion Molecule and Enhances Ifn-Gamma Secretion: Adhesion Is Mediated by Ig-Like Domain 1","volume":"167","author":"Martin","year":"2001","journal-title":"J Immunol"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/cells5020017","article-title":"The Regulation of Cellular Responses to Mechanical Cues by Rho Gtpases","volume":"5","author":"Hoon","year":"2016","journal-title":"Cells"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"100386","DOI":"10.1016\/j.jhepr.2021.100386","article-title":"Rock2 Inhibition Attenuates Profibrogenic Immune Cell Function to Reverse Thioacetamide-Induced Liver Fibrosis","volume":"4","author":"Nalkurthi","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S0022-2275(20)31998-2","article-title":"Distribution of Phospholipid Transfer Protein in Human Plasma: Presence of Two Forms of Phospholipid Transfer Protein, One Catalytically Active and the Other Inactive","volume":"41","author":"Oka","year":"2000","journal-title":"J. Lipid Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1161\/01.ATV.0000094433.98445.7F","article-title":"High Plasma Phospholipid Transfer Protein Levels as a Risk Factor for Coronary Artery Disease","volume":"23","author":"Schlitt","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature07725","article-title":"Aim2 Recognizes Cytosolic Dsdna and Forms a Caspase-1-Activating Inflammasome with Asc","volume":"458","author":"Hornung","year":"2009","journal-title":"Nature"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.3390\/ijms21186535","article-title":"The Emerging Relevance of Aim2 in Liver Disease","volume":"21","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1091\/mbc.e06-01-0060","article-title":"Oxysterol-Binding Protein and Vesicle-Associated Membrane Protein-Associated Protein Are Required for Sterol-Dependent Activation of the Ceramide Transport Protein","volume":"17","author":"Perry","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1161\/ATVBAHA.106.138545","article-title":"Oxysterol Binding Protein Induces Upregulation of Srebp-1c and Enhances Hepatic Lipogenesis","volume":"27","author":"Yan","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ng0193-7","article-title":"Isolation of a Candidate Gene for Menkes Disease and Evidence That It Encodes a Copper-Transporting Atpase","volume":"3","author":"Vulpe","year":"1993","journal-title":"Nat. Genet."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"106566","DOI":"10.1016\/j.phrs.2022.106566","article-title":"Targeting Csf-1r Represents an Effective Strategy in Modulating Inflammatory Diseases","volume":"187","author":"Xiang","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/hep.27328","article-title":"Il-34 and Macrophage Colony-Stimulating Factor Are Overexpressed in Hepatitis C Virus Fibrosis and Induce Profibrotic Macrophages That Promote Collagen Synthesis by Hepatic Stellate Cells","volume":"60","author":"Preisser","year":"2014","journal-title":"Hepatology"},{"key":"ref_96","first-page":"738","article-title":"Expression of Cell-Cell and Cell-Matrix Adhesion Proteins by Sinusoidal Endothelial Cells in the Normal and Cirrhotic Human Liver","volume":"143","author":"Couvelard","year":"1993","journal-title":"Am. J. Pathol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"G1205","DOI":"10.1152\/ajpgi.00157.2007","article-title":"The Proinflammatory Phenotype of Pecam-1-Deficient Mice Results in Atherogenic Diet-Induced Steatohepatitis","volume":"293","author":"Goel","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/22\/11875\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:26:39Z","timestamp":1760113599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/22\/11875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":97,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["ijms252211875"],"URL":"https:\/\/doi.org\/10.3390\/ijms252211875","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2024,11,5]]}}}