{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:58:33Z","timestamp":1781233113431,"version":"3.54.1"},"reference-count":49,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of Targu Mures Research","award":["163\/8\/10.01.2023"],"award-info":[{"award-number":["163\/8\/10.01.2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inflammation is involved in the pathomechanism of vascular diseases. Pro-inflammatory cytokines are important in perioperative monitoring. The aim of the study was the perioperative assessment of biochemical tests and inflammatory markers in patients with vasculopathy, focusing on the identification of subjects prone to complications. The study was performed between 2020 and 2023 at the Clinical County Hospital in T\u00e2rgu Mure\u0219 on enrolled diabetic and non-diabetic patients with vasculopathy and lower limb surgery (amputation or necrectomy). Pre- and postoperative inflammatory markers, biochemical, and hematological tests (n = 62) were performed. Positive correlation was found between preoperative C-reactive protein (CRP) and interleukin-6 (IL-6) levels, and between preoperative triglyceridemia and glycemia\/cholesterolemia. Positive correlation was present between pre- and postoperative values of IL-6, tumor necrosis factor-alfa (TNF-\u03b1), CRP, and fibrinogen. Preoperative TNF-\u03b1 values positively correlated with malondialdehyde (MDA) levels, postoperative TNF-\u03b1 values with transaminase enzymes. Diabetic patients presented higher IL-6 results compared to non-diabetic subjects. We can conclude that dynamic assessment of inflammatory markers is appropriate for monitoring perioperative course. Half of the subjects presented moderately increased preoperative IL-6 levels, and one quarter had critically high values, which might predict prolonged hospitalization. The assessment of oxidative stress, inflammatory markers and biochemical parameters enables the identification of patients prone to complications, so they can benefit from more complex management.<\/jats:p>","DOI":"10.3390\/ijms252211989","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:02:54Z","timestamp":1731038574000},"page":"11989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Predictive Role of Inflammatory Biomarkers and Their Correlation with the Biochemical Profile in Patients with Vasculopathy Undergoing Surgery"],"prefix":"10.3390","volume":"25","author":[{"given":"Orsolya-Zsuzsa","family":"Ak\u00e1csos-Sz\u00e1sz","sequence":"first","affiliation":[{"name":"Doctoral School, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-7947","authenticated-orcid":false,"given":"S\u00e1ndor","family":"P\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Department of Transfusion Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga-Ilona","family":"Nyulas","sequence":"additional","affiliation":[{"name":"Doctoral School, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nika","family":"Szilveszter","sequence":"additional","affiliation":[{"name":"Clinic of Plastic Surgery, Mure\u0219 County Emergency Hospital, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-5987","authenticated-orcid":false,"given":"Zsuzs\u00e1nna","family":"Simon-Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8319-8134","authenticated-orcid":false,"given":"L\u00f3r\u00e1nd","family":"D\u00e9nes","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Embryology, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1028-9579","authenticated-orcid":false,"given":"Erzs\u00e9bet","family":"M\u00e1jai","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Biopharmacy, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-1594","authenticated-orcid":false,"given":"Adina","family":"Hu\u021banu","sequence":"additional","affiliation":[{"name":"Center for Advanced Medical and Pharmaceutical Research, Department of Laboratory Medicine, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-4926","authenticated-orcid":false,"given":"Adina","family":"Stoian","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Cornelia","family":"Tilinca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u015f, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Nemes-Nagy","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Medical Biochemistry, Faculty of Medicine in English, George Emil 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Commun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-020-0352-5","article-title":"T cell subsets and functions in atherosclerosis","volume":"17","author":"Saigusa","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/physrev.00024.2005","article-title":"Cytokines in atherosclerosis: Pathogenic and regulatory pathways","volume":"86","author":"Tedgui","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1124\/pharmrev.120.000096","article-title":"Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies","volume":"73","author":"Xu","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41392-022-00955-7","article-title":"Inflammation and atherosclerosis: Signaling pathways and therapeutic intervention","volume":"7","author":"Kong","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., Tang, D., and Chen, R. (2018). Research Progress on the Relationship between Atherosclerosis and Inflammation. Biomolecules, 8.","DOI":"10.3390\/biom8030080"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.37358\/RC.18.7.6426","article-title":"The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions","volume":"69","author":"Nicolescu","year":"2018","journal-title":"Rev. Chim."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"108304","DOI":"10.1016\/j.jdiacomp.2022.108304","article-title":"Cytokine gene variants of TNF-\u03b1 and IL-10 in the propensity of type 2 diabetes in south Indian population","volume":"36","author":"Chikoti","year":"2022","journal-title":"J. Diabetes Complicat."