{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:00:05Z","timestamp":1791874805667,"version":"4.3.4"},"reference-count":54,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation","award":["20\/07765-6"],"award-info":[{"award-number":["20\/07765-6"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["12\/50079-0"],"award-info":[{"award-number":["12\/50079-0"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["2019\/19988-2"],"award-info":[{"award-number":["2019\/19988-2"]}]},{"name":"Funda\u00e7\u00e3o Faculdade de Medicina","award":["20\/07765-6"],"award-info":[{"award-number":["20\/07765-6"]}]},{"name":"Funda\u00e7\u00e3o Faculdade de Medicina","award":["12\/50079-0"],"award-info":[{"award-number":["12\/50079-0"]}]},{"name":"Funda\u00e7\u00e3o Faculdade de Medicina","award":["2019\/19988-2"],"award-info":[{"award-number":["2019\/19988-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancer-associated cachexia (CAC) is a severe wasting syndrome, marked by involuntary weight loss and muscle wasting. It is a leading cause of cancer-related morbidity and mortality, and is driven by systemic, chronic low-grade inflammation. Key cytokines, such as IL-6 and GDF15, activate catabolic pathways in many organs. This study examined the role of inflammation and metabolic disruption in the liver during CAC, focusing on its dual role as both a target and a source of inflammatory factors. The analysis covered protein and lipid metabolism disturbances, including the hepatic production of acute-phase proteins and insulin resistance. Hepatic inflammation contributes to systemic dysfunction in CAC. The increased production of C-Reactive Protein (CRP) impacts muscle wasting, while liver inflammation leads to insulin resistance and hepatic steatosis, aggravating the cachectic state. Therefore, understanding the molecular mechanisms of liver metabolism in CAC is essential for developing effective therapies. Potential interventions include anti-inflammatory treatments, anabolic strategies, and restoration of lipid metabolism. Further research is necessary to explore the liver\u2019s full contribution to CAC and its systemic effects, allowing to the development of liver-targeted therapeutic strategies.<\/jats:p>","DOI":"10.3390\/ijms252211945","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T04:22:56Z","timestamp":1730953376000},"page":"11945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Metabolic, Inflammatory, and Molecular Impact of Cancer Cachexia on the Liver"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-0174","authenticated-orcid":false,"given":"Daniela Caetano","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Departamento de Bioci\u00eancias, Universidade Federal de S\u00e3o Paulo (UNIFESP), Santos 11015-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio Pires","family":"Gomes","sequence":"additional","affiliation":[{"name":"Instituto de Bioci\u00eancias (IBB), Departamento de Biologia Estrutural e Funcional, Anatomy Sector, Universidade Estadual Paulista (Unesp), C\u00e2mpus Botucatu, S\u00e3o Paulo 01049-010, Brazil"},{"name":"LIM 26-HC, Departamento de Cirurgia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia","family":"Seelaender","sequence":"additional","affiliation":[{"name":"LIM 26-HC, Departamento de Cirurgia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. 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