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11220150100503CO"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Thyroid carcinoma (TC) is the most common endocrine neoplasia, with its incidence increasing in the last 40 years worldwide. The determination of genetic and\/or protein markers for thyroid carcinoma could increase diagnostic precision. Accumulated evidence shows that Protein kinase C alpha (PKC\u03b1) contributes to tumorigenesis and therapy resistance in cancer. However, the role of PKC\u03b1 in TC remains poorly studied. Our group and others have demonstrated that PKCs can mediate the proliferative effects of thyroid hormones (THs) through their membrane receptor, the integrin \u03b1v\u03b23, in several cancer types. We found that PKC\u03b1 is overexpressed in TC cell lines, and it also appeared as the predominant expressed isoform in public databases of TC patients. PKC\u03b1-depleted cells significantly reduced THs-induced proliferation, mediated by the integrin \u03b1v\u03b23 receptor, through AKT and Erk activation. In databases of TC patients, higher PKC\u03b1 expression was associated with lower overall survival. Further analyses showed a positive correlation between PKC\u03b1 and genes from the MAPK and PI3K-Akt pathways. Finally, immunohistochemical analysis showed abnormal upregulation of PKC\u03b1 in human thyroid tumors. Our findings establish a potential role for PKC\u03b1 in the control of hormone-induced proliferation that can be explored as a therapeutic and\/or diagnostic target for TC.<\/jats:p>","DOI":"10.3390\/ijms252212158","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T06:10:48Z","timestamp":1731478248000},"page":"12158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["PKC\u03b1 Activation via the Thyroid Hormone Membrane Receptor Is Key to Thyroid Cancer Growth"],"prefix":"10.3390","volume":"25","author":[{"given":"Mateo N.","family":"Campos Haedo","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (BIOMED), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Facultad de Ciencias M\u00e9dicas, Pontificia Universidad Cat\u00f3lica Argentina (UCA), Buenos Aires C1107AFB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna A.","family":"D\u00edaz Albuja","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (BIOMED), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Facultad de Ciencias M\u00e9dicas, Pontificia Universidad Cat\u00f3lica Argentina (UCA), Buenos Aires C1107AFB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Camarero","sequence":"additional","affiliation":[{"name":"Histopathology Service, Hospital de Pediatr\u00eda Garrahan, Buenos Aires C1245AAM, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Cayrol","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (BIOMED), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Facultad de Ciencias M\u00e9dicas, Pontificia Universidad Cat\u00f3lica Argentina (UCA), Buenos Aires C1107AFB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena A.","family":"Sterle","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (BIOMED), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Facultad de Ciencias M\u00e9dicas, Pontificia Universidad Cat\u00f3lica Argentina (UCA), Buenos Aires C1107AFB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda M.","family":"Debernardi","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (BIOMED), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Facultad de Ciencias M\u00e9dicas, Pontificia Universidad Cat\u00f3lica Argentina (UCA), Buenos Aires C1107AFB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-4549","authenticated-orcid":false,"given":"Marina","family":"Perona","sequence":"additional","affiliation":[{"name":"Departamento de Radiobiolog\u00eda, Comisi\u00f3n Nacional de Energ\u00eda At\u00f3mica (CNEA), Buenos Aires B1650KNA, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires C1425FQB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-4601","authenticated-orcid":false,"given":"Melina","family":"Saban","sequence":"additional","affiliation":[{"name":"Endocrinology Service, Hospital Brit\u00e1nico de Buenos Aires, Buenos Aires C1280AEB, 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