{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:11:00Z","timestamp":1789135860080,"version":"build-2803163510"},"reference-count":100,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Agency, Poland from state budget funds","award":["2021\/ABM\/03\/00037"],"award-info":[{"award-number":["2021\/ABM\/03\/00037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The treatment of diabetic wounds is impaired by the intricate nature of diabetes and its associated complications, necessitating novel strategies. The utilization of mesenchymal stem\/stromal cells (MSCs) as a therapeutic modality for chronic and recalcitrant wounds in diabetic patients is an active area of investigation aimed at enhancing its therapeutic potential covering tissue regeneration. The threat posed to the patient and their environment by the presence of a diabetic foot ulcer (DFU) is so significant that any additional therapeutic approach that opens new pathways to halt the progression of local changes, which subsequently lead to a generalized inflammatory process, offers a chance to reduce the risk of amputation or even death. This article explores the potential of MSCs in diabetic foot ulcer treatment, examining their mechanisms of action, clinical application challenges, and future directions for research and therapy.<\/jats:p>","DOI":"10.3390\/ijms252212171","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T06:10:48Z","timestamp":1731478248000},"page":"12171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Potential of Mesenchymal Stem\/Stromal Cells in Diabetic Wounds and Future Directions for Research and Therapy\u2014Is It Time for Use in Everyday Practice?"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4762-8738","authenticated-orcid":false,"given":"Damian","family":"Sie\u0144ko","sequence":"first","affiliation":[{"name":"Department of Diabetology and Internal Diseases, Medical University of Warsaw, 02-097 Warsaw, Poland"},{"name":"Doctoral School, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8649-1503","authenticated-orcid":false,"given":"Ilona","family":"Szab\u0142owska-Gadomska","sequence":"additional","affiliation":[{"name":"Laboratory for Cell Research and Application, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nowak-Szwed","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Internal Diseases, Medical University of Warsaw, 02-097 Warsaw, Poland"},{"name":"Doctoral School, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1122-5796","authenticated-orcid":false,"given":"Stefan","family":"Rudzi\u0144ski","sequence":"additional","affiliation":[{"name":"Laboratory for Cell Research and Application, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6738-1150","authenticated-orcid":false,"given":"Maksymilian","family":"Gofron","sequence":"additional","affiliation":[{"name":"Department of Urology, Municipal Complex Hospital, 42-200 Czestochowa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1404-7544","authenticated-orcid":false,"given":"Przemys\u0142aw","family":"Zygmunciak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7140-0541","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Lewandowska-Szumie\u0142","sequence":"additional","affiliation":[{"name":"Laboratory for Cell Research and Application, Medical University of Warsaw, 02-097 Warsaw, Poland"},{"name":"Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech Stanis\u0142aw","family":"Zgliczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leszek","family":"Czupryniak","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Internal Diseases, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1160-9204","authenticated-orcid":false,"given":"Beata","family":"Mrozikiewicz-Rakowska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. 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