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1016\/j.numecd.2021.07.015","article-title":"Effects of GLP-1 receptor agonists on myokine levels and pro-inflammatory cytokines in patients with type 2 diabetes mellitus","volume":"31","author":"Guarnotta","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.31128\/AJGP-11-19-5161","article-title":"The diabetic foot ulcer","volume":"49","author":"Reardon","year":"2020","journal-title":"Aust. J. Gen. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e3272","DOI":"10.1002\/dmrr.3272","article-title":"Diabetic foot ulcer classifications: A critical review","volume":"36","author":"Boyko","year":"2020","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_12","first-page":"e21952","article-title":"Interleukin-6 Levels in Patients with Diabetic Polyneuropathy","volume":"14","author":"Chanda","year":"2022","journal-title":"Cureus"},{"key":"ref_13","first-page":"12","article-title":"Clinical use of an analysis of oxidative stress and IL-6 as the promoters of diabetic polyneuropathy","volume":"18","author":"Karahmet","year":"2021","journal-title":"Med. Glas."},{"key":"ref_14","first-page":"153","article-title":"Interleukin-6 and hs-CRP as Early Diagnostic Biomarkers for Obesity-Related Peripheral Polyneuropathy in Non-Diabetic Patients","volume":"25","author":"Rashad","year":"2018","journal-title":"Egypt. J. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1902\/jop.2016.150713","article-title":"Tumor Necrosis Factor-\u03b1 and Interleukin (IL)-1\u03b2, IL-6, and IL-8 Impair In Vitro Migration and Induce Apoptosis of Gingival Fibroblasts and Epithelial Cells, Delaying Wound Healing","volume":"87","author":"Basso","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cyto.2014.09.005","article-title":"Contributions of cell subsets to cytokine production during normal and impaired wound healing","volume":"71","author":"Mirza","year":"2015","journal-title":"Cytokine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0161-5890(02)00207-9","article-title":"Reactive oxygen intermediates in TNF signaling","volume":"39","author":"Garg","year":"2002","journal-title":"Mol. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zheng, D., Liu, J., Piao, H., Zhu, Z., Wei, R., and Liu, K. (2022). ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1039241"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100649","DOI":"10.1016\/j.eclinm.2020.100649","article-title":"Proinflammatory cytokines predict the incidence of diabetic peripheral neuropathy over 5 years in Chinese type 2 diabetes patients: A prospective cohort study","volume":"31","author":"Zheng","year":"2021","journal-title":"EClinicalMedicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e280921196867","DOI":"10.2174\/1573399817666210928144706","article-title":"Inflammatory Biomarkers as Predictors of Infected Diabetic Foot Ulcer","volume":"18","author":"Dmitriyeva","year":"2022","journal-title":"Curr. Diabetes Rev."},{"key":"ref_21","first-page":"2535","article-title":"Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors","volume":"17","author":"Sun","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/iwj.13086","article-title":"Inflammatory biomarkers, vascular procedures of lower limbs, and wound healing","volume":"16","author":"Sapienza","year":"2019","journal-title":"Int. Wound J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10740","DOI":"10.1038\/s41598-019-47217-1","article-title":"A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients with Severe Limb Ischemia","volume":"9","author":"Gremmels","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.3889\/oamjms.2019.646","article-title":"Role of Inflammation in the Pathogenesis of Diabetic Peripheral Neuropathy","volume":"7","author":"Papazova","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12902-017-0189-z","article-title":"Elevated C-Reactive Protein, Interleukin 6, Tumor Necrosis Factor Alpha and Glycemic Load Associated with Type 2 Diabetes Mellitus in Rural Thais: A Cross-Sectional Study","volume":"17","author":"Phosat","year":"2017","journal-title":"BMC Endocr. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1161\/CIRCULATIONAHA.109.918417","article-title":"Inflammation in Peripheral Artery Disease","volume":"122","author":"Brevetti","year":"2010","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Saenz-Pipaon, G., Martinez-Aguilar, E., Orbe, J., Gonz\u00e1lez Miqueo, A., Fernandez-Alonso, L., Paramo, J.A., and Roncal, C. (2021). The Role of Circulating Biomarkers in Peripheral Arterial Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073601"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1001\/jama.286.11.1317","article-title":"Peripheral Arterial Disease Detection, Awareness, and Treatment in Primary Care","volume":"286","author":"Hirsch","year":"2001","journal-title":"JAMA"},{"key":"ref_29","first-page":"646","article-title":"Humoral Predictors of Ankle-Brachial Index in Patients with Peripheral Arterial Disease and Controls","volume":"119","author":"Valkova","year":"2018","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jvs.2014.06.116","article-title":"Association of Monocyte Tumor Necrosis Factor \u03b1 Expression and Serum Inflammatory Biomarkers with Walking Impairment in Peripheral Artery Disease","volume":"61","author":"Pande","year":"2015","journal-title":"J. Vasc. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cca.2015.05.003","article-title":"Biological Variation of Established and Novel Biomarkers for Atherosclerosis: Results from a Prospective, Parallel-Group Cohort Study","volume":"447","author":"Engelberger","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/CIRCULATIONAHA.104.513085","article-title":"C-Reactive Protein, Interleukin-6, and Soluble Adhesion Molecules as Predictors of Progressive Peripheral Atherosclerosis in the General Population: Edinburgh Artery Study","volume":"112","author":"Tzoulaki","year":"2005","journal-title":"Circulation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/01.CIR.97.5.425","article-title":"Plasma Concentration of C-Reactive Protein and Risk of Developing Peripheral Vascular Disease","volume":"97","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/1457496916683096","article-title":"Elevated Levels of Procalcitonin and Interleukin-6 Are Linked with Postoperative Complications in Cardiac Surgery","volume":"106","author":"Brocca","year":"2017","journal-title":"Scand. J. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1177\/1708538120921005","article-title":"Six-Month Results of Stenting of the Femoropopliteal Artery and Predictive Value of Interleukin-6: Comparison with High-Sensitivity C-Reactive Protein","volume":"28","author":"Guo","year":"2020","journal-title":"Vascular"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.medcli.2024.01.009","article-title":"The Potential Impact and Diagnostic Value of Inflammatory Markers on Diabetic Foot Progression in Type II Diabetes Mellitus: A Case-Control Study","volume":"162","author":"Mohamed","year":"2024","journal-title":"Med. Clin."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11154-019-09492-1","article-title":"Role of Growth Factors and Cytokines in Diabetic Foot Ulcer Healing: A Detailed Review","volume":"20","author":"Zubair","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Stoian, A., Muntean, C., Bab\u0103, D.-F., Manea, A., D\u00e9nes, L., Simon-Szab\u00f3, Z., Kosovski, I.B., Nemes-Nagy, E., Gliga, F.I., and Stoian, M. (2024). Update on Biomarkers of Chronic Inflammatory Processes Underlying Diabetic Neuropathy. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251910395"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0002-9343(02)01258-5","article-title":"van der Novel Risk Factors for Peripheral Arterial Disease in Young Women","volume":"113","author":"Bloemenkamp","year":"2002","journal-title":"Am. J. Med."},{"key":"ref_40","first-page":"A4975","article-title":"Increased risk of post-operative complications in patients with Crohn\u2019s disease treated with anti-tumor necrosis factor \u03b1 agents\u2014A systematic review","volume":"61","author":"Theede","year":"2014","journal-title":"Dan. Med. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.inmuno.2014.01.001","article-title":"Evaluation of serum levels of IL-6, TNF-\u03b1, IL-10, IL-2 and IL-4 in patients with chronic hepatitis","volume":"33","author":"Mourtzikou","year":"2014","journal-title":"Inmunolog\u00eda"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.avsg.2012.07.017","article-title":"Inflammatory \u201cadiposopathy\u201d in major amputation patients","volume":"27","author":"Mauro","year":"2013","journal-title":"Ann. Vasc. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"8618","DOI":"10.1038\/s41598-020-65581-1","article-title":"Inflammatory cytokines during cardiac rehabilitation after heart surgery and their association to postoperative atrial fibrillation","volume":"10","author":"Racca","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Monserrat-Mesquida, M., Quetglas-Llabr\u00e9s, M., Cap\u00f3, X., Bouzas, C., Mateos, D., Pons, A., Tur, J.A., and Sureda, A. (2020). Metabolic syndrome is associated with oxidative stress and proinflammatory state. Antioxidants, 9.","DOI":"10.3390\/antiox9030236"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Mueangson, O., Vongvaivanichakul, P., Kamdee, K., Jansakun, C., Chulrik, W., Pongpanitanont, P., Sathirapanya, P., and Chunglok, W. (2020). Malondialdehyde as a useful biomarker of low hand grip strength in community-dwelling stroke patients. Int. J. Environ. Res., 17.","DOI":"10.3390\/ijerph17217918"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.molimm.2020.10.006","article-title":"High serum IL-6 values increase the risk of mortality and the severity of pneumonia in patients diagnosed with COVID-19","volume":"128","author":"Guirao","year":"2020","journal-title":"Mol. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kurniawan, R.B., Siahaan, P.P., Saputra, P.B., Arnindita, J.N., Savitri, C.G., Faizah, N.N., Andira, L.H., D\u2019Oria, M., Eko Putranto, J.N., and Alkaff, F.F. (2024). Neutrophil-to-lymphocyte ratio as a prognostic biomarker in patients with peripheral artery disease: A systematic review and meta-analysis. Vasc. Med., 1358863X241281699.","DOI":"10.1177\/1358863X241281699"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.numecd.2017.10.022","article-title":"Neutrophil-to-Lymphocyte Ratio is a strong predictor of atherosclerotic carotid plaques in older adults","volume":"28","author":"Corriere","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_49","first-page":"319","article-title":"Malondialdehyde levels can be measured in serum and saliva by using a fast HPLC method with visible detection","volume":"24","author":"Fogarasi","year":"2016","journal-title":"Rev. Romana Med. Lab."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/22\/11989\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:28:29Z","timestamp":1760113709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/22\/11989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":49,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["ijms252211989"],"URL":"https:\/\/doi.org\/10.3390\/ijms252211989","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]}}}